AU2003230799A1 - Systems and methods for spectroscopy of biological tissue - Google Patents

Systems and methods for spectroscopy of biological tissue

Info

Publication number
AU2003230799A1
AU2003230799A1 AU2003230799A AU2003230799A AU2003230799A1 AU 2003230799 A1 AU2003230799 A1 AU 2003230799A1 AU 2003230799 A AU2003230799 A AU 2003230799A AU 2003230799 A AU2003230799 A AU 2003230799A AU 2003230799 A1 AU2003230799 A1 AU 2003230799A1
Authority
AU
Australia
Prior art keywords
spectroscopy
systems
methods
biological tissue
biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003230799A
Other languages
English (en)
Inventor
Ramachandra Dasari
Michael S. Feld
Luis H. Galindo
Saumil Gandhi
Abigail S. Haka
Martin Hunter
Jason T. Motz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/178,062 external-priority patent/US7647092B2/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of AU2003230799A1 publication Critical patent/AU2003230799A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519—Muscles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4742—Details of optical heads therefor, e.g. using optical fibres comprising optical fibres
    • G01N2021/4745—Fused bundle, i.e. for backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4752—Geometry
    • G01N2021/4759—Annular illumination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
AU2003230799A 2002-04-05 2003-04-04 Systems and methods for spectroscopy of biological tissue Abandoned AU2003230799A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37019702P 2002-04-05 2002-04-05
US60/370,197 2002-04-05
US10/178,062 US7647092B2 (en) 2002-04-05 2002-06-21 Systems and methods for spectroscopy of biological tissue
US10/178,062 2002-06-21
PCT/US2003/010307 WO2003087793A1 (en) 2002-04-05 2003-04-04 Systems and methods for spectroscopy of biological tissue

Publications (1)

Publication Number Publication Date
AU2003230799A1 true AU2003230799A1 (en) 2003-10-27

Family

ID=28677945

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003230799A Abandoned AU2003230799A1 (en) 2002-04-05 2003-04-04 Systems and methods for spectroscopy of biological tissue

Country Status (3)

Country Link
EP (1) EP1495309A1 (https=)
JP (2) JP4588324B2 (https=)
AU (1) AU2003230799A1 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4041421B2 (ja) * 2003-03-25 2008-01-30 独立行政法人理化学研究所 ラマンプローブ及びそれを用いたラマン散乱計測装置
GB0426993D0 (en) * 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
EP1726256A1 (en) * 2005-05-27 2006-11-29 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Phantom device
DE102005045088B4 (de) * 2005-09-21 2007-05-16 Siemens Ag Optisches Kohärenztomographie-System
GB0611981D0 (en) * 2006-06-16 2006-07-26 Renishaw Plc Spectroscopic analysis methods
JP4920507B2 (ja) * 2007-06-27 2012-04-18 オリンパス株式会社 画像処理装置および画像処理プログラム
JP5201920B2 (ja) * 2007-09-12 2013-06-05 キヤノン株式会社 測定装置
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
US20120046555A1 (en) * 2009-03-13 2012-02-23 Tetsuro Takamatsu Body tissue imaging using raman scattering light
RU2012128959A (ru) * 2009-12-17 2014-01-27 Бритиш Коламбиа Кансер Эйдженси Бранч Прибор и способы для характеристики тканей in vivo рамановской спектроскопией
US8223443B2 (en) * 2010-09-01 2012-07-17 Kla-Tencor Corporation Collection optics
CN103237489B (zh) * 2010-10-26 2016-08-03 柯尼卡美能达株式会社 探针
EP2653090A4 (en) 2010-12-16 2016-11-16 Konica Minolta Inc PROBE
JP2012189322A (ja) * 2011-03-08 2012-10-04 Olympus Corp 液状生体ファントム及び液状生体ファントムの作製方法
JP5814635B2 (ja) * 2011-06-07 2015-11-17 シャープ株式会社 検出装置
JP5389884B2 (ja) * 2011-09-30 2014-01-15 富士フイルム株式会社 内視鏡用照明光学系及び照明装置
JPWO2013061590A1 (ja) * 2011-10-25 2015-04-02 コニカミノルタ株式会社 光学プローブ及びその製造方法
JP5733163B2 (ja) * 2011-11-10 2015-06-10 コニカミノルタ株式会社 プローブの製造方法
WO2013090658A1 (en) 2011-12-14 2013-06-20 The Trustees Of The University Of Pennsylvania Fiber optic flow and oxygenation monitoring using diffuse correlation and reflectance
JPWO2013136664A1 (ja) 2012-03-13 2015-08-03 コニカミノルタ株式会社 プローブ
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
EP2885628A4 (en) * 2012-08-16 2016-07-20 Univ Singapore DIAGNOSTIC DEVICE AND METHODS RELATED TO RAM SPECTROSCOPY
JP6006036B2 (ja) * 2012-08-17 2016-10-12 オリンパス株式会社 分光スペクトル解析方法
JP6082273B2 (ja) * 2013-02-25 2017-02-15 日本板硝子株式会社 蛍光検出装置
JP6294614B2 (ja) * 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
JP6273470B2 (ja) * 2013-05-10 2018-02-07 ナノフォトン株式会社 分子振動の表示方法
JP6103700B2 (ja) * 2013-05-15 2017-03-29 京都府公立大学法人 ラマン散乱を用いた心臓組織の識別方法及び装置
JP2014224771A (ja) * 2013-05-16 2014-12-04 三菱重工業株式会社 燃料ガス計測装置及び方法
WO2015128946A1 (ja) 2014-02-25 2015-09-03 オリンパス株式会社 分光スペクトル解析方法
CN103932680A (zh) * 2014-04-15 2014-07-23 广州玖玖伍捌信息科技有限公司 一种人体肿瘤复发监测及热疗一体系统
FR3024546B1 (fr) * 2014-07-29 2018-08-24 Universite De Reims Champagne-Ardenne Procede de detection et de quantification de la fibrose
WO2016121811A1 (ja) * 2015-01-29 2016-08-04 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6336949B2 (ja) 2015-01-29 2018-06-06 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6630944B2 (ja) * 2016-01-19 2020-01-15 国立大学法人島根大学 ラマン散乱光の観測方法、ラマン散乱光の観測装置及びプログラム
WO2018116363A1 (ja) * 2016-12-19 2018-06-28 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
GB201701355D0 (en) * 2017-01-27 2017-03-15 Renishaw Plc Direct laser writing and chemical etching
JP6428825B2 (ja) * 2017-03-29 2018-11-28 セイコーエプソン株式会社 検出装置
US11672425B2 (en) 2018-02-15 2023-06-13 Speclipse, Inc. Stand-alone apparatus and methods for in vivo detection of tissue malignancy using laser spectroscopy
KR102375183B1 (ko) 2019-03-22 2022-03-16 스페클립스 주식회사 레이저 유도 붕괴 스펙트럼 분석을 이용하는 진단 방법 및 이를 수행하는 진단 장치
US12399126B2 (en) * 2020-01-29 2025-08-26 King's College London Raman spectroscopy method and system
EP4182674A4 (en) * 2020-07-14 2024-07-17 Eric Marple FIBER OPTICAL PROBE WITH COMPONENTS AND FEATURES THAT IMPROVE PERFORMANCE
JPWO2024185521A1 (https=) * 2023-03-03 2024-09-12

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230679B1 (en) * 1986-01-30 1990-08-08 The Dow Chemical Company Fiber-optic probe
DK130586A (da) * 1985-03-22 1986-09-23 Massachusetts Inst Technology Laser-kateter til indfoering i arterier
ATE187315T1 (de) * 1987-09-24 1999-12-15 Massachusetts Inst Technology Kathetersystem zur abbildung
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
JP2000515407A (ja) * 1996-08-02 2000-11-21 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 上皮被覆内臓組織の特徴付けのための方法および装置
JPH10267846A (ja) * 1997-03-27 1998-10-09 Jeol Ltd レーザ照射／取り込み光学装置
JP4486743B2 (ja) * 2000-10-31 2010-06-23 株式会社町田製作所 血管内壁の付着物質の分析システム

Also Published As

Publication number Publication date
JP4588324B2 (ja) 2010-12-01
JP2005522293A (ja) 2005-07-28
JP2010249835A (ja) 2010-11-04
EP1495309A1 (en) 2005-01-12

Similar Documents

Publication Publication Date Title
AU2003230799A1 (en) Systems and methods for spectroscopy of biological tissue
AU2003295634A1 (en) Apparatus and method for palpograhic chacterization of vulnerable plaque and other biological tissue
AU2003239957A1 (en) Optically-connected implants and related systems and methods of use
AU2003900780A0 (en) Analysis system and procedure
AU2003256253A1 (en) Aerosol for medical treatment and methods
AU2003231267A1 (en) Surgical retractors and method of operation
AU2003237571A1 (en) Method and system for controlling the development of biological entities
AU2003232485A1 (en) Neopeptides and methods useful for detection and treatment of cancer
EP1571969A3 (en) Systems and methods for electrosurgical tissue treatment
AU2003231048A1 (en) Transposon system and methods of use
AU2002335737A1 (en) Systems and methods for removing body tissue
AU2003209889A1 (en) Method and system of cost variance analysis
AU2003224788A1 (en) Method for treatment of tissue
AU2003237455A1 (en) System and method for open control and monitoring of biological instruments
AU2003237922A1 (en) Method and instrument for surgical navigation
AU2003207698A1 (en) Needle-suture combinations and methods of use
AU2003225779A1 (en) Tissue manipulation apparatus and method of use
AU2003286507A1 (en) Surgical instrument positioning system and method of use
AU2003280298A1 (en) Methods for the biological treatment of gas
AU2003203378A1 (en) Suture insrument for biological use
AU2003265645A1 (en) System and method of characterizing vascular tissue
AU2003290939A1 (en) Replication of biological tiussue
AU2003251289A1 (en) Methods and systems for the prediction of the biological function of biopolymers
AU2003223033A1 (en) System for point of care diagnosis and/or analysis
AU2003297494A1 (en) System and method of illuminating living cells for imaging

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase