ATE441664T1 - Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger - Google Patents
Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus nigerInfo
- Publication number
- ATE441664T1 ATE441664T1 AT04758768T AT04758768T ATE441664T1 AT E441664 T1 ATE441664 T1 AT E441664T1 AT 04758768 T AT04758768 T AT 04758768T AT 04758768 T AT04758768 T AT 04758768T AT E441664 T1 ATE441664 T1 AT E441664T1
- Authority
- AT
- Austria
- Prior art keywords
- aspergillus niger
- biological substance
- amylase
- mutants
- heterologous biological
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 5
- 241000228245 Aspergillus niger Species 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 230000007812 deficiency Effects 0.000 title 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Natural products OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 101710081721 Alpha-amylase A Proteins 0.000 abstract 1
- 101710081719 Alpha-amylase B Proteins 0.000 abstract 1
- 101100162670 Bacillus subtilis (strain 168) amyE gene Proteins 0.000 abstract 1
- 101100277447 Bacillus subtilis (strain 168) degQ gene Proteins 0.000 abstract 1
- 101150108358 GLAA gene Proteins 0.000 abstract 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 abstract 1
- 102100022624 Glucoamylase Human genes 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 101000971102 Thauera aromatica 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 108090000637 alpha-Amylases Proteins 0.000 abstract 1
- 102000004139 alpha-Amylases Human genes 0.000 abstract 1
- 229940024171 alpha-amylase Drugs 0.000 abstract 1
- 101150069712 amyA gene Proteins 0.000 abstract 1
- 101150009288 amyB gene Proteins 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 101150115781 prtT gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45990203P | 2003-03-31 | 2003-03-31 | |
| PCT/US2004/010126 WO2004090155A2 (en) | 2003-03-31 | 2004-03-31 | Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441664T1 true ATE441664T1 (de) | 2009-09-15 |
Family
ID=33159708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04758768T ATE441664T1 (de) | 2003-03-31 | 2004-03-31 | Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7303877B2 (https=) |
| EP (1) | EP1613761B1 (https=) |
| JP (1) | JP4638418B2 (https=) |
| CN (2) | CN101629204A (https=) |
| AT (1) | ATE441664T1 (https=) |
| DE (1) | DE602004022929D1 (https=) |
| DK (1) | DK1613761T3 (https=) |
| WO (1) | WO2004090155A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101094919B (zh) * | 2004-10-12 | 2014-09-03 | 帝斯曼知识产权资产管理有限公司 | 在生产多肽的方法中有用的真菌转录活化因子 |
| EP1831384B1 (en) | 2004-12-22 | 2015-08-12 | Novozymes A/S | Polypeptides having glucoamylase activity and polynucleotides encoding same |
| US7888489B2 (en) | 2005-01-24 | 2011-02-15 | Dsm Ip Assets B.V. | Method for producing a compound of interest in a filamentous fungal cell |
| EP1954812B1 (en) | 2005-11-29 | 2012-11-21 | DSM IP Assets B.V. | Dna binding site of a transcriptional activator useful in gene expression |
| WO2008000632A1 (en) | 2006-06-29 | 2008-01-03 | Dsm Ip Assets B.V. | A method for achieving improved polypeptide expression |
| EP2511372A1 (en) | 2006-11-02 | 2012-10-17 | DSM IP Assets B.V. | Improved production of secreted proteins by filamentous fungi |
| EA018840B1 (ru) | 2007-02-15 | 2013-11-29 | ДСМ АйПи АССЕТС Б.В. | Рекомбинантная клетка-хозяин для получения соединения, представляющего интерес |
| WO2009073709A1 (en) | 2007-12-06 | 2009-06-11 | Novozymes A/S | Polypeptides having acetylxylan esterase activity and polynucleotides encoding same |
| WO2010108918A1 (en) | 2009-03-24 | 2010-09-30 | Novozymes A/S | Polypeptides having acetyl xylan esterase activity and polynucleotides encoding same |
| EP2421986A1 (en) | 2009-04-22 | 2012-02-29 | DSM IP Assets B.V. | Process for the production of a recombinant polypeptide of interest |
| CA2758396C (en) | 2009-04-24 | 2018-06-12 | Dsm Ip Assets B.V. | Carbohydrate degrading polypeptide and uses thereof |
| DK2513290T3 (en) * | 2009-12-18 | 2016-01-25 | Novozymes Inc | Methods for Preparation of Polypeptides in Trichoderma Mutants with Protease Deficiency |
| US9133448B2 (en) | 2010-02-11 | 2015-09-15 | Dsm Ip Assets B.V. | Polypeptide having cellobiohydrolase activity and uses thereof |
| EA201201125A1 (ru) | 2010-02-11 | 2013-03-29 | ДСМ АйПи АССЕТС Б.В. | Клетка-хозяин, способная продуцировать ферменты, пригодные для деградации лигноцеллюлозного материала |
| CN101906393B (zh) * | 2010-06-28 | 2012-07-25 | 江南大学 | 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用 |
| MX2012015144A (es) | 2010-06-29 | 2013-03-05 | Dsm Ip Assets Bv | Polipeptido que tiene actividad de acetil-xilan-esterasa y usos del mismo. |
| EP2588493A1 (en) | 2010-06-29 | 2013-05-08 | DSM IP Assets B.V. | Polypeptide having swollenin activity and uses thereof |
| EP2588601A1 (en) | 2010-06-29 | 2013-05-08 | DSM IP Assets B.V. | Polypeptide having carbohydrate degrading activity and uses thereof |
| DK2588603T3 (en) | 2010-06-29 | 2017-07-03 | Dsm Ip Assets Bv | POLYPEPTIDE THAT HAS OR CONTRIBUTES TO CARBOHYDRATE MATERIAL DEGRADING ACTIVITIES AND APPLICATIONS THEREOF |
| WO2012000886A1 (en) | 2010-06-29 | 2012-01-05 | Dsm Ip Assets B.V. | Polypeptide having beta-glucosidase activity and uses thereof |
| ES2672125T3 (es) | 2010-06-29 | 2018-06-12 | Dsm Ip Assets B.V. | Polipéptido que tiene actividad beta-glucosidasa y usos del mismo |
| US9096871B2 (en) | 2010-10-06 | 2015-08-04 | Bp Corporation North America Inc. | Variant CBH I polypeptides with reduced product inhibition |
| US20120276247A1 (en) | 2011-04-29 | 2012-11-01 | Uwe Bornscheuer | Lipase Variants |
| JP5846476B2 (ja) * | 2011-07-08 | 2016-01-20 | 独立行政法人酒類総合研究所 | 微生物のコウジ酸生産性を向上させる方法 |
| CN102296032B (zh) * | 2011-08-31 | 2013-11-06 | 保龄宝生物股份有限公司 | 转葡糖苷酶及其制备和固定化方法 |
| JP5975236B2 (ja) * | 2011-11-02 | 2016-08-23 | ユニバーシティ プトゥラ マレーシア | 生体高分子の製造方法 |
| RU2645252C2 (ru) | 2012-01-05 | 2018-02-19 | Глюкос Финланд Ой | Клетка нитчатых грибов с дефицитом протеаз и способы ее применения |
| EP2852610B1 (en) | 2012-05-23 | 2018-07-11 | Glykos Finland Oy | Production of fucosylated glycoproteins |
| CN104603269A (zh) | 2012-08-17 | 2015-05-06 | 诺维信公司 | 用于在丝状真菌菌株中共沉默基因表达的方法及其应用 |
| SG11201600115SA (en) | 2013-07-10 | 2016-02-26 | Novartis Ag | Multiple proteases deficient filamentous fungal cells and methods of use thereof |
| US10619144B2 (en) | 2013-08-23 | 2020-04-14 | Novozymes A/S | Regulated PepC expression |
| SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| EP3445776B1 (en) * | 2016-04-19 | 2021-02-17 | Novozymes A/S | Rlma-inactivated filamentous fungal host cell |
| US10986850B2 (en) | 2016-12-21 | 2021-04-27 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
| CN108504615B (zh) * | 2018-03-30 | 2020-12-29 | 江南大学 | 一种产酸性蛋白酶的重组菌及其应用 |
| CN113301812A (zh) | 2018-10-17 | 2021-08-24 | 完美日股份有限公司 | 用于食物产品的重组组分和组合物 |
| US20220251581A1 (en) * | 2019-07-26 | 2022-08-11 | Novozymes A/S | Modified filamentous fungal host cell |
| CN113265417B (zh) * | 2020-02-14 | 2025-01-21 | 中国科学院天津工业生物技术研究所 | 有机酸产量提高的菌株及其构建方法和应用 |
| EP4228424A1 (en) | 2020-10-15 | 2023-08-23 | DSM IP Assets B.V. | Methods of modulating gastrointestinal metabolites |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| CN114736880B (zh) * | 2022-06-09 | 2022-09-27 | 中国农业科学院北京畜牧兽医研究所 | 酸稳定性提高葡萄糖氧化酶GoxM10的突变体D497N及其衍生突变体和应用 |
| WO2023242273A1 (en) * | 2022-06-14 | 2023-12-21 | Newmilkbuzz B.V. | Expression of milk caseins in filamentous fungi |
| WO2025230415A1 (en) | 2024-04-30 | 2025-11-06 | Ginkgo Bioworks Netherlands B.V. | Host cells expressing optb protein variants and uses thereof |
| CN119265158B (zh) * | 2024-09-27 | 2025-11-04 | 湖北大学 | 一种脂肪酶a突变体及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US5536661A (en) | 1987-03-10 | 1996-07-16 | Novo Nordisk A/S | Process for the production of protein products in aspergillus |
| US5252726A (en) | 1987-09-04 | 1993-10-12 | Novo Nordisk A/S | Promoters for use in aspergillus |
| DK0531372T4 (da) | 1990-05-09 | 2004-08-09 | Novozymes As | Cellulasepræparat omfattende et endoglucanaseenzym |
| DK88892D0 (da) | 1992-07-06 | 1992-07-06 | Novo Nordisk As | Forbindelse |
| FI964808A0 (fi) | 1994-06-03 | 1996-12-02 | Novo Nordisk Biotech Inc | Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot |
| CN101659926A (zh) | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| US5646025A (en) | 1995-05-05 | 1997-07-08 | Novo Nordisk A/S | Scytalidium catalase gene |
| KR20000069395A (ko) * | 1996-12-12 | 2000-11-25 | 프로헤 레오폴드 | 트리파레독신, 발현 플라스미드, 제조방법, 용도, 시험 시스템및 의약 제제 |
| JP5303084B2 (ja) * | 1997-04-11 | 2013-10-02 | コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ | 工業的組み換え生物を溝築するための手段としての遺伝子変換 |
| US6432371B1 (en) * | 1998-09-18 | 2002-08-13 | Jack Oliver, Jr. | Child proof chlorine dispenser with a three dimensional ornament |
| US6806062B1 (en) * | 1998-10-05 | 2004-10-19 | Novozymes A/S | Fungal transcriptional activator useful in methods for producing polypeptides |
| DK1117798T3 (da) | 1998-10-05 | 2007-04-10 | Novozymes As | Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider |
| EP1157100B1 (en) | 1999-02-22 | 2006-01-11 | Novozymes A/S | Oxaloacetate hydrolase deficient fungal host cells |
| CN100510096C (zh) | 1999-03-22 | 2009-07-08 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| DE60142226D1 (de) | 2000-03-14 | 2010-07-08 | Novozymes As | Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden |
| KR20020026456A (ko) * | 2000-04-13 | 2002-04-10 | 에말파브 마크 아론 | 사상균에서 발현된 ｄｎａ 라이브러리의 고산출량 스크리닝 |
-
2004
- 2004-03-31 JP JP2006509611A patent/JP4638418B2/ja not_active Expired - Lifetime
- 2004-03-31 CN CN200910167050A patent/CN101629204A/zh active Pending
- 2004-03-31 US US10/815,495 patent/US7303877B2/en not_active Expired - Lifetime
- 2004-03-31 AT AT04758768T patent/ATE441664T1/de not_active IP Right Cessation
- 2004-03-31 DE DE602004022929T patent/DE602004022929D1/de not_active Expired - Lifetime
- 2004-03-31 DK DK04758768T patent/DK1613761T3/da active
- 2004-03-31 EP EP04758768A patent/EP1613761B1/en not_active Expired - Lifetime
- 2004-03-31 WO PCT/US2004/010126 patent/WO2004090155A2/en not_active Ceased
- 2004-03-31 CN CNB2004800151129A patent/CN100547078C/zh not_active Expired - Lifetime
-
2007
- 2007-08-10 US US11/837,279 patent/US7771971B2/en not_active Expired - Fee Related
-
2010
- 2010-06-24 US US12/823,046 patent/US8445283B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040191864A1 (en) | 2004-09-30 |
| DK1613761T3 (da) | 2009-12-14 |
| US7303877B2 (en) | 2007-12-04 |
| WO2004090155A2 (en) | 2004-10-21 |
| EP1613761A2 (en) | 2006-01-11 |
| CN100547078C (zh) | 2009-10-07 |
| CN1798848A (zh) | 2006-07-05 |
| US7771971B2 (en) | 2010-08-10 |
| WO2004090155A3 (en) | 2005-01-06 |
| DE602004022929D1 (de) | 2009-10-15 |
| EP1613761A4 (en) | 2006-08-09 |
| JP4638418B2 (ja) | 2011-02-23 |
| JP2006521826A (ja) | 2006-09-28 |
| CN101629204A (zh) | 2010-01-20 |
| US8445283B2 (en) | 2013-05-21 |
| US20100323448A1 (en) | 2010-12-23 |
| EP1613761B1 (en) | 2009-09-02 |
| US20080044858A1 (en) | 2008-02-21 |
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