JP4355779B2 - マトリックス制御放出デバイス - Google Patents

マトリックス制御放出デバイス Download PDF

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Publication number
JP4355779B2
JP4355779B2 JP2000033446A JP2000033446A JP4355779B2 JP 4355779 B2 JP4355779 B2 JP 4355779B2 JP 2000033446 A JP2000033446 A JP 2000033446A JP 2000033446 A JP2000033446 A JP 2000033446A JP 4355779 B2 JP4355779 B2 JP 4355779B2
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Japan
Prior art keywords
drug
cellulose
phthalate
polymer
dispersion
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Expired - Fee Related
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JP2000033446A
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English (en)
Japanese (ja)
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JP2000229888A (ja
Inventor
レア・エリザベス・アッペル
ウィリアム・ジョン・キュラトロ
ドウェイン・トーマス・フリーセン
ジェームズ・アラン・シュライヴァー・ナイチンゲール
アヴィナシュ・ゴーヴィンド・ソンブレ
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Bend Research incorporated
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Bend Research incorporated
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
JP2000033446A 1999-02-10 2000-02-10 マトリックス制御放出デバイス Expired - Fee Related JP4355779B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11940099P 1999-02-10 1999-02-10
US60/119400 1999-02-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005226695A Division JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

Publications (2)

Publication Number Publication Date
JP2000229888A JP2000229888A (ja) 2000-08-22
JP4355779B2 true JP4355779B2 (ja) 2009-11-04

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ID=22384221

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JP2000033446A Expired - Fee Related JP4355779B2 (ja) 1999-02-10 2000-02-10 マトリックス制御放出デバイス
JP2005226695A Expired - Lifetime JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

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JP2005226695A Expired - Lifetime JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

Country Status (7)

Country Link
EP (1) EP1027887B1 (https=)
JP (2) JP4355779B2 (https=)
AT (1) ATE404178T1 (https=)
BR (1) BR0000359A (https=)
CA (1) CA2298245C (https=)
DE (1) DE60039802D1 (https=)
ES (1) ES2310164T3 (https=)

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ES2310164T3 (es) 2009-01-01
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CA2298245C (en) 2004-11-30
JP2005320354A (ja) 2005-11-17
EP1027887B1 (en) 2008-08-13
CA2298245A1 (en) 2000-08-10
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JP4694298B2 (ja) 2011-06-08
ATE404178T1 (de) 2008-08-15

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