JP4222503B2 - ボロン酸付加物を用いたグルコースの光学測定 - Google Patents
ボロン酸付加物を用いたグルコースの光学測定 Download PDFInfo
- Publication number
- JP4222503B2 JP4222503B2 JP2002548438A JP2002548438A JP4222503B2 JP 4222503 B2 JP4222503 B2 JP 4222503B2 JP 2002548438 A JP2002548438 A JP 2002548438A JP 2002548438 A JP2002548438 A JP 2002548438A JP 4222503 B2 JP4222503 B2 JP 4222503B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- quencher
- polymer
- glucose
- dye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 120
- 239000008103 glucose Substances 0.000 title claims description 116
- 238000005259 measurement Methods 0.000 title description 67
- 230000003287 optical effect Effects 0.000 title description 22
- 150000001642 boronic acid derivatives Chemical class 0.000 title description 2
- 229920000642 polymer Polymers 0.000 claims description 174
- 229910052757 nitrogen Inorganic materials 0.000 claims description 127
- 239000000975 dye Substances 0.000 claims description 98
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 97
- 150000001875 compounds Chemical class 0.000 claims description 70
- 239000000203 mixture Chemical group 0.000 claims description 62
- 239000011159 matrix material Substances 0.000 claims description 61
- 229920001223 polyethylene glycol Polymers 0.000 claims description 52
- 239000000017 hydrogel Substances 0.000 claims description 42
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 38
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 28
- 239000000178 monomer Substances 0.000 claims description 25
- 229940124530 sulfonamide Drugs 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 125000002947 alkylene group Chemical group 0.000 claims description 22
- 125000005647 linker group Chemical group 0.000 claims description 22
- 150000003456 sulfonamides Chemical class 0.000 claims description 22
- 239000007850 fluorescent dye Substances 0.000 claims description 21
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 150000002148 esters Chemical class 0.000 claims description 17
- BICAGYDGRXJYGD-UHFFFAOYSA-N hydrobromide;hydrochloride Chemical compound Cl.Br BICAGYDGRXJYGD-UHFFFAOYSA-N 0.000 claims description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims description 14
- 150000001412 amines Chemical group 0.000 claims description 13
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 238000000926 separation method Methods 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 239000002243 precursor Substances 0.000 claims description 12
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 12
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000004202 carbamide Substances 0.000 claims description 11
- 150000003457 sulfones Chemical class 0.000 claims description 11
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims description 10
- 150000001408 amides Chemical class 0.000 claims description 10
- 230000007062 hydrolysis Effects 0.000 claims description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims description 10
- 125000006239 protecting group Chemical group 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 7
- KXXXUIKPSVVSAW-UHFFFAOYSA-K pyranine Chemical class [Na+].[Na+].[Na+].C1=C2C(O)=CC(S([O-])(=O)=O)=C(C=C3)C2=C2C3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C2=C1 KXXXUIKPSVVSAW-UHFFFAOYSA-K 0.000 claims description 7
- 230000007935 neutral effect Effects 0.000 claims description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 6
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims description 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 5
- 125000004309 pyranyl group Chemical class O1C(C=CC=C1)* 0.000 claims description 5
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 5
- VXXRMBQHVJKWIC-UHFFFAOYSA-N 2-(1-pyridin-2-ylethenyl)pyridine Chemical group C=1C=CC=NC=1C(=C)C1=CC=CC=N1 VXXRMBQHVJKWIC-UHFFFAOYSA-N 0.000 claims description 4
- STGMORHGPQLXMT-UHFFFAOYSA-N 9h-indeno[2,1-c]pyridazine Chemical class C1=NN=C2CC3=CC=CC=C3C2=C1 STGMORHGPQLXMT-UHFFFAOYSA-N 0.000 claims description 4
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical class C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 230000029087 digestion Effects 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- BBEAQIROQSPTKN-UHFFFAOYSA-N antipyrene Natural products C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 claims 2
- 150000003220 pyrenes Chemical class 0.000 claims 2
- DLOBKMWCBFOUHP-UHFFFAOYSA-N pyrene-1-sulfonic acid Chemical class C1=C2C(S(=O)(=O)O)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 DLOBKMWCBFOUHP-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 144
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 138
- 229910052786 argon Inorganic materials 0.000 description 69
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 55
- 239000007787 solid Substances 0.000 description 46
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 45
- 238000000034 method Methods 0.000 description 44
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 43
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 41
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 33
- 239000008363 phosphate buffer Substances 0.000 description 31
- 238000010791 quenching Methods 0.000 description 31
- 239000000725 suspension Substances 0.000 description 31
- 230000000171 quenching effect Effects 0.000 description 29
- 239000000523 sample Substances 0.000 description 29
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- 230000005284 excitation Effects 0.000 description 27
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 26
- 238000006116 polymerization reaction Methods 0.000 description 26
- 238000001514 detection method Methods 0.000 description 25
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 24
- 239000012491 analyte Substances 0.000 description 24
- 238000005160 1H NMR spectroscopy Methods 0.000 description 22
- 238000006243 chemical reaction Methods 0.000 description 22
- 238000005481 NMR spectroscopy Methods 0.000 description 21
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 20
- 230000015572 biosynthetic process Effects 0.000 description 19
- 238000001727 in vivo Methods 0.000 description 19
- 238000003756 stirring Methods 0.000 description 19
- 238000003786 synthesis reaction Methods 0.000 description 18
- 239000002904 solvent Substances 0.000 description 17
- 229920001971 elastomer Polymers 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- 238000010992 reflux Methods 0.000 description 16
- 239000006228 supernatant Substances 0.000 description 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- 239000007983 Tris buffer Substances 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 15
- 229920001577 copolymer Polymers 0.000 description 15
- -1 glucose Chemical class 0.000 description 15
- LUAZZOXZPVVGSO-UHFFFAOYSA-N Benzyl viologen Chemical compound C=1C=C(C=2C=C[N+](CC=3C=CC=CC=3)=CC=2)C=C[N+]=1CC1=CC=CC=C1 LUAZZOXZPVVGSO-UHFFFAOYSA-N 0.000 description 14
- 125000005620 boronic acid group Chemical group 0.000 description 14
- 239000000872 buffer Substances 0.000 description 14
- 239000011521 glass Substances 0.000 description 14
- 239000010409 thin film Substances 0.000 description 14
- 239000012528 membrane Substances 0.000 description 13
- 239000002244 precipitate Substances 0.000 description 13
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 13
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 12
- 0 *CC1C=CC(CN)=CC1 Chemical compound *CC1C=CC(CN)=CC1 0.000 description 11
- 238000001506 fluorescence spectroscopy Methods 0.000 description 11
- 239000011550 stock solution Substances 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 102100026735 Coagulation factor VIII Human genes 0.000 description 10
- 229930091371 Fructose Natural products 0.000 description 10
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 10
- 239000005715 Fructose Substances 0.000 description 10
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 10
- 230000002572 peristaltic effect Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 239000000843 powder Substances 0.000 description 9
- MWVTWFVJZLCBMC-UHFFFAOYSA-N 4,4'-bipyridine Chemical group C1=NC=CC(C=2C=CN=CC=2)=C1 MWVTWFVJZLCBMC-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 description 8
- 239000013307 optical fiber Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000012456 homogeneous solution Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 229920006362 Teflon® Polymers 0.000 description 6
- GAIQIDITLZQBHB-UHFFFAOYSA-N [3,6,8-tris(chlorosulfonyl)pyren-1-yl] acetate Chemical compound C1=C2C(OC(=O)C)=CC(S(Cl)(=O)=O)=C(C=C3)C2=C2C3=C(S(Cl)(=O)=O)C=C(S(Cl)(=O)=O)C2=C1 GAIQIDITLZQBHB-UHFFFAOYSA-N 0.000 description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 6
- 239000007806 chemical reaction intermediate Substances 0.000 description 6
- 238000007334 copolymerization reaction Methods 0.000 description 6
- 230000008014 freezing Effects 0.000 description 6
- 238000007710 freezing Methods 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- FIKAKWIAUPDISJ-UHFFFAOYSA-L paraquat dichloride Chemical compound [Cl-].[Cl-].C1=C[N+](C)=CC=C1C1=CC=[N+](C)C=C1 FIKAKWIAUPDISJ-UHFFFAOYSA-L 0.000 description 6
- 229920003023 plastic Polymers 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 5
- MPNXSZJPSVBLHP-UHFFFAOYSA-N 2-chloro-n-phenylpyridine-3-carboxamide Chemical compound ClC1=NC=CC=C1C(=O)NC1=CC=CC=C1 MPNXSZJPSVBLHP-UHFFFAOYSA-N 0.000 description 5
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 5
- 239000005977 Ethylene Substances 0.000 description 5
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 5
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 5
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 5
- 239000012736 aqueous medium Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 239000010408 film Substances 0.000 description 5
