JP4903385B2 - 損傷した哺乳類神経組織を治療するためのピリジン類 - Google Patents

損傷した哺乳類神経組織を治療するためのピリジン類 Download PDF

Info

Publication number
JP4903385B2
JP4903385B2 JP2004559375A JP2004559375A JP4903385B2 JP 4903385 B2 JP4903385 B2 JP 4903385B2 JP 2004559375 A JP2004559375 A JP 2004559375A JP 2004559375 A JP2004559375 A JP 2004559375A JP 4903385 B2 JP4903385 B2 JP 4903385B2
Authority
JP
Japan
Prior art keywords
spinal cord
pharmaceutical composition
pyridyl
nerve
injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004559375A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006515585A5 (enExample
JP2006515585A (ja
Inventor
ボージェンス，リチャード・ビー
シ，リイ
バーン，スティーヴン・アール
スミス，ダニエル・ティー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of JP2006515585A publication Critical patent/JP2006515585A/ja
Publication of JP2006515585A5 publication Critical patent/JP2006515585A5/ja
Application granted granted Critical
Publication of JP4903385B2 publication Critical patent/JP4903385B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Devices For Medical Bathing And Washing (AREA)
JP2004559375A 2002-12-06 2003-12-05 損傷した哺乳類神経組織を治療するためのピリジン類 Expired - Fee Related JP4903385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43163702P 2002-12-06 2002-12-06
US60/431,637 2002-12-06
PCT/US2003/038834 WO2004052291A2 (en) 2002-12-06 2003-12-05 Pyridines for treating injured mammalian nerve tissue

Publications (3)

Publication Number Publication Date
JP2006515585A JP2006515585A (ja) 2006-06-01
JP2006515585A5 JP2006515585A5 (enExample) 2007-02-01
JP4903385B2 true JP4903385B2 (ja) 2012-03-28

Family

ID=32507771

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004559375A Expired - Fee Related JP4903385B2 (ja) 2002-12-06 2003-12-05 損傷した哺乳類神経組織を治療するためのピリジン類

Country Status (9)

