JP4490100B2 - 薬剤的に許容されるアモルファス形態のアレンドロ酸塩 - Google Patents
薬剤的に許容されるアモルファス形態のアレンドロ酸塩 Download PDFInfo
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- JP4490100B2 JP4490100B2 JP2003536247A JP2003536247A JP4490100B2 JP 4490100 B2 JP4490100 B2 JP 4490100B2 JP 2003536247 A JP2003536247 A JP 2003536247A JP 2003536247 A JP2003536247 A JP 2003536247A JP 4490100 B2 JP4490100 B2 JP 4490100B2
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- Prior art keywords
- amorphous
- alendroate
- sodium
- amorphous form
- alendronate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical class NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- CAKRAHQRJGUPIG-UHFFFAOYSA-M sodium;[4-azaniumyl-1-hydroxy-1-[hydroxy(oxido)phosphoryl]butyl]-hydroxyphosphinate Chemical compound [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O CAKRAHQRJGUPIG-UHFFFAOYSA-M 0.000 claims description 11
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 150000004684 trihydrates Chemical class 0.000 claims description 4
- 238000002441 X-ray diffraction Methods 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 229960004343 alendronic acid Drugs 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 claims 3
- 239000000463 material Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 239000007864 aqueous solution Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 7
- 229940062527 alendronate Drugs 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 208000006386 Bone Resorption Diseases 0.000 description 5
- 230000024279 bone resorption Effects 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 206010065687 Bone loss Diseases 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000634 powder X-ray diffraction Methods 0.000 description 3
- 208000010191 Osteitis Deformans Diseases 0.000 description 2
- 208000027868 Paget disease Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- -1 but in contrast Substances 0.000 description 2
- 239000002178 crystalline material Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000027202 mammary Paget disease Diseases 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000030991 negative regulation of bone resorption Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
実施例1
アレンドロ酸ナトリウム三水和物25gの250mlの水溶液を60℃に加熱して透明な溶液を得た。この溶液をラープ酵素植物スプレー乾燥機SD05において、200℃の入口温度、100℃の出口温度、0.3m3/hrの加圧空気速度、および15ml/分の流加速度で噴霧乾燥して、20gの生成物を得た。アモルファス産物を粉末X線回折によって特徴づけた。
結晶性アレンドロ酸ナトリウムガラクトース25gの500mlの水溶液を50℃に加熱して、ほとんど透明な溶液を得た。この溶液をLab Plant Spray Drier SD 05において、160℃の入口温度、80℃の出口温度、0.3m3/hrの加圧空気速度、および15ml/分の流加速度で噴霧乾燥して、18gの生成物を得た。
25gのアレンドロ酸の50mlの水溶液の懸濁液に、水酸化ナトリウムの20%溶液を添加し、pHを4.3〜4.4に調製して、透明な溶液を得た。この溶液をLab Plant Spray Drier SD 05において、180℃の入口温度、90℃の出口温度、0.3m3/hrの加圧空気速度、および15ml/分の流加速度で噴霧乾燥して、20gの生成物を得た。
Claims (10)
- アモルファス形態のアレンドロ酸一ナトリウム。
- 3%未満の水を含む、アモルファス形態のアレンドロ酸一ナトリウム。
- 1%未満の水を含む、請求項2に記載のアモルファス形態のアレンドロ酸一ナトリウム。
- 添付した図に示したとおりのX線回折パターンを有する、アモルファスアレンドロ酸一ナトリウム。
- 請求項1〜4のいずれか1項に記載のアモルファス形態のアモルファスアレンドロ酸一ナトリウムを生産するための方法であって、該方法は、請求項1〜4のいずれか1項に記載のアモルファス形態のアモルファスアレンドロ酸一ナトリウムを得るために、アモルファスアレンドロ酸一ナトリウムの溶液から噴霧乾燥により溶媒を除去することを含む方法。
- 前記溶媒が水を含む、請求項5に記載の方法。
- 前記溶液が、アレンドロ酸を水に懸濁して、水酸化ナトリウムを使用してpHを調整することによって生産される、請求項6に記載の方法。
- アモルファス形態のアレンドロ酸ナトリウムを生産するための方法であって、アレンドロ酸ナトリウム三水和物または結晶性アレンドロ酸ナトリウムガラクトースの溶液から噴霧乾燥により溶媒を除去することを含む方法。
- アモルファス形態のアレンドロ酸ナトリウムを生産するための方法であって、
−アレンドロ酸の水における懸濁液に水酸化ナトリウム溶液を添加して、アレンドロ酸ナトリウム溶液を調製するステップと、
−前記アレンドロ酸ナトリウム溶液から噴霧乾燥により溶媒を除去するステップと
を含んでなる方法。 - 請求項1〜4のいずれか1項に記載のアモルファス形態のアモルファスアレンドロ酸一ナトリウムの治療的に有効な量を、薬剤的に許容されるキャリア、希釈液、または賦形剤と共に含む薬学的組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0125081A GB2383042A (en) | 2001-10-18 | 2001-10-18 | Amorphous alendronate sodium |
PCT/GB2002/004730 WO2003033508A1 (en) | 2001-10-18 | 2002-10-18 | Pharmaceutically acceptable alendronate salts in amorphous form |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005521636A JP2005521636A (ja) | 2005-07-21 |
JP4490100B2 true JP4490100B2 (ja) | 2010-06-23 |
Family
ID=9924125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003536247A Expired - Fee Related JP4490100B2 (ja) | 2001-10-18 | 2002-10-18 | 薬剤的に許容されるアモルファス形態のアレンドロ酸塩 |
Country Status (22)
Country | Link |
---|---|
US (1) | US7112577B2 (ja) |
EP (1) | EP1436303B1 (ja) |
JP (1) | JP4490100B2 (ja) |
KR (1) | KR20040053186A (ja) |
AT (1) | ATE338761T1 (ja) |
AU (1) | AU2002334200B2 (ja) |
BR (1) | BR0213398A (ja) |
CA (1) | CA2463815C (ja) |
CL (1) | CL2004001372A1 (ja) |
DE (1) | DE60214576T2 (ja) |
EC (1) | ECSP045067A (ja) |
ES (1) | ES2271375T3 (ja) |
GB (1) | GB2383042A (ja) |
HK (1) | HK1066011A1 (ja) |
IL (1) | IL161360A0 (ja) |
MX (1) | MXPA04003549A (ja) |
NZ (1) | NZ532292A (ja) |
PT (1) | PT1436303E (ja) |
RU (1) | RU2334751C2 (ja) |
TN (1) | TNSN04067A1 (ja) |
WO (1) | WO2003033508A1 (ja) |
ZA (1) | ZA200403024B (ja) |
Families Citing this family (22)
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BR0215413A (pt) * | 2001-12-24 | 2004-12-14 | Teva Pharma | Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
ITMI20020146A1 (it) * | 2002-01-29 | 2003-07-29 | Lyogen Ltd | Alendronato monosodico amorfo e processo per la sua preparazione |
WO2005082915A1 (en) † | 2004-02-26 | 2005-09-09 | Zentiva, A.S. | Amorphous forms of risedronate monosodium |
ES2289650T3 (es) | 2004-03-03 | 2008-02-01 | Chemi S.P.A. | Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma. |
CZ297262B6 (cs) * | 2004-12-28 | 2006-10-11 | Zentiva, A. S. | Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové |
US20090118238A1 (en) * | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
WO2014043208A1 (en) | 2012-09-11 | 2014-03-20 | Medivation Prostate Therapeutics, Inc. | Formulations of enzalutamide |
BR112015005404A2 (pt) * | 2012-09-11 | 2017-08-22 | Dr Reddys Laboratories Ltd | Formas polimórficas de enzalutamida e sua preparação |
US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
CA3023851C (en) * | 2016-05-09 | 2021-01-26 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
CN109311905A (zh) * | 2016-06-16 | 2019-02-05 | 泽农医药公司 | 螺-吲哚酮化合物的固态形式 |
US10717715B2 (en) * | 2016-09-06 | 2020-07-21 | Indena S.P.A. | Solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) and method for preparing the same |
PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
US11369579B2 (en) | 2016-10-24 | 2022-06-28 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
US10336679B2 (en) * | 2016-10-24 | 2019-07-02 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
KR102335193B1 (ko) * | 2017-02-01 | 2021-12-03 | 아테아 파마슈티컬즈, 인크. | C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염 |
WO2018178133A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Patent Gmbh | Solid form of (s)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)methanol |
ES2959764T3 (es) * | 2017-11-22 | 2024-02-28 | Agios Pharmaceuticals Inc | Formas cristalinas de n-(4-(4-(ciclopropilmetil) piperazina-1-carbonil)fenil)quinolina-8-sulfonamida |
CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
Family Cites Families (8)
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US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
ATE289199T1 (de) * | 1995-06-06 | 2005-03-15 | Merck & Co Inc | Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
CZ2001629A3 (cs) | 1998-08-27 | 2001-08-15 | Teva Pharmaceutical Industries Ltd. | Nové formy hydrátů alendronátu sodného, způsob jejich výroby a farmaceutické kompozice na jejich bázi |
US6160165A (en) * | 1998-12-10 | 2000-12-12 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
EP1135397B1 (en) | 1998-12-10 | 2003-04-23 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
WO2001030788A1 (en) | 1999-10-26 | 2001-05-03 | A/S Gea Farmaceutisk Fabrik | Novel salts of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, their preparation and use |
-
2001
- 2001-10-18 GB GB0125081A patent/GB2383042A/en not_active Withdrawn
-
2002
- 2002-10-18 DE DE60214576T patent/DE60214576T2/de not_active Expired - Lifetime
- 2002-10-18 IL IL16136002A patent/IL161360A0/xx not_active IP Right Cessation
- 2002-10-18 PT PT02801429T patent/PT1436303E/pt unknown
- 2002-10-18 EP EP02801429A patent/EP1436303B1/en not_active Expired - Lifetime
- 2002-10-18 WO PCT/GB2002/004730 patent/WO2003033508A1/en active IP Right Grant
- 2002-10-18 CA CA002463815A patent/CA2463815C/en not_active Expired - Fee Related
- 2002-10-18 BR BR0213398-9A patent/BR0213398A/pt not_active Withdrawn
- 2002-10-18 ES ES02801429T patent/ES2271375T3/es not_active Expired - Lifetime
- 2002-10-18 JP JP2003536247A patent/JP4490100B2/ja not_active Expired - Fee Related
- 2002-10-18 AT AT02801429T patent/ATE338761T1/de not_active IP Right Cessation
- 2002-10-18 NZ NZ532292A patent/NZ532292A/en not_active IP Right Cessation
- 2002-10-18 AU AU2002334200A patent/AU2002334200B2/en not_active Ceased
- 2002-10-18 RU RU2004113306/04A patent/RU2334751C2/ru not_active IP Right Cessation
- 2002-10-18 KR KR10-2004-7005768A patent/KR20040053186A/ko not_active Application Discontinuation
- 2002-10-18 US US10/492,977 patent/US7112577B2/en not_active Expired - Fee Related
- 2002-10-18 MX MXPA04003549A patent/MXPA04003549A/es active IP Right Grant
-
2004
- 2004-04-16 TN TNP2004000067A patent/TNSN04067A1/en unknown
- 2004-04-16 EC EC2004005067A patent/ECSP045067A/es unknown
- 2004-04-21 ZA ZA200403024A patent/ZA200403024B/xx unknown
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ECSP045067A (es) | 2004-07-23 |
CA2463815C (en) | 2009-04-07 |
AU2002334200B2 (en) | 2008-04-03 |
EP1436303A1 (en) | 2004-07-14 |
ES2271375T3 (es) | 2007-04-16 |
GB2383042A (en) | 2003-06-18 |
WO2003033508A1 (en) | 2003-04-24 |
NZ532292A (en) | 2005-07-29 |
MXPA04003549A (es) | 2004-07-22 |
DE60214576T2 (de) | 2007-08-30 |
DE60214576D1 (de) | 2006-10-19 |
RU2004113306A (ru) | 2005-10-10 |
HK1066011A1 (en) | 2005-03-11 |
US7112577B2 (en) | 2006-09-26 |
RU2334751C2 (ru) | 2008-09-27 |
ATE338761T1 (de) | 2006-09-15 |
IL161360A0 (en) | 2004-09-27 |
PT1436303E (pt) | 2006-12-29 |
EP1436303B1 (en) | 2006-09-06 |
BR0213398A (pt) | 2005-01-11 |
ZA200403024B (en) | 2005-03-30 |
CA2463815A1 (en) | 2003-04-24 |
KR20040053186A (ko) | 2004-06-23 |
CL2004001372A1 (es) | 2005-05-06 |
GB0125081D0 (en) | 2001-12-12 |
TNSN04067A1 (en) | 2006-06-01 |
US20040259846A1 (en) | 2004-12-23 |
JP2005521636A (ja) | 2005-07-21 |
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