CA2603759A1 - Compact optical detection system for a microfluidic device - Google Patents
Compact optical detection system for a microfluidic device Download PDFInfo
- Publication number
- CA2603759A1 CA2603759A1 CA002603759A CA2603759A CA2603759A1 CA 2603759 A1 CA2603759 A1 CA 2603759A1 CA 002603759 A CA002603759 A CA 002603759A CA 2603759 A CA2603759 A CA 2603759A CA 2603759 A1 CA2603759 A1 CA 2603759A1
- Authority
- CA
- Canada
- Prior art keywords
- alignment marks
- microfluidic device
- channels
- optical
- lens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 80
- 238000001514 detection method Methods 0.000 title claims abstract description 55
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000005350 fused silica glass Substances 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims description 19
- 230000005284 excitation Effects 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 12
- 238000003491 array Methods 0.000 claims description 9
- 238000005286 illumination Methods 0.000 claims description 4
- 238000013480 data collection Methods 0.000 claims description 2
- 238000004049 embossing Methods 0.000 claims description 2
- 238000005530 etching Methods 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 238000004590 computer program Methods 0.000 claims 2
- 239000011521 glass Substances 0.000 description 10
- 239000003086 colorant Substances 0.000 description 7
- 239000000975 dye Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 230000007547 defect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 230000004075 alteration Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 229910001635 magnesium fluoride Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 241000511976 Hoya Species 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001444 catalytic combustion detection Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000005361 soda-lime glass Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/002—Measuring arrangements characterised by the use of optical techniques for measuring two or more coordinates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0162—Arrangements or apparatus for facilitating the optical investigation using microprocessors for control of a sequence of operations, e.g. test, powering, switching, processing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
- G01N2201/0627—Use of several LED's for spectral resolution
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67073605P | 2005-04-12 | 2005-04-12 | |
| US60/670,736 | 2005-04-12 | ||
| PCT/US2006/014313 WO2006115863A2 (en) | 2005-04-12 | 2006-04-12 | Compact optical detection system for microfluidic devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2603759A1 true CA2603759A1 (en) | 2006-11-02 |
Family
ID=37215227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002603759A Abandoned CA2603759A1 (en) | 2005-04-12 | 2006-04-12 | Compact optical detection system for a microfluidic device |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7518726B2 (enExample) |
| EP (2) | EP2453223B1 (enExample) |
| JP (2) | JP5069220B2 (enExample) |
| CN (1) | CN101663576B (enExample) |
| AU (1) | AU2006240184A1 (enExample) |
| CA (1) | CA2603759A1 (enExample) |
| WO (1) | WO2006115863A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| JP4996248B2 (ja) | 2003-07-31 | 2012-08-08 | ハンディーラブ インコーポレイテッド | 粒子含有サンプルの処理 |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8656949B2 (en) * | 2006-08-15 | 2014-02-25 | University Of Maryland College Park | Microfluidic devices and methods of fabrication |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| KR101334183B1 (ko) | 2007-06-01 | 2013-12-02 | 삼성전자주식회사 | 미세 반응을 위한 형광 검출 모듈과 이를 구비한 형광 검출시스템 |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8287820B2 (en) * | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8016260B2 (en) | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
