JP5009613B2 - 不斉合成における使用のためのキラル配位子 - Google Patents

不斉合成における使用のためのキラル配位子 Download PDF

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Publication number
JP5009613B2
JP5009613B2 JP2006515817A JP2006515817A JP5009613B2 JP 5009613 B2 JP5009613 B2 JP 5009613B2 JP 2006515817 A JP2006515817 A JP 2006515817A JP 2006515817 A JP2006515817 A JP 2006515817A JP 5009613 B2 JP5009613 B2 JP 5009613B2
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JP
Japan
Prior art keywords
formula
compound
bis
diyl
chr
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Expired - Lifetime
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JP2006515817A
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English (en)
Japanese (ja)
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JP2006527221A5 (enExample
JP2006527221A (ja
Inventor
メセゲル ベンハミン
アールト ディーター
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority claimed from DE2003127109 external-priority patent/DE10327109A1/de
Priority claimed from DE2003137013 external-priority patent/DE10337013A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of JP2006527221A publication Critical patent/JP2006527221A/ja
Publication of JP2006527221A5 publication Critical patent/JP2006527221A5/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/1875—Phosphinites (R2P(OR), their isomeric phosphine oxides (R3P=O) and RO-substitution derivatives thereof)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5329—Polyphosphine oxides or thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2006515817A 2003-06-13 2004-06-02 不斉合成における使用のためのキラル配位子 Expired - Lifetime JP5009613B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE2003127109 DE10327109A1 (de) 2003-06-13 2003-06-13 Liganden zur Anwendung in stereoselektiven Synthesen
DE10327109.0 2003-06-13
DE2003137013 DE10337013A1 (de) 2003-08-12 2003-08-12 Chirale Liganden zur Anwendung in asymmetrischen Synthesen
DE10337013.7 2003-08-12
PCT/EP2004/005930 WO2004111063A2 (de) 2003-06-13 2004-06-02 Chirale liganden zur anwendung in asymmetrischen synthesen

Publications (3)

Publication Number Publication Date
JP2006527221A JP2006527221A (ja) 2006-11-30
JP2006527221A5 JP2006527221A5 (enExample) 2007-06-07
JP5009613B2 true JP5009613B2 (ja) 2012-08-22

Family

ID=33553457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006515817A Expired - Lifetime JP5009613B2 (ja) 2003-06-13 2004-06-02 不斉合成における使用のためのキラル配位子

Country Status (5)

Country Link
US (2) US7396947B2 (enExample)
EP (1) EP1636243B1 (enExample)
JP (1) JP5009613B2 (enExample)
ES (1) ES2443994T3 (enExample)
WO (1) WO2004111063A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4905917B2 (ja) * 2005-12-27 2012-03-28 株式会社ダイセル ビニルエーテル化合物の製造法
WO2018189107A1 (en) * 2017-04-11 2018-10-18 Dsm Ip Assets B.V. A new chiral biphenyl diphosphine ligand and process for preparation thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE128140T1 (de) * 1989-05-18 1995-10-15 Hoffmann La Roche Phosphorverbindungen.
DE19522293A1 (de) 1995-06-20 1997-01-02 Bayer Ag Neue Bisphospine als Katalysatoren für asymmetrische Reaktionen
US6162929A (en) * 1997-12-23 2000-12-19 Hoffmann-La Roche Inc. Process for the manufacture of bisphosphine oxide and bisphosphonate compounds
JP3549390B2 (ja) * 1998-03-23 2004-08-04 高砂香料工業株式会社 ルテニウム−ホスフィン錯体及びその製造方法
JP3146187B2 (ja) * 1998-06-26 2001-03-12 高砂香料工業株式会社 ジホスフィンオキシドの新規な製造方法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
ES2263487T3 (es) 1999-09-20 2006-12-16 The Penn State Research Foundation Fosfinas quirales, complejos metalicos de transicion de las mismas y sus usos en reacciones asimetricas.
IT1313897B1 (it) * 1999-10-25 2002-09-26 Fata Group S P A Stazione automatica migliorata di assemblaggio e saldatura di scocchedi autoveicoli
JP2001131192A (ja) 1999-10-29 2001-05-15 Takasago Internatl Corp 新規な光学活性ジホスフィン化合物、その製造中間体、該化合物を配位子とする遷移金属錯体並びに該錯体を含む不斉水素化触媒。
CA2400183A1 (en) * 2000-02-10 2001-08-16 The Penn State Research Foundation Chiral ferrocene phosphines and their use in asymmetric catalytic reactions
DE10027154A1 (de) * 2000-05-31 2001-12-13 Bayer Ag Verfahren zur Herstellung optisch aktiver Trimethylmilchsäure und ihrer Ester
DE10044793A1 (de) 2000-09-11 2002-04-04 Bayer Ag Diphosphine
US6480513B1 (en) * 2000-10-03 2002-11-12 K2 Optronics, Inc. Tunable external cavity laser
AU2002216719A1 (en) * 2000-11-17 2002-05-27 The Penn State Research Foundation Ortho substituted chiral phosphines and phosphinites and their use in asymmetriccatayltic reactions
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US6743921B2 (en) * 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds

Also Published As

Publication number Publication date
US20070004927A1 (en) 2007-01-04
US20060161022A1 (en) 2006-07-20
US7396947B2 (en) 2008-07-08
ES2443994T3 (es) 2014-02-21
WO2004111063A2 (de) 2004-12-23
WO2004111063A3 (de) 2005-03-31
EP1636243B1 (de) 2013-11-06
JP2006527221A (ja) 2006-11-30
EP1636243A2 (de) 2006-03-22

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