JP4638418B2 - アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法 - Google Patents

アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法 Download PDF

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JP4638418B2
JP4638418B2 JP2006509611A JP2006509611A JP4638418B2 JP 4638418 B2 JP4638418 B2 JP 4638418B2 JP 2006509611 A JP2006509611 A JP 2006509611A JP 2006509611 A JP2006509611 A JP 2006509611A JP 4638418 B2 JP4638418 B2 JP 4638418B2
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gene
amylase
aspergillus niger
neutral
strain
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JP2006521826A5 (https=
JP2006521826A (ja
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コネリー，マライア
ブロディ，ハワード
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ノボザイムス，インコーポレイティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2006509611A 2003-03-31 2004-03-31 アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法 Expired - Lifetime JP4638418B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45990203P 2003-03-31 2003-03-31
PCT/US2004/010126 WO2004090155A2 (en) 2003-03-31 2004-03-31 Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger

Publications (3)

Publication Number Publication Date
JP2006521826A JP2006521826A (ja) 2006-09-28
JP2006521826A5 JP2006521826A5 (https=) 2010-09-09
JP4638418B2 true JP4638418B2 (ja) 2011-02-23

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JP2006509611A Expired - Lifetime JP4638418B2 (ja) 2003-03-31 2004-03-31 アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法

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US (3) US7303877B2 (https=)
EP (1) EP1613761B1 (https=)
JP (1) JP4638418B2 (https=)
CN (2) CN101629204A (https=)
AT (1) ATE441664T1 (https=)
DE (1) DE602004022929D1 (https=)
DK (1) DK1613761T3 (https=)
WO (1) WO2004090155A2 (https=)

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US9133448B2 (en) 2010-02-11 2015-09-15 Dsm Ip Assets B.V. Polypeptide having cellobiohydrolase activity and uses thereof
EA201201125A1 (ru) 2010-02-11 2013-03-29 ДСМ АйПи АССЕТС Б.В. Клетка-хозяин, способная продуцировать ферменты, пригодные для деградации лигноцеллюлозного материала
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
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DK2588603T3 (en) 2010-06-29 2017-07-03 Dsm Ip Assets Bv POLYPEPTIDE THAT HAS OR CONTRIBUTES TO CARBOHYDRATE MATERIAL DEGRADING ACTIVITIES AND APPLICATIONS THEREOF
WO2012000886A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having beta-glucosidase activity and uses thereof
ES2672125T3 (es) 2010-06-29 2018-06-12 Dsm Ip Assets B.V. Polipéptido que tiene actividad beta-glucosidasa y usos del mismo
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JP5846476B2 (ja) * 2011-07-08 2016-01-20 独立行政法人酒類総合研究所 微生物のコウジ酸生産性を向上させる方法
CN102296032B (zh) * 2011-08-31 2013-11-06 保龄宝生物股份有限公司 转葡糖苷酶及其制备和固定化方法
JP5975236B2 (ja) * 2011-11-02 2016-08-23 ユニバーシティ プトゥラ マレーシア 生体高分子の製造方法
RU2645252C2 (ru) 2012-01-05 2018-02-19 Глюкос Финланд Ой Клетка нитчатых грибов с дефицитом протеаз и способы ее применения
EP2852610B1 (en) 2012-05-23 2018-07-11 Glykos Finland Oy Production of fucosylated glycoproteins
CN104603269A (zh) 2012-08-17 2015-05-06 诺维信公司 用于在丝状真菌菌株中共沉默基因表达的方法及其应用
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US10619144B2 (en) 2013-08-23 2020-04-14 Novozymes A/S Regulated PepC expression
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3445776B1 (en) * 2016-04-19 2021-02-17 Novozymes A/S Rlma-inactivated filamentous fungal host cell
US10986850B2 (en) 2016-12-21 2021-04-27 Novozymes A/S Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
CN113301812A (zh) 2018-10-17 2021-08-24 完美日股份有限公司 用于食物产品的重组组分和组合物
US20220251581A1 (en) * 2019-07-26 2022-08-11 Novozymes A/S Modified filamentous fungal host cell
CN113265417B (zh) * 2020-02-14 2025-01-21 中国科学院天津工业生物技术研究所 有机酸产量提高的菌株及其构建方法和应用
EP4228424A1 (en) 2020-10-15 2023-08-23 DSM IP Assets B.V. Methods of modulating gastrointestinal metabolites
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Publication number Publication date
ATE441664T1 (de) 2009-09-15
US20040191864A1 (en) 2004-09-30
DK1613761T3 (da) 2009-12-14
US7303877B2 (en) 2007-12-04
WO2004090155A2 (en) 2004-10-21
EP1613761A2 (en) 2006-01-11
CN100547078C (zh) 2009-10-07
CN1798848A (zh) 2006-07-05
US7771971B2 (en) 2010-08-10
WO2004090155A3 (en) 2005-01-06
DE602004022929D1 (de) 2009-10-15
EP1613761A4 (en) 2006-08-09
JP2006521826A (ja) 2006-09-28
CN101629204A (zh) 2010-01-20
US8445283B2 (en) 2013-05-21
US20100323448A1 (en) 2010-12-23
EP1613761B1 (en) 2009-09-02
US20080044858A1 (en) 2008-02-21

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