JP4903583B2 - 携帯式個人透析用透析液再生システム - Google Patents
携帯式個人透析用透析液再生システム Download PDFInfo
- Publication number
- JP4903583B2 JP4903583B2 JP2006547442A JP2006547442A JP4903583B2 JP 4903583 B2 JP4903583 B2 JP 4903583B2 JP 2006547442 A JP2006547442 A JP 2006547442A JP 2006547442 A JP2006547442 A JP 2006547442A JP 4903583 B2 JP4903583 B2 JP 4903583B2
- Authority
- JP
- Japan
- Prior art keywords
- dialysate
- regenerator
- ion
- dialysis
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
- B01D61/244—Dialysis comprising multiple dialysis steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/30—Accessories; Auxiliary operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/06—Specific process operations in the permeate stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
Description
12、112……透析装置
14、114……再生器
16、116……透析液貯留槽
18、118……血液相
20、120……透析液相
22、122……半透過性膜
24、124……配管
30、130……取込径路
32、42……返流径路
52……取込口
54……カートリッジ頂部
56……O-リング
58……透析液再生用織布
60……支持スクリーン
62……ガスケット
64……ハウジング
66……排出口
68……抜出口
70……イオン選択的活性化繊維
72、73、74、217、219、221……曲線
82……疎水性半透過性膜
84……分離層
86……脂肪酸
88……親水性細孔
92……イオン交換樹脂
126……ポンプ
131……血液ポンプ
133、140……血流センサー
135……液量センサー
137……アンモニアセンサー
142……気泡センサー
223、225、227、229、231、233、241、243、245……縦帯
Claims (15)
- 毒素成分含有透析液から浄化透析液を生成する透析液再生器であって、当該透析液再生器は、
浄化透析液を生成するために、毒素成分含有透析液から毒素成分の実質的取り込みを選択的に行い、かつ非毒素成分の取り込みを最小限にするために構成される透析液再生用織布;および
当該浄化透析液を放出するための流出路
を含み、透析液再生用織布が、ウレアーゼが固定されたイオン選択的な活性化繊維を含み、
ウレアーゼが固定されたイオン選択的な活性化繊維は、
帯電したイオンを保持するために構成される孔を有する繊維;
繊維に付着し、繊維の孔隙から実質的に離れながら拡張するように形成される脂質鎖を実質的に含む疎水性のイオン選択的バリア;および、
イオン選択的バリアの内部に実質的に配置されるウレアーゼ
を含む、透析液再生器。 - 帯電したイオンが、アンモニウムイオンを含む請求項1に記載の透析液再生器。
- 透析液再生用織布が、さらに、必須カチオンの取り込みを最小限とするように構成される、請求項1又は2記載の透析液再生器。
- 必須カチオンが、カルシウムイオン(Ca2+)、マグネシウムイオン(Mg2+)、カリウムイオン(K+)またはナトリウムイオン(Na+)を含む請求項3に記載の透析液再生器。
- 毒素成分含有透析液を受け入れるために構成される取込口をさらに含む請求項1〜4のいずれかに記載の透析液再生器。
- 毒素成分が透析液再生器から放出されるように構成される排出口をさらに含む請求項1〜5のいずれかに記載の透析液再生器。
- 透析システムにおいて使用されるように構成され、さらに、多量の使用済透析液からの毒素成分の実質的な取り込みを行うことにより多量の浄化透析液を再生するように構成される、請求項1〜6のいずれかに記載の透析液再生器。
- 血液から老廃物を除去するシステムであって、当該システムが、
透析液相、血液相、および、当該透析物相と当該血液相との間に実質的に位置する半透過性膜を含む透析器;および、
請求項1〜7のいずれかに記載の透析液再生器
を含むシステム。 - 透析液再生器が、透析器から供給された使用済透析液を浄化するように構成される請求項8に記載のシステム。
- 携帯可能である請求項8又は9に記載のシステム。
- 透析液貯留槽をさらに含む請求項8〜10のいずれかに記載のシステム。
- 透析液が、透析液相および透析液再生器を含む閉鎖系回路を再循環する請求項11に記載のシステム。
- ウレアーゼが固定されたイオン選択的活性化繊維が、尿毒症毒素を除去するために構成される請求項8〜12のいずれかに記載のシステム。
- 血液透析処置のために用いられる請求項8〜13のいずれかに記載のシステム。
- 腹膜透析処置のために用いられる請求項8〜13のいずれかに記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53275903P | 2003-12-24 | 2003-12-24 | |
US60/532,759 | 2003-12-24 | ||
PCT/US2004/043546 WO2005062973A2 (en) | 2003-12-24 | 2004-12-22 | Dialysate regeneration system for portable human dialysis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007516793A JP2007516793A (ja) | 2007-06-28 |
JP4903583B2 true JP4903583B2 (ja) | 2012-03-28 |
Family
ID=34738834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006547442A Expired - Fee Related JP4903583B2 (ja) | 2003-12-24 | 2004-12-22 | 携帯式個人透析用透析液再生システム |
Country Status (8)
Country | Link |
---|---|
US (3) | US7435342B2 (ja) |
EP (1) | EP1701752B1 (ja) |
JP (1) | JP4903583B2 (ja) |
KR (1) | KR101269822B1 (ja) |
CN (1) | CN1897993B (ja) |
CA (1) | CA2575731C (ja) |
TW (1) | TWI365079B (ja) |
WO (1) | WO2005062973A2 (ja) |
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CN1897993A (zh) | 2007-01-17 |
US20050150832A1 (en) | 2005-07-14 |
US20090020471A1 (en) | 2009-01-22 |
TWI365079B (en) | 2012-06-01 |
EP1701752B1 (en) | 2016-05-18 |
US7988854B2 (en) | 2011-08-02 |
CA2575731C (en) | 2014-07-15 |
KR101269822B1 (ko) | 2013-05-31 |
CA2575731A1 (en) | 2005-07-14 |
TW200526281A (en) | 2005-08-16 |
JP2007516793A (ja) | 2007-06-28 |
WO2005062973A3 (en) | 2005-12-08 |
US7435342B2 (en) | 2008-10-14 |
EP1701752A4 (en) | 2012-09-26 |
US20120018377A1 (en) | 2012-01-26 |
CN1897993B (zh) | 2012-02-08 |
WO2005062973A2 (en) | 2005-07-14 |
EP1701752A2 (en) | 2006-09-20 |
KR20060113720A (ko) | 2006-11-02 |
US8911629B2 (en) | 2014-12-16 |
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