AU2006240184A1 - Compact optical detection system for a microfluidic devices - Google Patents

Compact optical detection system for a microfluidic devices Download PDF

Info

Publication number
AU2006240184A1
AU2006240184A1 AU2006240184A AU2006240184A AU2006240184A1 AU 2006240184 A1 AU2006240184 A1 AU 2006240184A1 AU 2006240184 A AU2006240184 A AU 2006240184A AU 2006240184 A AU2006240184 A AU 2006240184A AU 2006240184 A1 AU2006240184 A1 AU 2006240184A1
Authority
AU
Australia
Prior art keywords
alignment marks
channels
microfluidic device
optical
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2006240184A
Other languages
English (en)
Inventor
Morten J. Jensen
Ernest C.W. Lee
Aaron Rulison
Michael Slater
Jeffrey A. Wolk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliper Life Sciences Inc
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Publication of AU2006240184A1 publication Critical patent/AU2006240184A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/002—Measuring arrangements characterised by the use of optical techniques for measuring two or more coordinates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0162—Arrangements or apparatus for facilitating the optical investigation using microprocessors for control of a sequence of operations, e.g. test, powering, switching, processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0627—Use of several LED's for spectral resolution
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
AU2006240184A 2005-04-12 2006-04-12 Compact optical detection system for a microfluidic devices Abandoned AU2006240184A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67073605P 2005-04-12 2005-04-12
US60/670,736 2005-04-12
PCT/US2006/014313 WO2006115863A2 (en) 2005-04-12 2006-04-12 Compact optical detection system for microfluidic devices

Publications (1)

Publication Number Publication Date
AU2006240184A1 true AU2006240184A1 (en) 2006-11-02

Family

ID=37215227

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006240184A Abandoned AU2006240184A1 (en) 2005-04-12 2006-04-12 Compact optical detection system for a microfluidic devices

Country Status (7)

