JP4571861B2 - 薬剤形の被覆剤および結合剤を製造するための顆粒または粉末 - Google Patents

薬剤形の被覆剤および結合剤を製造するための顆粒または粉末 Download PDF

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Publication number
JP4571861B2
JP4571861B2 JP2004531794A JP2004531794A JP4571861B2 JP 4571861 B2 JP4571861 B2 JP 4571861B2 JP 2004531794 A JP2004531794 A JP 2004531794A JP 2004531794 A JP2004531794 A JP 2004531794A JP 4571861 B2 JP4571861 B2 JP 4571861B2
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Prior art keywords
granules
powders
sub
weight
acid
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Expired - Lifetime
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JP2004531794A
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English (en)
Japanese (ja)
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JP2005536555A (ja
Inventor
ペーテライト ハンス−ウルリヒ
マイアー クリスティアン
ロート エルナ
グリュツケ アンドレアス
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Roehm GmbH Darmstadt
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Evonik Roehm GmbH
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
JP2004531794A 2002-08-27 2003-07-08 薬剤形の被覆剤および結合剤を製造するための顆粒または粉末 Expired - Lifetime JP4571861B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10239999A DE10239999A1 (de) 2002-08-27 2002-08-27 Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
PCT/EP2003/007319 WO2004019918A1 (de) 2002-08-27 2003-07-08 Granulat oder pulver zur herstellung von überzugs- und bindemitteln für arzneiformen

Publications (2)

Publication Number Publication Date
JP2005536555A JP2005536555A (ja) 2005-12-02
JP4571861B2 true JP4571861B2 (ja) 2010-10-27

Family

ID=31197526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004531794A Expired - Lifetime JP4571861B2 (ja) 2002-08-27 2003-07-08 薬剤形の被覆剤および結合剤を製造するための顆粒または粉末

Country Status (16)

Country Link
US (1) US7175857B2 (cg-RX-API-DMAC7.html)
EP (1) EP1432409B1 (cg-RX-API-DMAC7.html)
JP (1) JP4571861B2 (cg-RX-API-DMAC7.html)
KR (1) KR100942667B1 (cg-RX-API-DMAC7.html)
AT (1) ATE408401T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003266232A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0306143B8 (cg-RX-API-DMAC7.html)
CA (1) CA2464502C (cg-RX-API-DMAC7.html)
DE (2) DE10239999A1 (cg-RX-API-DMAC7.html)
ES (1) ES2314275T3 (cg-RX-API-DMAC7.html)
IL (2) IL161145A0 (cg-RX-API-DMAC7.html)
IN (1) IN2004CH00875A (cg-RX-API-DMAC7.html)
MX (1) MX250472B (cg-RX-API-DMAC7.html)
PL (1) PL206233B1 (cg-RX-API-DMAC7.html)
SI (1) SI1432409T1 (cg-RX-API-DMAC7.html)
WO (1) WO2004019918A1 (cg-RX-API-DMAC7.html)

Families Citing this family (38)

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DE10208344A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen
DE10260920A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen
DE10260921A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
DE10260919A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug
DE10304403A1 (de) * 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
DE102004029573A1 (de) * 2004-06-18 2005-12-29 Gambro Lundia Ab MIF-Adsorbent
JP4895819B2 (ja) * 2004-10-29 2012-03-14 大鵬薬品工業株式会社 プロピベリン含有経口粉粒状製剤及びその製造法
EP1681049A1 (fr) * 2005-01-12 2006-07-19 Physica Pharma Composition pharmaceutique et forme galénique correspondante à délitement rapide en bouche, et procédé de fabrication de cette composition
US20060264458A1 (en) * 2005-05-03 2006-11-23 Jie Du Quinine dosage forms and methods of use thereof
DE102005042039A1 (de) * 2005-09-02 2007-03-08 Basf Ag Wässrige Polyvinylacetatdispersionen mit hoher Scherstabilität
AU2007280471B2 (en) * 2006-08-04 2012-10-18 Ethypharm Multilayer orally disintegrating tablet
US8790693B2 (en) 2007-08-02 2014-07-29 Basf Se Aqueous polymer dispersion based on N,N-diethylaminoethyl methacrylate, its preparation and use
WO2010030735A2 (en) * 2008-09-11 2010-03-18 Aethos Pharmaceuticals, Inc. Stabilized coating for pharmaceutical formulations
JP5693594B2 (ja) 2009-10-28 2015-04-01 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 医薬剤形用の安定な保護コーティング
US20110150986A1 (en) * 2009-12-18 2011-06-23 Kristin Arnold Quinine formulations, method of making, and metho of use thereof
AU2011226324B2 (en) * 2010-03-10 2015-09-24 Nogra Pharma Limited Compositions for colon lavage and methods of making and using same
EP2568964B1 (en) * 2010-05-10 2018-08-01 Evonik Röhm GmbH Pharmaceutical dosage form comprising one or more antiretroviral active ingredients
WO2012031934A1 (de) 2010-09-07 2012-03-15 Basf Se Verwendung von copolymeren auf basis von aminogruppenhaltigen polymeren als matrixbindemittel für die herstellung von wirkstoffhaltigen granulaten und darreichungsformen
US9795576B2 (en) 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
EP2621479B1 (de) 2010-09-27 2017-11-29 Basf Se Protektive überzüge für saure wirkstoffe
WO2012116940A1 (de) 2011-02-28 2012-09-07 Basf Se Herstellung von pulverförmigen überzugsmitteln für stabile protektive überzüge für pharmazeutische dosierungsformen
BR112013021510B1 (pt) 2011-02-28 2020-09-24 Basf Se Processo para a produção de composições de revestimento em pó, e, uso de um pó de polímero
US8865250B2 (en) 2011-02-28 2014-10-21 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US8962064B2 (en) 2011-02-28 2015-02-24 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US9044734B2 (en) 2011-09-23 2015-06-02 Basf Se Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion
US20130236505A1 (en) 2012-03-09 2013-09-12 Basf Se Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment
EP2636403A1 (de) * 2012-03-09 2013-09-11 Basf Se Herstellung von pharmazeutischen protektiven Überzügen mit guter Resistenz im neutralen Milieu
WO2013189776A1 (de) 2012-06-22 2013-12-27 Basf Se Wirkstoffhaltige festen dispersionen auf basis von diethylaminoethylmethacrylat-copolymeren
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
US20150290136A1 (en) * 2012-11-22 2015-10-15 Evonik Roehm Gmbh Process for preparing a granulated product from a powder composition
FR3027802B1 (fr) * 2014-10-31 2018-03-02 Ethypharm Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant
GR1008992B (el) * 2015-12-17 2017-03-23 Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης
EP3569225A1 (en) * 2018-05-18 2019-11-20 Pharmaceutical Oriented Services Ltd Solid dispersion containing ritonavir
JP7058763B2 (ja) * 2018-12-27 2022-04-22 興和株式会社 医薬品
AU2021391823A1 (en) 2020-12-03 2023-06-29 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
IL307454A (en) 2021-04-07 2023-12-01 Battelle Memorial Institute Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems

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DE3581428D1 (de) 1984-06-13 1991-02-28 Roehm Gmbh Verfahren zum ueberziehen von arzneiformen.
DE3920082A1 (de) 1989-06-20 1991-03-07 Roehm Gmbh Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung
DE29502547U1 (de) 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
DE19918435A1 (de) * 1998-07-23 2000-01-27 Roehm Gmbh Überzugs- und Bindemittel für orale oder dermale Arzneiformen
DE19958007A1 (de) * 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
BR0017261A (pt) * 2000-07-14 2003-07-29 Immunivest Corp Métodos para isolamento de uma bioentidade alvo de uma amostra biológica e de células de tumor com densidade de antìgeno baixa e, kits para inibir a agregação endógena de partìculas magnéticas coloidais no processamento de material biológico e, para isolamento de células de tumor de densidade de antìgeno baixa de uma amostra biológica com agregação ontrolada de partìculas magnéticas coloidais
SK288049B6 (sk) * 2001-02-27 2013-03-01 Evonik Rohm Gmbh Coating and binding agent, its use for production of cover oral or dermal pharmaceutical dosage forms, process for its production and dosage form containing same
DE10208344A1 (de) * 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen

Also Published As

Publication number Publication date
US20040249035A1 (en) 2004-12-09
ES2314275T3 (es) 2009-03-16
AU2003266232A1 (en) 2004-03-19
CA2464502A1 (en) 2004-03-11
JP2005536555A (ja) 2005-12-02
DE10239999A1 (de) 2004-03-04
PL368186A1 (en) 2005-03-21
BRPI0306143B1 (pt) 2016-03-08
MX250472B (es) 2007-10-17
US7175857B2 (en) 2007-02-13
BR0306143A (pt) 2004-10-19
EP1432409A1 (de) 2004-06-30
ATE408401T1 (de) 2008-10-15
DE50310506D1 (de) 2008-10-30
SI1432409T1 (sl) 2009-02-28
IL161145A0 (en) 2004-08-31
MXPA04003970A (es) 2004-06-22
US20050197434A9 (en) 2005-09-08
KR20050034620A (ko) 2005-04-14
WO2004019918A1 (de) 2004-03-11
IL161145A (en) 2010-11-30
CA2464502C (en) 2010-11-23
IN2004CH00875A (cg-RX-API-DMAC7.html) 2006-01-13
PL206233B1 (pl) 2010-07-30
EP1432409B1 (de) 2008-09-17
KR100942667B1 (ko) 2010-02-17
BRPI0306143B8 (pt) 2021-05-25

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