JP4171527B2 - カンプトテシン誘導体及び抗腫瘍剤としてのその利用 - Google Patents
カンプトテシン誘導体及び抗腫瘍剤としてのその利用 Download PDFInfo
- Publication number
- JP4171527B2 JP4171527B2 JP52979197A JP52979197A JP4171527B2 JP 4171527 B2 JP4171527 B2 JP 4171527B2 JP 52979197 A JP52979197 A JP 52979197A JP 52979197 A JP52979197 A JP 52979197A JP 4171527 B2 JP4171527 B2 JP 4171527B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- hydrogen
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000338A IT1282673B1 (it) | 1996-02-23 | 1996-02-23 | Derivati della camptotecina e loro uso come agenti antitumorali |
| IT96A000338 | 1996-02-23 | ||
| PCT/EP1997/000786 WO1997031003A1 (en) | 1996-02-23 | 1997-02-19 | Camptothecin derivatives and the use thereof as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000505448A JP2000505448A (ja) | 2000-05-09 |
| JP4171527B2 true JP4171527B2 (ja) | 2008-10-22 |
Family
ID=11373368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52979197A Expired - Fee Related JP4171527B2 (ja) | 1996-02-23 | 1997-02-19 | カンプトテシン誘導体及び抗腫瘍剤としてのその利用 |
Country Status (22)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000000238A1 (en) * | 1998-06-26 | 2000-01-06 | Quanam Medical Corporation | Topoisomerase inhibitors for prevention of restenosis |
| DK1044977T3 (da) * | 1999-03-09 | 2002-07-08 | Sigma Tau Ind Farmaceuti | Camptothecinderivater med antitumoraktivitet |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| AU2002258787A1 (en) * | 2001-04-11 | 2002-10-28 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
| RU2319482C2 (ru) * | 2001-11-23 | 2008-03-20 | Чугаи Сейяку Кабусики Кайся | Способ идентификации противоопухолевых целевых ферментов |
| IL163820A0 (en) * | 2002-03-01 | 2005-12-18 | Pharmacia Italia Spa | Crystalline polymorphic form of irinotecan hydrochloride |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
| PL1962850T3 (pl) | 2005-12-21 | 2012-07-31 | Sigma Tau Ind Farmaceuti | Leczenie lekoopornych nowotworów |
| WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
| CN101033230B (zh) * | 2006-03-10 | 2010-12-08 | 中国科学院上海药物研究所 | 一类喜树碱衍生物及其应用 |
| ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
| CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
| US20240376120A1 (en) * | 2021-09-01 | 2024-11-14 | Shanghai Best-Link Bioscience, Llc | Camptothecin compound, preparation method therefor and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| KR100516593B1 (ko) * | 1996-08-19 | 2005-09-22 | 바이오누머릭 파마슈티칼스, 인코포레이티드 | 고 친유성 캠프토테신 유도체 |
-
1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
-
1997
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active Expired - Fee Related
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Application Discontinuation
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
-
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4171527B2 (ja) | カンプトテシン誘導体及び抗腫瘍剤としてのその利用 | |
| KR100516593B1 (ko) | 고 친유성 캠프토테신 유도체 | |
| JP4624685B2 (ja) | フレデリカマイシン誘導体 | |
| KR100191193B1 (ko) | 6환 화합물 | |
| US5801167A (en) | Camptothecin derivatives and process for their preparation | |
| US20090326225A1 (en) | Novel Process for the Preparation of Hexacyclic Compounds | |
| JP4990620B2 (ja) | ７−置換カンプトテシンおよびカンプトテシン類似体ならびにそれらの調製方法 | |
| CN113248524A (zh) | 一种双吲哚生物碱化合物及其合成方法和用途 | |
| CN117510515A (zh) | 适用于抗体-药物偶联物的毒素分子 | |
| CA2247513C (en) | Camptothecin derivatives and the use thereof as antitumor agents | |
| PL188075B1 (pl) | Rozpuszczalne w wodzie C-pierścieniowe analogi 20(S)-kamptotecyny, kompozycja farmaceutyczna zawierająca te związki, ich zastosowanie oraz sposób wytwarzania | |
| HUP0203033A2 (hu) | Fenantrolin-7-on-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CA1051005A (en) | Thipyrano benzopyrans, intermediates for their preparation and method of making them | |
| CA1324606C (en) | Thiopyranodipyrazoles | |
| EP2096113A1 (en) | 9-substituted camptothecin derivatives as antitumor compounds | |
| JP2003507381A (ja) | フェナントロリン−７−オン誘導体及びその治療への使用 | |
| GB2402129A (en) | Novel furan derivatives and their use as antiproliferative agents | |
| ZA200200840B (en) | Ascididemin derivatives and their therapeutic applications. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040120 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071023 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080325 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080609 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080729 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080811 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110815 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |