JP4078600B2 - フローサイトメトリーに基づく血液学装置 - Google Patents

フローサイトメトリーに基づく血液学装置 Download PDF

Info

Publication number
JP4078600B2
JP4078600B2 JP2002502436A JP2002502436A JP4078600B2 JP 4078600 B2 JP4078600 B2 JP 4078600B2 JP 2002502436 A JP2002502436 A JP 2002502436A JP 2002502436 A JP2002502436 A JP 2002502436A JP 4078600 B2 JP4078600 B2 JP 4078600B2
Authority
JP
Japan
Prior art keywords
reagent
sample
blood cells
concentration
per liter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2002502436A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004506876A (ja
JP2004506876A5 (enExample
Inventor
ダブリュー． ロシェ，ジョン
ハンセン，ダブリュー．ピーター
エフ． ジュリアン，マーカス
シー．ジュニア フライン，ハロルド
ダブリュー． ラッセル，ジェームズ
エル． コールマン，ミシェル
アール． クルーズ，ハロルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idexx Laboratories Inc
Original Assignee
Idexx Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idexx Laboratories Inc filed Critical Idexx Laboratories Inc
Publication of JP2004506876A publication Critical patent/JP2004506876A/ja
Publication of JP2004506876A5 publication Critical patent/JP2004506876A5/ja
Application granted granted Critical
Publication of JP4078600B2 publication Critical patent/JP4078600B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L25/00—Baseband systems
    • H04L25/02—Details ; arrangements for supplying electrical power along data transmission lines
    • H04L25/06—DC level restoring means; Bias distortion correction ; Decision circuits providing symbol by symbol detection
    • H04L25/061—DC level restoring means; Bias distortion correction ; Decision circuits providing symbol by symbol detection providing hard decisions only; arrangements for tracking or suppressing unwanted low frequency components, e.g. removal of DC offset
    • H04L25/063—Setting decision thresholds using feedback techniques only
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/011—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G01N2015/014—Reticulocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Power Engineering (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
JP2002502436A 2000-06-02 2001-05-24 フローサイトメトリーに基づく血液学装置 Expired - Lifetime JP4078600B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20884900P 2000-06-02 2000-06-02
US09/715,593 US6784981B1 (en) 2000-06-02 2000-11-17 Flow cytometry-based hematology system
PCT/US2001/016814 WO2001094938A1 (en) 2000-06-02 2001-05-24 Flow cytometry-based hematology system

Publications (3)

Publication Number Publication Date
JP2004506876A JP2004506876A (ja) 2004-03-04
JP2004506876A5 JP2004506876A5 (enExample) 2005-02-03
JP4078600B2 true JP4078600B2 (ja) 2008-04-23

Family

ID=26903555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002502436A Expired - Lifetime JP4078600B2 (ja) 2000-06-02 2001-05-24 フローサイトメトリーに基づく血液学装置

Country Status (10)

Country Link
US (4) US6784981B1 (enExample)
EP (1) EP1297334B1 (enExample)
JP (1) JP4078600B2 (enExample)
AT (1) ATE546722T1 (enExample)
AU (1) AU6340501A (enExample)
BR (1) BRPI0111373B8 (enExample)
CA (1) CA2410894C (enExample)
ES (1) ES2378352T3 (enExample)
MX (1) MXPA02011826A (enExample)
WO (1) WO2001094938A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180082159A (ko) * 2017-01-10 2018-07-18 엘지이노텍 주식회사 입자 센싱 장치

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264428B1 (en) * 1997-01-31 2017-05-03 Xy, Llc Optical apparatus with focussing reflector for converging radiation onto a flow of particles
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
WO2000052446A1 (en) * 1999-03-02 2000-09-08 Qualigen, Inc. Methods and apparatus for separation of biological fluids
US6284142B1 (en) * 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US6618143B2 (en) * 2000-02-18 2003-09-09 Idexx Laboratories, Inc. High numerical aperture flow cytometer and method of using same
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7130046B2 (en) * 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
US8071051B2 (en) 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20040043433A1 (en) * 2002-01-25 2004-03-04 Satish Deshpande Light scatering determination of treatment potencies
ATE518181T1 (de) * 2001-02-01 2011-08-15 Spectradigital Corp Lichtstreubestimmung von behandlungspotenzen
DE10110066C1 (de) * 2001-03-02 2002-06-20 Parsum Ges Fuer Partikel Stroe Meßsonde zur in-line-Bestimmung der Größe von bewegten Partikeln in transparenten Medien
JP3902939B2 (ja) * 2001-10-26 2007-04-11 株式会社日立ハイテクノロジーズ 標本中の微小領域測定装置及び方法
CA2515064A1 (en) * 2002-02-14 2003-08-21 Mcgill University Device and method for determining parameters
FR2841653B1 (fr) * 2002-06-26 2005-05-27 Abx Sa Procede et dispositif d'analyse d'un echantillon de sang
EP2283724B8 (en) 2002-08-01 2016-03-16 Xy, Llc Heterospermic insemination to assess sperm function
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
EP2305171B1 (en) * 2003-03-28 2021-12-29 Inguran, LLC Apparatus and methods for providing sex-sorted animal sperm
US7092078B2 (en) * 2003-03-31 2006-08-15 Nihon Kohden Corporation Flow cytometer for classifying leukocytes and method for determining detection angle range of the same
NZ544103A (en) * 2003-05-15 2010-10-29 Xy Llc Efficient haploid cell sorting for flow cytometer systems
EP1664721A4 (en) * 2003-09-22 2008-05-21 Becton Dickinson Co QUANTIFYING ANALYSTS USING INNER STANDARDS
US7095492B2 (en) * 2003-12-19 2006-08-22 Beckman Coulter, Inc. Method and apparatus for measuring cell-by-cell hemoglobin
US7002682B2 (en) * 2004-02-13 2006-02-21 Hach Ultra Analytics, Inc. Method and apparatus for operating a laser in an extinction-type optical particle detector
WO2005085803A1 (de) * 2004-03-01 2005-09-15 Firma Cytecs Gmbh Vorrichtung zum messen von licht, welches von mikroskopisch kleinen partikeln oder biologischen zellen ausgeht
JP4417143B2 (ja) * 2004-03-11 2010-02-17 シスメックス株式会社 試料分析装置、プログラムおよびそのプログラムを記録した記録媒体
US20060155178A1 (en) * 2004-03-26 2006-07-13 Vadim Backman Multi-dimensional elastic light scattering
CN104974983A (zh) * 2004-03-29 2015-10-14 英格朗公司 用于授精的精子悬浮液
US7390662B2 (en) * 2005-11-09 2008-06-24 Beckman Coulter, Inc. Method and apparatus for performing platelet measurement
JP4746285B2 (ja) * 2004-06-30 2011-08-10 シスメックス株式会社 血液分析装置、分析プログラム、分画領域設定方法
MX2007000888A (es) * 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
CN100595564C (zh) * 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
US7256891B2 (en) * 2004-08-23 2007-08-14 Beckman Coulter, Inc. Sensor alignment apparatus for an analysis system
US7612871B2 (en) 2004-09-01 2009-11-03 Honeywell International Inc Frequency-multiplexed detection of multiple wavelength light for flow cytometry
FR2883971B1 (fr) * 2005-03-31 2007-11-16 C2 Diagnostics Sa Dispositif optique d'analyse sanguine, appareil d'analyse equipe d'un tel dispositif
FR2883970B1 (fr) * 2005-03-31 2007-11-16 C2 Diagnostics Sa Dispositif hydraulique pour appareil d'analyse sanguine, procede associe et appareil d'analyse equipe d'un tel dispositif
US7580120B2 (en) * 2005-04-07 2009-08-25 Sysmex Corporation Blood analyzer, sample analyzer, and flow cytometer
EP1907818A4 (en) * 2005-07-15 2012-03-14 Biovigilant Systems Inc PATHOGENIC AND PARTICULATE DETECTOR SYSTEM AND METHOD
JP2007024844A (ja) * 2005-07-21 2007-02-01 Sysmex Corp 血液分析方法及び血液分析装置
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
JP4593404B2 (ja) * 2005-08-29 2010-12-08 シスメックス株式会社 液体試料吸引監視方法及び装置、並びに液体試料分析装置
US20070179368A1 (en) * 2005-10-27 2007-08-02 Northwestern University Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content
US20090203977A1 (en) * 2005-10-27 2009-08-13 Vadim Backman Method of screening for cancer using parameters obtained by the detection of early increase in microvascular blood content
US9314164B2 (en) 2005-10-27 2016-04-19 Northwestern University Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps
US20070129615A1 (en) * 2005-10-27 2007-06-07 Northwestern University Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content
