JP4726297B2 - 分子内発光抑制式近赤外蛍光プローブ - Google Patents

分子内発光抑制式近赤外蛍光プローブ Download PDF

Info

Publication number
JP4726297B2
JP4726297B2 JP2000548012A JP2000548012A JP4726297B2 JP 4726297 B2 JP4726297 B2 JP 4726297B2 JP 2000548012 A JP2000548012 A JP 2000548012A JP 2000548012 A JP2000548012 A JP 2000548012A JP 4726297 B2 JP4726297 B2 JP 4726297B2
Authority
JP
Japan
Prior art keywords
probe
fluorescent
fluorescent dye
target tissue
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000548012A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002514610A5 (https=
JP2002514610A (ja
Inventor
ラルフ ウェイスリーダー
チン−スアン チュン
ウマー マームード
リー ジョセフソン
アレクセイ ボグダノフ
Original Assignee
ザ ジェネラル ホスピタル コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ ジェネラル ホスピタル コーポレイション filed Critical ザ ジェネラル ホスピタル コーポレイション
Publication of JP2002514610A publication Critical patent/JP2002514610A/ja
Publication of JP2002514610A5 publication Critical patent/JP2002514610A5/ja
Application granted granted Critical
Publication of JP4726297B2 publication Critical patent/JP4726297B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Surface Treatment Of Glass (AREA)
  • Polyesters Or Polycarbonates (AREA)
JP2000548012A 1998-05-14 1999-05-13 分子内発光抑制式近赤外蛍光プローブ Expired - Lifetime JP4726297B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/079,447 1998-05-14
US09/079,447 US6083486A (en) 1998-05-14 1998-05-14 Intramolecularly-quenched near infrared fluorescent probes
PCT/US1999/010589 WO1999058161A1 (en) 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011005396A Division JP5171970B2 (ja) 1998-05-14 2011-01-14 分子内発光抑制式近赤外蛍光プローブ

Publications (3)

Publication Number Publication Date
JP2002514610A JP2002514610A (ja) 2002-05-21
JP2002514610A5 JP2002514610A5 (https=) 2005-12-22
JP4726297B2 true JP4726297B2 (ja) 2011-07-20

Family

ID=22150620

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000548012A Expired - Lifetime JP4726297B2 (ja) 1998-05-14 1999-05-13 分子内発光抑制式近赤外蛍光プローブ
JP2011005396A Expired - Lifetime JP5171970B2 (ja) 1998-05-14 2011-01-14 分子内発光抑制式近赤外蛍光プローブ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011005396A Expired - Lifetime JP5171970B2 (ja) 1998-05-14 2011-01-14 分子内発光抑制式近赤外蛍光プローブ

Country Status (8)

Country Link
US (1) US6083486A (https=)
EP (2) EP1077731B1 (https=)
JP (2) JP4726297B2 (https=)
AT (1) ATE473017T1 (https=)
AU (1) AU770216B2 (https=)
CA (1) CA2328136C (https=)
DE (1) DE69942563D1 (https=)
WO (1) WO1999058161A1 (https=)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7107116B2 (en) * 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
EP1283728A2 (en) * 2000-05-23 2003-02-19 Amersham Health AS Contrast agents
GB0024351D0 (en) * 2000-10-04 2000-11-22 Amersham Pharm Biotech Uk Ltd Dye-labelled peptide and method
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1379284A4 (en) * 2001-01-05 2007-07-25 Gen Hospital ACTIVE IMAGING PROBES
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
GB2372256A (en) * 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
DE10151670A1 (de) * 2001-10-19 2003-05-08 Siemens Ag Bildgebungsverfahren und Bildgebungsvorrichtung, insbesondere für die Kleintierbildgebung
ATE536993T1 (de) * 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
WO2003061711A2 (en) * 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
WO2003082988A1 (en) * 2002-03-29 2003-10-09 The General Hospital Corporation Nir-fluorescent cyanine dyes, their synthesis and biological use
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
EP1481633B1 (de) * 2003-05-30 2007-05-02 Siemens Aktiengesellschaft Gerät zum Erfassen wenigstens einer Substanz in einem Stoffwechselprozess eines Lebewesens
US20080102036A1 (en) * 2003-06-04 2008-05-01 Poss Kirtland G Biocompatible Fluorescent Silicon Nanoparticles
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
US7985401B2 (en) 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
US20050272967A1 (en) * 2004-05-18 2005-12-08 Siemens Aktiengesellschaft Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams
US7585492B2 (en) 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
WO2005110495A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy control in radiation therapy with proton or ion beams
US20050259779A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
JP2006225270A (ja) * 2005-02-15 2006-08-31 Yoshihiro Futamura 性ホルモン修飾作用を有するトリペプチド又はそれを含有する抽出物、エイコサペンタエン酸を結合してなるトリペプチド、それからなる食品製剤、化粧品製剤、子宮内膜症治療剤
WO2007023398A2 (en) * 2005-05-16 2007-03-01 Universite De Geneve Compounds for photochemotherapy
WO2007005491A1 (en) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP5416970B2 (ja) 2005-09-02 2014-02-12 ビセン メディカル， インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団
US7947256B2 (en) * 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
US8478386B2 (en) 2006-01-10 2013-07-02 Accuvein Inc. Practitioner-mounted micro vein enhancer
US12408865B2 (en) 2006-01-10 2025-09-09 Accuvein Inc. Vein imaging device with differential image resolution at the center and the extremities of the vein image
US10238294B2 (en) 2006-06-29 2019-03-26 Accuvein, Inc. Scanned laser vein contrast enhancer using one laser
US9854977B2 (en) 2006-01-10 2018-01-02 Accuvein, Inc. Scanned laser vein contrast enhancer using a single laser, and modulation circuitry
US8489178B2 (en) 2006-06-29 2013-07-16 Accuvein Inc. Enhanced laser vein contrast enhancer with projection of analyzed vein data
US12471844B2 (en) 2006-06-29 2025-11-18 Accuvein, Inc. Scanned laser vein contrast enhancer with full stopping of scanner movement during scan line reversals
US11253198B2 (en) 2006-01-10 2022-02-22 Accuvein, Inc. Stand-mounted scanned laser vein contrast enhancer
US9492117B2 (en) 2006-01-10 2016-11-15 Accuvein, Inc. Practitioner-mounted micro vein enhancer
US10813588B2 (en) 2006-01-10 2020-10-27 Accuvein, Inc. Micro vein enhancer
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
US11278240B2 (en) 2006-01-10 2022-03-22 Accuvein, Inc. Trigger-actuated laser vein contrast enhancer
US12089951B2 (en) 2006-01-10 2024-09-17 AccuVeiw, Inc. Scanned laser vein contrast enhancer with scanning correlated to target distance
