JP4508630B2 - コンタクトレンズ装着液 - Google Patents
コンタクトレンズ装着液 Download PDFInfo
- Publication number
- JP4508630B2 JP4508630B2 JP2003427500A JP2003427500A JP4508630B2 JP 4508630 B2 JP4508630 B2 JP 4508630B2 JP 2003427500 A JP2003427500 A JP 2003427500A JP 2003427500 A JP2003427500 A JP 2003427500A JP 4508630 B2 JP4508630 B2 JP 4508630B2
- Authority
- JP
- Japan
- Prior art keywords
- contact lens
- lens mounting
- mounting liquid
- polyvinyl
- polymer compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
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- 229920003081 Povidone K 30 Polymers 0.000 description 1
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- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
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- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
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- 239000003889 eye drop Substances 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 239000010643 fennel seed oil Substances 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
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- 239000004325 lysozyme Substances 0.000 description 1
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- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 1
- LVBRFZFUCKKGDJ-HJWRJIQTSA-J magnesium;dipotassium;(2s)-2-aminobutanedioate;hydron Chemical compound [Mg+2].[K+].[K+].OC(=O)[C@@H](N)CC([O-])=O.OC(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O LVBRFZFUCKKGDJ-HJWRJIQTSA-J 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 229960004760 naphazoline hydrochloride Drugs 0.000 description 1
- 229960004186 naphazoline nitrate Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
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- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
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- 229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
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- 229940073490 sodium glutamate Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940068459 sodium pantothenate Drugs 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
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- 229940021790 tetrahydrozoline hydrochloride Drugs 0.000 description 1
- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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Landscapes
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
[1].ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー及びポリビニルメチルエーテルから選ばれるポリビニル系高分子化合物と、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、ヒドロキシメチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシエチルメチルセルロース及びカルボキシメチルセルロースから選ばれ、重量平均分子量が6〜11万であるセルロース系高分子化合物と、グリセリン1〜5W/V%とを含有することを特徴とするコンタクトレンズ装着液。
[2].上記ポリビニル系高分子化合物の重量平均分子量が2〜100万である[1]記載のコンタクトレンズ装着液。
[3].ポリビニル系高分子化合物とセルロース系高分子化合物の含有量が、それぞれ0.1〜5W/V%である[1]又は[2]記載のコンタクトレンズ装着液。
[4].粘度(20℃・E型回転粘度計測定)が5〜100mPa・sである[1]〜[3]のいずれかに記載のコンタクトレンズ装着液。
[5].ポリビニル系高分子化合物とセルロース系高分子化合物との含有量比が1:10〜20:1である[1]〜[4]のいずれかに記載のコンタクトレンズ装着液。
[6].コンタクトレンズに直接滴下したのち、コンタクトレンズを目に装着することを特徴とする[1]〜[5]のいずれかに記載のコンタクトレンズ装着液。
[7].酸素透過性ハードコンタクトレンズ又はソフトコンタクトレンズ用である[1]〜[6]のいずれかに記載のコンタクトレンズ装着液。
本発明のポリビニル系高分子化合物としては、通常、眼科用として使用されるものであれば特に制限はされない。例えば、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリビニルメチルエーテル等が挙げられる。これらは1種単独で又は2種以上を適且組み合わせて用いることができる。この中でもポリビニルアルコール、ポリビニルピロリドンが好適である。
防腐剤としては、例えば、塩化ベンザルコニウム、塩化ベンゼトニウム、グルコン酸クロルヘキシジン、ソルビン酸、ソルビン酸カリウム、クロロブタノール、パラオキシ安香酸エステル等が挙げられる。防腐剤の含有量は、装着液中0.001〜0.5W/V%の範囲であることが好ましい。
表1〜5の組成となるように(配合単位、g/100mL,W/V%)、表中の各配合成分を定法に準じて滅菌精製水に溶解した後、各溶液を無菌ろ過して、コンタクトレンズ装着液を調製した。得られた装着液について下記評価を行った。結果を表1〜5に併記する。
コンタクトレンズ使用者(ソフトコンタクトレンズ使用者5名、酸素透過性ハードコンタクトレンズ5名)をパネラーとした。各パネラーがそれぞれコンタクトレンズにコンタクトレンズ装着液を3滴つけ、装着した後の視界のぼやけ、装着中の使用感について下記評価基準に基づいて評価した。
5:装着後、視界のぼやけが1分以内に解消する
4:装着後、1分〜1分30秒間未満ぼやける
3:装着後、1分30秒〜2分間未満ぼやける
2:装着後、2分〜2分30秒間未満ぼやける
1:装着後、2分30秒以上ぼやける
表中には、パネラーの平均値が4以上のものについては◎とし、3以上4未満のものについては○とし、2以上3未満のものについては△とし、2未満のものについては×として視界のぼやけ評価を示す。
5:装着液を使用しない場合と比べて異物感や乾燥感等の不快感が非常に改善
4:装着液を使用しない場合と比べて異物感や乾燥感等の不快感が改善
3:装着液を使用しない場合と比べて異物感や乾燥感等の不快感がやや改善
2:装着液を使用しない場合と比べて異物感や乾燥感等の不快感が変わらない
1:装着液を使用しない場合と比べて異物感や乾燥感等の不快感が感じられる
表中には、パネラーの平均値が4以上のものについては◎とし、3以上4未満のものについては○とし、2以上3未満のものについては△とし、2未満のものについては×として使用感評価を示す。なお、コンタクトレンズ装着液としては○以上が好ましく、より好ましくは◎である。
PVA ゴーセノールEG−05:ポリビニルアルコール,日本合成化学工業(株)製
HPMC 60SH−50:ヒドロキシプロピルメチルセルロース メトローズ60SH−50(重量平均分子量10万),信越化学工業(株)製
HPMC 60SH−4000:ヒドロキシプロピルメチルセルロース メトローズ60SH−4000(重量平均分子量35万),信越化学工業(株)製
MC SM−15:メチルセルロース メトローズSM−15,(信越化学工業(株)製
PVP コリドン25:ポリビニルピロリドン,BASF(株)製
PVP コリドン30:ポリビニルピロリドン,BASF(株)製
Claims (7)
- ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー及びポリビニルメチルエーテルから選ばれるポリビニル系高分子化合物と、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、ヒドロキシメチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシエチルメチルセルロース及びカルボキシメチルセルロースから選ばれ、重量平均分子量が6〜11万であるセルロース系高分子化合物と、グリセリン1〜5W/V%とを含有することを特徴とするコンタクトレンズ装着液。
- 上記ポリビニル系高分子化合物の重量平均分子量が2〜100万である請求項1記載のコンタクトレンズ装着液。
- ポリビニル系高分子化合物とセルロース系高分子化合物の含有量が、それぞれ0.1〜5W/V%である請求項1又は2記載のコンタクトレンズ装着液。
- 粘度(20℃・E型回転粘度計測定)が5〜100mPa・sである請求項1〜3のいずれか1項記載のコンタクトレンズ装着液。
- ポリビニル系高分子化合物とセルロース系高分子化合物との含有量比が1:10〜20:1である請求項1〜4のいずれか1項記載のコンタクトレンズ装着液。
- コンタクトレンズに直接滴下したのち、コンタクトレンズを目に装着することを特徴とする請求項1〜5のいずれか1項記載のコンタクトレンズ装着液。
- 酸素透過性ハードコンタクトレンズ又はソフトコンタクトレンズ用である請求項1〜6のいずれか1項記載のコンタクトレンズ装着液。
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WO2009035034A1 (ja) * | 2007-09-14 | 2009-03-19 | Rohto Pharmaceutical Co., Ltd. | 眼科用組成物 |
JP2009096790A (ja) * | 2007-09-28 | 2009-05-07 | Rohto Pharmaceut Co Ltd | 疲れ目改善用及び/又はかすみ目改善用コンタクトレンズ装着液 |
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JP2003107416A (ja) * | 2001-09-27 | 2003-04-09 | Lion Corp | コンタクトレンズ用組成物及び洗眼剤組成物 |
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