Country Link
US (2) US7244748B2 (enExample)
EP (1) EP1567497B1 (enExample)
JP (1) JP4903385B2 (enExample)
CN (1) CN1745064A (enExample)
AT (1) ATE443699T1 (enExample)
AU (1) AU2003298034B2 (enExample)
CA (1) CA2508165C (enExample)
DE (1) DE60329415D1 (enExample)
WO (1) WO2004052291A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
WO2007061554A2 (en) * 2005-10-21 2007-05-31 Purdue Research Foundation Dosage of 4-aminopyridine derivatives for treatment of central nervous system injuries
US8066306B1 (en) 2008-07-18 2011-11-29 Chicago Tag & Label, Inc. Label sheet with wristband
US8181994B1 (en) 2008-07-18 2012-05-22 Chicago Tag & Label, Inc. Sheet with wristband
WO2012009204A1 (en) * 2010-07-15 2012-01-19 The Trustees Of Columbia University In The City Of New York Methods for diagnosing and treating concussive disorders
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
WO2013173746A2 (en) 2012-05-17 2013-11-21 The University Of Chicago Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging
US9617215B2 (en) 2012-05-17 2017-04-11 The University Of Chicago Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging
CN102702261A (zh) * 2012-05-29 2012-10-03 南京信息工程大学 制备1-取代苯基-4-乙氧羰基-5-( 二苯基膦氧)氨基-1 ,2 ,3-三唑的方法
SI2861595T1 (sl) 2012-06-13 2017-04-26 Incyte Holdings Corporation Substituirane triciklične spojine kot inhibitorji fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
LT2986610T (lt) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicikliniai heterociklai, kaip fgfr inhibitoriai
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
SG10201913036RA (en) 2015-02-20 2020-02-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR20210018264A (ko) 2018-05-04 2021-02-17 인사이트 코포레이션 Fgfr 억제제의 염
PL3788047T3 (pl) 2018-05-04 2025-04-14 Incyte Corporation Stałe postacie inhibitora fgfr i sposoby ich otrzymywania
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP7720840B2 (ja) 2019-12-04 2025-08-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
EP4352060A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1071035A (en) * 1964-09-02 1967-06-07 Rech Et Pharmacologie Improvements in and relating to new carbamates and thiocarbamates and the process of preparation and therapeutic applications thereof
US3433873A (en) * 1966-04-05 1969-03-18 Phillips Petroleum Co Compositions and methods for controlling birds
US3804844A (en) * 1970-12-02 1974-04-16 Dow Chemical Co Process for preparing pyridylcarbamates
GB1339764A (en) * 1971-03-29 1973-12-05 Ici Ltd Pyridine derivatives
IL39094A (en) * 1971-04-21 1976-05-31 Ciba Geigy Ag 7-(aminopyridiniumacetyl)-3-heterocyclylthiomethyl-cephalosporanic acid derivatives,their manufacture and pharmaceutical compositions containing them
SU464177A1 (ru) * 1973-01-08 1978-03-25 Донецкое Отделение Физико-Органической Химии Института Физической Химии Ан Украинской Сср Способ получени 4-галоидзамещенных имидазо- (4,5-с)-пиридин -2-она
US3995042A (en) * 1973-09-07 1976-11-30 E. R. Squibb & Sons, Inc. Pyridine containing compounds
US4304911A (en) * 1980-11-19 1981-12-08 Sterling Drug Inc. Benzoylphenyl lower alkanoyl piperidines
FR2624699B1 (fr) * 1987-12-18 1990-04-13 Bernard Lyon I Universite Clau Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-glycine ou beta-alanine utiles comme agents edulcorants
JPH03181462A (ja) * 1989-12-08 1991-08-07 Nippon Kayaku Co Ltd Ｎ―（４―ピリジル）カーバメート誘導体およびそれを有効成分とする開花促進剤
IE82916B1 (en) * 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
EP1063291A3 (en) * 1992-09-25 2001-04-25 Synaptic Pharmaceutical Corporation DNA encoding human alpha 1 adrenergic receptors and uses thereof
CA2085785C (en) * 1992-12-18 2005-03-15 Robert R. Hansebout The use of 4-aminopyridine in the treatment of a neurological condition
US5502498A (en) 1993-03-10 1996-03-26 Samsung Electronics Co., Ltd. Clamp signal generation-control circuit and a method therefor
JP2809883B2 (ja) * 1994-09-22 1998-10-15 ユコン リミテッド 新規のカルバメート化合物及びその製造方法
JP3583489B2 (ja) * 1994-12-22 2004-11-04 日清紡績株式会社 カルボジイミド誘導体
EP0822930B1 (en) * 1995-04-28 1999-07-28 Kumiai Chemical Industry Co., Ltd. Pyridine derivative and pesticide
US5880128A (en) * 1996-05-08 1999-03-09 Schering Corporation Carbonyl piperazinyl and piperidinyl compounds
AU719333B2 (en) * 1996-10-07 2000-05-04 Ortho-Mcneil Pharmaceutical, Inc. 5-heteroatom-containing alkyl substituted-3-oxo-p yrido(1,2-a) benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
US5961309A (en) * 1997-04-24 1999-10-05 Trw Inc. Gear pump with noise attenuation
JP2001519350A (ja) * 1997-10-07 2001-10-23 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ナフト−イミダゾ［１，２−ａ］ピリジン誘導体、その製造及び中枢神経系障害の処置におけるその使用
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
AUPP150098A0 (en) * 1998-01-27 1998-02-19 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
ATE430149T1 (de) * 1998-03-04 2009-05-15 Bristol Myers Squibb Co Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
ATE258934T1 (de) * 1998-10-30 2004-02-15 Lilly Co Eli Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
DE60014216T2 (de) * 1999-02-24 2006-03-02 F. Hoffmann-La Roche Ag 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
WO2000050400A1 (en) * 1999-02-25 2000-08-31 Pfizer Products Inc. 2-aminopyridines containing fused ring substituents
AU4007900A (en) * 1999-03-11 2000-10-16 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: nk3 receptor ligands
EP1208097B1 (en) * 1999-07-28 2009-02-18 Aventis Pharmaceuticals Inc. Substituted oxoazaheterocyclyl compounds
US6495550B2 (en) * 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
AU2155001A (en) * 1999-11-10 2001-06-06 Aventis Pharma Deutschland Gmbh N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa
FR2806722B1 (fr) * 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
DE10063294A1 (de) * 2000-12-19 2002-07-04 Aventis Pharma Gmbh Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CA2448561C (en) * 2001-05-31 2011-07-19 Sanofi-Synthelabo Aminoquinoline derivatives and their use as adenosine a3 ligands
JP2003073357A (ja) * 2001-09-03 2003-03-12 Mitsubishi Pharma Corp アミド化合物を含有するＲｈｏキナーゼ阻害剤
TWI317360B (en) * 2001-11-07 2009-11-21 Schering Corp Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1

