CA2328136C - Intramolecularly-quenched near infrared fluorescent probes - Google Patents

Intramolecularly-quenched near infrared fluorescent probes Download PDF

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Publication number
CA2328136C
CA2328136C CA002328136A CA2328136A CA2328136C CA 2328136 C CA2328136 C CA 2328136C CA 002328136 A CA002328136 A CA 002328136A CA 2328136 A CA2328136 A CA 2328136A CA 2328136 C CA2328136 C CA 2328136C
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CA
Canada
Prior art keywords
probe
fluorochrome
fluorescence
fluorochromes
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002328136A
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English (en)
French (fr)
Other versions
CA2328136A1 (en
Inventor
Ralph Weissleder
Ching-Hsuan Tung
Umar Mahmood
Lee Josephson
Alexei Bogdanov
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General Hospital Corp
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General Hospital Corp
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Publication date
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Publication of CA2328136A1 publication Critical patent/CA2328136A1/en
Application granted granted Critical
Publication of CA2328136C publication Critical patent/CA2328136C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Glass Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Surface Treatment Of Glass (AREA)
  • Polyesters Or Polycarbonates (AREA)
CA002328136A 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes Expired - Lifetime CA2328136C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/079,447 US6083486A (en) 1998-05-14 1998-05-14 Intramolecularly-quenched near infrared fluorescent probes
US09/079,447 1998-05-14
PCT/US1999/010589 WO1999058161A1 (en) 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes

Publications (2)

Publication Number Publication Date
CA2328136A1 CA2328136A1 (en) 1999-11-18
CA2328136C true CA2328136C (en) 2009-03-24

Family

ID=22150620

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328136A Expired - Lifetime CA2328136C (en) 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes

Country Status (8)

Country Link
US (1) US6083486A (https=)
EP (2) EP2251041A3 (https=)
JP (2) JP4726297B2 (https=)
AT (1) ATE473017T1 (https=)
AU (1) AU770216B2 (https=)
CA (1) CA2328136C (https=)
DE (1) DE69942563D1 (https=)
WO (1) WO1999058161A1 (https=)

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US6083486A (en) 2000-07-04
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EP1077731A1 (en) 2001-02-28
JP4726297B2 (ja) 2011-07-20
JP2002514610A (ja) 2002-05-21
JP2011095273A (ja) 2011-05-12
JP5171970B2 (ja) 2013-03-27
EP1077731B1 (en) 2010-07-07
WO1999058161A1 (en) 1999-11-18
DE69942563D1 (de) 2010-08-19
AU4077799A (en) 1999-11-29
HK1036752A1 (en) 2002-01-18
CA2328136A1 (en) 1999-11-18
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EP1077731A4 (en) 2004-05-12
AU770216B2 (en) 2004-02-19

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