JP4991693B2 - 呼吸器疾患の治療のための抗コリン作用薬及びロイコトリエン受容体アンタゴニストの組み合わせ剤 - Google Patents
呼吸器疾患の治療のための抗コリン作用薬及びロイコトリエン受容体アンタゴニストの組み合わせ剤 Download PDFInfo
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- JP4991693B2 JP4991693B2 JP2008501208A JP2008501208A JP4991693B2 JP 4991693 B2 JP4991693 B2 JP 4991693B2 JP 2008501208 A JP2008501208 A JP 2008501208A JP 2008501208 A JP2008501208 A JP 2008501208A JP 4991693 B2 JP4991693 B2 JP 4991693B2
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- glycopyrrolate
- montelukast
- leukotriene inhibitor
- copd
- medicament
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| US60/661,918 | 2005-03-16 | ||
| PCT/EP2006/002247 WO2006097250A1 (en) | 2005-03-16 | 2006-03-10 | The combination of anticholinergics and leukotriene recptor antagonists for the treatment of repiratory diseases |
Publications (3)
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| JP2008533072A JP2008533072A (ja) | 2008-08-21 |
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| US20050048614A1 (en) * | 2000-06-13 | 2005-03-03 | Children's Medical Center Corporation | Biosynthetic oncolytic molecules and uses therefor |
| UA87986C2 (uk) * | 2003-07-28 | 2009-09-10 | Янссен Фармацевтика Н.В. | Бензімідазольні, бензтіазольні та бензоксазольні похідні і їх застосування як lta4h модуляторів |
| PL1976828T3 (pl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4 |
| TW200906396A (en) * | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
| MX2010004262A (es) | 2007-10-18 | 2010-05-14 | Stiefel Res Australia Pty Ltd | Formulaciones topicas de glicopirrolato. |
| JP2011500731A (ja) * | 2007-10-25 | 2011-01-06 | メルク フロスト カナダ リミテツド | 併用療法 |
| WO2010144628A2 (en) * | 2009-06-09 | 2010-12-16 | Elevation Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
| US9378456B2 (en) * | 2012-11-19 | 2016-06-28 | Microsoft Technology Licensing, Llc | Task completion |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| KR20150119468A (ko) | 2013-02-28 | 2015-10-23 | 더미라, 인코포레이티드 | 글리코피롤레이트 염 |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| JP6527851B2 (ja) | 2013-03-12 | 2019-06-05 | セルタクシス，インコーポレイテッド | ロイコトリエンａ４加水分解酵素を阻害する方法 |
| EP2968264A4 (en) | 2013-03-14 | 2016-11-02 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
| US20150196521A1 (en) * | 2014-01-10 | 2015-07-16 | Dignity Sciences Limited | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same |
| CA3102077A1 (en) | 2018-05-31 | 2019-12-05 | Sanjeev AHUJA | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN120919118A (zh) * | 2019-01-10 | 2025-11-11 | 艾缇亚(上海)制药有限公司 | 含有白三烯受体拮抗剂的新型配制品 |
| AU2021215849B2 (en) * | 2020-02-03 | 2023-08-03 | Taro Pharmaceutical Industries Ltd. | Topical montelukast formulations |
| CN115792229B (zh) * | 2022-01-28 | 2024-06-18 | 华中科技大学同济医学院附属同济医院 | 鼻分泌物中tPA在制备鼻息肉及其预后检测剂中的应用 |
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| JPH0435038A (ja) * | 1990-05-31 | 1992-02-05 | Oki Electric Ind Co Ltd | 半導体素子及びその製造方法 |
| CN1046939C (zh) | 1993-07-02 | 1999-12-01 | 比克·古尔顿·劳姆贝尔格化学公司 | 氟烷氧基取代的苯甲酰胺类及其制备方法和应用 |
| EP0932401A1 (en) | 1996-07-01 | 1999-08-04 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
| DK0937041T3 (da) * | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
| IL131492A0 (en) * | 1997-04-30 | 2001-01-28 | Warner Lambert Co | Topical nasal antiinflammatory compositions |
| US6384038B1 (en) * | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
| AU7455498A (en) * | 1998-05-29 | 1999-12-20 | Citizen Watch Co. Ltd. | Method of subjecting ink jet printer to preuse treatment |
| AU749697B2 (en) | 1998-08-04 | 2002-07-04 | Jagotec Ag | Medicinal aerosol formulations |
| CA2347856C (en) * | 1998-11-13 | 2009-02-17 | Jagotec Ag | Dry powder for inhalation |
| US6086914A (en) * | 1999-03-12 | 2000-07-11 | Weinstein; Robert E. | Nonsedating formulations for allergic rhinitis which possess antihistaminic and anticholinergic activity |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US20040002548A1 (en) | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| SE9903995D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New combination |
| DE19961300A1 (de) | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
| DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0009583D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| HRP20030337A2 (en) * | 2000-10-31 | 2005-04-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Inhalative solution formulation containing a tiotropium salt |
| DE10110772A1 (de) | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| GB0029903D0 (en) | 2000-12-07 | 2001-01-24 | Arakis Ltd | Use of anti-muscarinic agents |
| PT1372608E (pt) | 2001-03-30 | 2008-01-04 | Jagotec Ag | Formulações de aerossol médicas |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| DE60216588T2 (de) | 2001-05-25 | 2007-09-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen |
| SK14312003A3 (sk) | 2001-05-25 | 2004-08-03 | Pfizer Inc. | Inhibítor PDE4 a anticholinergné činidlo v kombinácii na liečbu obštrukčných chorôb dýchacích ciest |
| GB0118373D0 (en) | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| MY148466A (en) * | 2001-10-26 | 2013-04-30 | Merck Frosst Canada Ltd | Granule formulation |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| DE60216242T2 (de) * | 2002-06-06 | 2007-05-24 | Chiesi Farmaceutici S.P.A. | Lösung von Wirkstoffen in HFA-Treibgasen mittels Emulsionen |
| US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| UA82323C2 (uk) | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| US20040053902A1 (en) * | 2002-09-13 | 2004-03-18 | Smith C. Steven | Novel composition and method for treatment of upper respiratory conditions |
| AU2003287132B2 (en) * | 2002-12-13 | 2009-03-12 | Adagit | Pharmaceutical porous particles |
| EP1452179A1 (en) * | 2003-02-27 | 2004-09-01 | CHIESI FARMACEUTICI S.p.A. | Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid |
| CA2519679C (en) | 2003-03-28 | 2012-08-28 | Altana Pharma Ag | Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases |
| JPWO2005055999A1 (ja) | 2003-12-08 | 2007-07-05 | 日本新薬株式会社 | 抗コリン作用剤 |
| GB0411056D0 (en) * | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
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2006
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- 2006-03-10 WO PCT/EP2006/002247 patent/WO2006097250A1/en not_active Ceased
- 2006-03-10 JP JP2008501208A patent/JP4991693B2/ja not_active Expired - Fee Related
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- 2006-03-10 RU RU2007138270/15A patent/RU2420285C2/ru not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101128196B (zh) | 2013-01-02 |
| DK1863476T3 (en) | 2016-05-17 |
| US20060211729A1 (en) | 2006-09-21 |
| CN101128196A (zh) | 2008-02-20 |
| AU2006224842B2 (en) | 2011-09-29 |
| CA2595791A1 (en) | 2006-09-21 |
| RU2420285C2 (ru) | 2011-06-10 |
| EP1863476A1 (en) | 2007-12-12 |
| CY1117571T1 (el) | 2017-04-26 |
| SI1863476T1 (sl) | 2016-05-31 |
| EP1863476B1 (en) | 2016-02-03 |
| PL1863476T3 (pl) | 2016-07-29 |
| AU2006224842A1 (en) | 2006-09-21 |
| WO2006097250A1 (en) | 2006-09-21 |
| NZ560206A (en) | 2009-09-25 |
| CA2595791C (en) | 2013-10-08 |
| US8268864B2 (en) | 2012-09-18 |
| NO20075287L (no) | 2007-12-05 |
| HUE027076T2 (en) | 2016-08-29 |
| NO340405B1 (no) | 2017-04-18 |
| RU2007138270A (ru) | 2009-04-27 |
| HRP20160373T1 (hr) | 2016-05-06 |
| MX2007011273A (es) | 2007-11-08 |
| JP2008533072A (ja) | 2008-08-21 |
| HK1114013A1 (en) | 2008-10-24 |
| ES2570332T3 (es) | 2016-05-17 |
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