| KR100953474B1 (ko) | 2008-06-28 | 2010-04-16 | 건국대학교 산학협력단 | 미세유동칩과 마이크로 ｐｉｖ 시스템을 이용한 전자인쇄용잉크의 레올로지 모델 선정방법 |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US8926906B2 (en) * | 2008-07-21 | 2015-01-06 | Concordia University | Microfluidic device and method for fabricating the microfluidic device |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| US8100293B2 (en) | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
| US8640555B2 (en) * | 2009-02-09 | 2014-02-04 | Bioaccel | Performance |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| EP2612132A4 (en) * | 2010-08-31 | 2014-03-12 | Canon Us Life Sciences Inc | HIGH RESOLUTION FUSION DETECTION OPTICAL SYSTEM |
| US9387476B2 (en) | 2010-10-27 | 2016-07-12 | Illumina, Inc. | Flow cells for biological or chemical analysis |
| WO2012072795A2 (en) * | 2010-12-03 | 2012-06-07 | ALERE TECHNOLOGIES GmbH | Transformation of material into an optically modulating state via laser radiation |
| CA3082652A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
| CN103959070B (zh) | 2011-09-30 | 2017-05-10 | 贝克顿·迪金森公司 | 组合试剂条 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| EP2780705B1 (en) | 2011-11-16 | 2018-09-19 | Becton, Dickinson and Company | Methods and systems for detecting an analyte in a sample |
| JP6211534B2 (ja) | 2011-12-21 | 2017-10-11 | シャハーフ，キャサリン，エム． | 組織表面を整列させる病変を撮像するためのシステム |
| ES2978107T3 (es) | 2012-02-03 | 2024-09-05 | Becton Dickinson Co | Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2912182B1 (en) | 2012-10-23 | 2021-12-08 | Caris Science, Inc. | Aptamers and uses thereof |
| WO2014100434A1 (en) | 2012-12-19 | 2014-06-26 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| AU2014205215B2 (en) | 2013-01-11 | 2019-02-14 | Becton, Dickinson And Company | Low-cost point-of-care assay device |
| CN103196878A (zh) * | 2013-03-18 | 2013-07-10 | 杭州德安奇生物工程有限公司 | 便携式荧光检测器 |
| CN103196879A (zh) * | 2013-03-20 | 2013-07-10 | 上海如海光电科技有限公司 | 一种激光诱导荧光光谱检测装置 |
| US20160319361A1 (en) | 2013-08-28 | 2016-11-03 | Caris Life Sciences Switzerland Holdings Gmbh | Oligonucleotide probes and uses thereof |
| WO2015069789A1 (en) | 2013-11-06 | 2015-05-14 | Becton, Dickinson And Company | Microfluidic devices, and methods of making and using the same |
| US10018640B2 (en) * | 2013-11-13 | 2018-07-10 | Becton, Dickinson And Company | Optical imaging system and methods for using the same |
| TWI498535B (zh) * | 2013-12-26 | 2015-09-01 | Chroma Ate Inc | An optical detection device with an on-line correction function |
| CN106605164B (zh) | 2014-03-04 | 2020-04-24 | 诺瓦达克技术公司 | 用于宽带成像的中继透镜系统 |
| US10948638B2 (en) | 2014-03-04 | 2021-03-16 | Stryker European Operations Limited | Spatial and spectral filtering apertures and optical imaging systems including the same |
| EP3239691B1 (en) | 2014-12-26 | 2021-11-17 | Sysmex Corporation | Cell imaging device, cell imaging method, and sample cell |
| WO2016145128A1 (en) | 2015-03-09 | 2016-09-15 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| US9989773B2 (en) | 2015-03-30 | 2018-06-05 | Novadaq Technologies, Inc. | Multi-channel wide field imaging system and optical system for use therein |
| US10590425B2 (en) | 2015-06-29 | 2020-03-17 | Caris Science, Inc. | Therapeutic oligonucleotides |
| US10941176B2 (en) | 2015-07-28 | 2021-03-09 | Caris Science, Inc. | Therapeutic oligonucleotides |
| CN108431649B (zh) | 2015-08-31 | 2021-08-24 | 史赛克欧洲运营有限公司 | 偏振依赖滤波器、使用其的系统以及相关联的工具包和方法 |