- 230000010354 integration Effects 0.000 description 5
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- XMAPHCGFUPXIEN-UHFFFAOYSA-N pyren-1-yl acetate Chemical compound C1=C2C(OC(=O)C)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 XMAPHCGFUPXIEN-UHFFFAOYSA-N 0.000 description 5
- 238000004611 spectroscopical analysis Methods 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 229920001187 thermosetting polymer Polymers 0.000 description 5
- 229920003169 water-soluble polymer Polymers 0.000 description 5
- BPAZNZINLQSFMN-UHFFFAOYSA-N 2-propan-2-yl-4,5-dihydro-1h-imidazole;dihydrochloride Chemical compound Cl.Cl.CC(C)C1=NCCN1 BPAZNZINLQSFMN-UHFFFAOYSA-N 0.000 description 4
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 4
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 238000000691 measurement method Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 150000002894 organic compounds Chemical class 0.000 description 4
- 238000012643 polycondensation polymerization Methods 0.000 description 4
- 229920006254 polymer film Polymers 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- WJKIGWPCVFLGAT-UHFFFAOYSA-N pyridine;dihydrobromide Chemical compound [Br-].[Br-].C1=CC=[NH+]C=C1.C1=CC=[NH+]C=C1 WJKIGWPCVFLGAT-UHFFFAOYSA-N 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 3
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 3
- HRDSRBLJAGNYDE-UHFFFAOYSA-N 4-ethenyl-3-methylidene-2H-pyridin-1-ium bromide Chemical compound [Br-].C=CC1=CC=[NH+]CC1=C HRDSRBLJAGNYDE-UHFFFAOYSA-N 0.000 description 3
- ABVCMDMBWDRVAG-UHFFFAOYSA-N 4-hydroxypyrene-1,2,3-trisulfonamide Chemical compound C1=CC=C2C=C(O)C3=C(S(N)(=O)=O)C(S(=O)(=O)N)=C(S(N)(=O)=O)C4=CC=C1C2=C43 ABVCMDMBWDRVAG-UHFFFAOYSA-N 0.000 description 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- ATRFDLFMCLYROQ-UHFFFAOYSA-N [3-(bromomethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC=CC(CBr)=C1 ATRFDLFMCLYROQ-UHFFFAOYSA-N 0.000 description 3
- MDHWQIJAIDTEKW-UHFFFAOYSA-N [Cl-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1 Chemical compound [Cl-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1 MDHWQIJAIDTEKW-UHFFFAOYSA-N 0.000 description 3
- LBSPZZSGTIBOFG-UHFFFAOYSA-N bis[2-(4,5-dihydro-1h-imidazol-2-yl)propan-2-yl]diazene;dihydrochloride Chemical compound Cl.Cl.N=1CCNC=1C(C)(C)N=NC(C)(C)C1=NCCN1 LBSPZZSGTIBOFG-UHFFFAOYSA-N 0.000 description 3
- 230000005587 bubbling Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 150000004985 diamines Chemical class 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 229920000620 organic polymer Polymers 0.000 description 3
- 239000008055 phosphate buffer solution Substances 0.000 description 3
- 229920000052 poly(p-xylylene) Polymers 0.000 description 3
- 229920000867 polyelectrolyte Polymers 0.000 description 3
- 229920005597 polymer membrane Polymers 0.000 description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 3
- 238000010526 radical polymerization reaction Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 125000000565 sulfonamide group Chemical group 0.000 description 3
- 150000000180 1,2-diols Chemical class 0.000 description 2
- 150000000185 1,3-diols Chemical class 0.000 description 2
- ZRZHXNCATOYMJH-UHFFFAOYSA-N 1-(chloromethyl)-4-ethenylbenzene Chemical compound ClCC1=CC=C(C=C)C=C1 ZRZHXNCATOYMJH-UHFFFAOYSA-N 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 2
- RIGMHOOYVULRLZ-UHFFFAOYSA-N 2-[3,5-bis(bromomethyl)phenyl]-1,3,2-dioxaborinane Chemical compound BrCC1=CC(CBr)=CC(B2OCCCO2)=C1 RIGMHOOYVULRLZ-UHFFFAOYSA-N 0.000 description 2
- YAIPUKTYJXXKKF-UHFFFAOYSA-N 2-methyl-N-(3-sulfamoylpropyl)prop-2-enamide Chemical compound CC(=C)C(=O)NCCCS(N)(=O)=O YAIPUKTYJXXKKF-UHFFFAOYSA-N 0.000 description 2
- DZSWBMLRWZDELR-UHFFFAOYSA-M 4-benzyl-4-ethenyl-3h-4,7-phenanthrolin-4-ium;chloride Chemical compound [Cl-].C1C=CC(C2=CC=CN=C2C=C2)=C2[N+]1(C=C)CC1=CC=CC=C1 DZSWBMLRWZDELR-UHFFFAOYSA-M 0.000 description 2
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 description 2
- OMPGKWICGUBROA-UHFFFAOYSA-N 4-sulfamoylbutanoic acid Chemical compound NS(=O)(=O)CCCC(O)=O OMPGKWICGUBROA-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 238000010549 co-Evaporation Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- XHIRWEVPYCTARV-UHFFFAOYSA-N n-(3-aminopropyl)-2-methylprop-2-enamide;hydrochloride Chemical compound Cl.CC(=C)C(=O)NCCCN XHIRWEVPYCTARV-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000027756 respiratory electron transport chain Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- MJGIKHNOXNRIHX-UHFFFAOYSA-M sodium;4-aminobutanoate Chemical compound [Na+].NCCCC([O-])=O MJGIKHNOXNRIHX-UHFFFAOYSA-M 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 125000000542 sulfonic acid group Chemical group 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920003176 water-insoluble polymer Polymers 0.000 description 2
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
- DJGHSJBYKIQHIK-UHFFFAOYSA-N (3,5-dimethylphenyl)boronic acid Chemical compound CC1=CC(C)=CC(B(O)O)=C1 DJGHSJBYKIQHIK-UHFFFAOYSA-N 0.000 description 1
- AMGNHZVUZWILSB-UHFFFAOYSA-N 1,2-bis(2-chloroethylsulfanyl)ethane Chemical compound ClCCSCCSCCCl AMGNHZVUZWILSB-UHFFFAOYSA-N 0.000 description 1
- PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- OZKOMUDCMCEDTM-UHFFFAOYSA-N 1,7-phenanthroline Chemical compound C1=CC=C2C3=NC=CC=C3C=CC2=N1 OZKOMUDCMCEDTM-UHFFFAOYSA-N 0.000 description 1
- OYKPJMYWPYIXGG-UHFFFAOYSA-N 2,2-dimethylbutane;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.CCC(C)(C)C OYKPJMYWPYIXGG-UHFFFAOYSA-N 0.000 description 1
- HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- OLYBTQCLJOBELT-UHFFFAOYSA-N 2-bromoethanamine;hydrochloride Chemical compound Cl.NCCBr OLYBTQCLJOBELT-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- LFCYHAXVBWPGQR-UHFFFAOYSA-N 2-propyl-4,5-dihydro-1h-imidazole Chemical compound CCCC1=NCCN1 LFCYHAXVBWPGQR-UHFFFAOYSA-N 0.000 description 1
- MSQCQZMTRWHMFQ-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propane-1-sulfonic acid;sodium Chemical compound [Na].CC(=C)C(=O)OCCCS(O)(=O)=O MSQCQZMTRWHMFQ-UHFFFAOYSA-N 0.000 description 1
- QVQULPDYQXRKFZ-UHFFFAOYSA-N 3-[[3-(bromomethyl)-5-(1,3,2-dioxaborinan-2-yl)phenyl]methoxy]propan-1-ol Chemical compound OCCCOCC1=CC(CBr)=CC(B2OCCCO2)=C1 QVQULPDYQXRKFZ-UHFFFAOYSA-N 0.000 description 1
- VJJZJBUCDWKPLC-UHFFFAOYSA-N 3-methoxyapigenin Chemical compound O1C2=CC(O)=CC(O)=C2C(=O)C(OC)=C1C1=CC=C(O)C=C1 VJJZJBUCDWKPLC-UHFFFAOYSA-N 0.000 description 1
- DATYUTWESAKQQM-UHFFFAOYSA-N 4,7-phenanthroline Chemical compound C1=CC=C2C3=CC=CN=C3C=CC2=N1 DATYUTWESAKQQM-UHFFFAOYSA-N 0.000 description 1
- RCOVTJVRTZGSBP-UHFFFAOYSA-N 4-(chloromethyl)benzoyl chloride Chemical compound ClCC1=CC=C(C(Cl)=O)C=C1 RCOVTJVRTZGSBP-UHFFFAOYSA-N 0.000 description 1
- XANUDEPDKYTCKN-UHFFFAOYSA-N 4-ethenyl-3-methylidene-2H-pyridine Chemical compound C=C1CN=CC=C1C=C XANUDEPDKYTCKN-UHFFFAOYSA-N 0.000 description 1
- MTYHUTYJKFVTJJ-UHFFFAOYSA-N 4-hydroxypyrene-1,2,3-trisulfonic acid Chemical class OS(=O)(=O)C1=C(S(O)(=O)=O)C(S(O)(=O)=O)=C2C(O)=CC3=CC=CC4=CC=C1C2=C34 MTYHUTYJKFVTJJ-UHFFFAOYSA-N 0.000 description 1
- NIXVAPHNPNMUIX-UHFFFAOYSA-N 6-amino-2-methylhex-2-enamide Chemical compound NC(=O)C(C)=CCCCN NIXVAPHNPNMUIX-UHFFFAOYSA-N 0.000 description 1
- GWWFKWJMIKQILK-UHFFFAOYSA-N B(C1=CC(=C(C(=C1CBr)CBr)C)C)(O)O Chemical compound B(C1=CC(=C(C(=C1CBr)CBr)C)C)(O)O GWWFKWJMIKQILK-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- MVVBHSMULFRKJC-UHFFFAOYSA-N C1=CC=NC2=CC=C3N=CC=CC3=C12.[Ar] Chemical compound C1=CC=NC2=CC=C3N=CC=CC3=C12.[Ar] MVVBHSMULFRKJC-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- CQAPMYMKBWBBNT-UHFFFAOYSA-N CC(CCOC)OCCC(C)OCCNC Chemical compound CC(CCOC)OCCC(C)OCCNC CQAPMYMKBWBBNT-UHFFFAOYSA-N 0.000 description 1
- HOVGFTKZAOQJEF-UHFFFAOYSA-N CC(c1ccccc1)I Chemical compound CC(c1ccccc1)I HOVGFTKZAOQJEF-UHFFFAOYSA-N 0.000 description 1
- AWSTVVFBPNNKCQ-UHFFFAOYSA-N CCc1c(ccc(c2c3cc4)c(C)cc3O)c2c4c(C)c1 Chemical compound CCc1c(ccc(c2c3cc4)c(C)cc3O)c2c4c(C)c1 AWSTVVFBPNNKCQ-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- NXWFYDFNTNZIGI-UHFFFAOYSA-N OBOCC1=CC=CC=C1 Chemical compound OBOCC1=CC=CC=C1 NXWFYDFNTNZIGI-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Chemical group 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 241000854711 Shinkai Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 108010021119 Trichosanthin Proteins 0.000 description 1
- NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 1
- WFXLKZPNPRXRJY-UHFFFAOYSA-N [3,5-bis(bromomethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC(CBr)=CC(CBr)=C1 WFXLKZPNPRXRJY-UHFFFAOYSA-N 0.000 description 1
- PDNOURKEZJZJNZ-UHFFFAOYSA-N [4-(bromomethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC=C(CBr)C=C1 PDNOURKEZJZJNZ-UHFFFAOYSA-N 0.000 description 1
- QLODTSXLOVCZBU-UHFFFAOYSA-M [Br-].C=CC1=CC[N+](=C)C=C1 Chemical compound [Br-].C=CC1=CC[N+](=C)C=C1 QLODTSXLOVCZBU-UHFFFAOYSA-M 0.000 description 1
- FYJBAVAOYUPRAU-UHFFFAOYSA-N [Na].[Na].[Na].CC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O Chemical compound [Na].[Na].[Na].CC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O FYJBAVAOYUPRAU-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000012644 addition polymerization Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229940124277 aminobutyric acid Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000002152 aqueous-organic solution Substances 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- UWCPYKQBIPYOLX-UHFFFAOYSA-N benzene-1,3,5-tricarbonyl chloride Chemical compound ClC(=O)C1=CC(C(Cl)=O)=CC(C(Cl)=O)=C1 UWCPYKQBIPYOLX-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- XFOZBWSTIQRFQW-UHFFFAOYSA-M benzyl-dimethyl-prop-2-enylazanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC1=CC=CC=C1 XFOZBWSTIQRFQW-UHFFFAOYSA-M 0.000 description 1
- 229910002056 binary alloy Inorganic materials 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
- HPNSNYBUADCFDR-UHFFFAOYSA-N chromafenozide Chemical compound CC1=CC(C)=CC(C(=O)N(NC(=O)C=2C(=C3CCCOC3=CC=2)C)C(C)(C)C)=C1 HPNSNYBUADCFDR-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 239000000295 fuel oil Substances 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 150000002390 heteroarenes Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 229920000592 inorganic polymer Polymers 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- QENHCSSJTJWZAL-UHFFFAOYSA-N magnesium sulfide Chemical compound [Mg+2].[S-2] QENHCSSJTJWZAL-UHFFFAOYSA-N 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- WFKDPJRCBCBQNT-UHFFFAOYSA-N n,2-dimethylprop-2-enamide Chemical compound CNC(=O)C(C)=C WFKDPJRCBCBQNT-UHFFFAOYSA-N 0.000 description 1
- HUMMCEUVDBVXTQ-UHFFFAOYSA-N naphthalen-1-ylboronic acid Chemical compound C1=CC=C2C(B(O)O)=CC=CC2=C1 HUMMCEUVDBVXTQ-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical group 0.000 description 1
- 238000007539 photo-oxidation reaction Methods 0.000 description 1
- 230000036211 photosensitivity Effects 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 125000005581 pyrene group Chemical group 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 150000003871 sulfonates Chemical group 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- UZNHKBFIBYXPDV-UHFFFAOYSA-N trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)NCCC[N+](C)(C)C UZNHKBFIBYXPDV-UHFFFAOYSA-N 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/731,323 US6627177B2 (en) | 2000-12-05 | 2000-12-05 | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| PCT/US2001/046658 WO2002046752A2 (en) | 2000-12-05 | 2001-12-05 | Optical determination of glucose utilizing boronic acid adducts |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008241613A Division JP5209424B2 (ja) | 2000-12-05 | 2008-09-19 | 消光剤前駆体組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536279A JP2004536279A (ja) | 2004-12-02 |
| JP2004536279A5 JP2004536279A5 (enExample) | 2005-05-26 |
| JP4222503B2 true JP4222503B2 (ja) | 2009-02-12 |
Family
ID=24939018
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002548438A Expired - Lifetime JP4222503B2 (ja) | 2000-12-05 | 2001-12-05 | ボロン酸付加物を用いたグルコースの光学測定 |
| JP2008241613A Expired - Lifetime JP5209424B2 (ja) | 2000-12-05 | 2008-09-19 | 消光剤前駆体組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008241613A Expired - Lifetime JP5209424B2 (ja) | 2000-12-05 | 2008-09-19 | 消光剤前駆体組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6627177B2 (enExample) |
| EP (1) | EP1340076A2 (enExample) |
| JP (2) | JP4222503B2 (enExample) |
| CN (1) | CN1479870A (enExample) |
| AU (2) | AU2002220230B2 (enExample) |
| CA (1) | CA2436590A1 (enExample) |
| NZ (1) | NZ526787A (enExample) |
| WO (1) | WO2002046752A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009091357A (ja) * | 2000-12-05 | 2009-04-30 | Regents Of The Univ Of California | ボロン酸付加物を用いたグルコースの光学測定 |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6766183B2 (en) * | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
| US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US7195923B2 (en) * | 2001-01-31 | 2007-03-27 | Scripps Laboratories, Inc. | Ratiometric determination of glycated protein |
| US20040087842A1 (en) * | 2002-05-30 | 2004-05-06 | Lakowicz Joseph R. | Fluorescent probes for saccharrides |
| EP1594551A2 (en) * | 2003-02-19 | 2005-11-16 | Sicel Technologies, Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| EP1644330B1 (en) * | 2003-06-27 | 2011-08-17 | The University Of Maryland | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids |
| US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
| US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US8165651B2 (en) * | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| US7713745B2 (en) * | 2004-04-13 | 2010-05-11 | Sensors For Medicine And Science, Inc. | Non-covalent immobilization of indicator molecules |
| WO2005119223A1 (en) * | 2004-04-14 | 2005-12-15 | Bioprocessors Corp. | Compositions of matter useful as ph indicators and related methods |
| US20080051764A1 (en) * | 2004-04-19 | 2008-02-28 | Board Of Regents, The University Of Texas System | Physiological Monitoring With Continuous Treatment |
| US20060088722A1 (en) * | 2004-10-25 | 2006-04-27 | Aller Robert C | Optical pH sensor |
| GB0426822D0 (en) | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
| GB0426823D0 (en) | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
| WO2007033353A2 (en) * | 2005-09-14 | 2007-03-22 | Therabit, Inc. | Chemical target-binding compositions |
| US7807473B2 (en) * | 2005-10-26 | 2010-10-05 | General Electric Company | Material compositions for sensors for determination of chemical species at trace concentrations and method of using sensors |
| EP1949083A1 (en) * | 2005-11-08 | 2008-07-30 | Smart Holograms Limited | Novel boronate complex and its use in a glucose sensor |
| US8211048B2 (en) * | 2006-02-22 | 2012-07-03 | Henry Ford Health System | System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits |
| US8133194B2 (en) | 2006-02-22 | 2012-03-13 | Henry Ford Health System | System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| ATE514755T1 (de) * | 2006-07-25 | 2011-07-15 | Glumetrics Inc | Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung |
| US20080200434A1 (en) * | 2006-09-14 | 2008-08-21 | Daniloff George Y | Chemical Target-Binding Compositions |
| US20080161666A1 (en) * | 2006-12-29 | 2008-07-03 | Abbott Diabetes Care, Inc. | Analyte devices and methods |
| US7824918B2 (en) * | 2007-08-06 | 2010-11-02 | Glumetrics, Inc. | HPTS-Mono and BIS Cys-Ma polymerizable fluorescent dyes for use in analyte sensors |
| US7751863B2 (en) * | 2007-02-06 | 2010-07-06 | Glumetrics, Inc. | Optical determination of ph and glucose |
| AU2008213677A1 (en) | 2007-02-06 | 2008-08-14 | Glumetrics, Inc. | Optical systems and methods for rationmetric measurement of blood glucose concentration |
| ATE506368T1 (de) * | 2007-05-01 | 2011-05-15 | Glumetrics Inc | Pyridin-boronsäure-quencher zur verwendung in analytsensoren |
| US7883898B2 (en) * | 2007-05-07 | 2011-02-08 | General Electric Company | Method and apparatus for measuring pH of low alkalinity solutions |
| JP2010527010A (ja) * | 2007-05-10 | 2010-08-05 | グルメトリクス、 インク. | 被分析物センサーを較正する装置および方法 |
| EP2162057A1 (en) * | 2007-05-10 | 2010-03-17 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
| WO2008143877A1 (en) | 2007-05-14 | 2008-11-27 | Brigham Young University | Fuel cell and method for generating electric power |
| EP2171471B1 (en) * | 2007-06-08 | 2015-11-18 | The Charles Stark Draper Laboratory, Inc. | Sensors for the detection of diols and carbohydrates using boronic acid chelators for glucose |
| DK2222686T3 (en) | 2007-07-11 | 2015-09-21 | Medtronic Minimed Inc | Polyviologenboronsyredeaktivatorer for use in analytsensorer |
| US8202731B2 (en) * | 2007-08-06 | 2012-06-19 | Glumetrics, Inc. | HPTS-mono and bis Cys-MA polymerizable fluorescent dyes for use in analyte sensors |
| WO2009067626A1 (en) | 2007-11-21 | 2009-05-28 | Glumetrics, Inc. | Use of an equilibrium intravascular sensor to achieve tight glycemic control |
| JP5434088B2 (ja) * | 2008-01-22 | 2014-03-05 | 三菱化学株式会社 | 架橋性有機化合物、有機電界発光素子用組成物、有機電界発光素子および有機elディスプレイ |
| WO2009124095A1 (en) * | 2008-03-31 | 2009-10-08 | Abbott Diabetes Care Inc. | Shallow implantable analyte sensor with rapid physiological response |
| WO2009129186A2 (en) | 2008-04-17 | 2009-10-22 | Glumetrics, Inc. | Sensor for percutaneous intravascular deployment without an indwelling cannula |
| WO2009135197A2 (en) * | 2008-05-02 | 2009-11-05 | Sri International | Optical microneedle-based spectrometer |
| CN101625344B (zh) * | 2008-07-10 | 2011-11-16 | 中国食品发酵工业研究院 | 一种检测葡萄酒中2,4,6-三氯茴香醚(tca)不良气味的检测方法 |
| US8620409B2 (en) | 2008-08-04 | 2013-12-31 | University Of Utah Research Foundation | Dye application for confocal imaging of cellular microstructure |
| CN101643479B (zh) * | 2008-08-07 | 2012-07-18 | 通用电气公司 | 含苯吡啶单元的化合物 |
| CN101598708B (zh) * | 2009-05-19 | 2011-11-09 | 烟台杰科检测服务有限公司 | 一种水果、蔬菜中农药多残留快速分析方法 |
| CN101598709B (zh) * | 2009-07-10 | 2011-08-24 | 中国烟草总公司郑州烟草研究院 | 一种测定烟草保润剂对烟丝中外加香料定香能力的方法 |
| CN101634648B (zh) * | 2009-08-21 | 2012-06-27 | 江南大学 | 超高压液相色谱—飞行时间质谱同时测定白酒中六种微量甜味剂的方法 |
| US20110077477A1 (en) * | 2009-09-30 | 2011-03-31 | Glumetrics, Inc. | Sensors with thromboresistant coating |
| US8467843B2 (en) | 2009-11-04 | 2013-06-18 | Glumetrics, Inc. | Optical sensor configuration for ratiometric correction of blood glucose measurement |
| TWI402501B (zh) * | 2009-12-09 | 2013-07-21 | Nat Univ Tsing Hua | 免疫檢測探針及利用免疫檢測方法 |
| US20110152658A1 (en) * | 2009-12-17 | 2011-06-23 | Glumetrics, Inc. | Identification of aberrant measurements of in vivo glucose concentration using temperature |
| JP2013519101A (ja) | 2010-02-08 | 2013-05-23 | グルメトリクス, インコーポレイテッド | 化学センサーの抗酸化剤保護 |
| US9151764B2 (en) | 2010-02-16 | 2015-10-06 | Lightship Medical Limited | Barrier layer for glucose sensor |
| EP2545373B1 (en) * | 2010-03-11 | 2022-08-24 | Medtronic Minimed, Inc. | Measuring analyte concentration incorporating temperature and ph correction |
| US10429380B2 (en) | 2010-12-17 | 2019-10-01 | Eyesense Ag | Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein |
| CN103370623B (zh) * | 2010-12-17 | 2016-05-04 | 视觉股份公司 | 水凝胶在具有提高的灵敏度的生物传感器中的用途 |
| GB201113435D0 (en) | 2011-08-03 | 2011-09-21 | Glysure Ltd | Sensor calibration |
| CN102353660B (zh) * | 2011-06-20 | 2013-01-02 | 山西大学 | 一种检测d-果糖的组合物及其制备方法 |
| WO2013012687A2 (en) | 2011-07-15 | 2013-01-24 | Glumetrics, Inc. | Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors |
| US9642568B2 (en) * | 2011-09-06 | 2017-05-09 | Medtronic Minimed, Inc. | Orthogonally redundant sensor systems and methods |
| US10352941B2 (en) | 2011-09-27 | 2019-07-16 | Medtronic Minimed, Inc. | Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| US8568991B2 (en) * | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| US9017622B2 (en) | 2012-04-10 | 2015-04-28 | Lightship Medical Limited | Calibrator for a sensor |
| US20130344619A1 (en) | 2012-06-21 | 2013-12-26 | Lightship Medical Limited | Glucose sensor |
| WO2014138197A1 (en) | 2013-03-06 | 2014-09-12 | General Electric Company | Methods of analyzing an h&e stained biological sample |
| AU2014374361B9 (en) | 2013-12-31 | 2019-07-04 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| JP2015151426A (ja) | 2014-02-12 | 2015-08-24 | セイコーエプソン株式会社 | 刺激応答性ゲル材料 |
| JP2015151427A (ja) * | 2014-02-12 | 2015-08-24 | セイコーエプソン株式会社 | 刺激応答性ゲル材料および刺激応答性ゲル材料の製造方法 |
| JP2015151436A (ja) | 2014-02-13 | 2015-08-24 | セイコーエプソン株式会社 | 刺激応答性ゲル材料 |
| EP3498718B1 (en) * | 2014-04-23 | 2020-04-15 | Terumo Kabushiki Kaisha | Non-enzymatic electrochemical sensor for measuring analytes |
| US10845305B1 (en) * | 2015-11-20 | 2020-11-24 | Verily Life Sciences Llc | Method for increasing sensor resolution by spectrally stacking responsive dyes |
| CN110642882B (zh) * | 2019-10-21 | 2021-12-24 | 内蒙古大学 | 一种兼具双氧水检测和光动力杀伤癌细胞活性的荧光探针及其制备方法和应用 |
| JP7712476B2 (ja) * | 2021-08-26 | 2025-07-23 | センセオニクス,インコーポレーテッド | インビボ分析物信号劣化の媒介 |
| DE102021127227A1 (de) | 2021-10-20 | 2023-04-20 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensor zur Messung eines pH-Werts |
| CN118459651B (zh) * | 2024-07-10 | 2024-09-20 | 西南石油大学 | 一种耐温自破胶压裂液稠化剂及其制备方法和应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659817A (en) | 1981-05-01 | 1987-04-21 | The Children's Medical Center Corporation | Reporter compounds containing boron |
| US4886338A (en) | 1986-10-10 | 1989-12-12 | Minnesota Mining And Manufacturing Company | Optical fiber event sensor |
| AT390517B (de) | 1988-08-04 | 1990-05-25 | Avl Verbrennungskraft Messtech | Optischer sensor und verfahren zu dessen herstellung |
| NO890029D0 (no) | 1989-01-04 | 1989-01-04 | Axis Research | Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes). |
| US5039491A (en) | 1989-01-27 | 1991-08-13 | Metricor, Inc. | Optical oxygen sensor |
| US5232858A (en) | 1989-04-25 | 1993-08-03 | Avl Medical Instruments Ag | Method for quantitative determination of at least one chemical parameter of a sample medium |
| US5137833A (en) * | 1989-09-21 | 1992-08-11 | Russell Anthony P | Method for detecting polyhydroxyl compounds |
| US5512246A (en) | 1989-09-21 | 1996-04-30 | Anthony P. Russell | Method and means for detecting polyhydroxyl compounds |
| GB9024775D0 (en) * | 1990-11-14 | 1991-01-02 | Axis Research | Chemical compounds |
| US5244562A (en) | 1991-07-31 | 1993-09-14 | Hewlett-Packard Company | Use of templated polymers for analyte-activated microelectronic switching devices |
| US5466798A (en) | 1992-03-06 | 1995-11-14 | The Regents Of The University Of California | Synthesis of lithium aminoborohydrides and reactions thereof |
| JP3200942B2 (ja) * | 1992-03-18 | 2001-08-20 | 日本油脂株式会社 | ボロン酸基含有モノマーおよびそのポリマー |
| KR0180315B1 (ko) * | 1993-06-30 | 1999-03-20 | 알렌 제이. 스피겔 | 환자혈액중의 다수 변수들의 생체내 측정을 위한 다-변수 카테터 |
| JP2883824B2 (ja) * | 1993-11-07 | 1999-04-19 | 科学技術振興事業団 | ボロン酸基を有する発蛍光性化合物 |
| GB2284809B (en) * | 1993-11-07 | 1998-04-29 | Japan Res Dev Corp | A fluorescent phenylboronic acid suitable for use in the detection of saccharides |
| US5631364A (en) | 1994-03-31 | 1997-05-20 | Axis Biochemicals Asa | Labelled boronic acid derivatives |
| PL316940A1 (en) | 1994-05-02 | 1997-02-17 | Ciba Geigy Ag | System of optical sensing elements for determining ph values and ionic strength |
| US5852126A (en) | 1994-05-02 | 1998-12-22 | Novartis Ag | Polymerisable composition and the use thereof |
| US5998594A (en) * | 1994-12-30 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use |
| US5517313A (en) | 1995-02-21 | 1996-05-14 | Colvin, Jr.; Arthur E. | Fluorescent optical sensor |
| JP2799837B2 (ja) | 1995-03-03 | 1998-09-21 | 科学技術振興事業団 | ビナフチル基を有するボロン酸化合物 |
| US5882494A (en) | 1995-03-27 | 1999-03-16 | Minimed, Inc. | Polyurethane/polyurea compositions containing silicone for biosensor membranes |
| US5786439A (en) | 1996-10-24 | 1998-07-28 | Minimed Inc. | Hydrophilic, swellable coatings for biosensors |
| US6002954A (en) * | 1995-11-22 | 1999-12-14 | The Regents Of The University Of California | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
| DE69633573T2 (de) | 1995-11-22 | 2005-10-06 | Medtronic MiniMed, Inc., Northridge | Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor |
| US6063637A (en) | 1995-12-13 | 2000-05-16 | California Institute Of Technology | Sensors for sugars and other metal binding analytes |
| US5894351A (en) | 1997-05-13 | 1999-04-13 | Colvin, Jr.; Arthur E. | Fluorescence sensing device |
| DE19811963A1 (de) * | 1998-03-19 | 1999-09-23 | Ewald Terpetschnig | Lumineszent Rezeptoren für Zucker auf der Grundlage von Metall-Liganden-Komplexen |
| JP3867400B2 (ja) * | 1998-05-08 | 2007-01-10 | 日本油脂株式会社 | ボロン酸基含有単量体およびその重合体 |
| US6485703B1 (en) | 1998-07-31 | 2002-11-26 | The Texas A&M University System | Compositions and methods for analyte detection |
| US6330464B1 (en) | 1998-08-26 | 2001-12-11 | Sensors For Medicine & Science | Optical-based sensing devices |
| US6304766B1 (en) | 1998-08-26 | 2001-10-16 | Sensors For Medicine And Science | Optical-based sensing devices, especially for in-situ sensing in humans |
| US6366793B1 (en) | 1999-09-10 | 2002-04-02 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analtes in vivo |
| AU2001251210A1 (en) | 2000-04-04 | 2001-10-15 | Medtronic Minimed, Inc. | Saccharide sensing molecules having enhanced fluorescent properties |
| US20010034479A1 (en) * | 2000-04-19 | 2001-10-25 | Ring Lawrence S. | Optically based transcutaneous blood gas sensor |
| US6387672B1 (en) | 2000-12-04 | 2002-05-14 | Beckman Coulter, Inc. | Photo-induced electron transfer fluorescent sensor molecules |
| US6653141B2 (en) * | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US20020127626A1 (en) * | 2001-01-05 | 2002-09-12 | Sensors For Medicine And Science, Inc. | Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone |
| US20020119581A1 (en) * | 2001-01-05 | 2002-08-29 | Daniloff George Y. | Detection of analytes |
-
2000
- 2000-12-05 US US09/731,323 patent/US6627177B2/en not_active Expired - Lifetime
-
2001
- 2001-12-05 AU AU2002220230A patent/AU2002220230B2/en not_active Ceased
- 2001-12-05 CA CA002436590A patent/CA2436590A1/en not_active Abandoned
- 2001-12-05 CN CNA018201202A patent/CN1479870A/zh active Pending
- 2001-12-05 AU AU2023002A patent/AU2023002A/xx active Pending
- 2001-12-05 EP EP01999808A patent/EP1340076A2/en not_active Withdrawn
- 2001-12-05 NZ NZ526787A patent/NZ526787A/en unknown
- 2001-12-05 WO PCT/US2001/046658 patent/WO2002046752A2/en not_active Ceased
- 2001-12-05 JP JP2002548438A patent/JP4222503B2/ja not_active Expired - Lifetime
-
2003
- 2003-06-05 US US10/456,895 patent/US20040028612A1/en not_active Abandoned
-
2008
- 2008-09-19 JP JP2008241613A patent/JP5209424B2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009091357A (ja) * | 2000-12-05 | 2009-04-30 | Regents Of The Univ Of California | ボロン酸付加物を用いたグルコースの光学測定 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5209424B2 (ja) | 2013-06-12 |
| NZ526787A (en) | 2006-09-29 |
| AU2023002A (en) | 2002-06-18 |
| JP2004536279A (ja) | 2004-12-02 |
| CA2436590A1 (en) | 2002-06-13 |
| EP1340076A2 (en) | 2003-09-03 |
| US6627177B2 (en) | 2003-09-30 |
| AU2002220230B2 (en) | 2007-03-22 |
| CN1479870A (zh) | 2004-03-03 |
| US20040028612A1 (en) | 2004-02-12 |
| WO2002046752A3 (en) | 2003-01-16 |
| JP2009091357A (ja) | 2009-04-30 |
| WO2002046752A9 (en) | 2002-08-29 |
| WO2002046752A2 (en) | 2002-06-13 |
| US20020106326A1 (en) | 2002-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4222503B2 (ja) | ボロン酸付加物を用いたグルコースの光学測定 | |
| JP2004536279A5 (enExample) | ||
| US6653141B2 (en) | Polyhydroxyl-substituted organic molecule sensing method and device | |
| AU2002220230A1 (en) | Optical determination of glucose utilizing boronic acid adducts | |
| EP1960779B1 (en) | Optical determination of glucose utilizing boronic acid adducts-ii | |
| AU2001278145B2 (en) | Detection of analytes in aqueous environments | |
| DK2769226T3 (en) | COMBINATIONS OF FLUORPHORES AND PYRIDINIUM BORIC ACID QUENCHERS FOR USE IN ANALYTICAL SENSORS | |
| AU2001278145A1 (en) | Detection of analytes in aqueous environments | |
| AU2007202790A1 (en) | Optical determination of glucose utilizing boronic acid adducts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041125 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070313 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070613 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070702 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070713 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070724 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070813 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20070813 |
|
| A072 | Dismissal of procedure [no reply to invitation to correct request for examination] |
Free format text: JAPANESE INTERMEDIATE CODE: A073 Effective date: 20080507 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080520 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080820 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080903 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080922 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20081028 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20081113 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4222503 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111128 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121128 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131128 Year of fee payment: 5 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |