JP4588324B2 - 組織測定用プローブ - Google Patents

組織測定用プローブ Download PDF

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Publication number
JP4588324B2
JP4588324B2 JP2003584690A JP2003584690A JP4588324B2 JP 4588324 B2 JP4588324 B2 JP 4588324B2 JP 2003584690 A JP2003584690 A JP 2003584690A JP 2003584690 A JP2003584690 A JP 2003584690A JP 4588324 B2 JP4588324 B2 JP 4588324B2
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Japan
Prior art keywords
raman
tissue
spectrum
probe
fiber
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Expired - Fee Related
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JP2003584690A
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English (en)
Japanese (ja)
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JP2005522293A5 (https=
JP2005522293A (ja
Inventor
モツツ,ジエイソン・テイ
ガリンド,ルイス・エイチ
ハンター,マーテイン
ハカ,アビゲイル・エス
ガンデイ,ソーミル
ダサリ,ラマチヤンドラ
フエルド,マイケル・エス
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Priority claimed from US10/178,062 external-priority patent/US7647092B2/en
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Publication of JP2005522293A5 publication Critical patent/JP2005522293A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519Muscles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4742Details of optical heads therefor, e.g. using optical fibres comprising optical fibres
    • G01N2021/4745Fused bundle, i.e. for backscatter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4752Geometry
    • G01N2021/4759Annular illumination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
JP2003584690A 2002-04-05 2003-04-04 組織測定用プローブ Expired - Fee Related JP4588324B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37019702P 2002-04-05 2002-04-05
US10/178,062 US7647092B2 (en) 2002-04-05 2002-06-21 Systems and methods for spectroscopy of biological tissue
PCT/US2003/010307 WO2003087793A1 (en) 2002-04-05 2003-04-04 Systems and methods for spectroscopy of biological tissue

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010136655A Division JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Publications (3)

Publication Number Publication Date
JP2005522293A JP2005522293A (ja) 2005-07-28
JP2005522293A5 JP2005522293A5 (https=) 2006-05-25
JP4588324B2 true JP4588324B2 (ja) 2010-12-01

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003584690A Expired - Fee Related JP4588324B2 (ja) 2002-04-05 2003-04-04 組織測定用プローブ
JP2010136655A Pending JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Family Applications After (1)

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JP2010136655A Pending JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Country Status (3)

Country Link
EP (1) EP1495309A1 (https=)
JP (2) JP4588324B2 (https=)
AU (1) AU2003230799A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013075027A (ja) * 2011-09-30 2013-04-25 Fujifilm Corp 内視鏡用照明光学系及び照明装置

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JP4041421B2 (ja) * 2003-03-25 2008-01-30 独立行政法人理化学研究所 ラマンプローブ及びそれを用いたラマン散乱計測装置
GB0426993D0 (en) * 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
EP1726256A1 (en) * 2005-05-27 2006-11-29 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Phantom device
DE102005045088B4 (de) * 2005-09-21 2007-05-16 Siemens Ag Optisches Kohärenztomographie-System
GB0611981D0 (en) * 2006-06-16 2006-07-26 Renishaw Plc Spectroscopic analysis methods
JP4920507B2 (ja) * 2007-06-27 2012-04-18 オリンパス株式会社 画像処理装置および画像処理プログラム
JP5201920B2 (ja) * 2007-09-12 2013-06-05 キヤノン株式会社 測定装置
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
US20120046555A1 (en) * 2009-03-13 2012-02-23 Tetsuro Takamatsu Body tissue imaging using raman scattering light
RU2012128959A (ru) * 2009-12-17 2014-01-27 Бритиш Коламбиа Кансер Эйдженси Бранч Прибор и способы для характеристики тканей in vivo рамановской спектроскопией
US8223443B2 (en) * 2010-09-01 2012-07-17 Kla-Tencor Corporation Collection optics
CN103237489B (zh) * 2010-10-26 2016-08-03 柯尼卡美能达株式会社 探针
EP2653090A4 (en) 2010-12-16 2016-11-16 Konica Minolta Inc PROBE
JP2012189322A (ja) * 2011-03-08 2012-10-04 Olympus Corp 液状生体ファントム及び液状生体ファントムの作製方法
JP5814635B2 (ja) * 2011-06-07 2015-11-17 シャープ株式会社 検出装置
JPWO2013061590A1 (ja) * 2011-10-25 2015-04-02 コニカミノルタ株式会社 光学プローブ及びその製造方法
JP5733163B2 (ja) * 2011-11-10 2015-06-10 コニカミノルタ株式会社 プローブの製造方法
WO2013090658A1 (en) 2011-12-14 2013-06-20 The Trustees Of The University Of Pennsylvania Fiber optic flow and oxygenation monitoring using diffuse correlation and reflectance
JPWO2013136664A1 (ja) 2012-03-13 2015-08-03 コニカミノルタ株式会社 プローブ
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
EP2885628A4 (en) * 2012-08-16 2016-07-20 Univ Singapore DIAGNOSTIC DEVICE AND METHODS RELATED TO RAM SPECTROSCOPY
JP6006036B2 (ja) * 2012-08-17 2016-10-12 オリンパス株式会社 分光スペクトル解析方法
JP6082273B2 (ja) * 2013-02-25 2017-02-15 日本板硝子株式会社 蛍光検出装置
JP6294614B2 (ja) * 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
JP6273470B2 (ja) * 2013-05-10 2018-02-07 ナノフォトン株式会社 分子振動の表示方法
JP6103700B2 (ja) * 2013-05-15 2017-03-29 京都府公立大学法人 ラマン散乱を用いた心臓組織の識別方法及び装置
JP2014224771A (ja) * 2013-05-16 2014-12-04 三菱重工業株式会社 燃料ガス計測装置及び方法
WO2015128946A1 (ja) 2014-02-25 2015-09-03 オリンパス株式会社 分光スペクトル解析方法
CN103932680A (zh) * 2014-04-15 2014-07-23 广州玖玖伍捌信息科技有限公司 一种人体肿瘤复发监测及热疗一体系统
FR3024546B1 (fr) * 2014-07-29 2018-08-24 Universite De Reims Champagne-Ardenne Procede de detection et de quantification de la fibrose
WO2016121811A1 (ja) * 2015-01-29 2016-08-04 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6336949B2 (ja) 2015-01-29 2018-06-06 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6630944B2 (ja) * 2016-01-19 2020-01-15 国立大学法人島根大学 ラマン散乱光の観測方法、ラマン散乱光の観測装置及びプログラム
WO2018116363A1 (ja) * 2016-12-19 2018-06-28 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
GB201701355D0 (en) * 2017-01-27 2017-03-15 Renishaw Plc Direct laser writing and chemical etching
JP6428825B2 (ja) * 2017-03-29 2018-11-28 セイコーエプソン株式会社 検出装置
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EP4182674A4 (en) * 2020-07-14 2024-07-17 Eric Marple FIBER OPTICAL PROBE WITH COMPONENTS AND FEATURES THAT IMPROVE PERFORMANCE
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Publication number Priority date Publication date Assignee Title
JP2013075027A (ja) * 2011-09-30 2013-04-25 Fujifilm Corp 内視鏡用照明光学系及び照明装置

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JP2005522293A (ja) 2005-07-28
AU2003230799A1 (en) 2003-10-27
JP2010249835A (ja) 2010-11-04
EP1495309A1 (en) 2005-01-12

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