JP4090200B2 - 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体 - Google Patents

抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体 Download PDF

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JP4090200B2
JP4090200B2 JP2000598494A JP2000598494A JP4090200B2 JP 4090200 B2 JP4090200 B2 JP 4090200B2 JP 2000598494 A JP2000598494 A JP 2000598494A JP 2000598494 A JP2000598494 A JP 2000598494A JP 4090200 B2 JP4090200 B2 JP 4090200B2
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methyl
chloro
aryl
alkyl
phenyl
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JP2002536444A (ja
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ヤング，ビンウェイ・ヴェラ
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ファイザー・プロダクツ・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000598494A 1999-02-11 2000-02-04 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体 Expired - Fee Related JP4090200B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11970299P 1999-02-11 1999-02-11
US60/119,702 1999-02-11
PCT/IB2000/000121 WO2000047574A1 (en) 1999-02-11 2000-02-04 Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents

Related Child Applications (2)

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JP2004029709A Division JP4216740B2 (ja) 1999-02-11 2004-02-05 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体
JP2004211298A Division JP2005002124A (ja) 1999-02-11 2004-07-20 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体

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JP2002536444A JP2002536444A (ja) 2002-10-29
JP4090200B2 true JP4090200B2 (ja) 2008-05-28

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JP2000598494A Expired - Fee Related JP4090200B2 (ja) 1999-02-11 2000-02-04 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体
JP2004029709A Expired - Fee Related JP4216740B2 (ja) 1999-02-11 2004-02-05 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体
JP2004211298A Pending JP2005002124A (ja) 1999-02-11 2004-07-20 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体

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JP2004211298A Pending JP2005002124A (ja) 1999-02-11 2004-07-20 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体

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US (3) US6258824B1 (OSRAM)
EP (1) EP1150973B1 (OSRAM)
JP (3) JP4090200B2 (OSRAM)
KR (1) KR20010102073A (OSRAM)
CN (1) CN1340051A (OSRAM)
AP (1) AP2001002241A0 (OSRAM)
AR (1) AR028985A1 (OSRAM)
AT (1) ATE297916T1 (OSRAM)
AU (1) AU2124800A (OSRAM)
BG (1) BG105860A (OSRAM)
BR (1) BR0008202A (OSRAM)
CA (1) CA2362394C (OSRAM)
CO (1) CO5140097A1 (OSRAM)
CZ (1) CZ20012910A3 (OSRAM)
DE (1) DE60020812T2 (OSRAM)
DZ (1) DZ3009A1 (OSRAM)
EA (1) EA200100766A1 (OSRAM)
EE (1) EE200100425A (OSRAM)
ES (1) ES2243228T3 (OSRAM)
GT (1) GT200000014A (OSRAM)
HK (1) HK1042096A1 (OSRAM)
HN (1) HN2000000019A (OSRAM)
HR (1) HRP20010574A2 (OSRAM)
HU (1) HUP0105231A3 (OSRAM)
ID (1) ID29584A (OSRAM)
IL (1) IL144307A0 (OSRAM)
IS (1) IS5997A (OSRAM)
MA (1) MA26718A1 (OSRAM)
NO (1) NO20013909L (OSRAM)
OA (1) OA11833A (OSRAM)
PA (1) PA8490601A1 (OSRAM)
PE (1) PE20001464A1 (OSRAM)
PL (1) PL349839A1 (OSRAM)
SK (1) SK11002001A3 (OSRAM)
SV (1) SV2001000020A (OSRAM)
TN (1) TNSN00028A1 (OSRAM)
TR (2) TR200201296T2 (OSRAM)
WO (1) WO2000047574A1 (OSRAM)
ZA (1) ZA200106520B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007326868A (ja) * 2000-01-21 2007-12-20 Osi Pharmaceuticals Inc 抗癌性化合物および前記化合物を合成するのに有用なエナンチオマー分離法

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