JP5069220B2 - マイクロ流体デバイス用の小型光学検出システム - Google Patents

マイクロ流体デバイス用の小型光学検出システム Download PDF

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JP5069220B2
JP5069220B2 JP2008506797A JP2008506797A JP5069220B2 JP 5069220 B2 JP5069220 B2 JP 5069220B2 JP 2008506797 A JP2008506797 A JP 2008506797A JP 2008506797 A JP2008506797 A JP 2008506797A JP 5069220 B2 JP5069220 B2 JP 5069220B2
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optical detection
detection system
light
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JP2008538813A (ja
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アーロン・ルリソン
ジェフリー・エー．・ウォーク
アーネスト・シー．ダブリュウ．・リー
マイケル・スレーター
モルテン・ジェイ．・ジェンセン
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カリパー・ライフ・サイエンシズ・インク．
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/002—Measuring arrangements characterised by the use of optical techniques for measuring two or more coordinates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0162—Arrangements or apparatus for facilitating the optical investigation using microprocessors for control of a sequence of operations, e.g. test, powering, switching, processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0627—Use of several LED's for spectral resolution
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
JP2008506797A 2005-04-12 2006-04-12 マイクロ流体デバイス用の小型光学検出システム Active JP5069220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67073605P 2005-04-12 2005-04-12
US60/670,736 2005-04-12
PCT/US2006/014313 WO2006115863A2 (en) 2005-04-12 2006-04-12 Compact optical detection system for microfluidic devices

Related Child Applications (1)

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JP2011035075A Division JP5078106B2 (ja) 2005-04-12 2011-02-21 マイクロ流体デバイス用の小型光学検出システム

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JP2008538813A JP2008538813A (ja) 2008-11-06
JP5069220B2 true JP5069220B2 (ja) 2012-11-07

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US (1) US7518726B2 (enExample)
EP (2) EP2453223B1 (enExample)
JP (2) JP5069220B2 (enExample)
CN (1) CN101663576B (enExample)
AU (1) AU2006240184A1 (enExample)
CA (1) CA2603759A1 (enExample)
WO (1) WO2006115863A2 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
KR101334183B1 (ko) 2007-06-01 2013-12-02 삼성전자주식회사 미세 반응을 위한 형광 검출 모듈과 이를 구비한 형광 검출시스템
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) * 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
KR100953474B1 (ko) 2008-06-28 2010-04-16 건국대학교 산학협력단 미세유동칩과 마이크로 ｐｉｖ 시스템을 이용한 전자인쇄용잉크의 레올로지 모델 선정방법
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8926906B2 (en) * 2008-07-21 2015-01-06 Concordia University Microfluidic device and method for fabricating the microfluidic device
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US8640555B2 (en) * 2009-02-09 2014-02-04 Bioaccel Performance
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
EP2612132A4 (en) * 2010-08-31 2014-03-12 Canon Us Life Sciences Inc HIGH RESOLUTION FUSION DETECTION OPTICAL SYSTEM
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
WO2012072795A2 (en) * 2010-12-03 2012-06-07 ALERE TECHNOLOGIES GmbH Transformation of material into an optically modulating state via laser radiation
CA3082652A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
CN103959070B (zh) 2011-09-30 2017-05-10 贝克顿·迪金森公司 组合试剂条
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
EP2780705B1 (en) 2011-11-16 2018-09-19 Becton, Dickinson and Company Methods and systems for detecting an analyte in a sample
JP6211534B2 (ja) 2011-12-21 2017-10-11 シャハーフ，キャサリン，エム． 組織表面を整列させる病変を撮像するためのシステム
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP2912182B1 (en) 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
WO2014100434A1 (en) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions and methods for aptamer screening
AU2014205215B2 (en) 2013-01-11 2019-02-14 Becton, Dickinson And Company Low-cost point-of-care assay device
CN103196878A (zh) * 2013-03-18 2013-07-10 杭州德安奇生物工程有限公司 便携式荧光检测器
CN103196879A (zh) * 2013-03-20 2013-07-10 上海如海光电科技有限公司 一种激光诱导荧光光谱检测装置
US20160319361A1 (en) 2013-08-28 2016-11-03 Caris Life Sciences Switzerland Holdings Gmbh Oligonucleotide probes and uses thereof
WO2015069789A1 (en) 2013-11-06 2015-05-14 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
US10018640B2 (en) * 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
TWI498535B (zh) * 2013-12-26 2015-09-01 Chroma Ate Inc An optical detection device with an on-line correction function
CN106605164B (zh) 2014-03-04 2020-04-24 诺瓦达克技术公司 用于宽带成像的中继透镜系统
US10948638B2 (en) 2014-03-04 2021-03-16 Stryker European Operations Limited Spatial and spectral filtering apertures and optical imaging systems including the same
EP3239691B1 (en) 2014-12-26 2021-11-17 Sysmex Corporation Cell imaging device, cell imaging method, and sample cell
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
US9989773B2 (en) 2015-03-30 2018-06-05 Novadaq Technologies, Inc. Multi-channel wide field imaging system and optical system for use therein
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
CN108431649B (zh) 2015-08-31 2021-08-24 史赛克欧洲运营有限公司 偏振依赖滤波器、使用其的系统以及相关联的工具包和方法
AU2017235661B2 (en) 2016-03-18 2023-06-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11293017B2 (en) 2016-05-25 2022-04-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
US20210069706A1 (en) * 2017-12-12 2021-03-11 Trustees Of Boston University Disposable fluidic cartridge for interferometric reflectance imaging sensor
US11561221B2 (en) 2018-05-02 2023-01-24 Trustees Of Boston University Dynamic tracking of captured targets for enhanced digital biosensing
US11344882B2 (en) 2018-07-26 2022-05-31 Boe Technology Group Co., Ltd. Microfluidic apparatus, and method of detecting substance in microfluidic apparatus
IL311084A (en) 2018-11-30 2024-04-01 Caris Mpi Inc New generation molecular characterization
CN109724955B (zh) * 2018-12-21 2021-07-06 南京理工大学 一种基于激发配准的塔姆耦合出射角测算方法与装置
CN109932162B (zh) * 2018-12-21 2020-11-06 南京理工大学 一种基于白光配准的腔模参数检测装置及检测方法
CN113316715B (zh) * 2019-01-31 2024-03-15 快速定量微生物学股份有限公司 一种布置光学装置的盒、组件以及方法
US10656368B1 (en) * 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
CN114829626A (zh) 2019-10-10 2022-07-29 1859公司 用于微流体筛选的方法和系统
CN114585958B (zh) * 2019-10-19 2024-05-28 美国赛库莱特生物有限公司 显微镜和用于使流体通道中的荧光标记成像的方法
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
CA3167961A1 (en) * 2020-02-15 2021-08-19 Heska Corporation Sample cartridges
WO2021202843A1 (en) * 2020-04-01 2021-10-07 Esbiolab Llc Systems and methods for fluorescence imaging
WO2025160418A1 (en) * 2024-01-24 2025-07-31 Armonica Technologies, Inc. Polymer sequencing apparatus, methods and fabrication and use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06281859A (ja) * 1993-01-26 1994-10-07 Minolta Camera Co Ltd 原稿読取用レンズ
US5539764A (en) * 1994-08-24 1996-07-23 Jamar Technologies Co. Laser generated X-ray source
JPH0882740A (ja) * 1994-09-12 1996-03-26 Olympus Optical Co Ltd 読取り用レンズ
US6008892A (en) * 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
FR2784189B3 (fr) * 1998-10-05 2000-11-03 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6533914B1 (en) * 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
WO2001090726A2 (en) * 2000-05-19 2001-11-29 Aclara Biosciences, Inc. Optical alignment in capillary detection using capillary wall scatter
US6970245B2 (en) * 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
JP2003014760A (ja) * 2001-04-27 2003-01-15 Canon Inc プローブ担体、プローブ固定用担体およびそれらの製造方法
US20020174686A1 (en) * 2001-05-07 2002-11-28 The Regents Of The University Of California Method for producing microchannels having circular cross-sections in glass
US7023007B2 (en) * 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
WO2003008902A1 (en) * 2001-07-17 2003-01-30 Caliper Technologies Corp. Methods and systems for alignment of detection optics
US7033910B2 (en) * 2001-09-12 2006-04-25 Reveo, Inc. Method of fabricating multi layer MEMS and microfluidic devices
GB0209329D0 (en) * 2002-04-24 2002-06-05 Imp College Innovations Ltd A device
EP1508029A4 (en) * 2002-05-28 2010-04-14 Autogenomics Inc MULTIREAGENZPACKUNG
DE10301775A1 (de) * 2003-01-18 2004-07-29 Hentze-Lissotschenko Patentverwaltungs Gmbh & Co.Kg Erfassungsvorrichtung für die optische Erfassung eines Objektes, Verfahren zum Betrieb einer derartigen Erfassungsvorrichtung sowie Scannvorrichtung und konfokales Mikroskop
US6985224B2 (en) * 2003-03-14 2006-01-10 The United States Of America As Represented By The Secretary Of The Navy Light emitting diode (LED) array for excitation emission matrix (EEM) fluorescence spectroscopy
JP2004325174A (ja) * 2003-04-23 2004-11-18 Olympus Corp 蛍光検出装置
US7695683B2 (en) * 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7654816B2 (en) * 2004-10-07 2010-02-02 Hewlett-Packard Development Company, L.P. Lithographic mask alignment
WO2006084283A2 (en) * 2005-01-31 2006-08-10 The Board Of Trustees Of The University Of Illinois Methods and devices for characterizing particles in clear and turbid media

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US7518726B2 (en) 2009-04-14
JP2008538813A (ja) 2008-11-06
WO2006115863A2 (en) 2006-11-02
WO2006115863A3 (en) 2009-09-24
CN101663576B (zh) 2012-05-23
CA2603759A1 (en) 2006-11-02
JP2011141286A (ja) 2011-07-21
EP2453223B1 (en) 2019-07-03
EP2453223A1 (en) 2012-05-16
US20060227325A1 (en) 2006-10-12
EP1880197B1 (en) 2019-06-12
JP5078106B2 (ja) 2012-11-21
EP1880197A2 (en) 2008-01-23
AU2006240184A1 (en) 2006-11-02

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