JP4259877B2 - Ｃｘｃｒ３アンタゴニスト - Google Patents

Ｃｘｃｒ３アンタゴニスト Download PDF

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JP4259877B2
JP4259877B2 JP2002580947A JP2002580947A JP4259877B2 JP 4259877 B2 JP4259877 B2 JP 4259877B2 JP 2002580947 A JP2002580947 A JP 2002580947A JP 2002580947 A JP2002580947 A JP 2002580947A JP 4259877 B2 JP4259877 B2 JP 4259877B2
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JP2004536796A (ja
JP2004536796A5 (OSRAM
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メディナ，ジュリオ，シー．
ジョンソン，マイケル，ジー．
リー，アン−ロン
リュウ，ジウェン
ファン，アラン，シー
ツー，リュウシェン
マルクス，アンドリュー，ピー．
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アムジエン・インコーポレーテツド
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
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  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Obesity (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002580947A 2000-12-11 2001-12-11 Ｃｘｃｒ３アンタゴニスト Expired - Fee Related JP4259877B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25524100P 2000-12-11 2000-12-11
US29649901P 2001-06-06 2001-06-06
PCT/US2001/047850 WO2002083143A1 (en) 2000-12-11 2001-12-11 Cxcr3 antagonists

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JP2004536796A JP2004536796A (ja) 2004-12-09
JP2004536796A5 JP2004536796A5 (OSRAM) 2005-12-22
JP4259877B2 true JP4259877B2 (ja) 2009-04-30

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US (3) US6964967B2 (OSRAM)
EP (1) EP1343505A1 (OSRAM)
JP (1) JP4259877B2 (OSRAM)
KR (1) KR100883184B1 (OSRAM)
CN (1) CN1575177A (OSRAM)
AU (1) AU2001297717B2 (OSRAM)
BR (1) BR0116096A (OSRAM)
CA (1) CA2431553A1 (OSRAM)
CZ (1) CZ20031910A3 (OSRAM)
EA (1) EA007538B1 (OSRAM)
HU (1) HUP0500880A2 (OSRAM)
IL (2) IL156304A0 (OSRAM)
MX (1) MXPA03005152A (OSRAM)
NO (1) NO325450B1 (OSRAM)
NZ (1) NZ526622A (OSRAM)
PL (1) PL366311A1 (OSRAM)
SK (1) SK8752003A3 (OSRAM)
WO (1) WO2002083143A1 (OSRAM)
ZA (1) ZA200304342B (OSRAM)

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US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7671200B2 (en) * 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
CZ20031910A3 (cs) 2000-12-11 2003-12-17 Tularik Inc. Sloučenina s antagonistickými účinky na CXCR3 a farmaceutický postředek
US6794379B2 (en) * 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
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US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
CN1596255A (zh) * 2001-12-21 2005-03-16 阿诺麦德股份有限公司 具有强效的与趋化因子受体结合的杂环化合物
JP2005529076A (ja) * 2002-02-15 2005-09-29 サイトキネティクス・インコーポレーテッド キナゾリノンの合成
ES2361403T3 (es) 2002-03-07 2011-06-16 X-Ceptor Therapeutics, Inc. Moduladores de quinazolinona de receptores nucleares.
AU2003226252A1 (en) 2002-04-04 2003-10-20 Cv Therapeutics, Inc. Compounds dor increasing abca-1 expression useful for treating coronary artery disease and atherosclerosis
WO2003088903A2 (en) 2002-04-17 2003-10-30 Cytokinetics, Inc. Compounds, compositions, and methods
WO2003097053A1 (en) * 2002-05-09 2003-11-27 Cytokinetics, Inc. Compounds, compositions, and methods
JP2006508030A (ja) 2002-05-09 2006-03-09 サイトキネティクス・インコーポレーテッド ピリミジノン化合物、組成物および方法
US7244555B2 (en) * 2002-05-14 2007-07-17 Renovak Inc Systems and methods for identifying organ transplant risk
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CN1575177A (zh) 2005-02-02
EA007538B1 (ru) 2006-10-27
PL366311A1 (en) 2005-01-24
CZ20031910A3 (cs) 2003-12-17
AU2001297717B2 (en) 2006-02-23
NO20032612D0 (no) 2003-06-10
KR100883184B1 (ko) 2009-02-12
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NZ526622A (en) 2006-07-28
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US20030055054A1 (en) 2003-03-20
EA200300663A1 (ru) 2004-06-24
BR0116096A (pt) 2005-10-18
HUP0500880A2 (en) 2006-05-29
NO325450B1 (no) 2008-05-05
KR20030080212A (ko) 2003-10-11
WO2002083143A1 (en) 2002-10-24
IL156304A0 (en) 2004-01-04
IL156304A (en) 2009-02-11
US7053215B2 (en) 2006-05-30
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