JP4836395B2 - シアニン色素フォスフォアミダイト - Google Patents

シアニン色素フォスフォアミダイト Download PDF

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Publication number
JP4836395B2
JP4836395B2 JP2002542003A JP2002542003A JP4836395B2 JP 4836395 B2 JP4836395 B2 JP 4836395B2 JP 2002542003 A JP2002542003 A JP 2002542003A JP 2002542003 A JP2002542003 A JP 2002542003A JP 4836395 B2 JP4836395 B2 JP 4836395B2
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JP
Japan
Prior art keywords
group
dye
chemical formula
phosphoramidite
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2002542003A
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English (en)
Japanese (ja)
Other versions
JP2004525196A (ja
JP2004525196A5 (enExample
Inventor
エム、 パラメスワラ レッディー、
ファーダス ファルークイ、
メイジド、 エイ マイクル、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
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Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Publication of JP2004525196A publication Critical patent/JP2004525196A/ja
Publication of JP2004525196A5 publication Critical patent/JP2004525196A5/ja
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/149—Particles, e.g. beads

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002542003A 2000-11-09 2001-11-02 シアニン色素フォスフォアミダイト Expired - Lifetime JP4836395B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/710,575 US6331632B1 (en) 2000-11-09 2000-11-09 Cyanine dye phosphoramidites
US09/710,575 2000-11-09
PCT/US2001/045286 WO2002038679A1 (en) 2000-11-09 2001-11-02 Cyanine dye phosphoramidites

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008149964A Division JP2009008673A (ja) 2000-11-09 2008-06-06 シアニン色素フォスフォアミダイト

Publications (3)

Publication Number Publication Date
JP2004525196A JP2004525196A (ja) 2004-08-19
JP2004525196A5 JP2004525196A5 (enExample) 2005-07-07
JP4836395B2 true JP4836395B2 (ja) 2011-12-14

Family

ID=24854600

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002542003A Expired - Lifetime JP4836395B2 (ja) 2000-11-09 2001-11-02 シアニン色素フォスフォアミダイト
JP2008149964A Pending JP2009008673A (ja) 2000-11-09 2008-06-06 シアニン色素フォスフォアミダイト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008149964A Pending JP2009008673A (ja) 2000-11-09 2008-06-06 シアニン色素フォスフォアミダイト

Country Status (4)

Country Link
US (1) US6331632B1 (enExample)
EP (1) EP1339799A1 (enExample)
JP (2) JP4836395B2 (enExample)
WO (1) WO2002038679A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3746214B2 (ja) * 2001-09-10 2006-02-15 大電株式会社 塞栓構造
US7705150B2 (en) * 2004-02-04 2010-04-27 Biosearch Technologies, Inc. Cyanine dyes
US7230117B2 (en) * 2004-07-12 2007-06-12 Beckman Coulter, Inc. Stable cyanine dye phosphoramidites
KR100591984B1 (ko) 2005-04-18 2006-06-20 한국화학연구원 근적외선 흡수 청색 색소로 유용한 헵타메틴계 시아닌화합물과 이의 제조방법
WO2009023676A1 (en) * 2007-08-12 2009-02-19 Integrated Dna Technologies, Inc. Microarray system with improved sequence specificity
US20090136916A1 (en) * 2007-08-13 2009-05-28 Trustees Of Tufts College Methods and microarrays for detecting enteric viruses
WO2009029868A1 (en) * 2007-08-31 2009-03-05 University Of Massachusetts Phosphoramidite nucleoside analogs
DE102008040513B4 (de) * 2008-07-17 2010-08-26 BAM Bundesanstalt für Materialforschung und -prüfung Verwendung einer langwellig emittierenden Cyaninverbindung als NIR-Fluoreszenzstandard und Kit zur Kalibrierung von Photolumineszenzmesssystemen
US8993737B2 (en) 2010-08-25 2015-03-31 Pacific Biosciences, Inc. Phospholinked dye analogs with an amino acid linker
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
WO2013173844A1 (en) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
CN111925311B (zh) * 2020-08-28 2021-11-02 上海库擘生物技术有限公司 肿瘤造影化合物、其制备方法及在肿瘤诊断成像中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571388A (en) 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US6048982A (en) * 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
JP3045404B2 (ja) * 1991-01-30 2000-05-29 日本化薬株式会社 インドレニン化合物及びこれを含有する光記録媒体
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5556959A (en) 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
DE4326466A1 (de) * 1993-08-06 1995-02-09 Boehringer Mannheim Gmbh Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
JP2000508709A (ja) * 1996-04-19 2000-07-11 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド スクアラート染料類および蛍光配列決定法におけるそれらの使用
US5916750A (en) * 1997-01-08 1999-06-29 Biogenex Laboratories Multifunctional linking reagents for synthesis of branched oligomers
US6027709A (en) * 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
US6110630A (en) * 1998-06-18 2000-08-29 Beckman Coulter, Inc. Efficient activated cyanine dyes
WO2000056933A1 (en) * 1999-03-24 2000-09-28 Princeton Separations Chemically reactive plane-rigidized cyanine dyes and their derivatives

Also Published As

Publication number Publication date
EP1339799A1 (en) 2003-09-03
US6331632B1 (en) 2001-12-18
JP2009008673A (ja) 2009-01-15
JP2004525196A (ja) 2004-08-19
WO2002038679A1 (en) 2002-05-16

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