JP4675628B2 - 4−オキソ−3−(1−オキソ−1h−イソキノリン−2−イルアセチルアミノ)−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用 - Google Patents

4−オキソ−3−(1−オキソ−1h−イソキノリン−2−イルアセチルアミノ)−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用 Download PDF

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JP4675628B2
JP4675628B2 JP2004563916A JP2004563916A JP4675628B2 JP 4675628 B2 JP4675628 B2 JP 4675628B2 JP 2004563916 A JP2004563916 A JP 2004563916A JP 2004563916 A JP2004563916 A JP 2004563916A JP 4675628 B2 JP4675628 B2 JP 4675628B2
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oxo
compound
isoquinolin
formula
pentanoic acid
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JP2006513220A (ja
JP2006513220A5 (https=
Inventor
ジーン−ダミアン シャリエ,
マイケル モルティモア,
ジョン アール. スタッドレー,
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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JP2004563916A 2002-12-20 2003-12-22 4−オキソ−3−(1−オキソ−1h−イソキノリン−2−イルアセチルアミノ)−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用 Expired - Fee Related JP4675628B2 (ja)

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US43513302P 2002-12-20 2002-12-20
PCT/US2003/040870 WO2004058718A1 (en) 2002-12-20 2003-12-22 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors

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CA2511235A1 (en) 2004-07-15
US7612091B2 (en) 2009-11-03
CN100366612C (zh) 2008-02-06
JP2006513220A (ja) 2006-04-20
US20100137359A1 (en) 2010-06-03
CN1745065A (zh) 2006-03-08
AU2003303345A1 (en) 2004-07-22
JP2007070368A (ja) 2007-03-22
WO2004058718A1 (en) 2004-07-15
TW200500343A (en) 2005-01-01
US8071618B2 (en) 2011-12-06
HK1087701A1 (zh) 2006-10-20
US20040192612A1 (en) 2004-09-30

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