US12295744B2 (en) 2006-01-10 2025-05-13 Accuvein, Inc. Micro vein enhancer with two lasers and two optical detectors configured for removing surface topology
US8594770B2 (en) 2006-06-29 2013-11-26 Accuvein, Inc. Multispectral detection and presentation of an object's characteristics
US8463364B2 (en) 2009-07-22 2013-06-11 Accuvein Inc. Vein scanner
US8730321B2 (en) 2007-06-28 2014-05-20 Accuvein, Inc. Automatic alignment of a contrast enhancement system
US8078264B2 (en) 2006-07-11 2011-12-13 Case Western Reserve University Intra-operative molecular imaging
ES2399147T3 (es) 2006-09-08 2013-03-26 Rhode Island Hospital Tratamiento, prevención y reversión de una enfermedad hepática alcohólica
US9308198B2 (en) 2006-09-08 2016-04-12 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced brain disease
RU2450832C2 (ru) * 2006-10-25 2012-05-20 Конинклейке Филипс Электроникс Н.В. Контрастные вещества для детекции рака предстательной железы
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US8221721B2 (en) * 2007-02-09 2012-07-17 Visen Medical, Inc. Polycyclo dyes and use thereof
CA2678717A1 (en) 2007-02-28 2008-09-04 Sanofi-Aventis Imaging probes
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US9271653B2 (en) 2007-06-12 2016-03-01 Case Western Reserve University Intra-operative molecular imaging
US7906106B2 (en) 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
WO2009019115A1 (en) 2007-08-03 2009-02-12 Sanofi-Aventis Caspase imaging probes
JP5448397B2 (ja) * 2007-09-07 2014-03-19 キヤノン株式会社 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
ES2658852T3 (es) 2008-01-18 2018-03-12 Visen Medical, Inc. Agentes de imaginología fluorescentes
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US8758727B2 (en) * 2008-03-31 2014-06-24 University Of Louisville Research Foundation, Inc. Site specific fluorescence and contrast marker for same
JP5278873B2 (ja) * 2008-05-14 2013-09-04 国立大学法人九州工業大学 癌診断用試薬
WO2010042815A2 (en) * 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
GB0823315D0 (en) * 2008-12-22 2009-01-28 Ge Healthcare As Fluorescent Probes
KR101043407B1 (ko) * 2009-02-19 2011-06-22 한국과학기술연구원 암 표적성이 우수한 단백질 복합체 및 이의 제조방법
EP2435096A1 (en) 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
JP2012533560A (ja) 2009-07-15 2012-12-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞における取り込みが制御可能なペプチド
US9061109B2 (en) 2009-07-22 2015-06-23 Accuvein, Inc. Vein scanner with user interface
US20120230918A1 (en) 2009-07-28 2012-09-13 Hoffmann-La-Roche Inc. Non-invasive in vivo optical imaging method
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
RU2012148816A (ru) 2010-05-07 2014-06-20 Ф. Хоффманн-Ля Рош Аг Метод диагностики для определения клеток ex vivo
CN103096935B (zh) * 2010-08-23 2017-06-16 株式会社岛津制作所 开关型荧光纳米颗粒探针及使用其的荧光分子成像法
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
EP2646059A4 (en) 2010-12-01 2016-07-27 Methodist Hospital System PROTEASE-DERIVABLE POLYPEPTIDES AND USES THEREOF
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
EP2682131B1 (en) * 2011-03-02 2020-05-13 Kyoto University Switching-type fluorescent nanoparticle probe, and fluorescent molecular imaging method using same
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
JP6385060B2 (ja) 2011-03-07 2018-09-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 治療的に活性な抗体のインビボにおける選択
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
WO2012159107A1 (en) 2011-05-19 2012-11-22 Rhode Island Hospital Inhibition of renal fibrosis
US20150031046A1 (en) * 2011-05-24 2015-01-29 Lijun Dai Bioanalytical Reagent used in Heterogeneous Phase and Usage Method Thereof
MX350082B (es) 2011-07-29 2017-08-24 Avelas Biosciences Inc Moleculas de entrega selectiva y metodos de uso.
WO2013081036A1 (ja) * 2011-11-29 2013-06-06 太陽誘電株式会社 マーカ分子
US9375493B2 (en) 2012-03-30 2016-06-28 Visen Medical, Inc. Bacterial imaging agents and methods of using same
US9072426B2 (en) 2012-08-02 2015-07-07 AccuVein, Inc Device for detecting and illuminating vasculature using an FPGA
