HK1044953A1 - C-吡唑a2a受體激動劑 - Google Patents

C-吡唑a2a受體激動劑 Download PDF

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Publication number
HK1044953A1
HK1044953A1 HK02106508.0A HK02106508A HK1044953A1 HK 1044953 A1 HK1044953 A1 HK 1044953A1 HK 02106508 A HK02106508 A HK 02106508A HK 1044953 A1 HK1044953 A1 HK 1044953A1
Authority
HK
Hong Kong
Prior art keywords
aryl
alkyl
optionally substituted
heteroaryl
halogen
Prior art date
Application number
HK02106508.0A
Other languages
English (en)
Chinese (zh)
Inventor
杰夫‧A‧扎布沃茨基
埃费提‧O‧埃尔策英
文卡塔‧P‧帕列
埃費提‧O‧埃爾策英
Original Assignee
Cv治疗公司
Cv治療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv治疗公司, Cv治療公司 filed Critical Cv治疗公司
Publication of HK1044953A1 publication Critical patent/HK1044953A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02106508.0A 1999-06-22 2000-06-21 C-吡唑a2a受體激動劑 HK1044953A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/338,327 1999-06-22
US09/338,327 US6214807B1 (en) 1999-06-22 1999-06-22 C-pyrazole 2A A receptor agonists
PCT/US2000/017095 WO2000078778A2 (en) 1999-06-22 2000-06-21 C-pyrazole a2a receptor agonists

Publications (1)

Publication Number Publication Date
HK1044953A1 true HK1044953A1 (zh) 2002-11-08

Family

ID=23324355

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106508.0A HK1044953A1 (zh) 1999-06-22 2000-06-21 C-吡唑a2a受體激動劑

Country Status (23)

Country Link
US (6) US6214807B1 (https=)
EP (1) EP1192169B1 (https=)
JP (1) JP4795591B2 (https=)
KR (1) KR100511733B1 (https=)
CN (1) CN1152041C (https=)
AR (1) AR033794A1 (https=)
AT (1) ATE240341T1 (https=)
AU (1) AU766712B2 (https=)
BR (1) BR0011854A (https=)
CA (1) CA2375430C (https=)
DE (1) DE60002722T2 (https=)
DK (1) DK1192169T3 (https=)
ES (1) ES2193969T3 (https=)
HK (1) HK1044953A1 (https=)
IL (2) IL147195A0 (https=)
MX (1) MXPA01013350A (https=)
NO (1) NO323163B1 (https=)
NZ (1) NZ516335A (https=)
PT (1) PT1192169E (https=)
TR (1) TR200200320T2 (https=)
TW (1) TW589321B (https=)
WO (1) WO2000078778A2 (https=)
ZA (1) ZA200200298B (https=)

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Also Published As

Publication number Publication date
AR033794A1 (es) 2004-01-07
AU5755800A (en) 2001-01-09
WO2000078778A3 (en) 2001-05-10
ZA200200298B (en) 2003-04-30
AU766712B2 (en) 2003-10-23
US6214807B1 (en) 2001-04-10
EP1192169A2 (en) 2002-04-03
ES2193969T3 (es) 2003-11-16
EP1192169B1 (en) 2003-05-14
MXPA01013350A (es) 2002-07-09
PT1192169E (pt) 2003-09-30
TR200200320T2 (tr) 2002-05-21
US7109180B2 (en) 2006-09-19
CN1358189A (zh) 2002-07-10
WO2000078778A2 (en) 2000-12-28
US6770634B1 (en) 2004-08-03
DE60002722D1 (de) 2003-06-18
IL147195A (en) 2007-10-31
US20040198692A1 (en) 2004-10-07
NO20016351D0 (no) 2001-12-21
US6855818B2 (en) 2005-02-15
NO20016351L (no) 2002-02-18
US20070207978A1 (en) 2007-09-06
NZ516335A (en) 2003-10-31
KR100511733B1 (ko) 2005-08-31
CA2375430C (en) 2006-03-14
US7553823B2 (en) 2009-06-30
US20100081810A1 (en) 2010-04-01
BR0011854A (pt) 2002-06-11
ATE240341T1 (de) 2003-05-15
US20010018428A1 (en) 2001-08-30
JP2003506460A (ja) 2003-02-18
KR20020028911A (ko) 2002-04-17
DK1192169T3 (da) 2003-08-04
CA2375430A1 (en) 2000-12-28
DE60002722T2 (de) 2004-04-08
TW589321B (en) 2004-06-01
CN1152041C (zh) 2004-06-02
JP4795591B2 (ja) 2011-10-19
IL147195A0 (en) 2002-08-14
NO323163B1 (no) 2007-01-08

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