ITMI20031096A1 - Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento - Google Patents

Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento

Info

Publication number
ITMI20031096A1
ITMI20031096A1 IT001096A ITMI20031096A ITMI20031096A1 IT MI20031096 A1 ITMI20031096 A1 IT MI20031096A1 IT 001096 A IT001096 A IT 001096A IT MI20031096 A ITMI20031096 A IT MI20031096A IT MI20031096 A1 ITMI20031096 A1 IT MI20031096A1
Authority
IT
Italy
Prior art keywords
coacervation
microcaps
coating polymer
containing drug
drug incorporated
Prior art date
Application number
IT001096A
Other languages
English (en)
Italian (it)
Inventor
Luigi Boltri
Robeerto Golzi
Christian Stollberg
Original Assignee
Eurand Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Spa filed Critical Eurand Spa
Priority to IT001096A priority Critical patent/ITMI20031096A1/it
Publication of ITMI20031096A0 publication Critical patent/ITMI20031096A0/it
Priority to PCT/EP2004/050962 priority patent/WO2004105725A2/en
Priority to AT04741678T priority patent/ATE378041T1/de
Priority to DK04741678T priority patent/DK1628640T3/da
Priority to PL04741678T priority patent/PL1628640T3/pl
Priority to ES04741678T priority patent/ES2297439T3/es
Priority to EP04741678A priority patent/EP1628640B1/en
Priority to JP2006530223A priority patent/JP4968829B2/ja
Priority to US10/558,948 priority patent/US20070048385A1/en
Publication of ITMI20031096A1 publication Critical patent/ITMI20031096A1/it
Priority to US13/681,727 priority patent/US20130156934A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/206—Hardening; drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT001096A 2003-05-30 2003-05-30 Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento ITMI20031096A1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT001096A ITMI20031096A1 (it) 2003-05-30 2003-05-30 Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento
US10/558,948 US20070048385A1 (en) 2003-05-30 2004-05-28 Microcapsules by coacervation containing a pharmaceutical incorporated in the coating polymer
PL04741678T PL1628640T3 (pl) 2003-05-30 2004-05-28 Mikrokapsułki wytworzone przez koacerwację zawierające farmaceutyk włączony w etylocelulozową powłokę
AT04741678T ATE378041T1 (de) 2003-05-30 2004-05-28 Durch coazervation hergestellte mikrokapseln mit einem wirkstoff in ethylcellulose als hüllpolymer
DK04741678T DK1628640T3 (da) 2003-05-30 2004-05-28 Fremstilling af mikrokapsler ved coacervering, hvilke mikrokapsler indeholder et farmaceutisk middel der er inkorporeret i ethylcelluloseovertrækket
PCT/EP2004/050962 WO2004105725A2 (en) 2003-05-30 2004-05-28 Microcapsules by coacervation containing a pharmaceutical incorporated in the coating polymer
ES04741678T ES2297439T3 (es) 2003-05-30 2004-05-28 Microcapsulas obtenidas por coacervacion que contienen una sustancia farmaceutica incorporada en el recubrimiento de etilcelulosa.
EP04741678A EP1628640B1 (en) 2003-05-30 2004-05-28 Microcapsules by coacervation containing a pharmaceutical incorporated in the ethylcellulose coating
JP2006530223A JP4968829B2 (ja) 2003-05-30 2004-05-28 コアセルベーションによりコーティングポリマーに導入された薬物を有するマイクロカプセル
US13/681,727 US20130156934A1 (en) 2003-05-30 2012-11-20 Microcapsules by coacervation containing a pharmaceutical incorporated in the coating polymer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001096A ITMI20031096A1 (it) 2003-05-30 2003-05-30 Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento

Publications (2)

Publication Number Publication Date
ITMI20031096A0 ITMI20031096A0 (it) 2003-05-30
ITMI20031096A1 true ITMI20031096A1 (it) 2004-11-30

Family

ID=30131119

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001096A ITMI20031096A1 (it) 2003-05-30 2003-05-30 Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento

Country Status (9)

Country Link
US (2) US20070048385A1 (enExample)
EP (1) EP1628640B1 (enExample)
JP (1) JP4968829B2 (enExample)
AT (1) ATE378041T1 (enExample)
DK (1) DK1628640T3 (enExample)
ES (1) ES2297439T3 (enExample)
IT (1) ITMI20031096A1 (enExample)
PL (1) PL1628640T3 (enExample)
WO (1) WO2004105725A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101351680B1 (ko) * 2007-03-22 2014-01-15 주식회사 엘지생활건강 마이크로 캡슐，그 제조방법 및 마이크로 캡슐을 포함하는기능성 조성물
EP3003031A1 (en) 2013-06-04 2016-04-13 Vyome Biosciences Pvt Ltd Coated particles and compositions comprising same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394287A (en) * 1981-04-10 1983-07-19 Eurand America, Inc. Incorporation of finely divided additives at the surface of microcapsule walls
US4634587A (en) * 1982-07-09 1987-01-06 Key Pharmaceuticals, Inc. Sustained release quinidine dosage form
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
JPS62135419A (ja) * 1985-12-06 1987-06-18 Ikeda Mohandou:Kk ジクロフエナク塩の粒状組成物及びその製造法
JPH0832625B2 (ja) * 1987-01-29 1996-03-29 武田薬品工業株式会社 有核顆粒およびその製造法
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5252337A (en) * 1991-06-25 1993-10-12 Eurand America, Inc. Controlled release calcium channel blocker microcapsules
EP0706794B1 (en) * 1994-10-14 2001-12-12 Japan Energy Corporation Anti-aids pharmaceutical preparations and processes for the production thereof
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
TR199802718T2 (xx) * 1996-06-28 1999-03-22 Schering Corporation Bir triazol mantara kar�� bile�i�ini i�eren a��zdan al�nan bile�im.
FR2758461A1 (fr) * 1997-01-17 1998-07-24 Pharma Pass Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
EP1072257A1 (en) * 1998-04-17 2001-01-31 Taisho Pharmaceutical Co., Ltd Multiple-unit sustained release tablets
DE19930795A1 (de) * 1999-07-03 2001-01-11 Encapbiosystems Ag Schiers Verfahren zur Verkapselung von Substanzen sowie Teilchen dafür

Also Published As

Publication number Publication date
JP2007509844A (ja) 2007-04-19
EP1628640B1 (en) 2007-11-14
ES2297439T3 (es) 2008-05-01
DK1628640T3 (da) 2008-03-17
WO2004105725A2 (en) 2004-12-09
EP1628640A2 (en) 2006-03-01
ATE378041T1 (de) 2007-11-15
US20070048385A1 (en) 2007-03-01
WO2004105725A3 (en) 2005-05-26
PL1628640T3 (pl) 2008-06-30
US20130156934A1 (en) 2013-06-20
JP4968829B2 (ja) 2012-07-04
ITMI20031096A0 (it) 2003-05-30

Similar Documents

Publication Publication Date Title
DE602007002905D1 (de) Mikrokügelchen mit nanokapseln, die ein lipophiles arzneimittel enthalten
WO2002072033A3 (en) Chronotherapeutic dosage forms containing glucocorticosteroid
EP2062898A3 (de) Spirocyclische Cyclohexan-Derivate
CA2124012A1 (fr) Formulation de diltiazem a liberation prolongee
BR0011999A (pt) Formas de dosagem farmacêutica para liberação controlada produzindo pelo menos um pulso cronometrado
ATE420762T1 (de) Systeme, verfahren und geräte zur herstellung von dosierungsformen
AU2001298061A1 (en) Microencapsulation of drugs by solvent exchange
WO2003028660A3 (en) Drug delivery devices and methods
CA2398555A1 (en) Sustained release preparation and method for producing the same
ATE455541T1 (de) Transdermales therapeutisches system (tts) mit dem wirkstoff fentanyl
EA200600598A1 (ru) Лекарственные формы замедленного высвобождения
GR910100283A (el) Στερεά από του στόματος χορηγουμένη φαρμακευτική μορφή δοσιμετρήσεως προγραμματισμένου ρυ?μού απελευ?ερώσεως.
SG164281A1 (en) Controlled release preparation
WO2007023495A3 (en) Method for production of single- and multi-layer microcapsules
BRPI0503833A (pt) método de corrosão seletiva utilizando camada de interrupção de corrosão
WO2005027843A3 (en) Chronotherapeutic dosage forms
WO2004028504A8 (en) Modified release dosage forms
EP0061217A3 (en) Ibuprofen-containing sustained release pharmaceutical composition
WO2009030351A3 (de) Transdermales therapeutisches system enthaltend längliche hohlkörper
WO2004096896A3 (en) Microfabrication of polymer microparticles
FR2868442B1 (fr) Fer a repasser comportant un reservoir d'additif
ITMI20031096A1 (it) Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento
WO2004066984A3 (en) Improved taste masking pharmaceutical composition and process for its preparation
EP1550667A4 (en) AGENTS FOR REGULATING TYROSINASE ACTIVITY, PROCESS FOR PRODUCING SAID AGENTS AND EXTERNAL PREPARATIONS CONTAINING THE SAME
WO2007039569A3 (en) Controlled release pharmaceutical composition of venlafaxine hydrochloride, and process for preparation thereof