JP4968829B2 - コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル - Google Patents

コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル Download PDF

Info

Publication number
JP4968829B2
JP4968829B2 JP2006530223A JP2006530223A JP4968829B2 JP 4968829 B2 JP4968829 B2 JP 4968829B2 JP 2006530223 A JP2006530223 A JP 2006530223A JP 2006530223 A JP2006530223 A JP 2006530223A JP 4968829 B2 JP4968829 B2 JP 4968829B2
Authority
JP
Japan
Prior art keywords
polymer
microcapsule
water
active ingredient
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006530223A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007509844A (ja
JP2007509844A5 (enExample
Inventor
ゴルツィ・ロベルト
ボルトリ・ルイージ
ストルベルグ・クリスチャン
Original Assignee
アプタリス ファルマ ソシエタ ア レスポンサビリタ リミタータ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプタリス ファルマ ソシエタ ア レスポンサビリタ リミタータ filed Critical アプタリス ファルマ ソシエタ ア レスポンサビリタ リミタータ
Publication of JP2007509844A publication Critical patent/JP2007509844A/ja
Publication of JP2007509844A5 publication Critical patent/JP2007509844A5/ja
Application granted granted Critical
Publication of JP4968829B2 publication Critical patent/JP4968829B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/206—Hardening; drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006530223A 2003-05-30 2004-05-28 コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル Expired - Fee Related JP4968829B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001096A ITMI20031096A1 (it) 2003-05-30 2003-05-30 Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento
ITMI2003A001096 2003-05-30
PCT/EP2004/050962 WO2004105725A2 (en) 2003-05-30 2004-05-28 Microcapsules by coacervation containing a pharmaceutical incorporated in the coating polymer

Publications (3)

Publication Number Publication Date
JP2007509844A JP2007509844A (ja) 2007-04-19
JP2007509844A5 JP2007509844A5 (enExample) 2011-01-27
JP4968829B2 true JP4968829B2 (ja) 2012-07-04

Family

ID=30131119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006530223A Expired - Fee Related JP4968829B2 (ja) 2003-05-30 2004-05-28 コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル

Country Status (9)

Country Link
US (2) US20070048385A1 (enExample)
EP (1) EP1628640B1 (enExample)
JP (1) JP4968829B2 (enExample)
AT (1) ATE378041T1 (enExample)
DK (1) DK1628640T3 (enExample)
ES (1) ES2297439T3 (enExample)
IT (1) ITMI20031096A1 (enExample)
PL (1) PL1628640T3 (enExample)
WO (1) WO2004105725A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101814895B1 (ko) 2013-06-04 2018-01-04 바이옴 바이오사이언스 피브이티. 엘티디. 코팅된 입자 및 이를 포함하는 조성물

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101351680B1 (ko) * 2007-03-22 2014-01-15 주식회사 엘지생활건강 마이크로 캡슐，그 제조방법 및 마이크로 캡슐을 포함하는기능성 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394287A (en) * 1981-04-10 1983-07-19 Eurand America, Inc. Incorporation of finely divided additives at the surface of microcapsule walls
US4634587A (en) * 1982-07-09 1987-01-06 Key Pharmaceuticals, Inc. Sustained release quinidine dosage form
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
JPS62135419A (ja) * 1985-12-06 1987-06-18 Ikeda Mohandou:Kk ジクロフエナク塩の粒状組成物及びその製造法
JPH0832625B2 (ja) * 1987-01-29 1996-03-29 武田薬品工業株式会社 有核顆粒およびその製造法
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5252337A (en) * 1991-06-25 1993-10-12 Eurand America, Inc. Controlled release calcium channel blocker microcapsules
EP0706794B1 (en) * 1994-10-14 2001-12-12 Japan Energy Corporation Anti-aids pharmaceutical preparations and processes for the production thereof
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
TR199802718T2 (xx) * 1996-06-28 1999-03-22 Schering Corporation Bir triazol mantara kar�� bile�i�ini i�eren a��zdan al�nan bile�im.
FR2758461A1 (fr) * 1997-01-17 1998-07-24 Pharma Pass Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
EP1072257A1 (en) * 1998-04-17 2001-01-31 Taisho Pharmaceutical Co., Ltd Multiple-unit sustained release tablets
DE19930795A1 (de) * 1999-07-03 2001-01-11 Encapbiosystems Ag Schiers Verfahren zur Verkapselung von Substanzen sowie Teilchen dafür

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101814895B1 (ko) 2013-06-04 2018-01-04 바이옴 바이오사이언스 피브이티. 엘티디. 코팅된 입자 및 이를 포함하는 조성물

Also Published As

Publication number Publication date
JP2007509844A (ja) 2007-04-19
EP1628640B1 (en) 2007-11-14
ITMI20031096A1 (it) 2004-11-30
ES2297439T3 (es) 2008-05-01
DK1628640T3 (da) 2008-03-17
WO2004105725A2 (en) 2004-12-09
EP1628640A2 (en) 2006-03-01
ATE378041T1 (de) 2007-11-15
US20070048385A1 (en) 2007-03-01
WO2004105725A3 (en) 2005-05-26
PL1628640T3 (pl) 2008-06-30
US20130156934A1 (en) 2013-06-20
ITMI20031096A0 (it) 2003-05-30

Similar Documents

Publication Publication Date Title
JP2542122B2 (ja) 球状核、球形顆粒およびその製造方法
AU644887B2 (en) Process for the manufacture of porous cellulose matrices
JP3707831B2 (ja) デュロキセチン腸溶性ペレット
CN1052398C (zh) 球状药用制剂
CN1202814C (zh) 具有贮存稳定释放模式的控释曲马朵制剂和其制备方法
JPH0237327B2 (enExample)
JP2000516946A (ja) ミルナシプランの持続性放出を伴うガレヌス製剤形態
JP2010500393A5 (enExample)
CZ298948B6 (cs) Lékové formy pro orální podávání se zpoždeným úcinkem
JP4234427B2 (ja) 活性成分をベースとする微小顆粒およびその製造方法
JP4447166B2 (ja) 硫酸モルヒネマイクロ顆粒剤、製法および医薬調製物
EP1722821B1 (en) Composition for oral administration of tamsulosin hydrochloride and controlled release granule formulation comprising same
JP4785000B2 (ja) コーティング方法
JP2002332226A (ja) 薬物顆粒の製造方法、および薬物顆粒、ならびにそれを用いた医薬製剤
JP4968829B2 (ja) コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル
JP2005075826A (ja) 多孔質シリカ担体を含有する徐放性製剤
ZA200505180B (en) Process for manufacturing sustained release microbeads containing venlafaxine HCI
CN113616621B (zh) 一种左旋多巴和卡比多巴控释制剂及其制备方法
JPWO2002034268A1 (ja) ５−アセチル−４，６−ジメチル−２−［２−［４−（２−メトキシフェニル）ピペラジニル］エチルアミノ］ピリミジン・三塩酸塩を有効成分として含有する徐放性製剤
RU2727721C2 (ru) Фармацевтическая композиция с замедленным высвобождением, содержащая ривастигмин
US20070092568A1 (en) Galantamine compositions
Chiao et al. Modification of gelatin beadlets for zero-order sustained release
EP3184101A1 (en) Levodopa and carbidopa modified release composition
Govender et al. Formulation and preparation of controlled release pellets of salbutamol by the air suspension technique
JP2007509844A5 (enExample)

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070411

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20100527

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100531

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100818

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100825

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100928

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101005

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101027

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101104

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20101130

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20101202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20101202

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110908

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111207

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120106

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120207

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120309

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120330

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150413

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees