JP4795591B2 - アデノシンａ２ａ受容体アゴニストであるｃ−ピラゾール誘導体 - Google Patents

アデノシンａ２ａ受容体アゴニストであるｃ−ピラゾール誘導体 Download PDF

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Publication number
JP4795591B2
JP4795591B2 JP2001515875A JP2001515875A JP4795591B2 JP 4795591 B2 JP4795591 B2 JP 4795591B2 JP 2001515875 A JP2001515875 A JP 2001515875A JP 2001515875 A JP2001515875 A JP 2001515875A JP 4795591 B2 JP4795591 B2 JP 4795591B2
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halo
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JP2003506460A5 (https=
JP2003506460A (ja
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ジェフ エイ． ザブロッキー、
エルファティー オー． エルザイン、
ヴェンカタ ピー． パレ、
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Gilead Palo Alto Inc
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CV Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2001515875A 1999-06-22 2000-06-21 アデノシンａ２ａ受容体アゴニストであるｃ−ピラゾール誘導体 Expired - Lifetime JP4795591B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/338,327 1999-06-22
US09/338,327 US6214807B1 (en) 1999-06-22 1999-06-22 C-pyrazole 2A A receptor agonists
PCT/US2000/017095 WO2000078778A2 (en) 1999-06-22 2000-06-21 C-pyrazole a2a receptor agonists

Publications (3)

Publication Number Publication Date
JP2003506460A JP2003506460A (ja) 2003-02-18
JP2003506460A5 JP2003506460A5 (https=) 2007-08-16
JP4795591B2 true JP4795591B2 (ja) 2011-10-19

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JP2001515875A Expired - Lifetime JP4795591B2 (ja) 1999-06-22 2000-06-21 アデノシンａ２ａ受容体アゴニストであるｃ−ピラゾール誘導体

Country Status (23)

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US (6) US6214807B1 (https=)
EP (1) EP1192169B1 (https=)
JP (1) JP4795591B2 (https=)
KR (1) KR100511733B1 (https=)
CN (1) CN1152041C (https=)
AR (1) AR033794A1 (https=)
AT (1) ATE240341T1 (https=)
AU (1) AU766712B2 (https=)
BR (1) BR0011854A (https=)
CA (1) CA2375430C (https=)
DE (1) DE60002722T2 (https=)
DK (1) DK1192169T3 (https=)
ES (1) ES2193969T3 (https=)
HK (1) HK1044953A1 (https=)
IL (2) IL147195A0 (https=)
MX (1) MXPA01013350A (https=)
NO (1) NO323163B1 (https=)
NZ (1) NZ516335A (https=)
PT (1) PT1192169E (https=)
TR (1) TR200200320T2 (https=)
TW (1) TW589321B (https=)
WO (1) WO2000078778A2 (https=)
ZA (1) ZA200200298B (https=)

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Publication number Publication date
AR033794A1 (es) 2004-01-07
AU5755800A (en) 2001-01-09
WO2000078778A3 (en) 2001-05-10
ZA200200298B (en) 2003-04-30
AU766712B2 (en) 2003-10-23
US6214807B1 (en) 2001-04-10
EP1192169A2 (en) 2002-04-03
ES2193969T3 (es) 2003-11-16
EP1192169B1 (en) 2003-05-14
MXPA01013350A (es) 2002-07-09
PT1192169E (pt) 2003-09-30
TR200200320T2 (tr) 2002-05-21
US7109180B2 (en) 2006-09-19
CN1358189A (zh) 2002-07-10
WO2000078778A2 (en) 2000-12-28
US6770634B1 (en) 2004-08-03
DE60002722D1 (de) 2003-06-18
IL147195A (en) 2007-10-31
US20040198692A1 (en) 2004-10-07
NO20016351D0 (no) 2001-12-21
US6855818B2 (en) 2005-02-15
NO20016351L (no) 2002-02-18
US20070207978A1 (en) 2007-09-06
NZ516335A (en) 2003-10-31
KR100511733B1 (ko) 2005-08-31
CA2375430C (en) 2006-03-14
US7553823B2 (en) 2009-06-30
US20100081810A1 (en) 2010-04-01
BR0011854A (pt) 2002-06-11
ATE240341T1 (de) 2003-05-15
US20010018428A1 (en) 2001-08-30
JP2003506460A (ja) 2003-02-18
KR20020028911A (ko) 2002-04-17
DK1192169T3 (da) 2003-08-04
CA2375430A1 (en) 2000-12-28
DE60002722T2 (de) 2004-04-08
TW589321B (en) 2004-06-01
CN1152041C (zh) 2004-06-02
IL147195A0 (en) 2002-08-14
HK1044953A1 (zh) 2002-11-08
NO323163B1 (no) 2007-01-08

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