JP4140862B2 - 組換体ポックスウイルス−狂犬病組成物および組合せ組成物並びに使用 - Google Patents

組換体ポックスウイルス−狂犬病組成物および組合せ組成物並びに使用 Download PDF

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JP4140862B2
JP4140862B2 JP50027897A JP50027897A JP4140862B2 JP 4140862 B2 JP4140862 B2 JP 4140862B2 JP 50027897 A JP50027897 A JP 50027897A JP 50027897 A JP50027897 A JP 50027897A JP 4140862 B2 JP4140862 B2 JP 4140862B2
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rabies
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alvac
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パオレッティ,エンゾ
マキ,ジョアンヌ
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ヴァイロジェネティクス コーポレイション
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JP50027897A 1995-06-07 1996-06-03 組換体ポックスウイルス−狂犬病組成物および組合せ組成物並びに使用 Expired - Lifetime JP4140862B2 (ja)

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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767449B1 (en) 1981-12-24 2010-08-03 Health Research Incorporated Methods using modified vaccinia virus
US5505941A (en) * 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US7374768B1 (en) 1990-09-25 2008-05-20 Xenova Research Limited Viral vaccines
US6309647B1 (en) * 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
DE69229390T2 (de) 1991-08-26 1999-11-11 Immuno Ag, Wien Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus
JP3911010B2 (ja) * 1994-04-29 2007-05-09 イムノ・アクテイエンゲゼルシヤフト 必須領域に外来ポリヌクレオチドを有する組換えポックスウイルス
FR2750865B1 (fr) * 1996-06-27 1998-12-04 Rhone Merieux Vaccin vivant recombinant a base d'herpesvirus canin, notamment contre la maladie de carre, la rage ou le virus parainfluenza de type 2
US7294338B2 (en) * 1996-07-19 2007-11-13 Merial Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
US6368603B1 (en) * 1997-03-05 2002-04-09 Merial Limited Lyme combination compositions and uses
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
ES2306670T3 (es) 1999-10-22 2008-11-16 Sanofi Pasteur Limited Procedimiento de induccion y/o intensificacion de la respuesta inmunitaria frente a antigenos tumorales.
PT1248646E (pt) * 1999-12-21 2008-03-19 Merial Sas Composições e vacinas contendo antigénio(s) de cryptosporidium parvum e de outro patógeno entérico
WO2001074845A2 (en) * 2000-03-31 2001-10-11 Aventis Pasteur Limited Immunogenic peptides derived from prostate-specific membrane antigen (psma) and uses thereof
PT1282702E (pt) 2000-05-10 2007-02-28 Ludwig Inst Cancer Res Polipéptidos imunogénicos codificados por minigenes mage e suas utilizações
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
CN101676389A (zh) * 2000-11-23 2010-03-24 巴法里安诺迪克有限公司 改良安卡拉痘苗病毒变体
FR2823222B1 (fr) 2001-04-06 2004-02-06 Merial Sas Vaccin contre le virus de la fievre du nil
US20030228327A1 (en) * 2001-11-05 2003-12-11 Lasher Alfred W. DNA-based plasmid formulations and vaccines and prophylactics containing the same
US20070269456A1 (en) * 2001-11-05 2007-11-22 Lasher Alfred W DNA-based plasmid formulations and vaccines and prophylactics containing the same
PL220781B1 (pl) * 2002-04-19 2016-01-29 Bavarian Nordic As Zastosowanie wirusa krowianki Ankara (MVA) szczepu MVA-BN
EP1499635B8 (en) 2002-05-02 2014-04-16 David Lovejoy Teneurin c-terminal associated peptides (tcap) and uses thereof
DK1434858T4 (en) * 2002-09-05 2019-04-01 Bavarian Nordic As PROCEDURE FOR AMPLIFICATION OF A POXVIRUS UNDER SERUM-FREE CONDITIONS
CN1726276A (zh) * 2002-12-13 2006-01-25 艾文蒂斯·帕斯图尔公司 Alvac在禽胚胎干细胞上的生产
JP2006514549A (ja) * 2002-12-16 2006-05-11 アメリカ合衆国 Il−15を発現する組換えワクチンウイルスおよびその使用方法
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
WO2004110482A1 (en) * 2003-06-13 2004-12-23 Isis Innovation Limited Improved vaccines
US7871768B2 (en) 2003-08-04 2011-01-18 The Hospital For Sick Children Lafora's disease gene
WO2005049794A2 (en) 2003-11-13 2005-06-02 University Of Georgia Research Foundation, Inc. Methods of characterizing infectious bursal disease virus
US20080038353A1 (en) * 2004-06-02 2008-02-14 The Governors Of The University Of Alberta Polymer Based Nano-Carriers For The Solubilization And Delivery Of Hydrophobic Drugs
US7998733B2 (en) 2004-10-05 2011-08-16 Merial Limited Chimeric vectors
RS51324B (sr) 2005-04-25 2010-12-31 Merial Ltd. Vakcine protiv nipah virusa
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
EP3147296A1 (en) 2005-11-14 2017-03-29 Merial, Inc. Gene therapy for renal failure
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
EP2759307B1 (en) 2006-03-29 2016-11-09 Merial Limited Vaccine against Streptococci
US7682619B2 (en) 2006-04-06 2010-03-23 Cornell Research Foundation, Inc. Canine influenza virus
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
EP2094301A4 (en) 2006-11-30 2012-02-01 Taplmmune Inc TREATMENT OF POXVIRIDAE WITH TAP-1 AND / OR TAP-2 AS MOLECULAR ADJUVANS
BRPI0721630A2 (pt) 2007-05-02 2013-10-15 Merial Ltd Plasmídeo de dna tendo expressão e estabilidade aperfeiçoadas
WO2009137577A2 (en) 2008-05-08 2009-11-12 Merial Limited Leishmania vaccine using sand fly salivary immunogen
ES2908705T3 (es) 2008-06-27 2022-05-03 Microsintesis Inc Análisis de moléculas de interferencia de la señal de lactobacillus acidophilus La-5
BR122019001455B1 (pt) 2008-10-24 2021-01-19 Merial, Inc. vacina contra o vírus da doença equina africana
ES2861576T3 (es) 2011-03-21 2021-10-06 Altimmune Inc Agente terapéutico inmunológico de acción rápida y prolongada
US9216213B2 (en) 2011-04-20 2015-12-22 Merial, Inc. Adjuvanted rabies vaccine with improved viscosity profile
ES2674439T3 (es) 2011-06-01 2018-06-29 Merial, Inc. Administración sin aguja de vacunas contra el VSRRP
WO2013012446A1 (en) 2011-07-20 2013-01-24 Merial Limited Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene
WO2013025274A1 (en) 2011-08-12 2013-02-21 Merial Limited Vacuum -assisted preservation of biological products, in particular of vaccines
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
WO2013123242A1 (en) 2012-02-14 2013-08-22 Merial Limited Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom
JP6201166B2 (ja) 2012-03-20 2017-09-27 メリアル インコーポレイテッド 変異糖タンパク質cを含む組換えウマヘルペスウイルス‐1ワクチン及びその使用
WO2013142965A1 (en) 2012-03-27 2013-10-03 The University Of Western Ontario Sh2 domain variants
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
EP2968435B1 (en) 2013-03-12 2019-01-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Synthetic peptides for the treatment of autoimmune diseases
AU2015343369B2 (en) 2014-11-03 2018-11-22 Georgia Tech Research Corporation Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
EP3042666A1 (en) 2015-01-06 2016-07-13 Rheinisch-Westfälische Technische Hochschule Aachen ITIH5 fragments for the treatment of cancer
AU2016253988B2 (en) 2015-04-28 2021-06-10 Avivagen Inc. Oxidized carotenoids and components thereof for preventing necrotic enteritis
TW202203966A (zh) * 2020-03-31 2022-02-01 澳大利亞商賽門蒂斯公司 用於防範covid-19之以減毒的痘病毒載體為底質之疫苗
CN116656730B (zh) * 2023-05-25 2024-03-19 军事科学院军事医学研究院军事兽医研究所 一种表达狂犬病病毒g、m蛋白的重组金丝雀痘病毒及其构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100242671B1 (ko) * 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
US5349741A (en) * 1992-06-24 1994-09-27 L.H. Carbide Corporation Method of making an interlocked core spaced for anneal penetration

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EP0835133A1 (en) 1998-04-15
WO1996040241A1 (en) 1996-12-19
CA2223416A1 (en) 1996-12-19
US5843456A (en) 1998-12-01
EP0835133A4 (en) 2003-01-02
JP2000500115A (ja) 2000-01-11
ES2314980T3 (es) 2009-03-16
DK0835133T3 (da) 2008-12-01
DE69637642D1 (de) 2008-09-25
ATE404220T1 (de) 2008-08-15
AU711472B2 (en) 1999-10-14
EP0835133B1 (en) 2008-08-13

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