Also Published As

Publication number Publication date
EP1567497B1 (en) 2009-09-23
CA2508165C (en) 2014-05-06
DE60329415D1 (de) 2009-11-05
EP1567497A2 (en) 2005-08-31
US20080039490A1 (en) 2008-02-14
CN1745064A (zh) 2006-03-08
AU2003298034A1 (en) 2004-06-30
ATE443699T1 (de) 2009-10-15
WO2004052291A3 (en) 2004-10-14
US7244748B2 (en) 2007-07-17
CA2508165A1 (en) 2004-06-24
JP2006515585A (ja) 2006-06-01
AU2003298034B2 (en) 2011-04-21
WO2004052291A2 (en) 2004-06-24
EP1567497A4 (en) 2006-11-15
US8097638B2 (en) 2012-01-17
US20040171587A1 (en) 2004-09-02

Similar Documents

Publication Publication Date Title
JP4903385B2 (ja) 損傷した哺乳類神経組織を治療するためのピリジン類
WO2007061554A2 (en) Dosage of 4-aminopyridine derivatives for treatment of central nervous system injuries
EP1135370B1 (en) Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds
DE69724108T2 (de) Isochinolinderivate und arzneimittel
EP0656353B1 (de) Aminochinolin-Derivate mit einer Wirksamkeit gegen Malariaerreger
JPH0873438A (ja) 中枢神経作用性の新規なベンズイミダゾール系医薬組成物
US8729107B2 (en) Pyridines for treating injured mammalian nerve tissue
DD290884A5 (de) Verfahren zur herstellung von pyridyl- und pyrimidylderivaten
JP2008515982A (ja) 高眼圧症を治療するための眼科組成物
KR20180031532A (ko) 말초신경계 질환의 치료 또는 예방용 약학 조성물
JP2021506810A (ja) フッ素化４−（置換アミノ）フェニルカルバメート誘導体
JPH069560A (ja) 新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用
EP0508370B1 (de) Kondensierte Diazepinone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Mittel zur Behandlung von Erkrankungen des Zentralnervensystems und zur Förderung der cerebralen Durchblutung
DE69818679T2 (de) Pyrazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE69011602T2 (de) Substituierte 4-Aminochinoline.
JP2003506356A (ja) 神経学的疾患の治療のための環状アミン誘導体
JP2023507461A (ja) ＲＯＲγモジュレーターのホスフェート誘導体及びその使用
JP2003503484A (ja) アミノアルキル誘導体
EP4545526A1 (en) Benzothiazole compound and use thereof
EP0379953A2 (de) Substituierte Benzo (b) pyrane, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen
JP4708567B2 (ja) Ｎ−複素環化合物のカルボン酸およびカルボン酸アイソスター
US20020028814A1 (en) Aza compounds, pharmaceutical compositions and methods of use
JP2003503480A (ja) ニューロン活性を有するｎ−ヘテロ環誘導体
RU2562773C2 (ru) Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения
EP0705834A1 (de) Azaaliphatisch Überbrückte Chinoxalin-2,3-dione

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061205

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20100331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100408

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100708

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100802

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100806

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100908

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100915

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101008

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110719

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111019

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20111206

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120105

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150113

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees