JP5069220B2 - マイクロ流体デバイス用の小型光学検出システム - Google Patents
マイクロ流体デバイス用の小型光学検出システム Download PDFInfo
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- JP5069220B2 JP5069220B2 JP2008506797A JP2008506797A JP5069220B2 JP 5069220 B2 JP5069220 B2 JP 5069220B2 JP 2008506797 A JP2008506797 A JP 2008506797A JP 2008506797 A JP2008506797 A JP 2008506797A JP 5069220 B2 JP5069220 B2 JP 5069220B2
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Classifications
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- G01B11/00—Measuring arrangements characterised by the use of optical techniques
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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Description
本出願は米国仮特許出願第60/670,736号、2005年4月12日出願、標題「マイクロ流体デバイスのための光学検出(Optical Detection for Microfluidic Devices)」の優先権を主張すると共に該米国仮特許出願をあらゆる目的のためここで援用する。
一般に本発明は検出光学の分野に関する。特に、本発明は蛍光信号を検出するための小型光学システムと、小型光学検出システムに適合するドライフォーカス式マイクロ流体デバイスとに関するものである。
本発明の態様の一つは、マイクロ流体デバイス用の光学検出システムである。本システムは発光ダイオード(LED)と;LEDにより発せられた光を平行にするための手段と;非球面の溶融石英製対物レンズと;平行光を対物レンズを通してマイクロ流体デバイス上に向かわせるための手段と;マイクロ流体デバイスから発せられる蛍光信号を検出するための手段とを備える。システムは第2の外部光源を含むこともでき、これはLED又はレーザーでよい。対物レンズからマイクロ流体デバイスまでの作動距離の大きさは、LED又はレーザーからの光が対角経路に沿って取り込まれてマイクロ流体デバイスを照射できるような大きさとし得る。
図面の簡単な説明
110 LED光源
120 スリット
130 スリットレンズ
140 励起帯域通過フィルター
150 ビームスプリッター
160 対物レンズ
165 マイクロ流体デバイス
170 除去フィルター
180 回折格子
190 CCDレンズ
195 CCDアレー
Claims (5)
- 光学検出システムに用いられるドライフォーカス式マイクロ流体デバイスであって、
第1の基板と;
少なくとも1つのチャンネルがマイクロ流体チャンネルである前記第1の基板内に形成された複数のチャンネルと;
前記複数のチャンネルから間隔をあけて前記第1の基板内に形成された複数の光学位置合せマークであって、当該複数の位置合せマークの各々は湾曲壁を有するものであると共に、外部から光が斜めに取り入れられると当該光を前記光学検出システムに向ける角度にて前記湾曲壁で反射させるものであり、前記光は前記光学検出システムを形成するために用いられるものである、前記複数の光学位置合せマークと;
前記チャンネルが覆われると共に前記光学検出システム位置合せマークが閉鎖されるように前記第1の基板に接着される第2の基板と
を備え、
前記複数のチャンネルのうち少なくとも1つのチャンネルが少なくとも2つの光学位置合わせマークの間に配置されており、当該少なくとも1つのチャンネルから発せられる蛍光信号は前記光学検出システム内に配置された検出手段によって検出されるものであり、
このドライフォーカス式マイクロ流体デバイスは、前記光学検出システムが前記少なくとも1つのチャンネルからの蛍光信号を感知するように、前記光学検出システムにおける所定の位置に配置されるものである
ことを特徴とするドライフォーカス式マイクロ流体デバイス。 - 前記光学位置合せマークが2つの列を形成し、前記複数のチャンネルが少なくとも2つの平行なチャンネルを含み、前記平行なチャンネルが前記2つの列の間に配置される、請求項1に記載のデバイス。
- 前記光学位置合せマークがエッチング、スタンピング、エンボス加工、モールディング、レーザーアブレーション、及びそれらの組み合わせからなる群から選択された方法によって形成される、請求項1に記載のデバイス。
- 前記光学位置合せマークが等方性エッチ液と10×10μmの正方形のマスクとを用いて前記基板中にエッチングされる、請求項1に記載のデバイス。
- 前記デバイスが12個以上の平行なチャンネルと22個以上の光学位置合せマークとを含み、前記光学位置合せマークが各列11個の光学位置合せマークを2列形成し、該列が前記チャンネルの外側にて前記チャンネルに平行に配置される、請求項1に記載のデバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67073605P | 2005-04-12 | 2005-04-12 | |
US60/670,736 | 2005-04-12 | ||
PCT/US2006/014313 WO2006115863A2 (en) | 2005-04-12 | 2006-04-12 | Compact optical detection system for microfluidic devices |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011035075A Division JP5078106B2 (ja) | 2005-04-12 | 2011-02-21 | マイクロ流体デバイス用の小型光学検出システム |
Publications (2)
Publication Number | Publication Date |
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JP2008538813A JP2008538813A (ja) | 2008-11-06 |
JP5069220B2 true JP5069220B2 (ja) | 2012-11-07 |
Family
ID=37215227
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008506797A Active JP5069220B2 (ja) | 2005-04-12 | 2006-04-12 | マイクロ流体デバイス用の小型光学検出システム |
JP2011035075A Active JP5078106B2 (ja) | 2005-04-12 | 2011-02-21 | マイクロ流体デバイス用の小型光学検出システム |
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JP2011035075A Active JP5078106B2 (ja) | 2005-04-12 | 2011-02-21 | マイクロ流体デバイス用の小型光学検出システム |
Country Status (7)
Country | Link |
---|---|
US (1) | US7518726B2 (ja) |
EP (2) | EP2453223B1 (ja) |
JP (2) | JP5069220B2 (ja) |
CN (1) | CN101663576B (ja) |
AU (1) | AU2006240184A1 (ja) |
CA (1) | CA2603759A1 (ja) |
WO (1) | WO2006115863A2 (ja) |
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CN101663576B (zh) | 2012-05-23 |
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WO2006115863A3 (en) | 2009-09-24 |
EP2453223B1 (en) | 2019-07-03 |
US7518726B2 (en) | 2009-04-14 |
WO2006115863A2 (en) | 2006-11-02 |
CN101663576A (zh) | 2010-03-03 |
JP2011141286A (ja) | 2011-07-21 |
EP1880197A2 (en) | 2008-01-23 |
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