Country Link
US (1) US7518726B2 (enExample)
EP (2) EP2453223B1 (enExample)
JP (2) JP5069220B2 (enExample)
CN (1) CN101663576B (enExample)
AU (1) AU2006240184A1 (enExample)
CA (1) CA2603759A1 (enExample)
WO (1) WO2006115863A2 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
KR101334183B1 (ko) 2007-06-01 2013-12-02 삼성전자주식회사 미세 반응을 위한 형광 검출 모듈과 이를 구비한 형광 검출시스템
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
KR100953474B1 (ko) 2008-06-28 2010-04-16 건국대학교 산학협력단 미세유동칩과 마이크로 piv 시스템을 이용한 전자인쇄용잉크의 레올로지 모델 선정방법
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CA2731413A1 (en) * 2008-07-21 2010-01-28 Valorbec S.E.C. A microfluidic device and method for fabricating the microfluidic device
EP2350320A4 (en) 2008-11-12 2012-11-14 Caris Life Sciences Luxembourg Holdings METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
JP2013544490A (ja) * 2010-08-31 2013-12-19 キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッド 高分解能熱融解の検出のための光学システム
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
CN103442809B (zh) * 2010-12-03 2016-09-14 美艾利尔技术公司 通过激光照射把材料转换成光学调制状态
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
DK2761305T3 (da) 2011-09-30 2017-11-20 Becton Dickinson Co Forenet reagensstrimmel
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
US9523682B2 (en) 2011-11-16 2016-12-20 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
EP3466335B1 (en) 2011-12-21 2024-07-31 Catherine M. Shachaf Fluorescence imaging autofocus method
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
AU2014205215B2 (en) 2013-01-11 2019-02-14 Becton, Dickinson And Company Low-cost point-of-care assay device
CN103196878A (zh) * 2013-03-18 2013-07-10 杭州德安奇生物工程有限公司 便携式荧光检测器
CN103196879A (zh) * 2013-03-20 2013-07-10 上海如海光电科技有限公司 一种激光诱导荧光光谱检测装置
BR112016004153A2 (pt) 2013-08-28 2019-09-17 Caris Life Sciences Switzerland Holdings Gmbh "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero
CN113477149B (zh) 2013-11-06 2023-09-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
JP6518245B2 (ja) * 2013-11-13 2019-05-22 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 光学撮像システム及びそれを用いた方法
TWI498535B (zh) * 2013-12-26 2015-09-01 Chroma Ate Inc An optical detection device with an on-line correction function
KR101949571B1 (ko) 2014-03-04 2019-02-18 노바다크 테크놀러지즈 유엘씨 광대역 이미징을 위한 릴레이 렌즈 시스템
JP6479035B2 (ja) 2014-03-04 2019-03-06 ノバダック テクノロジーズ ユーエルシー 空間およびスペクトルフィルタリング開口およびそれを含む光学イメージングシステム
WO2016103728A1 (ja) * 2014-12-26 2016-06-30 シスメックス株式会社 細胞撮像装置、細胞撮像方法及び試料セル
US20180066262A1 (en) 2015-03-09 2018-03-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP4056967B1 (en) * 2015-03-30 2025-03-12 Stryker Corporation Multi-channel wide field imaging system and optical system for use therein
WO2017004243A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
EP3345024B1 (en) 2015-08-31 2023-05-31 Stryker European Operations Limited Imaging system comprising a polarization filter and method of filtering polarized light in an imaging system
AU2017235661B2 (en) 2016-03-18 2023-06-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
IL298701B2 (en) 2016-05-25 2024-03-01 Caris Science Inc Oligonucleotide probes and uses thereof
US20210069706A1 (en) * 2017-12-12 2021-03-11 Trustees Of Boston University Disposable fluidic cartridge for interferometric reflectance imaging sensor
US11561221B2 (en) 2018-05-02 2023-01-24 Trustees Of Boston University Dynamic tracking of captured targets for enhanced digital biosensing
WO2020019809A1 (en) * 2018-07-26 2020-01-30 Boe Technology Group Co., Ltd. Microfluidic apparatus, method of detecting substance in microfluidic apparatus, and spectrometer
KR20210111254A (ko) 2018-11-30 2021-09-10 캐리스 엠피아이, 아이엔씨. 차세대 분자 프로파일링
CN109932162B (zh) * 2018-12-21 2020-11-06 南京理工大学 一种基于白光配准的腔模参数检测装置及检测方法
CN109724955B (zh) * 2018-12-21 2021-07-06 南京理工大学 一种基于激发配准的塔姆耦合出射角测算方法与装置
CN113316715B (zh) * 2019-01-31 2024-03-15 快速定量微生物学股份有限公司 一种布置光学装置的盒、组件以及方法
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
AU2020361681A1 (en) 2019-10-10 2022-05-05 1859, Inc. Methods and systems for microfluidic screening
CN114585958B (zh) * 2019-10-19 2024-05-28 美国赛库莱特生物有限公司 显微镜和用于使流体通道中的荧光标记成像的方法
IL293489A (en) 2019-12-02 2022-08-01 Caris Mpi Inc predictor of pan-cancer platinum response
MX2022009999A (es) 2020-02-14 2023-01-19 Caris Mpi Inc Puntuacion de prevalencia genomica panomica.
US20210252508A1 (en) * 2020-02-15 2021-08-19 Heska Corporation Sample cartridges
CN114829628A (zh) * 2020-04-01 2022-07-29 艾斯生物实验室有限责任公司 用于荧光成像的系统和方法
AU2021416188A1 (en) 2020-12-31 2023-07-06 Orlucent, Inc. Systems and methods for assessing tissue remodeling
US20250172488A1 (en) * 2022-02-28 2025-05-29 Bio-Rad Laboratories, Inc. Wide-spectrum analysis system
CN117451623A (zh) * 2022-07-18 2024-01-26 中国石油化工股份有限公司 用于光学检测的消色差准直光源和光学检测系统
WO2025160418A1 (en) * 2024-01-24 2025-07-31 Armonica Technologies, Inc. Polymer sequencing apparatus, methods and fabrication and use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06281859A (ja) * 1993-01-26 1994-10-07 Minolta Camera Co Ltd 原稿読取用レンズ
US5539764A (en) * 1994-08-24 1996-07-23 Jamar Technologies Co. Laser generated X-ray source
JPH0882740A (ja) * 1994-09-12 1996-03-26 Olympus Optical Co Ltd 読取り用レンズ
US6008892A (en) 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
FR2784189B3 (fr) * 1998-10-05 2000-11-03 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6533914B1 (en) * 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
ATE340025T1 (de) * 2000-01-06 2006-10-15 Caliper Life Sciences Inc Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US6515753B2 (en) 2000-05-19 2003-02-04 Aclara Biosciences, Inc. Optical alignment in capillary detection using capillary wall scatter
US6970245B2 (en) 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
JP2003014760A (ja) * 2001-04-27 2003-01-15 Canon Inc プローブ担体、プローブ固定用担体およびそれらの製造方法
US20020174686A1 (en) * 2001-05-07 2002-11-28 The Regents Of The University Of California Method for producing microchannels having circular cross-sections in glass
US7023007B2 (en) * 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
WO2003008902A1 (en) * 2001-07-17 2003-01-30 Caliper Technologies Corp. Methods and systems for alignment of detection optics
US7033910B2 (en) * 2001-09-12 2006-04-25 Reveo, Inc. Method of fabricating multi layer MEMS and microfluidic devices
GB0209329D0 (en) 2002-04-24 2002-06-05 Imp College Innovations Ltd A device
EP1508028A4 (en) * 2002-05-28 2009-05-20 Autogenomics Inc Integrated sample preparation platform
DE10301775A1 (de) 2003-01-18 2004-07-29 Hentze-Lissotschenko Patentverwaltungs Gmbh & Co.Kg Erfassungsvorrichtung für die optische Erfassung eines Objektes, Verfahren zum Betrieb einer derartigen Erfassungsvorrichtung sowie Scannvorrichtung und konfokales Mikroskop
US6985224B2 (en) 2003-03-14 2006-01-10 The United States Of America As Represented By The Secretary Of The Navy Light emitting diode (LED) array for excitation emission matrix (EEM) fluorescence spectroscopy
JP2004325174A (ja) * 2003-04-23 2004-11-18 Olympus Corp 蛍光検出装置
CA2526368A1 (en) * 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7654816B2 (en) * 2004-10-07 2010-02-02 Hewlett-Packard Development Company, L.P. Lithographic mask alignment
MX2007009124A (es) * 2005-01-31 2007-10-08 Univ Illinois Metodos y dispositivos para caracterizar particulas en medios transparentes y turbios.

Also Published As

Publication number Publication date
JP5069220B2 (ja) 2012-11-07
EP1880197A2 (en) 2008-01-23
US7518726B2 (en) 2009-04-14
WO2006115863A3 (en) 2009-09-24
EP1880197B1 (en) 2019-06-12
JP2011141286A (ja) 2011-07-21
US20060227325A1 (en) 2006-10-12
EP2453223A1 (en) 2012-05-16
JP5078106B2 (ja) 2012-11-21
WO2006115863A2 (en) 2006-11-02
CN101663576A (zh) 2010-03-03
EP2453223B1 (en) 2019-07-03
JP2008538813A (ja) 2008-11-06
CA2603759A1 (en) 2006-11-02
CN101663576B (zh) 2012-05-23

Similar Documents

Publication Publication Date Title
US7518726B2 (en) Compact optical detection system for a microfluidic device
JP7097969B2 (ja) 顕微鏡システムおよびこの種の顕微鏡システムを用いた顕微鏡結像のための方法
US7692783B2 (en) Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US8149399B2 (en) Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP2745094B1 (en) Optical biosensor with a plurality of sensor regions
EP2622397B1 (en) Calibration targets for microscope imaging
US9581550B2 (en) Analytical devices having compact lens train arrays
CN101467089B (zh) 具有多个快门元件的成像装置
CN114002197B (zh) 发光检测装置
US10634890B1 (en) Miniaturized microscope for phase contrast and multicolor fluorescence imaging
WO2007115357A1 (en) Imaging apparatus with a plurality of shutter elements
GB2363857A (en) Nipkow disk confocal scanner with optical image separation system
JP6975704B2 (ja) 多色検出装置
KR100429637B1 (ko) 다중 광로 광원장치 및 그 동작방법
US20250172488A1 (en) Wide-spectrum analysis system
AU2011202922A1 (en) Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted