JP4795021B2 - 敗血症治療における経口用ラクトフェリン - Google Patents
敗血症治療における経口用ラクトフェリン Download PDFInfo
- Publication number
- JP4795021B2 JP4795021B2 JP2005508468A JP2005508468A JP4795021B2 JP 4795021 B2 JP4795021 B2 JP 4795021B2 JP 2005508468 A JP2005508468 A JP 2005508468A JP 2005508468 A JP2005508468 A JP 2005508468A JP 4795021 B2 JP4795021 B2 JP 4795021B2
- Authority
- JP
- Japan
- Prior art keywords
- lactoferrin
- composition
- sepsis
- rhlf
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43139302P | 2002-12-06 | 2002-12-06 | |
| US60/431,393 | 2002-12-06 | ||
| US49832703P | 2003-08-27 | 2003-08-27 | |
| US60/498,327 | 2003-08-27 | ||
| PCT/US2003/038621 WO2004052281A2 (en) | 2002-12-06 | 2003-12-05 | Oral lactoferrin in the treatment of sepsis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265361A Division JP2011068666A (ja) | 2002-12-06 | 2010-11-29 | 敗血症治療における経口用ラクトフェリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514111A JP2006514111A (ja) | 2006-04-27 |
| JP2006514111A5 JP2006514111A5 (enExample) | 2006-11-24 |
| JP4795021B2 true JP4795021B2 (ja) | 2011-10-19 |
Family
ID=32511559
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005508468A Expired - Fee Related JP4795021B2 (ja) | 2002-12-06 | 2003-12-05 | 敗血症治療における経口用ラクトフェリン |
| JP2010265361A Pending JP2011068666A (ja) | 2002-12-06 | 2010-11-29 | 敗血症治療における経口用ラクトフェリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265361A Pending JP2011068666A (ja) | 2002-12-06 | 2010-11-29 | 敗血症治療における経口用ラクトフェリン |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040152624A1 (enExample) |
| EP (1) | EP1581243A4 (enExample) |
| JP (2) | JP4795021B2 (enExample) |
| AU (2) | AU2003298906A1 (enExample) |
| CA (1) | CA2508912A1 (enExample) |
| WO (1) | WO2004052281A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022145536A1 (ko) * | 2020-12-30 | 2022-07-07 | 경상대학교병원 | 급성 호흡 곤란 증후군 환자의 예후 예측을 위한 정보제공방법 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| SI2298338T1 (sl) | 2002-09-16 | 2012-11-30 | Agennix Inc | Laktoferinski sestavki in postopki za zdravljenjekožnih ran |
| EP1581243A4 (en) * | 2002-12-06 | 2008-01-02 | Agennix Inc | ORAL LACTOFERRIN FOR SEPSIS TREATMENT |
| AU2003296447A1 (en) * | 2002-12-10 | 2004-06-30 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
| AU2004289170B2 (en) * | 2003-06-06 | 2009-12-17 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| US7183381B2 (en) * | 2004-10-26 | 2007-02-27 | Agennix, Inc. | Composition of lactoferrin related peptides and uses thereof |
| ITMI20052351A1 (it) † | 2005-12-09 | 2007-06-10 | Microbo Srl | Nuovo uso farmaceutico delle transferrine e composizioni farmaceutiche derivate |
| WO2007109681A2 (en) * | 2006-03-20 | 2007-09-27 | Glanbia Nutritionals (Ireland) Limited | Compositions and methods for enhancing vasodilation |
| JP5087297B2 (ja) * | 2007-03-05 | 2012-12-05 | 森永乳業株式会社 | インターロイキン−11産生促進剤 |
| ITRM20080163A1 (it) * | 2008-03-26 | 2009-09-27 | Maurizio Acri | Uso della lattoferrina per la prevenzione delle sepsi neonatali in neonati prematuri |
| EP2416800A1 (en) * | 2010-02-25 | 2012-02-15 | Agennix AG | Oral lactoferrin in the treatment of severe sepsis |
| CN101829075B (zh) * | 2010-04-27 | 2011-07-20 | 中国人民解放军第三军医大学第一附属医院 | 苦柯胺a和苦柯胺b的用途 |
| CN105101989B (zh) * | 2013-04-09 | 2019-10-18 | 加贺谷伸治 | 白细胞的细胞外诱捕网形成的抑制剂 |
| WO2021222584A2 (en) * | 2020-04-29 | 2021-11-04 | The Regents Of The University Of Michigan | Inhibition of sars-cov-2 viral entry through administration of lactoferrin and uses thereof |
| WO2023178060A1 (en) * | 2022-03-14 | 2023-09-21 | The Children's Mercy Hospital | Prophylaxis of neonatal escherichia coli sepsis |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873499A (ja) * | 1994-09-01 | 1996-03-19 | Snow Brand Milk Prod Co Ltd | 新規ペプチドおよび免疫賦活剤 |
| JPH08165248A (ja) * | 1994-12-15 | 1996-06-25 | Nobuo Kuriiwa | エンドトキシンによる炎症の抑止剤 |
| WO2001051079A1 (en) * | 2000-01-14 | 2001-07-19 | Meiji Dairies Corporation | Antigen-specific ige antibody production inhibitors |
| JP2001333737A (ja) * | 2000-03-24 | 2001-12-04 | Meiji Milk Prod Co Ltd | グラム陰性菌のリピドaに対する特異的抗体産生を誘導する組成物。 |
| JP2002515893A (ja) * | 1997-02-03 | 2002-05-28 | ファーミング インテレクチュアル プロパティ ビーブイ | ヒトラクトフェリンおよびその改変体の有用な特性 |
| JP2002541066A (ja) * | 1999-02-05 | 2002-12-03 | エンドゲン・リサーチ・ペーハー・アクチボラゲット | 抗微生物薬/エンドトキシンを中和するポリペプチド |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2710997C3 (de) * | 1977-03-14 | 1980-08-14 | Dr. Karl Thomae Gmbh, 7950 Biberach | 4-Alkoxy carbonylamino-phenyläthanolamine, deren Herstellung und deren Verwendung als Arzneimittel |
| US4977137B1 (en) * | 1987-06-03 | 1994-06-28 | Baylor College Medicine | Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract |
| US5457093A (en) * | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| US5849881A (en) * | 1989-05-05 | 1998-12-15 | Baylor College Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms |
| US5766939A (en) * | 1989-05-05 | 1998-06-16 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US6100054A (en) * | 1989-05-05 | 2000-08-08 | Baylor College Of Medicine | Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
| US5198419A (en) * | 1989-12-08 | 1993-03-30 | Immuno Japan Inc. | Formulated medicines for enhancing the efficacy of beta-lactam antibiotics in prophylaxis and treatment against infectious disease due to pathogenic bacteria |
| US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
| US5240909B1 (en) * | 1990-03-14 | 1998-01-20 | Dietrich Nitsche | Use of lactoferrin for treatment of toxic effects of endotoxins |
| EP0579830B1 (en) * | 1990-11-13 | 1997-02-05 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for corneal lesion |
| US5564109A (en) * | 1991-09-13 | 1996-10-08 | Eastman Kodak Company | Remote user interface for prioritizing and selecting from a plurality of document production peripheral devices |
| DE69322896T2 (de) * | 1992-03-02 | 1999-05-27 | Immuno Japan Inc., Tokio/Tokyo | Verwendung von Proteinen der Transferrin/Lactoferrin-Familie zur Stimulation des Immunsystems |
| JPH06145068A (ja) * | 1992-04-02 | 1994-05-24 | Imuno Japan:Kk | 生体防御能賦活剤・感染症治療剤・生体防御能賦活性食品 |
| ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
| ES2145072T3 (es) * | 1993-05-13 | 2000-07-01 | American Cyanamid Co | Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos. |
| US20020016289A1 (en) * | 1995-06-01 | 2002-02-07 | Orla M. Conneely | Methods for treatment and prevention of helicobacter pylori infection using lactoferrin |
| US6025326A (en) * | 1995-07-07 | 2000-02-15 | Intrabiotics Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of oral mucositis |
| US5834424A (en) * | 1995-07-12 | 1998-11-10 | Gambit International Limited | Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus |
| US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
| CN1262625A (zh) * | 1997-04-10 | 2000-08-09 | 阿吉尼克斯股份有限公司 | 乳铁蛋白在治疗过敏原诱发疾病中的应用 |
| US5981830A (en) * | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
| US6096731A (en) * | 1998-06-24 | 2000-08-01 | Institute For Drug Research, Inc. | Method for preventing tissue damage associated with graft-versus-host or host-versus-graft disease following transplantation |
| US20030203839A1 (en) * | 1999-10-29 | 2003-10-30 | Kruzel Marian L. | Immune enhancing composition containing lactoferrin |
| US6613741B2 (en) * | 1999-10-29 | 2003-09-02 | Ferro Dynamics, Inc. | Method for treating aseptic SIRS in humans and other animals |
| US7087578B2 (en) * | 2000-05-24 | 2006-08-08 | Eli Lilly And Company | Formulations and methods for treating hypercoagulable states |
| JP4683740B2 (ja) * | 2001-02-15 | 2011-05-18 | 明治乳業株式会社 | 炎症に伴う症状の軽減剤 |
| US20030096736A1 (en) * | 2001-05-09 | 2003-05-22 | Kruzel Marian L. | Lactoferrin for age related disorders in humans |
| WO2003094952A1 (en) * | 2002-05-10 | 2003-11-20 | Agennix Incorporated | Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| AU2003233583A1 (en) * | 2002-05-24 | 2003-12-12 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
| SI2298338T1 (sl) * | 2002-09-16 | 2012-11-30 | Agennix Inc | Laktoferinski sestavki in postopki za zdravljenjekožnih ran |
| AU2003291206A1 (en) * | 2002-12-04 | 2004-06-23 | Agennix Incorporated | Lactoferrin in the reduction of circulating cholesterol, vascular inflammation, atherosclerosis and cardiovascular disease |
| EP1581243A4 (en) * | 2002-12-06 | 2008-01-02 | Agennix Inc | ORAL LACTOFERRIN FOR SEPSIS TREATMENT |
| AU2003296447A1 (en) * | 2002-12-10 | 2004-06-30 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
| AU2003293500A1 (en) * | 2002-12-12 | 2004-07-09 | Agennix Incorporated | Lactoferrin in the reduction of pain |
| US7034126B2 (en) * | 2003-05-14 | 2006-04-25 | Agennix, Inc. | Lactoferrin in the treatment of diabetes mellitus |
| AU2004289170B2 (en) * | 2003-06-06 | 2009-12-17 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| WO2005018542A2 (en) * | 2003-07-10 | 2005-03-03 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
-
2003
- 2003-12-05 EP EP03796665A patent/EP1581243A4/en not_active Withdrawn
- 2003-12-05 AU AU2003298906A patent/AU2003298906A1/en not_active Abandoned
- 2003-12-05 US US10/728,521 patent/US20040152624A1/en not_active Abandoned
- 2003-12-05 JP JP2005508468A patent/JP4795021B2/ja not_active Expired - Fee Related
- 2003-12-05 WO PCT/US2003/038621 patent/WO2004052281A2/en not_active Ceased
- 2003-12-05 CA CA002508912A patent/CA2508912A1/en not_active Abandoned
-
2010
- 2010-01-19 AU AU2010200210A patent/AU2010200210A1/en not_active Abandoned
- 2010-02-08 US US12/702,216 patent/US20100210510A1/en not_active Abandoned
- 2010-11-29 JP JP2010265361A patent/JP2011068666A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873499A (ja) * | 1994-09-01 | 1996-03-19 | Snow Brand Milk Prod Co Ltd | 新規ペプチドおよび免疫賦活剤 |
| JPH08165248A (ja) * | 1994-12-15 | 1996-06-25 | Nobuo Kuriiwa | エンドトキシンによる炎症の抑止剤 |
| JP2002515893A (ja) * | 1997-02-03 | 2002-05-28 | ファーミング インテレクチュアル プロパティ ビーブイ | ヒトラクトフェリンおよびその改変体の有用な特性 |
| JP2002541066A (ja) * | 1999-02-05 | 2002-12-03 | エンドゲン・リサーチ・ペーハー・アクチボラゲット | 抗微生物薬/エンドトキシンを中和するポリペプチド |
| WO2001051079A1 (en) * | 2000-01-14 | 2001-07-19 | Meiji Dairies Corporation | Antigen-specific ige antibody production inhibitors |
| JP2001333737A (ja) * | 2000-03-24 | 2001-12-04 | Meiji Milk Prod Co Ltd | グラム陰性菌のリピドaに対する特異的抗体産生を誘導する組成物。 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022145536A1 (ko) * | 2020-12-30 | 2022-07-07 | 경상대학교병원 | 급성 호흡 곤란 증후군 환자의 예후 예측을 위한 정보제공방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1581243A2 (en) | 2005-10-05 |
| CA2508912A1 (en) | 2004-06-24 |
| AU2003298906A1 (en) | 2004-06-30 |
| WO2004052281A3 (en) | 2004-09-10 |
| AU2010200210A1 (en) | 2010-02-11 |
| JP2011068666A (ja) | 2011-04-07 |
| EP1581243A4 (en) | 2008-01-02 |
| US20100210510A1 (en) | 2010-08-19 |
| US20040152624A1 (en) | 2004-08-05 |
| JP2006514111A (ja) | 2006-04-27 |
| WO2004052281A2 (en) | 2004-06-24 |
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