JP4679020B2 - 胃内滞留性制御放出医薬剤形 - Google Patents
胃内滞留性制御放出医薬剤形 Download PDFInfo
- Publication number
- JP4679020B2 JP4679020B2 JP2001539427A JP2001539427A JP4679020B2 JP 4679020 B2 JP4679020 B2 JP 4679020B2 JP 2001539427 A JP2001539427 A JP 2001539427A JP 2001539427 A JP2001539427 A JP 2001539427A JP 4679020 B2 JP4679020 B2 JP 4679020B2
- Authority
- JP
- Japan
- Prior art keywords
- drug
- polymer
- matrix
- formulation
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13319699A IL133196A0 (en) | 1999-11-29 | 1999-11-29 | Gastroretentive controlled release pharmaceutical dosage forms |
| IL133196 | 1999-11-29 | ||
| PCT/IL2000/000774 WO2001037812A2 (en) | 1999-11-29 | 2000-11-20 | Gastroretentive controlled release pharmaceutical dosage forms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003514845A JP2003514845A (ja) | 2003-04-22 |
| JP2003514845A5 JP2003514845A5 (cg-RX-API-DMAC7.html) | 2006-05-18 |
| JP4679020B2 true JP4679020B2 (ja) | 2011-04-27 |
Family
ID=11073546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001539427A Expired - Lifetime JP4679020B2 (ja) | 1999-11-29 | 2000-11-20 | 胃内滞留性制御放出医薬剤形 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6685962B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1235557B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4679020B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE300286T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU783062B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2392361C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60021604T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2243327T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL133196A0 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2002114348A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001037812A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200204268B (cg-RX-API-DMAC7.html) |
Families Citing this family (90)
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| US20040219186A1 (en) * | 2001-08-16 | 2004-11-04 | Ayres James W. | Expandable gastric retention device |
| TWI312285B (en) * | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| AUPR951501A0 (en) * | 2001-12-14 | 2002-01-24 | Smart Drug Systems Inc | Modified sustained release pharmaceutical system |
| US20040192582A1 (en) | 2002-12-19 | 2004-09-30 | Burnett Daniel R. | Ingestible formulations for transient, noninvasive reduction of gastric volume |
| US7554452B2 (en) * | 2003-07-18 | 2009-06-30 | Cary Cole | Ingestible tracking and locating device |
| JP4988345B2 (ja) * | 2003-09-04 | 2012-08-01 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプレゼンティッド・バイ・ザ・デパートメント・オブ・ヴェテランズ・アフェアーズ | 眼用ハイドロゲルナノコンポジット |
| JP2007507491A (ja) * | 2003-09-29 | 2007-03-29 | シージェー コーポレーション | 徐放性製剤 |
| CA2549195A1 (en) * | 2003-12-09 | 2005-06-23 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| US20080089933A1 (en) * | 2006-10-16 | 2008-04-17 | Amir Alon | Device and method for reducing calorie intake |
| US20050196355A1 (en) * | 2004-03-03 | 2005-09-08 | Constantine Georgiades | Film products having controlled disintegration properties |
| US8007827B2 (en) * | 2004-04-02 | 2011-08-30 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties |
| US8226977B2 (en) | 2004-06-04 | 2012-07-24 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
| US20080311191A1 (en) * | 2004-08-27 | 2008-12-18 | Avinash Nangia | Multi-Layer Tablets and Bioadhesive Dosage Forms |
