JP4188839B2 - ホスファターゼインヒビーターとしてのピリミドトリアジン - Google Patents

ホスファターゼインヒビーターとしてのピリミドトリアジン Download PDF

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Publication number
JP4188839B2
JP4188839B2 JP2003556413A JP2003556413A JP4188839B2 JP 4188839 B2 JP4188839 B2 JP 4188839B2 JP 2003556413 A JP2003556413 A JP 2003556413A JP 2003556413 A JP2003556413 A JP 2003556413A JP 4188839 B2 JP4188839 B2 JP 4188839B2
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JP
Japan
Prior art keywords
ylmethyl
diamine
pyrimido
triazine
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2003556413A
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English (en)
Japanese (ja)
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JP2005517677A5 (Direct
JP2005517677A (ja
Inventor
ガーティン，ケビン・リチャード
セッティ，リナ・クアットロッチオ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2005517677A publication Critical patent/JP2005517677A/ja
Publication of JP2005517677A5 publication Critical patent/JP2005517677A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2003556413A 2001-12-27 2002-12-27 ホスファターゼインヒビーターとしてのピリミドトリアジン Expired - Fee Related JP4188839B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34393701P 2001-12-27 2001-12-27
US39911002P 2002-07-26 2002-07-26
PCT/EP2002/014771 WO2003055883A1 (en) 2001-12-27 2002-12-27 Pyrimidotriazines as phosphatase inhibitors

Publications (3)

Publication Number Publication Date
JP2005517677A JP2005517677A (ja) 2005-06-16
JP2005517677A5 JP2005517677A5 (Direct) 2005-12-22
JP4188839B2 true JP4188839B2 (ja) 2008-12-03

Family

ID=26993696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003556413A Expired - Fee Related JP4188839B2 (ja) 2001-12-27 2002-12-27 ホスファターゼインヒビーターとしてのピリミドトリアジン

Country Status (19)

Country Link
US (1) US6642381B2 (Direct)
EP (1) EP1467996B1 (Direct)
JP (1) JP4188839B2 (Direct)
KR (1) KR100601769B1 (Direct)
CN (1) CN100402530C (Direct)
AT (1) ATE311388T1 (Direct)
AU (1) AU2002367190B2 (Direct)
BR (1) BR0215395A (Direct)
CA (1) CA2471265C (Direct)
DE (1) DE60207759T2 (Direct)
ES (1) ES2252554T3 (Direct)
JO (1) JO2242B1 (Direct)
MX (1) MXPA04006266A (Direct)
PA (1) PA8562901A1 (Direct)
PE (1) PE20030896A1 (Direct)
PL (1) PL371180A1 (Direct)
TW (1) TW200306313A (Direct)
UY (1) UY27606A1 (Direct)
WO (1) WO2003055883A1 (Direct)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696231B2 (en) * 2001-10-30 2010-04-13 Laboratoires Serono Sa Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)
ATE427951T1 (de) 2002-11-18 2009-04-15 Hoffmann La Roche Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren
AU2004210711B2 (en) * 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
US20040186151A1 (en) * 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
NZ569329A (en) * 2006-01-30 2011-09-30 Transtech Pharma Inc Substituted imidazole derivatives and their use as PTPase inhibitors
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2010083645A1 (en) * 2009-01-21 2010-07-29 Shanghai Targetdrug Co., Ltd PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486433B2 (en) 2012-10-12 2016-11-08 Mochida Pharmaceuticals Co. Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR20150127599A (ko) 2013-03-15 2015-11-17 모치다 세이야쿠 가부시키가이샤 비알코올성 지방간염을 치료하기 위한 조성물 및 방법
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
GB0022079D0 (en) 2000-09-08 2000-10-25 Inst Of Molecul & Cell Biology Novel protein tyrosine phosphatase inhibitor

Also Published As

Publication number Publication date
DE60207759T2 (de) 2006-08-03
UY27606A1 (es) 2003-06-30
TW200306313A (en) 2003-11-16
AU2002367190A1 (en) 2003-07-15
ATE311388T1 (de) 2005-12-15
ES2252554T3 (es) 2006-05-16
MXPA04006266A (es) 2004-09-27
KR20040068981A (ko) 2004-08-02
AU2002367190B2 (en) 2006-10-05
JO2242B1 (en) 2004-10-07
BR0215395A (pt) 2004-12-07
DE60207759D1 (de) 2006-01-05
KR100601769B1 (ko) 2006-07-19
PA8562901A1 (es) 2003-07-28
CA2471265C (en) 2010-02-09
EP1467996B1 (en) 2005-11-30
PE20030896A1 (es) 2003-11-05
US6642381B2 (en) 2003-11-04
PL371180A1 (en) 2005-06-13
WO2003055883A1 (en) 2003-07-10
CN100402530C (zh) 2008-07-16
JP2005517677A (ja) 2005-06-16
EP1467996A1 (en) 2004-10-20
CN1610683A (zh) 2005-04-27
US20030153756A1 (en) 2003-08-14
CA2471265A1 (en) 2003-07-10

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