JP4712296B2 - ポスト処理用皮膚外用剤およびそれを用いた化粧方法 - Google Patents
ポスト処理用皮膚外用剤およびそれを用いた化粧方法 Download PDFInfo
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- JP4712296B2 JP4712296B2 JP2003412662A JP2003412662A JP4712296B2 JP 4712296 B2 JP4712296 B2 JP 4712296B2 JP 2003412662 A JP2003412662 A JP 2003412662A JP 2003412662 A JP2003412662 A JP 2003412662A JP 4712296 B2 JP4712296 B2 JP 4712296B2
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- Prior art keywords
- skin
- water
- extract
- external preparation
- cosmetic
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Description
閉塞性(%)=(1−TEWL(試料適用)/TEWL(試料無し))x100
表1に示す各種油性基剤から成る皮膚外用剤(実施例1から6、比較例1)について閉塞性を測定した。閉塞性は、ヒト前腕内部部位に試料を適用(5mg/cm2)し、1時間後の経皮水分蒸散量(TEWL)を水分蒸散計(Tewameter TM210:Courage+Khazaka社製)によって測定し、下記の式で算出した:
閉塞性(%)=(1−TEWL(試料適用)/TEWL(試料無し))x100
表1に示すように、ワセリン(実施例1)、アルキル変性シリコーン(実施例2から5)、および異性化ホホバオイル(実施例6)から成る皮膚外用剤において50%以上の高い閉塞性が認められた。
表1に示す各種油性基剤から成る皮膚外用剤(実施例1から6、比較例1)について、水溶性薬剤としてアルブチンを用いて、水溶性薬剤の経皮吸収の測定を実施した。ヒト前腕内側部位にアルブチン水溶液(1μl/cm2)を適用し、乾燥後、皮膚外用剤を適用(5μg/cm2)し、6時間後の角質中のアルブチン濃度を測定した。対照では、同様にアルブチン水溶液を適用後、その上から皮膚外用剤を適用しないで6時間後の角質中のアルブチン濃度を測定した。対照での値を1として、各皮膚外用剤でポスト処理した場合のアルブチン濃度を相対値で表し、表1に示す。
Claims (2)
- 化粧方法(医療行為を除く)であって、水溶性薬剤を含む皮膚化粧料を皮膚に適用した後、常温で半固形状のワセリン、アルキル変性シリコーンおよび異性化ホホバオイルよりなる群から選択される油性基剤を主成分としかつ50%以上の閉塞性を有する皮膚外用剤をその上にさらに適用することを含み、該皮膚外用剤中の水および水溶性成分の量はそれぞれ1質量%以下であることを特徴とする化粧方法。
- 前記水溶性薬剤が、美白剤、保湿剤、抗酸化剤、抗炎症剤、ビタミン類、ホルモン剤、酵素、血行促進剤、アミノ酸類、育毛用薬剤および動植物抽出物(医薬用を除く)より成る群から選択される1種または2種以上であることを特徴とする請求項1記載の化粧方法。
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JPS6475419A (en) * | 1987-09-14 | 1989-03-22 | Katsuo Ogami | Remedy for athlete's foot |
JP3251717B2 (ja) * | 1992-06-29 | 2002-01-28 | 花王株式会社 | 皮膚外用剤 |
JP2002370989A (ja) * | 2001-06-13 | 2002-12-24 | Satake:Kk | アトピー性皮膚炎の簡易な治療方法 |
FR2833268B1 (fr) * | 2001-12-12 | 2005-07-08 | Fabre Pierre Dermo Cosmetique | Nouvelle association contenant un poloxamer et de l'acide chondroitine sulfurique et/ou une glycoproteine et son utilisation |
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