| CA2592605C (en) * | 2004-12-27 | 2010-12-07 | Eisai R&D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
| US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
| US20060246003A1 (en) * | 2004-12-27 | 2006-11-02 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
| US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
| IL166183A0 (en) * | 2005-01-06 | 2006-01-15 | Yissum Res Dev Co | Novel diagnostic and imaging techniques of the gi tract |
| KR100822519B1 (ko) * | 2005-02-15 | 2008-04-16 | 주식회사종근당 | 위장 내에서 제어방출되는 단일 매트릭스 정제 |
| EP1933811A2 (en) * | 2005-09-30 | 2008-06-25 | Alza Corporation | Banded controlled release nanoparticle active agent formulation dosage forms and methods |
| US20070092565A1 (en) * | 2005-10-25 | 2007-04-26 | Pharmascience Inc. | Gastric retention drug delivery system |
| TR201902010T4 (tr) | 2006-01-18 | 2019-03-21 | Intec Pharma Ltd | Bir ajanın oral alımına yönelik taşıyıcı cihaz. |
| WO2007093999A1 (en) * | 2006-02-15 | 2007-08-23 | Intec Pharma Ltd. | A gastro-retentive system for the delivery of macromolecules |
| WO2007103286A2 (en) * | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| US20080139655A1 (en) * | 2006-09-08 | 2008-06-12 | Drugtech Corporation | Sustained-release composition and method of use thereof |
| ZA200904573B (en) | 2006-12-22 | 2010-09-29 | Ironwood Pharmaceuticals Inc | Compositions comprising bile acid sequestrants for treating esophageal disorders |
| WO2008115597A2 (en) * | 2007-03-21 | 2008-09-25 | Cytologic, Inc. | Cytokine muteins and methods for enhancing immune responses in mammals |
| PT2192946T (pt) | 2007-09-25 | 2022-11-17 | Otsuka Pharma Co Ltd | Dispositivo no corpo com amplificação de sinal dipolo virtual |
| ES2463774T3 (es) | 2007-11-12 | 2014-05-29 | Pharmaceutics International, Inc. | Complejos trimoleculares y su uso en sistemas de administración de fármacos |
| EP2276473B1 (en) * | 2008-04-18 | 2016-09-14 | Intec Pharma Ltd. | Gastroretentive drug delivery for carbidopa/levodopa |
| US7981760B2 (en) * | 2008-05-08 | 2011-07-19 | Panasonic Corporation | Method for manufacturing nonvolatile storage element and method for manufacturing nonvolatile storage device |
| US8287902B2 (en) * | 2008-07-23 | 2012-10-16 | Rainbow Medical Ltd. | Enhanced-diffusion capsule |
| WO2010064139A2 (en) * | 2008-12-04 | 2010-06-10 | Intec Pharma Ltd. | Zaleplon gastroretentive drug delivery system |
| US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
| US8828953B2 (en) * | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
| JP2012524125A (ja) | 2009-04-20 | 2012-10-11 | エルセリクス セラピューティクス インコーポレイテッド | 化学感覚受容体リガンドに基づく治療法 |
| US8414559B2 (en) * | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
| US20100286628A1 (en) * | 2009-05-07 | 2010-11-11 | Rainbow Medical Ltd | Gastric anchor |
| US20110066175A1 (en) * | 2009-05-07 | 2011-03-17 | Rainbow Medical Ltd. | Gastric anchor |
| WO2011048494A2 (en) * | 2009-10-19 | 2011-04-28 | Intec Pharma Ltd. | Novel gastroretentive dosage forms of poorly soluble drugs |
| CA2780294C (en) | 2009-11-09 | 2018-01-16 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| CN107033368A (zh) | 2009-11-09 | 2017-08-11 | 聚光灯技术合伙有限责任公司 | 碎裂水凝胶 |
| JP5753187B2 (ja) | 2009-12-18 | 2015-07-22 | ヴィセラ・バイオメディカル・リミテッド | 医用生体材料 |
| WO2011073968A1 (en) * | 2009-12-18 | 2011-06-23 | Vysera Biomedical Limited | A drug delivery system |
| EP2544666A2 (en) | 2010-03-09 | 2013-01-16 | Council of Scientific and Industrial Research | Gastroretentive, extended release composition of therapeutic agent |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| SG189444A1 (en) | 2010-10-19 | 2013-05-31 | Elcelyx Therapeutics Inc | Chemosensory receptor ligand-based therapies |
| HRP20201731T1 (hr) | 2011-01-07 | 2020-12-25 | Anji Pharma (Us) Llc | Terapije na bazi liganda kemozensoričkog receptora |
| US8722066B2 (en) | 2011-03-29 | 2014-05-13 | Primigenia, LLC | Devices and methods for weight control and weight loss |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| WO2014039951A1 (en) | 2012-09-10 | 2014-03-13 | Novartis Ag | Enteral pharmaceutical compositions |
| US9682081B2 (en) | 2013-04-25 | 2017-06-20 | Sun Pharmaceutical Industries Limited | Pharmaceutical gastro-retentive solid oral dosage form of nilotinib |
| US10166207B2 (en) | 2013-06-05 | 2019-01-01 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| EP3083031B1 (en) * | 2013-12-20 | 2019-10-16 | Fresenius Kabi Deutschland GmbH | Microcapsules with polymeric coating comprising a lipid and an active agent |
| CN106535878B (zh) | 2014-06-02 | 2022-11-01 | 科莱西奥生物科技有限公司 | 可张开的胃内滞留剂型 |
| CN106573999A (zh) | 2014-06-11 | 2017-04-19 | 麻省理工学院 | 驻留结构及相关方法 |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| US9492396B2 (en) | 2014-07-15 | 2016-11-15 | Yossi Gross | Enhanced drug delivery pill |
| CN206120771U (zh) * | 2015-06-03 | 2017-04-26 | 南京三迭纪医药科技有限公司 | 药品剂型 |
| EP3302442B1 (en) * | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| MA42196A (fr) | 2015-06-17 | 2018-04-25 | Biogen Ma Inc | Particules de fumarate de diméthyle et leurs compositions pharmaceutiques |
| WO2017070612A1 (en) | 2015-10-23 | 2017-04-27 | Lyndra, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| US11129798B2 (en) | 2016-08-19 | 2021-09-28 | Aron H. Blaesi | Fibrous dosage form |
| US11478427B2 (en) * | 2015-10-26 | 2022-10-25 | Aron H. Blaesi | Dosage form comprising structural framework of two-dimensional elements |
| EP3368010B1 (en) * | 2015-10-26 | 2025-12-10 | Blaesi, Aron H. | Solid dosage form immediate drug release and apparatus and method for manufacture thereof |
| CN108601724A (zh) * | 2015-12-01 | 2018-09-28 | 克雷西奥生物科技有限公司 | 胃滞留装置 |
| CA3007165A1 (en) * | 2015-12-02 | 2017-06-08 | Clexio Biosciences Ltd. | Device for preparing gastroretentive dosage forms |
| ES2963058T3 (es) | 2015-12-08 | 2024-03-25 | Lyndra Therapeutics Inc | Configuraciones geométricas para sistemas de residencia gástrica |
| CA3017797A1 (en) | 2016-03-17 | 2017-09-21 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US12109305B2 (en) | 2016-05-27 | 2024-10-08 | Lyndra Therapeutics, Inc. | Materials architecture for gastric residence systems |
| SG11201811209QA (en) * | 2016-07-11 | 2019-01-30 | Intec Pharma Ltd | Oral gastroretentive formulations and uses thereof |
| WO2018064630A1 (en) | 2016-09-30 | 2018-04-05 | Lyndra, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| CN110035718B (zh) | 2016-12-02 | 2021-04-06 | 克雷西奥生物科技有限公司 | 胃内滞留系统 |
| WO2018137686A1 (en) | 2017-01-26 | 2018-08-02 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| ES3024932T3 (en) | 2017-09-20 | 2025-06-05 | Thiogenesis Therapeutics Inc | Compounds for the treatment of cysteamine sensitive disorders |
| US11547839B2 (en) | 2017-12-04 | 2023-01-10 | Clexio Biosciences Ltd. | Long acting gastric residence system |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| CN114191307A (zh) | 2020-09-17 | 2022-03-18 | 上海汉都医药科技有限公司 | 一种口腔滞留装置及其制备方法 |
| WO2019223753A1 (zh) | 2018-05-23 | 2019-11-28 | 上海汉都医药科技有限公司 | 活性药物成分的控释系统及其制备方法 |
| US11911513B2 (en) | 2018-05-23 | 2024-02-27 | Shanghai Wd Pharmaceutical Co., Ltd | Controlled-release system of active pharmaceutical ingredient and preparation method therefor |
| US10675248B2 (en) | 2018-08-14 | 2020-06-09 | Alma Therapeutics Ltd. | Expandable pill |
| EP4477215A3 (en) | 2020-12-08 | 2025-02-19 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
| WO2022245913A1 (en) | 2021-05-20 | 2022-11-24 | E Ink California, Llc | Benefit agent delivery system using electroplating |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3574820A (en) | 1968-01-08 | 1971-04-13 | Upjohn Co | Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix |
| US4207890A (en) | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| US4434153A (en) | 1982-03-22 | 1984-02-28 | Alza Corporation | Drug delivery system comprising a reservoir containing a plurality of tiny pills |
| US4735804A (en) | 1985-05-10 | 1988-04-05 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4758436A (en) | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| US5217712A (en) | 1989-09-20 | 1993-06-08 | Merck & Co., Inc. | Bioerodible thermoset elastomers |
| US5047464A (en) | 1989-09-20 | 1991-09-10 | Merck & Co., Inc. | Bioerodible thermoset elastomers |
| IT1265240B1 (it) * | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
| DE4406424A1 (de) | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
-
1999
- 1999-11-29 IL IL13319699A patent/IL133196A0/xx unknown
-
2000
- 2000-11-20 RU RU2002114348/15A patent/RU2002114348A/ru not_active Application Discontinuation
- 2000-11-20 DE DE60021604T patent/DE60021604T2/de not_active Expired - Lifetime
- 2000-11-20 JP JP2001539427A patent/JP4679020B2/ja not_active Expired - Lifetime
- 2000-11-20 EP EP00978993A patent/EP1235557B1/en not_active Expired - Lifetime
- 2000-11-20 AT AT00978993T patent/ATE300286T1/de not_active IP Right Cessation
- 2000-11-20 CA CA002392361A patent/CA2392361C/en not_active Expired - Lifetime
- 2000-11-20 WO PCT/IL2000/000774 patent/WO2001037812A2/en not_active Ceased
- 2000-11-20 AU AU16477/01A patent/AU783062B2/en not_active Expired
- 2000-11-20 ES ES00978993T patent/ES2243327T3/es not_active Expired - Lifetime
-
2002
- 2002-05-26 IL IL149853A patent/IL149853A/en unknown
- 2002-05-28 ZA ZA200204268A patent/ZA200204268B/xx unknown
- 2002-05-29 US US10/157,325 patent/US6685962B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU783062B2 (en) | 2005-09-22 |
| RU2002114348A (ru) | 2004-01-10 |
| US6685962B2 (en) | 2004-02-03 |
| JP2003514845A (ja) | 2003-04-22 |
| IL149853A (en) | 2006-12-31 |
| EP1235557A2 (en) | 2002-09-04 |
| ZA200204268B (en) | 2003-08-28 |
| US20030021845A1 (en) | 2003-01-30 |
| ES2243327T3 (es) | 2005-12-01 |
| DE60021604D1 (de) | 2005-09-01 |
| WO2001037812A3 (en) | 2002-02-21 |
| WO2001037812A2 (en) | 2001-05-31 |
| IL133196A0 (en) | 2001-03-19 |
| ATE300286T1 (de) | 2005-08-15 |
| CA2392361A1 (en) | 2001-05-31 |
| AU1647701A (en) | 2001-06-04 |
| EP1235557B1 (en) | 2005-07-27 |
| CA2392361C (en) | 2010-01-19 |
| DE60021604T2 (de) | 2006-06-01 |
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