JP2004525196A5 - - Google Patents
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- Publication number
- JP2004525196A5 JP2004525196A5 JP2002542003A JP2002542003A JP2004525196A5 JP 2004525196 A5 JP2004525196 A5 JP 2004525196A5 JP 2002542003 A JP2002542003 A JP 2002542003A JP 2002542003 A JP2002542003 A JP 2002542003A JP 2004525196 A5 JP2004525196 A5 JP 2004525196A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- dye
- phosphoramidite
- chemical formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 32
- 239000000126 substance Substances 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000008300 phosphoramidites Chemical class 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000004122 cyclic group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 150000001450 anions Chemical class 0.000 claims 10
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- -1 6-hydroxyhexyl Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- SXADIBFZNXBEGI-UHFFFAOYSA-N phosphoramidous acid Chemical group NP(O)O SXADIBFZNXBEGI-UHFFFAOYSA-N 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- FCMCSZXRVWDVAW-UHFFFAOYSA-N 6-bromo-1-hexanol Chemical compound OCCCCCCBr FCMCSZXRVWDVAW-UHFFFAOYSA-N 0.000 claims 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229960003328 benzoyl peroxide Drugs 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/710,575 | 2000-11-09 | ||
| US09/710,575 US6331632B1 (en) | 2000-11-09 | 2000-11-09 | Cyanine dye phosphoramidites |
| PCT/US2001/045286 WO2002038679A1 (en) | 2000-11-09 | 2001-11-02 | Cyanine dye phosphoramidites |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008149964A Division JP2009008673A (ja) | 2000-11-09 | 2008-06-06 | シアニン色素フォスフォアミダイト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525196A JP2004525196A (ja) | 2004-08-19 |
| JP2004525196A5 true JP2004525196A5 (enExample) | 2005-07-07 |
| JP4836395B2 JP4836395B2 (ja) | 2011-12-14 |
Family
ID=24854600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542003A Expired - Lifetime JP4836395B2 (ja) | 2000-11-09 | 2001-11-02 | シアニン色素フォスフォアミダイト |
| JP2008149964A Pending JP2009008673A (ja) | 2000-11-09 | 2008-06-06 | シアニン色素フォスフォアミダイト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008149964A Pending JP2009008673A (ja) | 2000-11-09 | 2008-06-06 | シアニン色素フォスフォアミダイト |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6331632B1 (enExample) |
| EP (1) | EP1339799A1 (enExample) |
| JP (2) | JP4836395B2 (enExample) |
| WO (1) | WO2002038679A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3746214B2 (ja) * | 2001-09-10 | 2006-02-15 | 大電株式会社 | 塞栓構造 |
| US7705150B2 (en) * | 2004-02-04 | 2010-04-27 | Biosearch Technologies, Inc. | Cyanine dyes |
| US7230117B2 (en) * | 2004-07-12 | 2007-06-12 | Beckman Coulter, Inc. | Stable cyanine dye phosphoramidites |
| KR100591984B1 (ko) | 2005-04-18 | 2006-06-20 | 한국화학연구원 | 근적외선 흡수 청색 색소로 유용한 헵타메틴계 시아닌화합물과 이의 제조방법 |
| US8067164B2 (en) * | 2007-08-12 | 2011-11-29 | Integrated Dna Technologies, Inc. | Microarray system with improved sequence specificity |
| US20090136916A1 (en) * | 2007-08-13 | 2009-05-28 | Trustees Of Tufts College | Methods and microarrays for detecting enteric viruses |
| WO2009029868A1 (en) * | 2007-08-31 | 2009-03-05 | University Of Massachusetts | Phosphoramidite nucleoside analogs |
| DE102008040513B4 (de) * | 2008-07-17 | 2010-08-26 | BAM Bundesanstalt für Materialforschung und -prüfung | Verwendung einer langwellig emittierenden Cyaninverbindung als NIR-Fluoreszenzstandard und Kit zur Kalibrierung von Photolumineszenzmesssystemen |
| US8993737B2 (en) | 2010-08-25 | 2015-03-31 | Pacific Biosciences, Inc. | Phospholinked dye analogs with an amino acid linker |
| EP2850086B1 (en) | 2012-05-18 | 2023-07-05 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes |
| US9315864B2 (en) | 2012-05-18 | 2016-04-19 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes with sulfonic acid substituents |
| CN111925311B (zh) * | 2020-08-28 | 2021-11-02 | 上海库擘生物技术有限公司 | 肿瘤造影化合物、其制备方法及在肿瘤诊断成像中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571388A (en) | 1984-03-29 | 1996-11-05 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US5627027A (en) | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US6048982A (en) * | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
| US4981977A (en) | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
| JP3045404B2 (ja) * | 1991-01-30 | 2000-05-29 | 日本化薬株式会社 | インドレニン化合物及びこれを含有する光記録媒体 |
| US5556959A (en) | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| DE4326466A1 (de) * | 1993-08-06 | 1995-02-09 | Boehringer Mannheim Gmbh | Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion |
| IT1276833B1 (it) * | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| WO1997040104A1 (en) * | 1996-04-19 | 1997-10-30 | Amersham Pharmacia Biotech Uk Limited | Squarate dyes and their use in fluorescent sequencing method |
| US5916750A (en) * | 1997-01-08 | 1999-06-29 | Biogenex Laboratories | Multifunctional linking reagents for synthesis of branched oligomers |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| US6110630A (en) * | 1998-06-18 | 2000-08-29 | Beckman Coulter, Inc. | Efficient activated cyanine dyes |
| EP1163372A4 (en) * | 1999-03-24 | 2002-10-02 | Princeton Separations | CHEMICALLY REACTIVE CYANINE DYES AND DERIVATIVES IN A LEVEL |
-
2000
- 2000-11-09 US US09/710,575 patent/US6331632B1/en not_active Expired - Lifetime
-
2001
- 2001-11-02 EP EP01989818A patent/EP1339799A1/en not_active Ceased
- 2001-11-02 WO PCT/US2001/045286 patent/WO2002038679A1/en not_active Ceased
- 2001-11-02 JP JP2002542003A patent/JP4836395B2/ja not_active Expired - Lifetime
-
2008
- 2008-06-06 JP JP2008149964A patent/JP2009008673A/ja active Pending
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