| AU2017235661B2 (en) | 2016-03-18 | 2023-06-08 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| US11293017B2 (en) | 2016-05-25 | 2022-04-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| US20210069706A1 (en) * | 2017-12-12 | 2021-03-11 | Trustees Of Boston University | Disposable fluidic cartridge for interferometric reflectance imaging sensor |
| US11561221B2 (en) | 2018-05-02 | 2023-01-24 | Trustees Of Boston University | Dynamic tracking of captured targets for enhanced digital biosensing |
| US11344882B2 (en) | 2018-07-26 | 2022-05-31 | Boe Technology Group Co., Ltd. | Microfluidic apparatus, and method of detecting substance in microfluidic apparatus |
| IL311084A (en) | 2018-11-30 | 2024-04-01 | Caris Mpi Inc | New generation molecular characterization |
| CN109724955B (zh) * | 2018-12-21 | 2021-07-06 | 南京理工大学 | 一种基于激发配准的塔姆耦合出射角测算方法与装置 |
| CN109932162B (zh) * | 2018-12-21 | 2020-11-06 | 南京理工大学 | 一种基于白光配准的腔模参数检测装置及检测方法 |
| CN113316715B (zh) * | 2019-01-31 | 2024-03-15 | 快速定量微生物学股份有限公司 | 一种布置光学装置的盒、组件以及方法 |
| US10656368B1 (en) * | 2019-07-24 | 2020-05-19 | Omniome, Inc. | Method and system for biological imaging using a wide field objective lens |
| CN114829626A (zh) | 2019-10-10 | 2022-07-29 | 1859公司 | 用于微流体筛选的方法和系统 |
| CN114585958B (zh) * | 2019-10-19 | 2024-05-28 | 美国赛库莱特生物有限公司 | 显微镜和用于使流体通道中的荧光标记成像的方法 |
| WO2021112918A1 (en) | 2019-12-02 | 2021-06-10 | Caris Mpi, Inc. | Pan-cancer platinum response predictor |
| CA3167961A1 (en) * | 2020-02-15 | 2021-08-19 | Heska Corporation | Sample cartridges |
| WO2021202843A1 (en) * | 2020-04-01 | 2021-10-07 | Esbiolab Llc | Systems and methods for fluorescence imaging |
| WO2025160418A1 (en) * | 2024-01-24 | 2025-07-31 | Armonica Technologies, Inc. | Polymer sequencing apparatus, methods and fabrication and use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06281859A (ja) * | 1993-01-26 | 1994-10-07 | Minolta Camera Co Ltd | 原稿読取用レンズ |
| US5539764A (en) * | 1994-08-24 | 1996-07-23 | Jamar Technologies Co. | Laser generated X-ray source |
| JPH0882740A (ja) * | 1994-09-12 | 1996-03-26 | Olympus Optical Co Ltd | 読取り用レンズ |
| US6008892A (en) * | 1997-05-23 | 1999-12-28 | Molecular Dynamics, Inc. | Optical substrate for enhanced detectability of fluorescence |
| FR2784189B3 (fr) * | 1998-10-05 | 2000-11-03 | Commissariat Energie Atomique | Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire |
| US6498497B1 (en) * | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration |
| US6533914B1 (en) * | 1999-07-08 | 2003-03-18 | Shaorong Liu | Microfabricated injector and capillary array assembly for high-resolution and high throughput separation |
| US6620625B2 (en) * | 2000-01-06 | 2003-09-16 | Caliper Technologies Corp. | Ultra high throughput sampling and analysis systems and methods |
| US6589729B2 (en) * | 2000-02-04 | 2003-07-08 | Caliper Technologies Corp. | Methods, devices, and systems for monitoring time dependent reactions |
| WO2001090726A2 (en) * | 2000-05-19 | 2001-11-29 | Aclara Biosciences, Inc. | Optical alignment in capillary detection using capillary wall scatter |
| US6970245B2 (en) * | 2000-08-02 | 2005-11-29 | Honeywell International Inc. | Optical alignment detection system |
| US7097809B2 (en) * | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
| JP2003014760A (ja) * | 2001-04-27 | 2003-01-15 | Canon Inc | プローブ担体、プローブ固定用担体およびそれらの製造方法 |
| US20020174686A1 (en) * | 2001-05-07 | 2002-11-28 | The Regents Of The University Of California | Method for producing microchannels having circular cross-sections in glass |
| US7023007B2 (en) * | 2001-07-17 | 2006-04-04 | Caliper Life Sciences, Inc. | Methods and systems for alignment of detection optics |
