DK1653844T3 - Prionspecifikke peptidreagenser - Google Patents

Prionspecifikke peptidreagenser

Info

Publication number
DK1653844T3
DK1653844T3 DK04781105.4T DK04781105T DK1653844T3 DK 1653844 T3 DK1653844 T3 DK 1653844T3 DK 04781105 T DK04781105 T DK 04781105T DK 1653844 T3 DK1653844 T3 DK 1653844T3
Authority
DK
Denmark
Prior art keywords
prion
specific peptide
peptide reagents
reagents
specific
Prior art date
Application number
DK04781105.4T
Other languages
English (en)
Inventor
Melissa D Michelitsch
Celine Hu
Roland N Zuckermann
Michael D Connolly
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Application granted granted Critical
Publication of DK1653844T3 publication Critical patent/DK1653844T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2828Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
DK04781105.4T 2003-08-13 2004-08-13 Prionspecifikke peptidreagenser DK1653844T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49496203P 2003-08-13 2003-08-13
US57036804P 2004-05-12 2004-05-12
US58650904P 2004-07-09 2004-07-09
PCT/US2004/026363 WO2005016127A2 (en) 2003-08-13 2004-08-13 Prion-specific peptide reagents

Publications (1)

Publication Number Publication Date
DK1653844T3 true DK1653844T3 (da) 2013-03-11

Family

ID=34198970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04781105.4T DK1653844T3 (da) 2003-08-13 2004-08-13 Prionspecifikke peptidreagenser

Country Status (14)

Country Link
US (1) US7439041B2 (da)
EP (1) EP1653844B1 (da)
JP (3) JP4709149B2 (da)
KR (1) KR101166012B1 (da)
AU (2) AU2004264953B2 (da)
BR (1) BRPI0413495A (da)
CA (1) CA2535261C (da)
DK (1) DK1653844T3 (da)
ES (1) ES2398394T3 (da)
HK (1) HK1090275A1 (da)
IL (1) IL173480A0 (da)
MX (1) MXPA06001588A (da)
NZ (2) NZ545385A (da)
WO (1) WO2005016127A2 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
MXPA03011000A (es) 2001-05-31 2004-02-27 Arete Associates Metodo de sensor de proteinas deformadas.
WO2005016127A2 (en) * 2003-08-13 2005-02-24 Chiron Corporation Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic ISOLATION OF PATHOGENIC PRIONS
WO2006076687A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Elisa assays using prion-specific peptide reagents
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
EP1888644A1 (en) * 2005-06-01 2008-02-20 Micromet AG Anti-il2 antibodies
KR20080048527A (ko) 2005-09-09 2008-06-02 노파르티스 아게 프리온-특이적 펩토이드 시약
GB0519198D0 (en) * 2005-09-20 2005-10-26 Univ Cambridge Tech Tse detection
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
EP2142934B1 (en) * 2007-04-04 2011-10-26 Novartis AG Prion assay
WO2008124100A1 (en) * 2007-04-04 2008-10-16 Novartis Ag Prion elisa
WO2009041902A1 (en) * 2007-09-25 2009-04-02 Loefgren Kajsa Prion protein derived cell penetrating peptides and their uses
US8709472B1 (en) * 2007-11-13 2014-04-29 Abbott Cardiovascular Systems Inc. Bioactive agent-loaded heart-targeting nanoparticles
US20110189692A1 (en) * 2008-04-30 2011-08-04 Novartis Ag Assay for pathogenic conformers
EP2128618A1 (en) * 2008-05-30 2009-12-02 Prion Diagnostica S.r.l. A process for monitoring the presence of pathogenic agents in biological fluids by nanostructured materials
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
EP2627357B1 (en) 2010-10-15 2017-05-03 The Board of Regents of The University of Texas System Antibodies that bind amyloid oligomers
CN108347916B (zh) 2015-10-14 2022-02-08 先时迈纳米生物科技股份有限公司 一种减少冰晶形成的组合物及其方法
KR102201144B1 (ko) * 2016-05-10 2021-01-11 엘지전자 주식회사 이동 로봇 및 그 제어방법
US11000571B2 (en) 2016-06-27 2021-05-11 Florida State University Research Foundation, Inc. Modified fragments from the octarepeat region of prion protein as hemin binders
WO2018053472A1 (en) 2016-09-19 2018-03-22 University Of Houston System Compositions and methods of targeting cancer stem cells
JP2021004175A (ja) * 2017-09-04 2021-01-14 国立大学法人東北大学 コンフォメーション病治療用材料、及びその製造方法、並びにコンフォメーション病医薬のスクリーニング方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4233604B2 (ja) 1991-12-03 2009-03-04 プロセリックス メディスンズ ディベロップメント リミテッド プリオンタンパク質のフラグメント
WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
EP1416280A3 (en) 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE250767T1 (de) 1997-02-06 2003-10-15 Enfer Technology Ltd Immunoassay für spongiforme encephalopathien
EP0861900A1 (en) 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
DE19741607A1 (de) 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
JP2002522009A (ja) * 1998-04-14 2002-07-23 スージェン・インコーポレーテッド Ste−20関連蛋白質キナーゼ
US6211149B1 (en) 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
FI982480A0 (fi) 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nisäkkäiden tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
WO2000043791A2 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
EP1194164B8 (en) 1999-06-23 2007-03-21 IDEXX Laboratories Inc Prion protein peptides and uses thereof
JP2003506327A (ja) 1999-07-27 2003-02-18 インペリアル・カレッジ・イノベイションズ・リミテッド 疾患の診断および治療に使用できる生物学的物質および方法
AU5241100A (en) * 1999-09-28 2001-04-30 Universitat Zurich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis
FR2801106B1 (fr) 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
JP2003530554A (ja) 2000-04-05 2003-10-14 ブイ.アイ.テクノロジーズ,インコーポレイテッド プリオン結合ペプチドリガンドおよび同一物を使用する方法
AU2001255735A1 (en) * 2000-04-28 2001-11-12 Synuthane International, Inc. Double metal cyanide catalysts containing polyglycol ether complexing agents
IL148202A0 (en) 2000-06-20 2002-09-12 Caprion Pharmaceuticals Inc Copolymers and methods of treating prion-related diseases
RS51523B (sr) 2000-07-07 2011-06-30 Laboratoires Serono Sa. Rana dijagnoza konformacionih bolesti
GB0103508D0 (en) * 2001-02-13 2001-03-28 Univ Dundee Screening method and agents
MXPA03011000A (es) 2001-05-31 2004-02-27 Arete Associates Metodo de sensor de proteinas deformadas.
CA2466841A1 (en) 2001-11-21 2003-06-05 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid .beta., prion protein, amylin, .alpha.-synuclein, or polyglutamine repeats for induction of an immune response thereto
EP1481001A2 (en) 2001-12-10 2004-12-01 Applied Research Systems ARS Holding N.V. Prion inhibiting peptides and derivatives thereof
NZ535276A (en) 2002-02-28 2008-04-30 Microsens Biophage Ltd Binding of pathological forms of prion proteins
US7939641B2 (en) 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US20040208919A1 (en) 2002-06-13 2004-10-21 Nicolau Yves C. Vaccination against prion diseases
DE10230141B4 (de) 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20060057636A1 (en) 2002-08-21 2006-03-16 Peter Heegaard Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
DE60219215T2 (de) 2002-10-23 2008-01-03 Centre For Research And Technology Hellas/Intitute Of Agrobiotechnology In.A, Thermi Prionen-bindende peptidsequenzen
AU2002352042A1 (en) 2002-11-18 2004-06-15 Prionics Ag Method for the detection of prpsc
DK2317317T3 (da) 2002-12-03 2015-03-02 Univ North Carolina State Prion-proteinligander samt fremgangsmåder til anvendelse deraf
EP1457500A1 (en) 2003-03-14 2004-09-15 University of Zurich Soluble hybrid prion proteins and their use in the diagnosis, prevention and treatment of transmissible spongiform encephalophathies
PL1615992T3 (pl) 2003-04-04 2014-03-31 Pathogen Removal And Diagnostic Tech Inc Materiały wiążące białko prionowe i sposoby ich zastosowania
CN1806053A (zh) 2003-04-14 2006-07-19 美国红十字会 对蛋白的结构同工型特异的配体的鉴定方法
WO2005016127A2 (en) * 2003-08-13 2005-02-24 Chiron Corporation Prion-specific peptide reagents
DE102004043782A1 (de) 2004-09-08 2006-03-09 Heinrich-Heine-Universität Düsseldorf Polypeptide und Verfahren zur spezifischen Bindung von Prionen
US20060057671A1 (en) 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins

Also Published As

Publication number Publication date
US20050118645A1 (en) 2005-06-02
WO2005016127A2 (en) 2005-02-24
EP1653844B1 (en) 2012-12-12
BRPI0413495A (pt) 2006-10-17
NZ580256A (en) 2011-07-29
KR101166012B1 (ko) 2012-07-23
IL173480A0 (en) 2006-06-11
AU2004264953B2 (en) 2009-07-23
EP1653844A2 (en) 2006-05-10
ES2398394T3 (es) 2013-03-15
JP2007502120A (ja) 2007-02-08
CA2535261A1 (en) 2005-02-24
JP2010158247A (ja) 2010-07-22
NZ545385A (en) 2010-12-24
AU2009225337A1 (en) 2009-11-05
AU2004264953A1 (en) 2005-02-24
WO2005016127A3 (en) 2006-12-21
HK1090275A1 (en) 2006-12-22
EP1653844A4 (en) 2009-01-14
JP2013033060A (ja) 2013-02-14
US7439041B2 (en) 2008-10-21
MXPA06001588A (es) 2006-08-25
AU2009225337B2 (en) 2012-12-06
CA2535261C (en) 2015-11-24
JP4709149B2 (ja) 2011-06-22
KR20060066088A (ko) 2006-06-15

Similar Documents

Publication Publication Date Title
DK1653844T3 (da) Prionspecifikke peptidreagenser
NO2014013I2 (no) Linaclotide
DE602004009744D1 (de) Reagenzbehälter
NO20055459D0 (no) Prosesser
DE602004020635D1 (de) Lanzetten betreffende verbesserungen
NO20044347L (no) Anti-alfavbeta6-antistoff
DK1599463T3 (da) Cyan-anthranilamidinsekticider
ATE418924T1 (de) Marknagel
DE50311137D1 (de) Eriebauteile
DE602004003535D1 (de) Flüssigskeitskühlmodul
IS8297A (is) Múskarínasetýlkólínviðtakamótlyf
DK1752470T3 (da) GAG-bindende proteiner
DE602004001550D1 (de) Ausrücksvorrichtung
ATE462365T1 (de) Marknagel
DE602004020735D1 (de) Berwachungsvorrichtung
ATE375761T1 (de) Marknagel
DE602004007256D1 (de) Titanchelatdispersionen
NO20030752L (no) Bolgedempningsanordning
DE502004002978D1 (de) N-biarylamide
DK1625148T3 (da) Peptidkompleks
DE502004010244D1 (de) En
DE502004005162D1 (de) Leistungsregelvorricthung
DE502004006563D1 (de) Brieftaubenkonstatiersystem
DE602004025937D1 (de) 2-aminobenzoylderivate
ATA16232003A (de) Sortierer