JP4494020B2 - Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド - Google Patents

Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド Download PDF

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Publication number
JP4494020B2
JP4494020B2 JP2003575904A JP2003575904A JP4494020B2 JP 4494020 B2 JP4494020 B2 JP 4494020B2 JP 2003575904 A JP2003575904 A JP 2003575904A JP 2003575904 A JP2003575904 A JP 2003575904A JP 4494020 B2 JP4494020 B2 JP 4494020B2
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Prior art keywords
naphthyridine
hydroxy
dioxide
alkyl
carbonyl
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Expired - Fee Related
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JP2003575904A
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Japanese (ja)
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JP2005527521A (ja
JP2005527521A5 (https=
Inventor
エグバートソン，メリツサ
ラングフオード，エイチ・マリー
メラムド，ジエフリー・ワイ
ワイ，ジヨン・エス
ハン，ウエイ
パーロウ，デビー・エス
チユワン，リンハン
エンブリー，マーク
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Merck and Co Inc
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Merck and Co Inc
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Publication of JP2005527521A publication Critical patent/JP2005527521A/ja
Publication of JP2005527521A5 publication Critical patent/JP2005527521A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003575904A 2002-03-15 2003-03-12 Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド Expired - Fee Related JP4494020B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36492902P 2002-03-15 2002-03-15
PCT/US2003/007448 WO2003077850A2 (en) 2002-03-15 2003-03-12 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors

Publications (3)

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JP2005527521A JP2005527521A (ja) 2005-09-15
JP2005527521A5 JP2005527521A5 (https=) 2006-04-13
JP4494020B2 true JP4494020B2 (ja) 2010-06-30

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JP2003575904A Expired - Fee Related JP4494020B2 (ja) 2002-03-15 2003-03-12 Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド

Country Status (8)

Country Link
US (1) US7323460B2 (https=)
EP (1) EP1496836B1 (https=)
JP (1) JP4494020B2 (https=)
AT (1) ATE409187T1 (https=)
AU (2) AU2003218130A1 (https=)
CA (1) CA2478310A1 (https=)
DE (1) DE60323743D1 (https=)
WO (2) WO2003077857A2 (https=)

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PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
WO2004080402A2 (en) * 2003-03-12 2004-09-23 Merck & Co. Inc. Potassium salt of an hiv integrase inhibitor
US20070185007A1 (en) 2003-09-19 2007-08-09 Haolun Jin Aza-quinolinol phosphonate integrase inhibitor compounds
CA2542047A1 (en) 2003-10-20 2005-05-12 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors
WO2005075475A1 (ja) * 2004-02-04 2005-08-18 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するナフチリジン誘導体
EP1725556A1 (en) * 2004-03-09 2006-11-29 Merck & Co., Inc. Hiv integrase inhibitors
WO2005103003A2 (en) * 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
BRPI0510306A (pt) 2004-04-26 2007-09-04 Pfizer inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso
JP2009513640A (ja) * 2005-10-27 2009-04-02 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼインヒビター
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CN106117196A (zh) * 2016-06-09 2016-11-16 青岛辰达生物科技有限公司 一种制备抗癌药物达沙替尼的方法
CN107722106A (zh) * 2016-08-11 2018-02-23 重庆大学 Hiv抑制剂
CN112409267A (zh) * 2019-08-22 2021-02-26 江苏阿尔法药业有限公司 一种索菲布韦中间体的制备方法
AR122928A1 (es) * 2020-07-10 2022-10-19 Goldfinch Bio Inc 1,6-naftiridinas sustituidas inhibidoras de cdk5

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Also Published As

Publication number Publication date
AU2003220170A1 (en) 2003-09-29
DE60323743D1 (en) 2008-11-06
EP1496836B1 (en) 2008-09-24
AU2003218130A8 (en) 2003-09-29
WO2003077850A2 (en) 2003-09-25
AU2003218130A1 (en) 2003-09-29
JP2005527521A (ja) 2005-09-15
AU2003220170B2 (en) 2008-12-11
ATE409187T1 (de) 2008-10-15
EP1496836A4 (en) 2006-03-22
WO2003077850A3 (en) 2004-11-11
US20050176955A1 (en) 2005-08-11
EP1496836A2 (en) 2005-01-19
CA2478310A1 (en) 2003-09-25
WO2003077857A2 (en) 2003-09-25
US7323460B2 (en) 2008-01-29
WO2003077857A3 (en) 2006-06-08

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