JP4602547B2 - ペプチド合成のための方法および組成物 - Google Patents

ペプチド合成のための方法および組成物 Download PDF

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Publication number
JP4602547B2
JP4602547B2 JP2000537561A JP2000537561A JP4602547B2 JP 4602547 B2 JP4602547 B2 JP 4602547B2 JP 2000537561 A JP2000537561 A JP 2000537561A JP 2000537561 A JP2000537561 A JP 2000537561A JP 4602547 B2 JP4602547 B2 JP 4602547B2
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Japan
Prior art keywords
seq
peptide
fmoc
formula
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2000537561A
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English (en)
Japanese (ja)
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JP2002507576A (ja
JP2002507576A5 (enExample
Inventor
カン,ミュン−チョル
ブレイ,ブライアン
リクティー,メイナード
メイダー,キャサリーン
チェスラ,スコット
Original Assignee
トリメリス,インコーポレーテッド
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Priority claimed from US09/045,920 external-priority patent/US6281331B1/en
Application filed by トリメリス,インコーポレーテッド filed Critical トリメリス,インコーポレーテッド
Publication of JP2002507576A publication Critical patent/JP2002507576A/ja
Publication of JP2002507576A5 publication Critical patent/JP2002507576A5/ja
Application granted granted Critical
Publication of JP4602547B2 publication Critical patent/JP4602547B2/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000537561A 1998-03-23 1999-03-22 ペプチド合成のための方法および組成物 Expired - Fee Related JP4602547B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/045,920 1998-03-23
US09/045,920 US6281331B1 (en) 1998-03-23 1998-03-23 Methods and compositions for peptide synthesis
US09/071,877 1998-05-01
US09/071,877 US6015881A (en) 1998-03-23 1998-05-01 Methods and compositions for peptide synthesis
PCT/US1999/006230 WO1999048513A1 (en) 1998-03-23 1999-03-22 Methods and compositions for peptide synthesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009247579A Division JP4755713B2 (ja) 1998-03-23 2009-10-28 ペプチド合成のための方法および組成物

Publications (3)

Publication Number Publication Date
JP2002507576A JP2002507576A (ja) 2002-03-12
JP2002507576A5 JP2002507576A5 (enExample) 2006-06-08
JP4602547B2 true JP4602547B2 (ja) 2010-12-22

Family

ID=26723345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000537561A Expired - Fee Related JP4602547B2 (ja) 1998-03-23 1999-03-22 ペプチド合成のための方法および組成物

Country Status (13)

Country Link
EP (1) EP1071442B9 (enExample)
JP (1) JP4602547B2 (enExample)
CN (1) CN100383158C (enExample)
AT (1) ATE299029T1 (enExample)
AU (1) AU751358B2 (enExample)
BR (1) BR9909018A (enExample)
CA (1) CA2324348C (enExample)
DE (1) DE69926061T2 (enExample)
DK (1) DK1071442T3 (enExample)
ES (1) ES2245505T3 (enExample)
NZ (1) NZ507083A (enExample)
TW (1) TWI233931B (enExample)
WO (1) WO1999048513A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
ES2525317T3 (es) 2001-06-15 2014-12-22 F. Hoffmann-La Roche Ag Producción recombinante de inhibidores de la fusión antivirales peptídicos
AU2003257467B2 (en) * 2002-07-24 2008-02-28 F. Hoffmann-La Roche Ag Pegylated T20 polypeptide
DE602004017057D1 (de) 2003-12-31 2008-11-20 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden
EP1701976A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
EP1701969B1 (en) 2003-12-31 2007-10-24 F.Hoffmann-La Roche Ag Process for peptide synthesis using a reduced amount of deprotection agent
CA2592438C (en) * 2004-12-30 2013-09-03 F.Hoffmann-La Roche Ag Synthesis of peptide t-20 using peptide intermediate fragments
CA2651070A1 (en) 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
WO2009014177A1 (ja) * 2007-07-25 2009-01-29 Ajinomoto Co., Inc. ジベンゾフルベン誘導体の淘汰方法
JP5473925B2 (ja) * 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
AU2008334783A1 (en) * 2007-12-11 2009-06-18 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
EP2322498B1 (en) * 2008-08-06 2014-04-16 Ajinomoto Co., Inc. Processes for removing dibenzofulvene
US20110288235A1 (en) * 2008-09-03 2011-11-24 Scinopharm Taiwan Ltd. Process for the Preparation of Pramlintide
AU2009288036A1 (en) * 2008-09-03 2010-03-11 Scinopharm Taiwan, Ltd. Process for the preparation of pramlintide
WO2011095989A2 (en) * 2010-02-04 2011-08-11 Matrix Laboratories Ltd An improved process for the preparation of enfuvirtide
PL219569B1 (pl) * 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
CN103374054B (zh) * 2012-04-28 2014-12-24 上海第一生化药业有限公司 一步法固相合成多肽的方法
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
CA3167047A1 (en) * 2020-02-05 2021-08-12 Martin D. Johnson Three resin reactors in series peptide synthesizer
CN114315957B (zh) * 2021-12-30 2023-07-07 深圳瑞德林生物技术有限公司 一种多肽的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007616A1 (en) * 1986-06-12 1987-12-17 Biogen N.V. Peptides involved in the pathogenesis of hiv infection
US4787222A (en) * 1986-11-24 1988-11-29 Novatek Medical Inc. Combination lock for blood identification system
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
EP0708659A4 (en) * 1993-06-07 2000-08-23 Genentech Inc HIV ENVELOPE POLYPEPTIDE
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
JPH09502348A (ja) * 1993-09-11 1997-03-11 ポリムン・シエンティフィーク・イムノビオロギッシェ・フォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 遺伝学的に分岐したhiv−1株に対する中和抗体を誘導するペプチド
AU722895B2 (en) * 1996-02-09 2000-08-10 F. Hoffmann-La Roche Ag Synthesis of VIP analog

Also Published As

Publication number Publication date
AU751358B2 (en) 2002-08-15
NZ507083A (en) 2003-10-31
ES2245505T3 (es) 2006-01-01
CN100383158C (zh) 2008-04-23
TWI233931B (en) 2005-06-11
AU3109799A (en) 1999-10-18
ATE299029T1 (de) 2005-07-15
WO1999048513A1 (en) 1999-09-30
JP2002507576A (ja) 2002-03-12
DK1071442T3 (da) 2005-10-24
CN1303299A (zh) 2001-07-11
EP1071442A4 (en) 2002-06-05
EP1071442B1 (en) 2005-07-06
DE69926061T2 (de) 2006-06-01
EP1071442B9 (en) 2006-01-18
CA2324348A1 (en) 1999-09-30
EP1071442A1 (en) 2001-01-31
DE69926061D1 (de) 2005-08-11
CA2324348C (en) 2006-03-14
BR9909018A (pt) 2001-10-16

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EP1372686B1 (en) Methods and compositions for peptide synthesis
CA2592438C (en) Synthesis of peptide t-20 using peptide intermediate fragments
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