JP4856294B2 - 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 - Google Patents
癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 Download PDFInfo
- Publication number
- JP4856294B2 JP4856294B2 JP50081799A JP50081799A JP4856294B2 JP 4856294 B2 JP4856294 B2 JP 4856294B2 JP 50081799 A JP50081799 A JP 50081799A JP 50081799 A JP50081799 A JP 50081799A JP 4856294 B2 JP4856294 B2 JP 4856294B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- cancer
- nitroxide
- prodrug
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4772497P | 1997-05-27 | 1997-05-27 | |
US60/047,724 | 1997-05-27 | ||
PCT/US1998/010685 WO1998053835A1 (en) | 1997-05-27 | 1998-05-27 | The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009062262A Division JP5270413B2 (ja) | 1997-05-27 | 2009-03-16 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002500671A JP2002500671A (ja) | 2002-01-08 |
JP4856294B2 true JP4856294B2 (ja) | 2012-01-18 |
Family
ID=21950574
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50081799A Expired - Fee Related JP4856294B2 (ja) | 1997-05-27 | 1998-05-27 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
JP2009062262A Expired - Fee Related JP5270413B2 (ja) | 1997-05-27 | 2009-03-16 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
JP2013003496A Pending JP2013121964A (ja) | 1997-05-27 | 2013-01-11 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009062262A Expired - Fee Related JP5270413B2 (ja) | 1997-05-27 | 2009-03-16 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
JP2013003496A Pending JP2013121964A (ja) | 1997-05-27 | 2013-01-11 | 癌の予防および治療処置におけるニトロキシドまたはそのプロドラッグの使用 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0986393B1 (de) |
JP (3) | JP4856294B2 (de) |
AT (1) | ATE262330T1 (de) |
AU (1) | AU746505B2 (de) |
CA (1) | CA2289017C (de) |
DE (1) | DE69822626T8 (de) |
DK (1) | DK0986393T3 (de) |
ES (1) | ES2216286T3 (de) |
PT (1) | PT986393E (de) |
WO (1) | WO1998053835A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
AU765110B2 (en) * | 1998-06-26 | 2003-09-11 | Georgetown University Medical Center | Compositions and methods for inducing cell death |
US20040219201A1 (en) * | 2001-12-06 | 2004-11-04 | Yechezkel Barenholz | Tempamine compositions and methods of use |
US20070010506A1 (en) * | 2003-05-29 | 2007-01-11 | Kenneth Chang | Methods of using nitroxides in conjuction with photosensitzers and sonosensitizers |
US20120046314A1 (en) * | 2005-02-02 | 2012-02-23 | Mitos, Inc. | Nitroxides for use in treating or preventing neoplastic disease |
EP2139522A2 (de) * | 2007-03-06 | 2010-01-06 | Colby Pharmaceutical Company | Auf mitochondrien gerichtete kationische antioxidationsverbindungen zur prävention, therapie oder behandlung von hyperproliferativen erkrankungen, neoplasien und karzinomen |
US8466130B2 (en) | 2009-09-04 | 2013-06-18 | Colby Pharmaceutical Company | Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers |
US8853277B2 (en) | 2009-11-30 | 2014-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC) |
JP2019509352A (ja) * | 2016-03-23 | 2019-04-04 | ルイス ハバシュ, | ヒトの被験物質をニトロキシドで処理することによってapoptosis関連遺伝子の発現レベルを増加させる |
US20180078539A1 (en) | 2016-03-23 | 2018-03-22 | Louis Habash | T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide |
US10231959B2 (en) | 2016-03-23 | 2019-03-19 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758580A (en) * | 1985-06-26 | 1988-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts |
ES2065434T3 (es) * | 1990-06-21 | 1995-02-16 | Edith Dr Huland | Utilizacion de aerosoles que contienen citocinas y aerosoles que contienen citocinas propiamente dichos. |
US6605619B1 (en) * | 1992-03-20 | 2003-08-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxides as protectors against oxidatives stress |
BR9607427A (pt) * | 1995-02-16 | 1998-06-23 | Hoffmann La Roche | Inibiçao de angiogêne usando interleucina 12 |
-
1998
- 1998-05-27 WO PCT/US1998/010685 patent/WO1998053835A1/en active IP Right Grant
- 1998-05-27 EP EP98923772A patent/EP0986393B1/de not_active Expired - Lifetime
- 1998-05-27 DK DK98923772T patent/DK0986393T3/da active
- 1998-05-27 DE DE69822626T patent/DE69822626T8/de active Active
- 1998-05-27 AT AT98923772T patent/ATE262330T1/de active
- 1998-05-27 CA CA002289017A patent/CA2289017C/en not_active Expired - Fee Related
- 1998-05-27 AU AU75987/98A patent/AU746505B2/en not_active Ceased
- 1998-05-27 JP JP50081799A patent/JP4856294B2/ja not_active Expired - Fee Related
- 1998-05-27 ES ES98923772T patent/ES2216286T3/es not_active Expired - Lifetime
- 1998-05-27 PT PT98923772T patent/PT986393E/pt unknown
-
2009
- 2009-03-16 JP JP2009062262A patent/JP5270413B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-11 JP JP2013003496A patent/JP2013121964A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2009185034A (ja) | 2009-08-20 |
DE69822626T8 (de) | 2005-02-03 |
PT986393E (pt) | 2004-06-30 |
DE69822626T2 (de) | 2004-08-12 |
DE69822626D1 (de) | 2004-04-29 |
CA2289017C (en) | 2008-07-22 |
EP0986393B1 (de) | 2004-03-24 |
ES2216286T3 (es) | 2004-10-16 |
AU746505B2 (en) | 2002-05-02 |
DK0986393T3 (da) | 2004-07-05 |
JP2002500671A (ja) | 2002-01-08 |
ATE262330T1 (de) | 2004-04-15 |
EP0986393A1 (de) | 2000-03-22 |
JP2013121964A (ja) | 2013-06-20 |
AU7598798A (en) | 1998-12-30 |
CA2289017A1 (en) | 1998-12-03 |
JP5270413B2 (ja) | 2013-08-21 |
WO1998053835A1 (en) | 1998-12-03 |
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