CN100366612C - 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 - Google Patents
4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 Download PDFInfo
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43513302P | 2002-12-20 | 2002-12-20 | |
| US60/435,133 | 2002-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1745065A CN1745065A (zh) | 2006-03-08 |
| CN100366612C true CN100366612C (zh) | 2008-02-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2003801092852A Expired - Fee Related CN100366612C (zh) | 2002-12-20 | 2003-12-22 | 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7612091B2 (https=) |
| EP (1) | EP1581501A1 (https=) |
| JP (2) | JP4675628B2 (https=) |
| CN (1) | CN100366612C (https=) |
| AU (1) | AU2003303345A1 (https=) |
| CA (1) | CA2511235A1 (https=) |
| TW (1) | TW200500343A (https=) |
| WO (1) | WO2004058718A1 (https=) |
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| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| PE20040728A1 (es) | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) * | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| ES2614113T3 (es) * | 2004-09-17 | 2017-05-29 | Biomas Ltd. | Uso de tricloro (dioxietilen-O,O) telurato de amonio (AS101) para la inhibición de la enzima convertidora de interleucina-1 beta |
| ATE543803T1 (de) * | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
| FR2923160B1 (fr) | 2007-11-02 | 2013-07-26 | Pasteur Institut | Composes destines a prevenir ou traiter une infection virale. |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| CN107286091B (zh) * | 2016-04-11 | 2020-06-19 | 中国海洋大学 | 一种胺基Sclerotiorin衍生物在制备抗结核药物中的应用 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| US11447497B2 (en) | 2018-06-29 | 2022-09-20 | Histogen, Inc. | (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| WO2020222541A1 (ko) * | 2019-04-30 | 2020-11-05 | 주식회사 엘지화학 | 캐스파제 저해제의 프로드럭 |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
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| WO2001042216A2 (en) * | 1999-12-08 | 2001-06-14 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
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| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| DD232699A1 (de) | 1983-11-18 | 1986-02-05 | Adw Ddr | Verfahren zur herstellung von chinazolin-4-on-3-alkansaeuren und deren estern |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
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| DK1176956T3 (da) | 1999-05-07 | 2008-05-26 | Encysive Pharmaceuticals Inc | Carboxylsyrederivater, som inhiberer bindingen af integriner til deres receptorer |
| KR100322546B1 (ko) | 2000-05-08 | 2002-03-18 | 윤종용 | 독립적인 전원 전압을 사용하는 메모리와 메모리 컨트롤러간의 인터페이스 시스템 |
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| JP4428926B2 (ja) * | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
| AU2002348533A1 (en) | 2001-10-09 | 2003-05-26 | Vertex Pharmaceuticals Incorporated | Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof |
| US7410956B2 (en) * | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
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| TW200500343A (en) | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| FI117148B (fi) | 2004-07-09 | 2006-06-30 | Kone Corp | Menetelmä ja laitteisto aksiaalivuo-kestomagneettitahtikoneen kokoonpanoa varten |
| US7296449B2 (en) * | 2004-09-21 | 2007-11-20 | Ball Corporation | Dry hydraulic can shaping |
| ATE543803T1 (de) | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
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2003
- 2003-12-22 TW TW092136402A patent/TW200500343A/zh unknown
- 2003-12-22 CA CA002511235A patent/CA2511235A1/en not_active Abandoned
- 2003-12-22 AU AU2003303345A patent/AU2003303345A1/en not_active Abandoned
- 2003-12-22 EP EP03814289A patent/EP1581501A1/en not_active Withdrawn
- 2003-12-22 JP JP2004563916A patent/JP4675628B2/ja not_active Expired - Fee Related
- 2003-12-22 CN CNB2003801092852A patent/CN100366612C/zh not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2001042216A2 (en) * | 1999-12-08 | 2001-06-14 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
Also Published As
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| EP1581501A1 (en) | 2005-10-05 |
| CA2511235A1 (en) | 2004-07-15 |
| JP4675628B2 (ja) | 2011-04-27 |
| US7612091B2 (en) | 2009-11-03 |
| JP2006513220A (ja) | 2006-04-20 |
| US20100137359A1 (en) | 2010-06-03 |
| CN1745065A (zh) | 2006-03-08 |
| AU2003303345A1 (en) | 2004-07-22 |
| JP2007070368A (ja) | 2007-03-22 |
| WO2004058718A1 (en) | 2004-07-15 |
| TW200500343A (en) | 2005-01-01 |
| US8071618B2 (en) | 2011-12-06 |
| HK1087701A1 (zh) | 2006-10-20 |
| US20040192612A1 (en) | 2004-09-30 |
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