JP4878732B2 - 規制物質の濫用を防ぐための新規な持続放出製薬化合物 - Google Patents
規制物質の濫用を防ぐための新規な持続放出製薬化合物 Download PDFInfo
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- JP4878732B2 JP4878732B2 JP2003570793A JP2003570793A JP4878732B2 JP 4878732 B2 JP4878732 B2 JP 4878732B2 JP 2003570793 A JP2003570793 A JP 2003570793A JP 2003570793 A JP2003570793 A JP 2003570793A JP 4878732 B2 JP4878732 B2 JP 4878732B2
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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Landscapes
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US35836802P | 2002-02-22 | 2002-02-22 | |
| US60/358,368 | 2002-02-22 | ||
| US36208202P | 2002-03-07 | 2002-03-07 | |
| US60/362,082 | 2002-03-07 | ||
| PCT/US2003/005525 WO2003072046A2 (en) | 2002-02-22 | 2003-02-24 | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
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| JP2005524648A JP2005524648A (ja) | 2005-08-18 |
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| EP (2) | EP2319540A1 (enExample) |
| JP (1) | JP4878732B2 (enExample) |
| KR (1) | KR100822498B1 (enExample) |
| AU (2) | AU2003219863C1 (enExample) |
| CA (1) | CA2477004C (enExample) |
| ES (1) | ES2500117T3 (enExample) |
| IL (2) | IL163667A0 (enExample) |
| WO (1) | WO2003072046A2 (enExample) |
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| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20070060500A1 (en) * | 2000-08-22 | 2007-03-15 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
| US8394813B2 (en) * | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US20090306228A1 (en) * | 2000-11-14 | 2009-12-10 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
| US20040156844A1 (en) * | 2002-05-22 | 2004-08-12 | Curtis Wright | Tamper resistant oral dosage form |
| US6913768B2 (en) * | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
| US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
| EP1594513B1 (en) * | 2003-01-13 | 2011-08-10 | Shire LLC | Carbohydrate conjugates to prevent abuse of controlled substances |
| EP1603597B1 (en) * | 2003-03-13 | 2010-01-06 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| AU2004251647B2 (en) * | 2003-05-29 | 2010-01-14 | Takeda Pharmaceutical Company Limited | Abuse resistant amphetamine compounds |
| AU2004277400B2 (en) * | 2003-09-30 | 2009-01-22 | Shire Llc | Pharmaceutical compositions for prevention of overdose or abuse |
| WO2005044236A1 (en) * | 2003-10-27 | 2005-05-19 | Control Delivery Systems, Inc. | Suspension delivery system for the sustained and controlled local release of pharmaceuticals |
| AU2005304751A1 (en) * | 2004-11-08 | 2006-05-18 | Shire Llc | Synergistic effects of combined administration of mirtazapine and a stimulant compound |
| WO2006055729A1 (en) * | 2004-11-16 | 2006-05-26 | Transcutaneous Technologies Inc. | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
| JP2006296511A (ja) * | 2005-04-15 | 2006-11-02 | Transcutaneous Technologies Inc | 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ |
| AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| US20070135754A1 (en) * | 2005-09-30 | 2007-06-14 | Hidero Akiyama | Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same |
| JP2009509677A (ja) * | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | 小胞封入活性物質のイオントフォレーシス送達 |
| KR20080080087A (ko) * | 2005-09-30 | 2008-09-02 | 티티아이 엘뷰 가부시키가이샤 | 신규 약학 담체를 이용한 경피 약물 전달시스템, 장치 및방법 |
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| KR100822498B1 (ko) | 2008-04-16 |
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| EP1531844A4 (en) | 2007-06-13 |
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| IL163667A (en) | 2011-03-31 |
| AU2008229978B2 (en) | 2012-03-22 |
| CA2477004A1 (en) | 2003-09-04 |
| AU2003219863A1 (en) | 2003-09-09 |
| CA2477004C (en) | 2011-05-10 |
| ES2500117T3 (es) | 2014-09-30 |
| KR20040095228A (ko) | 2004-11-12 |
| AU2008229978A1 (en) | 2008-11-06 |
| IL163667A0 (en) | 2005-12-18 |
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