JP6370785B2 (ja) 2012-08-15 2018-08-08 ビセン メディカル， インコーポレイテッド 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法
CA2884309A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity
US20150258217A1 (en) * 2012-10-04 2015-09-17 The General Hospital Corporation Methods of Synthesizing and Using Peg-Like Fluorochromes
US9650674B2 (en) 2012-10-19 2017-05-16 Bioventures, Llc Nucleic acid probes and methods of using the same
US9950053B2 (en) 2012-10-22 2018-04-24 The Board Of Regents For Oklahoma State University Use of the Salmonella SPP type III secretion proteins as a protective vaccination
US10548962B2 (en) 2012-10-22 2020-02-04 The Board Of Regents For Oklahoma State University Use of the salmonella SPP type III secretion proteins as a protective vaccination
US10517483B2 (en) 2012-12-05 2019-12-31 Accuvein, Inc. System for detecting fluorescence and projecting a representative image
NL2010040C2 (en) * 2012-12-21 2014-06-24 Internat Inst For Diagnostic And Analitical Affairs B V Cleavable coating material having microbial functionality.
WO2014120837A2 (en) 2013-01-29 2014-08-07 The Regents Of The University Of California Pretargeted activatable cell penetrating peptide with intracellulary releaseable prodrug
AU2014212308B2 (en) 2013-01-30 2018-08-09 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US9439976B2 (en) 2013-02-13 2016-09-13 The Methodist Hospital System Compositions and methods for using cathepsin E cleavable substrates
US10791937B2 (en) 2013-03-14 2020-10-06 Lumicell, Inc. Medical imaging device and methods of use
WO2014160037A2 (en) 2013-03-14 2014-10-02 The Regents Of The University Of California Activatable membrane-interacting peptides and methods of use
CN105339436B (zh) 2013-03-15 2018-05-25 文森医学公司 4,4-二取代环己基桥连七甲川花菁染料及其应用
JP6606487B2 (ja) 2013-03-15 2019-11-13 ビセン メディカル， インコーポレイテッド ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素
AU2014296253A1 (en) 2013-07-30 2016-02-04 President And Fellows Of Harvard College Quantitative DNA-based imaging and super-resolution imaging
US10610608B2 (en) 2013-08-01 2020-04-07 Rochester Institute Of Technology Modular imaging agents containing amino acids and peptides
EP2848696A1 (en) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Caspase-1 imaging probes
CN104673274A (zh) * 2013-12-02 2015-06-03 复旦大学 一种用于肿瘤转移倾向评估的靶向示踪的酸敏感近红外荧光探针
WO2015099094A1 (ja) 2013-12-27 2015-07-02 国立大学法人東京医科歯科大学 アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法
EP4245859A3 (en) 2014-03-11 2023-11-08 President and Fellows of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
AU2015292498B2 (en) 2014-07-23 2020-11-05 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72)
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
NL2013786B1 (en) * 2014-11-13 2016-10-07 Original G B V Quenched coating.
US10596259B2 (en) 2015-05-20 2020-03-24 The Regents Of The University Of California Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
US20180224461A1 (en) 2015-08-07 2018-08-09 President And Fellows Of Harvard College Super resolution imaging of protein-protein interactions
CN106280533B (zh) * 2016-08-17 2018-03-09 赣南师范大学 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记
JP2020504600A (ja) 2016-12-09 2020-02-13 アルティヴュー， インク． 標識化核酸イメージング剤を使用した多重イメージングのための改善された方法
JP6977287B2 (ja) * 2017-03-29 2021-12-08 東ソー株式会社 複数の蛍光物質を用いた標識方法
CN110944985B (zh) 2017-05-24 2022-12-13 特拉维夫大学拉玛特有限公司 用于蛋白酶的成像/检测的化学发光探针
FI3749781T3 (fi) * 2018-02-06 2024-12-27 Gen Probe Inc Kaukopunaväriaineen koetinformulaatioita
CN111704716B (zh) * 2020-07-03 2021-07-13 浙江大学 一种荧光聚赖氨酸树枝状大分子、其制备方法和应用
EP4211468A4 (en) 2020-09-11 2024-10-09 Glympse Bio, Inc. DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES
WO2022147171A1 (en) 2020-12-30 2022-07-07 Hawkeye Bio, Limited Pristine graphene based biosensor for biomarker detection and related core particles, materials compositions methods and systems

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335902B1 (en) * 1986-12-15 1993-12-01 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5384241A (en) * 1987-09-11 1995-01-24 Enzo Diagnostics, Inc. Specific binding assay compound with inhibitive self-quenching characteristics
ES2061923T3 (es) * 1989-12-27 1994-12-16 Nestle Sa Procedimiento de la reaccion de un dextranomero injertado y de un colorante ftalocianinico y su utilizacion.
US5641878A (en) * 1991-05-15 1997-06-24 Diatron Corporation Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
EP0529002B1 (en) * 1990-05-15 2001-10-04 Hyperion, Inc. Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1991018007A1 (en) * 1990-05-15 1991-11-28 Diatron Corporation Phthalocyanatopolyethylene glycol, and phthalocyanato saccharides as fluorescent digoxin reagents
CA2082936C (en) * 1990-05-15 2003-09-23 Peter O. G. Arrhenius Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
ES2199226T3 (es) * 1992-09-04 2004-02-16 The General Hospital Corporation Polimeros biocompatibles que contienen mitades diagnosticas o terapeuticas.
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay

Also Published As

Publication number Publication date
ATE473017T1 (de) 2010-07-15
EP1077731A1 (en) 2001-02-28
US6083486A (en) 2000-07-04
EP1077731B1 (en) 2010-07-07
HK1036752A1 (en) 2002-01-18
AU770216B2 (en) 2004-02-19
EP2251041A3 (en) 2010-12-01
CA2328136A1 (en) 1999-11-18
CA2328136C (en) 2009-03-24
WO1999058161A1 (en) 1999-11-18
DE69942563D1 (de) 2010-08-19
JP2011095273A (ja) 2011-05-12
EP1077731A4 (en) 2004-05-12
EP2251041A2 (en) 2010-11-17
JP5171970B2 (ja) 2013-03-27
AU4077799A (en) 1999-11-29
JP2002514610A (ja) 2002-05-21

Similar Documents

Publication Publication Date Title
JP4726297B2 (ja) 分子内発光抑制式近赤外蛍光プローブ
US6592847B1 (en) Intramolecularly-quenched near infrared flourescent probes
Bremer et al. Optical-based molecular imaging: contrast agents and potential medical applications
CN110741242B (zh) 比率荧光成像方法
JP4699575B2 (ja) 化合物
Etrych et al. Fluorescence optical imaging in anticancer drug delivery
US20030044353A1 (en) Activatable imaging probes
Bogdanov Jr et al. Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment
Huang et al. Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma
EP1379284A2 (en) Activatable imaging probes
Ferber et al. Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release
WO2007109364A2 (en) Intramolecularly quenched fluorochrome conjugates and methods of use
CA2961095C (en) Upar targeting peptide for use in perioperative optical imaging of invasive cancer
US20060147378A1 (en) Azulene dimer-quenched, near-infrared fluorescent probes
Özel et al. Enzymatically activated near infrared nanoprobes based on amphiphilic block copolymers for optical detection of cancer
US20090074672A1 (en) Tumor Boundary Imaging
US20160051704A1 (en) Molecular imaging probes for lung cancer intraoperative guidance
Napp et al. Optical imaging in vivo with a focus on paediatric disease: technical progress, current preclinical and clinical applications and future perspectives
HK1036752B (en) Intramolecularly-quenched near infrared fluorescent probes
Moin et al. Fluorescent imaging of tumors
GB2337523A (en) Light imaging contrast agents
Eisenblätter et al. Optical and Optoacoustic Imaging Probes
Zhou et al. NIR imaging the delivery of cathepsin B probe to breast tumors
Bornhop et al. Fluorescent probes in biomedical applications
Jaffer et al. Molecular Imaging of Cancer Using Fluorescent Probe Technology

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040729

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060404

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20090206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090518

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090817

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090824

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100916

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110228

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20110303

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110324

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110412

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140422

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term