JP4220673B2 - 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド - Google Patents

遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド Download PDF

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Publication number
JP4220673B2
JP4220673B2 JP2000561339A JP2000561339A JP4220673B2 JP 4220673 B2 JP4220673 B2 JP 4220673B2 JP 2000561339 A JP2000561339 A JP 2000561339A JP 2000561339 A JP2000561339 A JP 2000561339A JP 4220673 B2 JP4220673 B2 JP 4220673B2
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gene
expression
sequence
vector
promoter
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JP2002522027A (ja
JP2002522027A5 (enExample
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マイケル アントニオ，
ロバート クロンビー，
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EMD Millipore Corp
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Millipore Corp
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Priority claimed from GBGB9815879.3A external-priority patent/GB9815879D0/en
Priority claimed from GBGB9906712.6A external-priority patent/GB9906712D0/en
Priority claimed from GBGB9909494.8A external-priority patent/GB9909494D0/en
Application filed by Millipore Corp filed Critical Millipore Corp
Publication of JP2002522027A publication Critical patent/JP2002522027A/ja
Publication of JP2002522027A5 publication Critical patent/JP2002522027A5/ja
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
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  • Zoology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
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  • Biophysics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000561339A 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド Expired - Lifetime JP4220673B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GBGB9815879.3A GB9815879D0 (en) 1998-07-21 1998-07-21 A polynucleotide
US10768898P 1998-11-09 1998-11-09
US60/107,688 1998-11-09
GBGB9906712.6A GB9906712D0 (en) 1999-03-23 1999-03-23 A polynucleotide
US12741099P 1999-04-01 1999-04-01
US60/127,410 1999-04-01
GBGB9909494.8A GB9909494D0 (en) 1999-04-23 1999-04-23 A plasmid
US13401699P 1999-05-12 1999-05-12
US9906712.6 1999-05-12
US60/134,016 1999-05-12
US9815879.3 1999-05-12
US9909494.8 1999-05-12
PCT/GB1999/002357 WO2000005393A2 (en) 1998-07-21 1999-07-21 A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)

Related Child Applications (1)

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JP2004293969A Division JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Publications (3)

Publication Number Publication Date
JP2002522027A JP2002522027A (ja) 2002-07-23
JP2002522027A5 JP2002522027A5 (enExample) 2005-11-17
JP4220673B2 true JP4220673B2 (ja) 2009-02-04

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JP2000561339A Expired - Lifetime JP4220673B2 (ja) 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2004293969A Pending JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

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JP2004293969A Pending JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Country Status (8)

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EP (2) EP2348118A1 (enExample)
JP (4) JP4220673B2 (enExample)
KR (3) KR100795626B1 (enExample)
CN (1) CN100365127C (enExample)
AU (1) AU771111B2 (enExample)
CA (1) CA2333852C (enExample)
MX (1) MXPA01000830A (enExample)
WO (1) WO2000005393A2 (enExample)

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ATE471988T1 (de) 2003-02-01 2010-07-15 Millipore Corp Verbesserte genetische elemente für eine erhöhte genexpression
KR101269656B1 (ko) 2003-10-24 2013-05-30 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
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US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
BRPI0517380A (pt) 2004-11-08 2008-10-07 Chromagenics Bv molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse
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CN104531699B (zh) * 2014-10-09 2017-03-15 河南农业大学 一种增强外源基因表达的猪的ucoe调控元件片段
EP4589006A3 (en) * 2014-12-16 2025-08-13 Garvan Institute of Medical Research Sequencing controls
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US10801021B2 (en) 2017-04-03 2020-10-13 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for multiplexed quantitative analysis of cell lineages
WO2019113378A1 (en) * 2017-12-07 2019-06-13 Integrity Biosolutions, Llc Engineered ubiquitous chromatin opening elements and uses thereof
KR102873620B1 (ko) * 2018-05-24 2025-10-21 국립대학법인 홋가이도 다이가쿠 신규 벡터 및 그 이용
JP7431802B2 (ja) 2018-08-15 2024-02-15 イルミナ インコーポレイテッド ライブラリー富化を改善するための組成物および方法
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CN116574735B (zh) * 2023-07-03 2023-11-10 艾米能斯(苏州)生物科技有限公司 一种多核苷酸及其应用

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CN100365127C (zh) 2008-01-30
AU5053499A (en) 2000-02-14
KR20010083131A (ko) 2001-08-31
WO2000005393A2 (en) 2000-02-03
HK1035740A1 (en) 2001-12-07
EP1098986B1 (en) 2011-12-28
AU771111B2 (en) 2004-03-11
KR20090117675A (ko) 2009-11-12
JP2002522027A (ja) 2002-07-23
KR20070108336A (ko) 2007-11-09
JP2005052149A (ja) 2005-03-03
CN1334878A (zh) 2002-02-06
EP1098986A2 (en) 2001-05-16
EP2348118A1 (en) 2011-07-27
CA2333852C (en) 2007-05-29
KR100795626B1 (ko) 2008-01-17
WO2000005393A3 (en) 2000-08-17
JP2008109931A (ja) 2008-05-15
JP2009102331A (ja) 2009-05-14
MXPA01000830A (es) 2002-06-04

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