JP4733326B2 - 患者サンプル中の止血機能障害の存在を予測する方法 - Google Patents

患者サンプル中の止血機能障害の存在を予測する方法 Download PDF

Info

Publication number
JP4733326B2
JP4733326B2 JP2001517176A JP2001517176A JP4733326B2 JP 4733326 B2 JP4733326 B2 JP 4733326B2 JP 2001517176 A JP2001517176 A JP 2001517176A JP 2001517176 A JP2001517176 A JP 2001517176A JP 4733326 B2 JP4733326 B2 JP 4733326B2
Authority
JP
Japan
Prior art keywords
patient
dic
sample
reagent
precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2001517176A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003507713A (ja
JP2003507713A5 (enExample
Inventor
トー，チェン・ホック
ダウニー，コリン
フィッシャー，ティモシー・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux Inc
Original Assignee
Biomerieux Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux Inc filed Critical Biomerieux Inc
Publication of JP2003507713A publication Critical patent/JP2003507713A/ja
Publication of JP2003507713A5 publication Critical patent/JP2003507713A5/ja
Application granted granted Critical
Publication of JP4733326B2 publication Critical patent/JP4733326B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2001517176A 1999-08-12 2000-08-02 患者サンプル中の止血機能障害の存在を予測する方法 Expired - Fee Related JP4733326B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/372,954 US6429017B1 (en) 1999-02-04 1999-08-12 Method for predicting the presence of haemostatic dysfunction in a patient sample
US09/372,954 1999-08-12
PCT/US2000/021022 WO2001013125A1 (en) 1999-08-12 2000-08-02 A method for predicting the presence of haemostatic dysfunction in a patient sample

Publications (3)

Publication Number Publication Date
JP2003507713A JP2003507713A (ja) 2003-02-25
JP2003507713A5 JP2003507713A5 (enExample) 2007-10-04
JP4733326B2 true JP4733326B2 (ja) 2011-07-27

Family

ID=23470305

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001517176A Expired - Fee Related JP4733326B2 (ja) 1999-08-12 2000-08-02 患者サンプル中の止血機能障害の存在を予測する方法

Country Status (7)

Country Link
US (2) US6429017B1 (enExample)
EP (1) EP1200837A4 (enExample)
JP (1) JP4733326B2 (enExample)
KR (1) KR20020021811A (enExample)
AU (1) AU6617900A (enExample)
CA (1) CA2380622C (enExample)
WO (1) WO2001013125A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429017B1 (en) * 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
JP4486260B2 (ja) * 1999-02-04 2010-06-23 バイオメリュー・インコーポレイテッド 患者サンプルにおける止血機能不全の存在を予測するための方法および装置
EP1522860A1 (en) * 1999-02-04 2005-04-13 bioMérieux, Inc. A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
AUPP971299A0 (en) * 1999-04-12 1999-05-06 South Eastern Sydney Area Health Service Procoagulant assay
CA2412317C (en) * 2000-06-09 2016-03-22 Biomerieux, Inc. A method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
US7179612B2 (en) * 2000-06-09 2007-02-20 Biomerieux, Inc. Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
WO2003083490A2 (en) * 2001-06-29 2003-10-09 Biomerieux, Inc. Method for predicting antiphospholid syndrome
WO2003073099A1 (en) * 2002-02-27 2003-09-04 Biomerieux, Inc. Method for diagnosing and monitoring hemostatic dysfunction, severe infection and systematic inflammatory response syndrome
ES2275980T3 (es) * 2002-08-09 2007-06-16 Dade Behring Marburg Gmbh Combinacion de proteina c reactiva y dimero-d para el diagnostico de trombosis venosa profunda (tvp).
WO2004036226A1 (en) * 2002-10-15 2004-04-29 The University Of Tennessee Research Foundation Methods for assessment of platelet aggregation
MXPA05005073A (es) * 2002-11-12 2005-11-17 Becton Dickinson Co Diagnostico de la sepsis o sirs usando perfiles de biomarcadores.
AU2003291484A1 (en) 2002-11-12 2004-06-03 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
CA2505921A1 (en) 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
GB2404981A (en) 2003-08-15 2005-02-16 Univ Geneve Diagnostic method for stroke
WO2006060386A1 (en) * 2004-12-01 2006-06-08 Biomerieux, Inc. Method for diagnosing critically ill patients
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
WO2006113529A2 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
RU2360610C1 (ru) * 2008-01-29 2009-07-10 Федеральное государственное учреждение "Ивановский научно-исследовательский институт материнства и детства имени В.Н. Городкова Федерального агентства по высокотехнологичной медицинской помощи" Способ прогнозирования возникновения осложнений у женщин с климактерическим синдромом на фоне заместительной гормональной терапии
WO2009101242A1 (en) * 2008-02-14 2009-08-20 Orion Diagnostica Oy Method for predicting a future property
WO2009123737A2 (en) 2008-04-03 2009-10-08 Becton, Dickinson And Company Advanced detection of sepsis
DE102008022884A1 (de) * 2008-05-08 2009-11-12 Zander, Rolf, Prof. Dr.Med. Vorrichtung und Verfahren für die Blutgerinnungsdiagnostik
GB2547930A (en) 2016-03-03 2017-09-06 Sepsense Ltd Assay device
US10872410B2 (en) 2016-09-29 2020-12-22 Animantis, Llc Methods and apparatus for assessing immune system activity and therapeutic efficacy
CN108344875B (zh) * 2017-01-22 2021-11-02 上海长岛生物技术有限公司 提高活化部分凝血活酶时间试剂对肝素敏感性的方法及用途

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2458287A (en) * 1944-08-31 1949-01-04 Signode Steel Strapping Co Snubber plate
US3307392A (en) 1964-05-04 1967-03-07 Research Corp Automatic prothrombin timer apparatus and method
US3458287A (en) 1965-04-29 1969-07-29 Medical Laboratory Automation Method and means of determining endpoint times in blood clotting tests
US3658480A (en) 1970-04-13 1972-04-25 Bio Data Corp Coagulation timing apparatus, and method
US4047890A (en) 1973-11-01 1977-09-13 Bio/Data Corporation Method and apparatus for determining deficiencies in enzymatic reactors particularly clotting factor levels in blood plasmas
SU590665A1 (ru) 1976-02-11 1978-01-30 Новосибирский государственный медицинский институт Способ исследовани процесса свертывани крови
US4040788A (en) * 1976-04-05 1977-08-09 Sanford L. Simons Apparatus, instrumentation, and method for comparing samples
US4157871A (en) * 1976-06-02 1979-06-12 Beckman Instruments, Inc. System for rate immunonephelometric analysis
DE2635081C3 (de) 1976-08-04 1980-08-07 Bio/Data Corp., Willow Grove, Pa. (V.St.A.) Verfahren und Vorrichtung zur Bestimmung von Blutplasma-Gerinnungsfaktorpegeln
FR2364453A1 (fr) 1976-09-08 1978-04-07 Lacombe Pierre Dispositif electronique apportant un perfectionnement aux appareils destines a analyser la coagulation sanguine : prothrombinometre citrate-oxalate
US4199748A (en) 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
JPS5451893A (en) 1977-09-30 1979-04-24 Sankyo Co Measuring of blood coagulating time
JPS5822703B2 (ja) 1978-08-30 1983-05-10 三共株式会社 血液凝固測定方法
US4289498A (en) 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
AU543007B2 (en) * 1980-04-15 1985-03-28 Technicon Instruments Corportion Agglutination immunoassay
US4766083A (en) 1982-04-04 1988-08-23 Wako Pure Chemical Industries, Ltd. Method for the photometric determination of biological agglutination
SU1076086A1 (ru) 1982-12-28 1984-02-29 Всесоюзный Научно-Исследовательский И Конструкторский Институт Медицинской Лабораторной Техники Гемокоагулограф
US4705756A (en) 1983-01-26 1987-11-10 University Of Medicine And Dentistry Of New Jersey Method of determining the existence and/or the monitoring of a pathological condition in a mammal
EP0115459A3 (en) 1983-01-26 1986-11-20 University Of Medicine And Dentistry Of New Jersey Hematological prediction of sepsis and other disease states
JPS59203959A (ja) 1983-05-04 1984-11-19 Toa Medical Electronics Co Ltd 血液凝固時間測定装置
JPH0695095B2 (ja) 1983-11-25 1994-11-24 株式会社島津製作所 全自動血液分析装置
DE3502878A1 (de) 1985-01-29 1986-07-31 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur bestimmung des fibrinolytischen zustands von plasma
JPS61272655A (ja) 1985-05-28 1986-12-02 Iryo Kogaku Kenkyusho:Kk 血小板凝集能の定量的判定方法
GB8516081D0 (en) 1985-06-25 1985-07-31 Ciba Geigy Ag Assay & purification of amyloid components
US4902630A (en) 1985-07-22 1990-02-20 Abbott Laboratories Fluorescence polarization immunoassy and reagents for measurement of c-reactive protein
ATE134880T1 (de) 1988-04-04 1996-03-15 Lawrence A Potempa Bindung von immunkomplexen durch modifizierte formen von c-reaktiven proteinen
US5593897A (en) 1988-04-04 1997-01-14 Northwestern University Binding of immune complexes by modified forms of C-reactive protein
US4965725B1 (en) 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5156974A (en) 1988-05-27 1992-10-20 Biodata Corporation Method for determining the fibrinogen level of a blood sample
US5003065A (en) 1988-06-14 1991-03-26 Carey Merritt Compounds and process for measuring c-reactive protein
US5697369A (en) 1988-12-22 1997-12-16 Biofield Corp. Method and apparatus for disease, injury and bodily condition screening or sensing
DE3901458A1 (de) * 1989-01-19 1990-07-26 Behringwerke Ag Verwendung von zwei- oder dreiwertigen kationen in immunchemischen tests
US5055412A (en) * 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
US5500345A (en) 1989-04-25 1996-03-19 Iatron Laboratories, Inc. Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein
AU642430B2 (en) 1989-06-27 1993-10-21 Rush - Presbyterian - St. Luke's Medical Center Monoclonal antibodies to c-reactive protein
US5051357A (en) 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
WO1991001383A1 (en) 1989-07-14 1991-02-07 Michigan State University Method for diagnosing blood clotting disorders
AU6067190A (en) 1989-07-20 1991-02-22 Analytical Control Systems, Inc. Improved stable coagulation controls
SU1691741A1 (ru) 1989-08-25 1991-11-15 Донецкий государственный медицинский институт Способ прогнозировани геморрагических осложнений при травматической болезни
US4998535A (en) 1989-09-05 1991-03-12 Univ. of Washington New England Medical Center Hospitals, Inc. Thrombolysis predictive instrument
US5262303A (en) 1989-10-13 1993-11-16 Trustees Of Boston University Ligand/anti-ligand assays for adherent proteins
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
IE904244A1 (en) 1989-12-01 1991-06-05 Akzo Nv Direct fibrinogen assay
US5169786A (en) 1989-12-19 1992-12-08 Ortho Diagnostic Systems, Inc. Method of determining levels of extrinsic and intrinsic clotting factors and protein c
WO1991016453A1 (en) 1990-04-17 1991-10-31 Analytical Control Systems, Inc. Coagulation assays and reagents
US5862304A (en) 1990-05-21 1999-01-19 Board Of Regents, The University Of Texas System Method for predicting the future occurrence of clinically occult or non-existent medical conditions
US5218529A (en) 1990-07-30 1993-06-08 University Of Georgia Research Foundation, Inc. Neural network system and methods for analysis of organic materials and structures using spectral data
CA2052316C (en) * 1990-10-10 1997-12-23 Edward A. Oakley Sludge flow measuring system
JPH04254760A (ja) 1991-01-30 1992-09-10 Eiken Chem Co Ltd 血清アミロイドａ標準物質、およびその設定方法
US5221628A (en) 1991-03-19 1993-06-22 Northwestern University Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component
RU2012877C1 (ru) 1991-04-01 1994-05-15 Белорусский научно-исследовательский институт охраны материнства и детства Способ прогнозирования синдрома дыхательных расстройств у недоношенных новорожденных
DE69122752T2 (de) 1991-08-02 1997-04-10 Grifols Grupo Sa Verfahren und Vorrichtung zur Bestimmung der Gerinnungszeit von Blut und Plasma
WO1993007491A1 (en) 1991-10-04 1993-04-15 Board Of Regents Of The University Of Nebraska A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
US5716795A (en) 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
JP3222135B2 (ja) 1991-11-04 2001-10-22 アデザ バイオメディカル コーポレイション 早期分娩の危険が増大している女性を特定するスクリーニング方法
JPH05180835A (ja) 1991-12-27 1993-07-23 S R L:Kk ループスアンチコアグラントの測定方法
US5318958A (en) 1992-05-29 1994-06-07 Queen's University At Kingston Amyloid precursor protein
JP2934557B2 (ja) 1992-07-10 1999-08-16 国際試薬株式会社 血液凝固時間測定方法とその装置
JPH0636061A (ja) 1992-07-21 1994-02-10 Fujitsu Ltd 階層型ニューラルネットワークの学習方式
US5388164A (en) 1992-08-19 1995-02-07 Olympus Optical Co., Ltd. Method for judging particle agglutination patterns using neural networks
JP3224607B2 (ja) * 1992-09-11 2001-11-05 株式会社アズウェル 血液凝固第ｘｉｉｉ因子活性測定方法および該測定用試薬キット
US5369484A (en) 1992-11-09 1994-11-29 Akzo N.V. Multiple discrete analyzer test apparatus and method
US5358852A (en) 1992-12-21 1994-10-25 Eastman Kodak Company Use of calcium in immunoassay for measurement of C-reactive protein
RU2070327C1 (ru) 1992-12-25 1996-12-10 Безруков Александр Васильевич Устройство для измерения времени свертывания крови
US5344754A (en) 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
JP2938302B2 (ja) 1993-02-25 1999-08-23 国際試薬株式会社 血液凝固時間測定方法とその装置
JPH06249857A (ja) 1993-02-26 1994-09-09 Hitachi Ltd 自動分析装置
RU2061953C1 (ru) 1993-03-10 1996-06-10 Тюменский государственный медицинский институт МЗ РФ Способ количественного определения общей коагуляционной активности тромбоцитов
US5670329A (en) 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
ATE177536T1 (de) * 1993-06-30 1999-03-15 Diagnostische Forsch Stiftung Messung des aktivierten partiellen thromboplastinzeit (aptt) in einer einstufen- reaktion
DE69434128T2 (de) 1993-08-16 2005-11-10 Biomerieux, Inc. Methode und gerät zur automatischen durchführung von analysen bezüglich thrombose und blutgerinnung
US5526111A (en) 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
US5472852A (en) 1993-09-15 1995-12-05 Oklahoma Medical Research Foundation Assay for detection of selective Protein C inhibition by patients
US5473732A (en) 1993-11-02 1995-12-05 Chang; Hou-Mei H. Relational artificial intelligence system
US5553616A (en) 1993-11-30 1996-09-10 Florida Institute Of Technology Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator
US5856114A (en) 1994-03-21 1999-01-05 The University Of Vermont Immunologic detection of factor VA fragments in hemorrhagic and thrombotic clinical settings
JPH08512139A (ja) 1994-04-28 1996-12-17 デイド、インターナショナル、インコーポレイテッド プロトロンビン時間（ｐｔ）アッセイ用のキャリブレーター
WO1996006624A1 (en) 1994-08-26 1996-03-07 Immtech International, Inc. A mutant protein and methods and materials for making and using it
US5504011A (en) 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
SE9403833D0 (sv) * 1994-11-08 1994-11-08 Global Hemostasis Inst Mgr Ab Analysförfarande och kit
US5705395A (en) 1994-11-14 1998-01-06 The Scripps Research Institute Method for diagnosis of thrombotic disorders
US5567596A (en) 1994-12-29 1996-10-22 Research Foundation Of State University Of New York Rapid assay of activators and inhibitors of clotting
WO1996021740A1 (en) 1995-01-10 1996-07-18 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
US5708591A (en) 1995-02-14 1998-01-13 Akzo Nobel N.V. Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions
US5646045A (en) * 1995-05-17 1997-07-08 Protein Technologies International Cellulose in food matrix quantification
US6321164B1 (en) * 1995-06-07 2001-11-20 Akzo Nobel N.V. Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade
US6429017B1 (en) * 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
US5780255A (en) 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
JPH11510596A (ja) 1995-07-21 1999-09-14 ザ・プロヴォスト，フェローズ・アンド・スカラーズ・オブ・ザ・カレッジ・オブ・ザ・ホーリー・アンド・アンディヴァイデッド・トリニティー・オブ・クイーン・エリザベス・ニアー・ダブリン ヒト急性期血清アミロイドａタンパク質、組換えタンパク質、特異的抗体の定量的測定法
US5766869A (en) 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
AU717559B2 (en) 1996-03-22 2000-03-30 Dade Behring Inc. Combination reagent holding and test device
JPH1026621A (ja) 1996-07-12 1998-01-27 Dai Ichi Pure Chem Co Ltd イムノアッセイ法
US5684007A (en) 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
JP3876022B2 (ja) 1996-09-26 2007-01-31 生化学工業株式会社 血液凝固時間に影響を与える物質の定量方法
EP0841566A1 (en) 1996-11-11 1998-05-13 Pentapharm A.G. Positive control plasma for lupus anticoagulant
PT1493439E (pt) 1997-04-02 2012-01-10 Brigham & Womens Hospital Meio de avaliação do perfil de risco de um indivíduo para uma doença aterosclerótica
US6010911A (en) 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
ES2162361T3 (es) 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
CN1309770A (zh) 1998-07-31 2001-08-22 华莱士·E·卡罗尔 确定抗凝治疗因子的设备和方法
US7179612B2 (en) * 2000-06-09 2007-02-20 Biomerieux, Inc. Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality

Also Published As

Publication number Publication date
AU6617900A (en) 2001-03-13
US6429017B1 (en) 2002-08-06
CA2380622C (en) 2013-12-10
WO2001013125A1 (en) 2001-02-22
JP2003507713A (ja) 2003-02-25
EP1200837A4 (en) 2003-07-02
US20030049851A1 (en) 2003-03-13
KR20020021811A (ko) 2002-03-22
EP1200837A1 (en) 2002-05-02
CA2380622A1 (en) 2001-02-22

Similar Documents

Publication Publication Date Title
JP4733326B2 (ja) 患者サンプル中の止血機能障害の存在を予測する方法
AU2008201621B8 (en) A method for predicting the presence of haemostatic dysfunction in a patient sample
US20070155018A1 (en) Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
JP5662802B2 (ja) フォン−ビルブランド病ならびにフォン−ビルブランド病および血小板機能の後天性または先天性障害に関連する出血リスクの増加を評価するためのインビトロ診断法
CN115190973B (zh) 基于可溶性clec-2与血小板数的血小板活化测定方法
US9297815B2 (en) Method and kit for detecting condition in patient with disturbance of consciousness
AU2001266795A1 (en) A method for detecting a lipoprotein-acute phase protein complex
US7179612B2 (en) Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
US10094839B2 (en) Biomarker of renal dysfunction
EP4636404A2 (en) Method for evaluating risk of acute cerebral vascular disease using soluble clec2
JP6158825B2 (ja) テネイシンｃおよび関節リウマチにおけるその使用
RU2789822C1 (ru) Способ оптимизации лабораторной диагностики тромбинемии у пациентов с инфекцией COVID-19
US10371706B2 (en) Biomarker of renal dysfunction
AU2005201099A1 (en) Method for predicting the presence of haemostatic dysfunction in a patient sample
Martin et al. Alexander Gombert1, Drosos Kotelis1, Marcia V. Rückbeil2, Mohammad Barbati1
HK40105374A (en) Method for evaluating risk of acute cerebral vascular disease using soluble clec2
JP2020153767A (ja) 被検動物における急性期のｂａｄの発症可能性の評価方法及び急性期の分岐粥腫型梗塞の診断薬

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20050513

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20050513

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070802

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070814

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100115

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20100121

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100415

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100514

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100813

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101115

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101122

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101209

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101216

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110112

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110127

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110325

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110422

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140428

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees