JP4709149B2 - プリオン特異的ペプチド試薬 - Google Patents

プリオン特異的ペプチド試薬 Download PDF

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JP4709149B2
JP4709149B2 JP2006523408A JP2006523408A JP4709149B2 JP 4709149 B2 JP4709149 B2 JP 4709149B2 JP 2006523408 A JP2006523408 A JP 2006523408A JP 2006523408 A JP2006523408 A JP 2006523408A JP 4709149 B2 JP4709149 B2 JP 4709149B2
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pathogenic
prion
sample
peptide reagent
peptide
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JP2007502120A (ja
Inventor
メリッサ ディー． マイケルイッチ，
セリーヌ フー，
ロナルド ザッカーマン，
マイケル ディー． コナリー，
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ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
JP2006523408A 2003-08-13 2004-08-13 プリオン特異的ペプチド試薬 Expired - Fee Related JP4709149B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US49496203P 2003-08-13 2003-08-13
US60/494,962 2003-08-13
US57036804P 2004-05-12 2004-05-12
US60/570,368 2004-05-12
US58650904P 2004-07-09 2004-07-09
US60/586,509 2004-07-09
PCT/US2004/026363 WO2005016127A2 (en) 2003-08-13 2004-08-13 Prion-specific peptide reagents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010034088A Division JP2010158247A (ja) 2003-08-13 2010-02-18 プリオン特異的ペプチド試薬

Publications (2)

Publication Number Publication Date
JP2007502120A JP2007502120A (ja) 2007-02-08
JP4709149B2 true JP4709149B2 (ja) 2011-06-22

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ID=34198970

Family Applications (3)

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JP2006523408A Expired - Fee Related JP4709149B2 (ja) 2003-08-13 2004-08-13 プリオン特異的ペプチド試薬
JP2010034088A Withdrawn JP2010158247A (ja) 2003-08-13 2010-02-18 プリオン特異的ペプチド試薬
JP2012230552A Withdrawn JP2013033060A (ja) 2003-08-13 2012-10-18 プリオン特異的ペプチド試薬

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010034088A Withdrawn JP2010158247A (ja) 2003-08-13 2010-02-18 プリオン特異的ペプチド試薬
JP2012230552A Withdrawn JP2013033060A (ja) 2003-08-13 2012-10-18 プリオン特異的ペプチド試薬

Country Status (13)

Country Link
US (1) US7439041B2 (enExample)
EP (1) EP1653844B1 (enExample)
JP (3) JP4709149B2 (enExample)
KR (1) KR101166012B1 (enExample)
AU (2) AU2004264953B2 (enExample)
BR (1) BRPI0413495A (enExample)
CA (1) CA2535261C (enExample)
DK (1) DK1653844T3 (enExample)
ES (1) ES2398394T3 (enExample)
IL (1) IL173480A0 (enExample)
MX (1) MXPA06001588A (enExample)
NZ (2) NZ545385A (enExample)
WO (1) WO2005016127A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) * 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
ES2398394T3 (es) * 2003-08-13 2013-03-15 Novartis Vaccines And Diagnostics, Inc. Reactivos peptídicos específicos de prión
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
WO2006076497A2 (en) 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Osplation of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
CN101189265B (zh) * 2005-06-01 2012-07-04 米克罗麦特股份公司 抗il2抗体
WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
GB0519198D0 (en) * 2005-09-20 2005-10-26 Univ Cambridge Tech Tse detection
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
EP2140272A1 (en) * 2007-04-04 2010-01-06 Novartis Ag Prion elisa
JP2010523977A (ja) * 2007-04-04 2010-07-15 ノバルティス アーゲー プリオンアッセイ
WO2009041902A1 (en) * 2007-09-25 2009-04-02 Loefgren Kajsa Prion protein derived cell penetrating peptides and their uses
US8709472B1 (en) * 2007-11-13 2014-04-29 Abbott Cardiovascular Systems Inc. Bioactive agent-loaded heart-targeting nanoparticles
JP2011520108A (ja) * 2008-04-30 2011-07-14 ノバルティス アーゲー 病原性配座異性体についてのアッセイ
EP2128618A1 (en) * 2008-05-30 2009-12-02 Prion Diagnostica S.r.l. A process for monitoring the presence of pathogenic agents in biological fluids by nanostructured materials
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
CA2817973C (en) 2010-10-15 2019-06-25 The Board Of Regents Of The University Of Texas System Antibodies that bind amyloid oligomers
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
KR102201144B1 (ko) * 2016-05-10 2021-01-11 엘지전자 주식회사 이동 로봇 및 그 제어방법
US11000571B2 (en) * 2016-06-27 2021-05-11 Florida State University Research Foundation, Inc. Modified fragments from the octarepeat region of prion protein as hemin binders
US11660325B2 (en) 2016-09-19 2023-05-30 University Of Houston System Compositions and methods of targeting cancer stem cells
JP2021004175A (ja) * 2017-09-04 2021-01-14 国立大学法人東北大学 コンフォメーション病治療用材料、及びその製造方法、並びにコンフォメーション病医薬のスクリーニング方法

Family Cites Families (40)

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WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
EP1416280A3 (en) 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
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Publication number Publication date
AU2009225337A1 (en) 2009-11-05
HK1090275A1 (en) 2006-12-22
IL173480A0 (en) 2006-06-11
AU2004264953A1 (en) 2005-02-24
EP1653844A4 (en) 2009-01-14
KR101166012B1 (ko) 2012-07-23
NZ580256A (en) 2011-07-29
KR20060066088A (ko) 2006-06-15
JP2013033060A (ja) 2013-02-14
ES2398394T3 (es) 2013-03-15
NZ545385A (en) 2010-12-24
JP2010158247A (ja) 2010-07-22
CA2535261A1 (en) 2005-02-24
AU2009225337B2 (en) 2012-12-06
WO2005016127A3 (en) 2006-12-21
US20050118645A1 (en) 2005-06-02
DK1653844T3 (da) 2013-03-11
EP1653844B1 (en) 2012-12-12
US7439041B2 (en) 2008-10-21
BRPI0413495A (pt) 2006-10-17
WO2005016127A2 (en) 2005-02-24
EP1653844A2 (en) 2006-05-10
JP2007502120A (ja) 2007-02-08
CA2535261C (en) 2015-11-24
MXPA06001588A (es) 2006-08-25
AU2004264953B2 (en) 2009-07-23

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