JP4222503B2 - ボロン酸付加物を用いたグルコースの光学測定 - Google Patents

ボロン酸付加物を用いたグルコースの光学測定 Download PDF

Info

Publication number
JP4222503B2
JP4222503B2 JP2002548438A JP2002548438A JP4222503B2 JP 4222503 B2 JP4222503 B2 JP 4222503B2 JP 2002548438 A JP2002548438 A JP 2002548438A JP 2002548438 A JP2002548438 A JP 2002548438A JP 4222503 B2 JP4222503 B2 JP 4222503B2
Authority
JP
Japan
Prior art keywords
group
quencher
polymer
glucose
dye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2002548438A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004536279A (ja
JP2004536279A5 (enExample
Inventor
シンガラム バクザン
エイ ウェスリング リッチー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of JP2004536279A publication Critical patent/JP2004536279A/ja
Publication of JP2004536279A5 publication Critical patent/JP2004536279A5/ja
Application granted granted Critical
Publication of JP4222503B2 publication Critical patent/JP4222503B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2002548438A 2000-12-05 2001-12-05 ボロン酸付加物を用いたグルコースの光学測定 Expired - Lifetime JP4222503B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/731,323 US6627177B2 (en) 2000-12-05 2000-12-05 Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
PCT/US2001/046658 WO2002046752A2 (en) 2000-12-05 2001-12-05 Optical determination of glucose utilizing boronic acid adducts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008241613A Division JP5209424B2 (ja) 2000-12-05 2008-09-19 消光剤前駆体組成物

Publications (3)

Publication Number Publication Date
JP2004536279A JP2004536279A (ja) 2004-12-02
JP2004536279A5 JP2004536279A5 (enExample) 2005-05-26
JP4222503B2 true JP4222503B2 (ja) 2009-02-12

Family

ID=24939018

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002548438A Expired - Lifetime JP4222503B2 (ja) 2000-12-05 2001-12-05 ボロン酸付加物を用いたグルコースの光学測定
JP2008241613A Expired - Lifetime JP5209424B2 (ja) 2000-12-05 2008-09-19 消光剤前駆体組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008241613A Expired - Lifetime JP5209424B2 (ja) 2000-12-05 2008-09-19 消光剤前駆体組成物

Country Status (8)

Country Link
US (2) US6627177B2 (enExample)
EP (1) EP1340076A2 (enExample)
JP (2) JP4222503B2 (enExample)
CN (1) CN1479870A (enExample)
AU (2) AU2002220230B2 (enExample)
CA (1) CA2436590A1 (enExample)
NZ (1) NZ526787A (enExample)
WO (1) WO2002046752A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009091357A (ja) * 2000-12-05 2009-04-30 Regents Of The Univ Of California ボロン酸付加物を用いたグルコースの光学測定

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6766183B2 (en) * 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
US20040087842A1 (en) * 2002-05-30 2004-05-06 Lakowicz Joseph R. Fluorescent probes for saccharrides
EP1594551A2 (en) * 2003-02-19 2005-11-16 Sicel Technologies, Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
EP1644330B1 (en) * 2003-06-27 2011-08-17 The University Of Maryland Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8165651B2 (en) * 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7713745B2 (en) * 2004-04-13 2010-05-11 Sensors For Medicine And Science, Inc. Non-covalent immobilization of indicator molecules
WO2005119223A1 (en) * 2004-04-14 2005-12-15 Bioprocessors Corp. Compositions of matter useful as ph indicators and related methods
US20080051764A1 (en) * 2004-04-19 2008-02-28 Board Of Regents, The University Of Texas System Physiological Monitoring With Continuous Treatment
US20060088722A1 (en) * 2004-10-25 2006-04-27 Aller Robert C Optical pH sensor
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
WO2007033353A2 (en) * 2005-09-14 2007-03-22 Therabit, Inc. Chemical target-binding compositions
US7807473B2 (en) * 2005-10-26 2010-10-05 General Electric Company Material compositions for sensors for determination of chemical species at trace concentrations and method of using sensors
EP1949083A1 (en) * 2005-11-08 2008-07-30 Smart Holograms Limited Novel boronate complex and its use in a glucose sensor
US8211048B2 (en) * 2006-02-22 2012-07-03 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US8133194B2 (en) 2006-02-22 2012-03-13 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
ATE514755T1 (de) * 2006-07-25 2011-07-15 Glumetrics Inc Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung
US20080200434A1 (en) * 2006-09-14 2008-08-21 Daniloff George Y Chemical Target-Binding Compositions
US20080161666A1 (en) * 2006-12-29 2008-07-03 Abbott Diabetes Care, Inc. Analyte devices and methods
US7824918B2 (en) * 2007-08-06 2010-11-02 Glumetrics, Inc. HPTS-Mono and BIS Cys-Ma polymerizable fluorescent dyes for use in analyte sensors
US7751863B2 (en) * 2007-02-06 2010-07-06 Glumetrics, Inc. Optical determination of ph and glucose
AU2008213677A1 (en) 2007-02-06 2008-08-14 Glumetrics, Inc. Optical systems and methods for rationmetric measurement of blood glucose concentration
ATE506368T1 (de) * 2007-05-01 2011-05-15 Glumetrics Inc Pyridin-boronsäure-quencher zur verwendung in analytsensoren
US7883898B2 (en) * 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
JP2010527010A (ja) * 2007-05-10 2010-08-05 グルメトリクス、 インク. 被分析物センサーを較正する装置および方法
EP2162057A1 (en) * 2007-05-10 2010-03-17 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
WO2008143877A1 (en) 2007-05-14 2008-11-27 Brigham Young University Fuel cell and method for generating electric power
EP2171471B1 (en) * 2007-06-08 2015-11-18 The Charles Stark Draper Laboratory, Inc. Sensors for the detection of diols and carbohydrates using boronic acid chelators for glucose
DK2222686T3 (en) 2007-07-11 2015-09-21 Medtronic Minimed Inc Polyviologenboronsyredeaktivatorer for use in analytsensorer
US8202731B2 (en) * 2007-08-06 2012-06-19 Glumetrics, Inc. HPTS-mono and bis Cys-MA polymerizable fluorescent dyes for use in analyte sensors
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
JP5434088B2 (ja) * 2008-01-22 2014-03-05 三菱化学株式会社 架橋性有機化合物、有機電界発光素子用組成物、有機電界発光素子および有機elディスプレイ
WO2009124095A1 (en) * 2008-03-31 2009-10-08 Abbott Diabetes Care Inc. Shallow implantable analyte sensor with rapid physiological response
WO2009129186A2 (en) 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
WO2009135197A2 (en) * 2008-05-02 2009-11-05 Sri International Optical microneedle-based spectrometer
CN101625344B (zh) * 2008-07-10 2011-11-16 中国食品发酵工业研究院 一种检测葡萄酒中2,4,6-三氯茴香醚(tca)不良气味的检测方法
US8620409B2 (en) 2008-08-04 2013-12-31 University Of Utah Research Foundation Dye application for confocal imaging of cellular microstructure
CN101643479B (zh) * 2008-08-07 2012-07-18 通用电气公司 含苯吡啶单元的化合物
CN101598708B (zh) * 2009-05-19 2011-11-09 烟台杰科检测服务有限公司 一种水果、蔬菜中农药多残留快速分析方法
CN101598709B (zh) * 2009-07-10 2011-08-24 中国烟草总公司郑州烟草研究院 一种测定烟草保润剂对烟丝中外加香料定香能力的方法
CN101634648B (zh) * 2009-08-21 2012-06-27 江南大学 超高压液相色谱—飞行时间质谱同时测定白酒中六种微量甜味剂的方法
US20110077477A1 (en) * 2009-09-30 2011-03-31 Glumetrics, Inc. Sensors with thromboresistant coating
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
TWI402501B (zh) * 2009-12-09 2013-07-21 Nat Univ Tsing Hua 免疫檢測探針及利用免疫檢測方法
US20110152658A1 (en) * 2009-12-17 2011-06-23 Glumetrics, Inc. Identification of aberrant measurements of in vivo glucose concentration using temperature
JP2013519101A (ja) 2010-02-08 2013-05-23 グルメトリクス, インコーポレイテッド 化学センサーの抗酸化剤保護
US9151764B2 (en) 2010-02-16 2015-10-06 Lightship Medical Limited Barrier layer for glucose sensor
EP2545373B1 (en) * 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
US10429380B2 (en) 2010-12-17 2019-10-01 Eyesense Ag Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein
CN103370623B (zh) * 2010-12-17 2016-05-04 视觉股份公司 水凝胶在具有提高的灵敏度的生物传感器中的用途
GB201113435D0 (en) 2011-08-03 2011-09-21 Glysure Ltd Sensor calibration
CN102353660B (zh) * 2011-06-20 2013-01-02 山西大学 一种检测d-果糖的组合物及其制备方法
WO2013012687A2 (en) 2011-07-15 2013-01-24 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
US9642568B2 (en) * 2011-09-06 2017-05-09 Medtronic Minimed, Inc. Orthogonally redundant sensor systems and methods
US10352941B2 (en) 2011-09-27 2019-07-16 Medtronic Minimed, Inc. Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
US8568991B2 (en) * 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
US9017622B2 (en) 2012-04-10 2015-04-28 Lightship Medical Limited Calibrator for a sensor
US20130344619A1 (en) 2012-06-21 2013-12-26 Lightship Medical Limited Glucose sensor
WO2014138197A1 (en) 2013-03-06 2014-09-12 General Electric Company Methods of analyzing an h&e stained biological sample
AU2014374361B9 (en) 2013-12-31 2019-07-04 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
JP2015151426A (ja) 2014-02-12 2015-08-24 セイコーエプソン株式会社 刺激応答性ゲル材料
JP2015151427A (ja) * 2014-02-12 2015-08-24 セイコーエプソン株式会社 刺激応答性ゲル材料および刺激応答性ゲル材料の製造方法
JP2015151436A (ja) 2014-02-13 2015-08-24 セイコーエプソン株式会社 刺激応答性ゲル材料
EP3498718B1 (en) * 2014-04-23 2020-04-15 Terumo Kabushiki Kaisha Non-enzymatic electrochemical sensor for measuring analytes
US10845305B1 (en) * 2015-11-20 2020-11-24 Verily Life Sciences Llc Method for increasing sensor resolution by spectrally stacking responsive dyes
CN110642882B (zh) * 2019-10-21 2021-12-24 内蒙古大学 一种兼具双氧水检测和光动力杀伤癌细胞活性的荧光探针及其制备方法和应用
JP7712476B2 (ja) * 2021-08-26 2025-07-23 センセオニクス,インコーポレーテッド インビボ分析物信号劣化の媒介
DE102021127227A1 (de) 2021-10-20 2023-04-20 Endress+Hauser Conducta Gmbh+Co. Kg Sensor zur Messung eines pH-Werts
CN118459651B (zh) * 2024-07-10 2024-09-20 西南石油大学 一种耐温自破胶压裂液稠化剂及其制备方法和应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659817A (en) 1981-05-01 1987-04-21 The Children's Medical Center Corporation Reporter compounds containing boron
US4886338A (en) 1986-10-10 1989-12-12 Minnesota Mining And Manufacturing Company Optical fiber event sensor
AT390517B (de) 1988-08-04 1990-05-25 Avl Verbrennungskraft Messtech Optischer sensor und verfahren zu dessen herstellung
NO890029D0 (no) 1989-01-04 1989-01-04 Axis Research Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes).
US5039491A (en) 1989-01-27 1991-08-13 Metricor, Inc. Optical oxygen sensor
US5232858A (en) 1989-04-25 1993-08-03 Avl Medical Instruments Ag Method for quantitative determination of at least one chemical parameter of a sample medium
US5137833A (en) * 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
US5512246A (en) 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
GB9024775D0 (en) * 1990-11-14 1991-01-02 Axis Research Chemical compounds
US5244562A (en) 1991-07-31 1993-09-14 Hewlett-Packard Company Use of templated polymers for analyte-activated microelectronic switching devices
US5466798A (en) 1992-03-06 1995-11-14 The Regents Of The University Of California Synthesis of lithium aminoborohydrides and reactions thereof
JP3200942B2 (ja) * 1992-03-18 2001-08-20 日本油脂株式会社 ボロン酸基含有モノマーおよびそのポリマー
KR0180315B1 (ko) * 1993-06-30 1999-03-20 알렌 제이. 스피겔 환자혈액중의 다수 변수들의 생체내 측정을 위한 다-변수 카테터
JP2883824B2 (ja) * 1993-11-07 1999-04-19 科学技術振興事業団 ボロン酸基を有する発蛍光性化合物
GB2284809B (en) * 1993-11-07 1998-04-29 Japan Res Dev Corp A fluorescent phenylboronic acid suitable for use in the detection of saccharides
US5631364A (en) 1994-03-31 1997-05-20 Axis Biochemicals Asa Labelled boronic acid derivatives
PL316940A1 (en) 1994-05-02 1997-02-17 Ciba Geigy Ag System of optical sensing elements for determining ph values and ionic strength
US5852126A (en) 1994-05-02 1998-12-22 Novartis Ag Polymerisable composition and the use thereof
US5998594A (en) * 1994-12-30 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use
US5517313A (en) 1995-02-21 1996-05-14 Colvin, Jr.; Arthur E. Fluorescent optical sensor
JP2799837B2 (ja) 1995-03-03 1998-09-21 科学技術振興事業団 ビナフチル基を有するボロン酸化合物
US5882494A (en) 1995-03-27 1999-03-16 Minimed, Inc. Polyurethane/polyurea compositions containing silicone for biosensor membranes
US5786439A (en) 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
US6002954A (en) * 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
DE69633573T2 (de) 1995-11-22 2005-10-06 Medtronic MiniMed, Inc., Northridge Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor
US6063637A (en) 1995-12-13 2000-05-16 California Institute Of Technology Sensors for sugars and other metal binding analytes
US5894351A (en) 1997-05-13 1999-04-13 Colvin, Jr.; Arthur E. Fluorescence sensing device
DE19811963A1 (de) * 1998-03-19 1999-09-23 Ewald Terpetschnig Lumineszent Rezeptoren für Zucker auf der Grundlage von Metall-Liganden-Komplexen
JP3867400B2 (ja) * 1998-05-08 2007-01-10 日本油脂株式会社 ボロン酸基含有単量体およびその重合体
US6485703B1 (en) 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
US6330464B1 (en) 1998-08-26 2001-12-11 Sensors For Medicine & Science Optical-based sensing devices
US6304766B1 (en) 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
US6366793B1 (en) 1999-09-10 2002-04-02 Beckman Coulter, Inc. Minimally invasive methods for measuring analtes in vivo
AU2001251210A1 (en) 2000-04-04 2001-10-15 Medtronic Minimed, Inc. Saccharide sensing molecules having enhanced fluorescent properties
US20010034479A1 (en) * 2000-04-19 2001-10-25 Ring Lawrence S. Optically based transcutaneous blood gas sensor
US6387672B1 (en) 2000-12-04 2002-05-14 Beckman Coulter, Inc. Photo-induced electron transfer fluorescent sensor molecules
US6653141B2 (en) * 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US6627177B2 (en) * 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US20020127626A1 (en) * 2001-01-05 2002-09-12 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
US20020119581A1 (en) * 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009091357A (ja) * 2000-12-05 2009-04-30 Regents Of The Univ Of California ボロン酸付加物を用いたグルコースの光学測定

Also Published As

Publication number Publication date
JP5209424B2 (ja) 2013-06-12
NZ526787A (en) 2006-09-29
AU2023002A (en) 2002-06-18
JP2004536279A (ja) 2004-12-02
CA2436590A1 (en) 2002-06-13
EP1340076A2 (en) 2003-09-03
US6627177B2 (en) 2003-09-30
AU2002220230B2 (en) 2007-03-22
CN1479870A (zh) 2004-03-03
US20040028612A1 (en) 2004-02-12
WO2002046752A3 (en) 2003-01-16
JP2009091357A (ja) 2009-04-30
WO2002046752A9 (en) 2002-08-29
WO2002046752A2 (en) 2002-06-13
US20020106326A1 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
JP4222503B2 (ja) ボロン酸付加物を用いたグルコースの光学測定
JP2004536279A5 (enExample)
US6653141B2 (en) Polyhydroxyl-substituted organic molecule sensing method and device
AU2002220230A1 (en) Optical determination of glucose utilizing boronic acid adducts
EP1960779B1 (en) Optical determination of glucose utilizing boronic acid adducts-ii
AU2001278145B2 (en) Detection of analytes in aqueous environments
DK2769226T3 (en) COMBINATIONS OF FLUORPHORES AND PYRIDINIUM BORIC ACID QUENCHERS FOR USE IN ANALYTICAL SENSORS
AU2001278145A1 (en) Detection of analytes in aqueous environments
AU2007202790A1 (en) Optical determination of glucose utilizing boronic acid adducts

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070313

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070613

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070702

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070713

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070724

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070813

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20070813

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20080507

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080520

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080820

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080903

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080922

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20081028

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20081113

R150 Certificate of patent or registration of utility model

Ref document number: 4222503

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111128

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121128

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131128

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term