| WO2003008902A1 (en) * | 2001-07-17 | 2003-01-30 | Caliper Technologies Corp. | Methods and systems for alignment of detection optics |
| US7033910B2 (en) * | 2001-09-12 | 2006-04-25 | Reveo, Inc. | Method of fabricating multi layer MEMS and microfluidic devices |
| GB0209329D0 (en) * | 2002-04-24 | 2002-06-05 | Imp College Innovations Ltd | A device |
| EP1508029A4 (en) * | 2002-05-28 | 2010-04-14 | Autogenomics Inc | MULTIREAGENZPACKUNG |
| DE10301775A1 (de) * | 2003-01-18 | 2004-07-29 | Hentze-Lissotschenko Patentverwaltungs Gmbh & Co.Kg | Erfassungsvorrichtung für die optische Erfassung eines Objektes, Verfahren zum Betrieb einer derartigen Erfassungsvorrichtung sowie Scannvorrichtung und konfokales Mikroskop |
| US6985224B2 (en) * | 2003-03-14 | 2006-01-10 | The United States Of America As Represented By The Secretary Of The Navy | Light emitting diode (LED) array for excitation emission matrix (EEM) fluorescence spectroscopy |
| JP2004325174A (ja) * | 2003-04-23 | 2004-11-18 | Olympus Corp | 蛍光検出装置 |
| US7695683B2 (en) * | 2003-05-20 | 2010-04-13 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
| US7654816B2 (en) * | 2004-10-07 | 2010-02-02 | Hewlett-Packard Development Company, L.P. | Lithographic mask alignment |
| WO2006084283A2 (en) * | 2005-01-31 | 2006-08-10 | The Board Of Trustees Of The University Of Illinois | Methods and devices for characterizing particles in clear and turbid media |
-
2006
- 2006-04-12 JP JP2008506797A patent/JP5069220B2/ja active Active
- 2006-04-12 AU AU2006240184A patent/AU2006240184A1/en not_active Abandoned
- 2006-04-12 CA CA002603759A patent/CA2603759A1/en not_active Abandoned
- 2006-04-12 US US11/404,043 patent/US7518726B2/en active Active
- 2006-04-12 EP EP11190622.8A patent/EP2453223B1/en active Active
- 2006-04-12 EP EP06769836.5A patent/EP1880197B1/en active Active
- 2006-04-12 CN CN200680011481XA patent/CN101663576B/zh active Active
- 2006-04-12 WO PCT/US2006/014313 patent/WO2006115863A2/en not_active Ceased
-
2011
- 2011-02-21 JP JP2011035075A patent/JP5078106B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101663576A (zh) | 2010-03-03 |
| US7518726B2 (en) | 2009-04-14 |
| JP2008538813A (ja) | 2008-11-06 |
| WO2006115863A2 (en) | 2006-11-02 |
| WO2006115863A3 (en) | 2009-09-24 |
| CN101663576B (zh) | 2012-05-23 |
| JP2011141286A (ja) | 2011-07-21 |
| JP5069220B2 (ja) | 2012-11-07 |
| EP2453223B1 (en) | 2019-07-03 |
| EP2453223A1 (en) | 2012-05-16 |
| US20060227325A1 (en) | 2006-10-12 |
| EP1880197B1 (en) | 2019-06-12 |
| JP5078106B2 (ja) | 2012-11-21 |
| EP1880197A2 (en) | 2008-01-23 |
| AU2006240184A1 (en) | 2006-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7518726B2 (en) | Compact optical detection system for a microfluidic device | |
| JP7097969B2 (ja) | 顕微鏡システムおよびこの種の顕微鏡システムを用いた顕微鏡結像のための方法 | |
| US8149399B2 (en) | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources | |
| EP2745094B1 (en) | Optical biosensor with a plurality of sensor regions | |
| EP2960644B1 (en) | System and method for telecentric wide-field fluorescence imaging | |
| US9945781B2 (en) | Analytical devices having dichroic prism arrays | |
| EP2622397B1 (en) | Calibration targets for microscope imaging | |
| WO2007095235A2 (en) | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources | |
| US20090109518A1 (en) | Imaging apparatus with a plurality of shutter elements | |
| US11092794B2 (en) | Angularly-selective illumination | |
| US20200132975A1 (en) | Miniaturized microscope for phase contrast and multicolor fluorescence imaging | |
| EP1168029A2 (en) | Optical image separation system and confocal scanner unit | |
| JP6975704B2 (ja) | 多色検出装置 | |
| CN101467089B (zh) | 具有多个快门元件的成像装置 | |
| AU2011202922A1 (en) | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |