JP4312403B2 - （ポリ）ペプチド／タンパク質を、ジスルフィド結合を介してバクテリオファージ粒子に表示させる新規方法 - Google Patents

（ポリ）ペプチド／タンパク質を、ジスルフィド結合を介してバクテリオファージ粒子に表示させる新規方法 Download PDF

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JP4312403B2
JP4312403B2 JP2001511164A JP2001511164A JP4312403B2 JP 4312403 B2 JP4312403 B2 JP 4312403B2 JP 2001511164 A JP2001511164 A JP 2001511164A JP 2001511164 A JP2001511164 A JP 2001511164A JP 4312403 B2 JP4312403 B2 JP 4312403B2
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protein
bacteriophage
phage
peptide
coat
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JP2003505025A (ja
JP2003505025A5 (https=
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コリンナ・レーニング
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Morphosys GmbH
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2001511164A 1999-07-20 2000-07-20 （ポリ）ペプチド／タンパク質を、ジスルフィド結合を介してバクテリオファージ粒子に表示させる新規方法 Expired - Lifetime JP4312403B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99114072.4 1999-07-20
EP99114072 1999-07-20
EP00103551.8 2000-02-18
EP00103551 2000-02-18
PCT/EP2000/006968 WO2001005950A2 (en) 1999-07-20 2000-07-20 Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds

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JP2003505025A JP2003505025A (ja) 2003-02-12
JP2003505025A5 JP2003505025A5 (https=) 2008-09-25
JP4312403B2 true JP4312403B2 (ja) 2009-08-12

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US (3) US6753136B2 (https=)
EP (2) EP1990409A3 (https=)
JP (1) JP4312403B2 (https=)
AT (1) ATE417925T1 (https=)
AU (1) AU781396B2 (https=)
CA (1) CA2347973C (https=)
DE (1) DE60041119D1 (https=)
DK (1) DK1144607T5 (https=)
ES (1) ES2327382T3 (https=)
IL (2) IL142025A0 (https=)
NO (1) NO331199B1 (https=)
PT (1) PT1144607E (https=)
WO (1) WO2001005950A2 (https=)

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