US7344890B2 (en) * 2005-11-09 2008-03-18 Beckman Coulter, Inc. Method for discriminating platelets from red blood cells
US7299135B2 (en) * 2005-11-10 2007-11-20 Idexx Laboratories, Inc. Methods for identifying discrete populations (e.g., clusters) of data within a flow cytometer multi-dimensional data set
JP4825562B2 (ja) * 2006-03-30 2011-11-30 シスメックス株式会社 試料測定装置及び試料測定方法
CN101074949B (zh) * 2006-05-17 2011-07-13 深圳迈瑞生物医疗电子股份有限公司 进行样本分配和清洗的装置及方法
EP1862793A1 (en) * 2006-05-29 2007-12-05 Biotest AG High throughput particle counter
FR2907226B1 (fr) * 2006-10-13 2008-12-12 Rhodia Recherches & Tech Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants
CN1945326A (zh) * 2006-10-13 2007-04-11 江西特康科技有限公司 基于视觉形态的五分类全血细胞分析方法
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US7674622B2 (en) * 2006-12-22 2010-03-09 Abbott Laboratories, Inc. Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer
EP3680643A1 (en) 2007-02-01 2020-07-15 Sysmex Corporation Sample analyzer and computer program product
JP4861874B2 (ja) * 2007-03-29 2012-01-25 シスメックス株式会社 分析装置
ATE538377T1 (de) 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
CL2008002118A1 (es) * 2007-07-19 2008-12-19 Xy Llc Metodo para la produccion de un embrion equino de sexo seleccionado mediante la inyeccion intracitoplasmatica de esperma utilizando espermatozoides de equino seleccionados por sexo.
JP5025388B2 (ja) * 2007-08-27 2012-09-12 シスメックス株式会社 試料分析装置及び試料分析方法
US8102528B2 (en) * 2007-09-13 2012-01-24 Brightwell Technologies Inc. Particle standard and method of calibrating or validating an optical particle analyzer
CA2699319A1 (en) * 2007-09-17 2009-03-26 Luminex Corporation Systems, storage mediums, and methods for identifying particles in flow
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8159670B2 (en) * 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US8628976B2 (en) 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
JP5324598B2 (ja) 2007-12-04 2013-10-23 パーティクル・メージャーリング・システムズ・インコーポレーテッド 非直角粒子検出システム及び方法
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
WO2012030313A1 (en) * 2008-04-25 2012-03-08 James Winkelman Method of determining a complete blood count and a white blood cell differential count
US9602777B2 (en) 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
US20100015690A1 (en) * 2008-07-16 2010-01-21 Ortho-Clinical Diagnostics, Inc. Use of fluid aspiration/dispensing tip as a microcentrifuge tube
US8094299B2 (en) * 2008-07-24 2012-01-10 Beckman Coulter, Inc. Transducer module
DK2316022T3 (en) * 2008-08-21 2017-01-16 Xy Llc DEVICE AND METHODS FOR CELL ANALYSIS
EP2335079B1 (en) 2008-09-25 2015-07-01 Agilent Technologies, Inc. Light scattering flow cell device
US8154273B2 (en) * 2008-10-10 2012-04-10 Beckman Coulter, Inc. Detecting and handling coincidence in particle analysis
US8046175B2 (en) * 2008-10-13 2011-10-25 Actherm Inc Analytical strip reading apparatus and the analyical strip used therein
WO2010063141A1 (zh) * 2008-12-05 2010-06-10 红电医学科技股份有限公司 具有可拆卸式韧体装置的检测试片读取机
HU227875B1 (en) 2008-10-13 2012-05-29 Diatron Medicinai Instr Laboratoriumi Diagnosztikai Fejlesztoe Gyarto Zartkoerueen Muekoedoe Reszven Optical circulation cytometer furthermore testing method
PL2356465T3 (pl) * 2008-11-13 2015-04-30 Beckman Coulter Inc Sposób korekcji interferencji cząsteczkowej przy oznaczaniu hemoglobiny
ES2643134T3 (es) * 2008-11-28 2017-11-21 F. Hoffmann-La Roche Ag Sistema y método para el procesamiento de muestras líquidas
US8233146B2 (en) * 2009-01-13 2012-07-31 Becton, Dickinson And Company Cuvette for flow-type particle analyzer
US20100329927A1 (en) * 2009-06-26 2010-12-30 Perez Carlos A Pipelining Assembly For A Blood Analyzing Instrument
WO2011001201A1 (en) * 2009-06-30 2011-01-06 Microbix Biosystems Inc. Method and apparatus for limiting effects of refraction in cytometry
US8665439B2 (en) * 2009-06-30 2014-03-04 Microbix Biosystems, Inc. Method and apparatus for limiting effects of refraction in cytometry
JP5496581B2 (ja) * 2009-08-31 2014-05-21 シスメックス株式会社 検体処理装置
EP2293032A1 (en) 2009-09-04 2011-03-09 Radisens Diagnostic Limited An Integrated Cytometric Sensor System and Method
JP5667353B2 (ja) * 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
JP5530691B2 (ja) * 2009-09-25 2014-06-25 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
US20110129864A1 (en) * 2009-12-02 2011-06-02 Idexx Laboratories, Inc. Method for analyzing lymph node aspirate using multi-angle light scatter flow cytometer
DE102010008446B4 (de) * 2010-02-18 2015-09-03 Hydac Filter Systems Gmbh Vorrichtung zur Bestimmung der Partikeldichte in einem Fluid
RU2587328C2 (ru) * 2010-05-05 2016-06-20 БЕКМАН КАУЛТЕР БАЙОМЕДИКАЛ, ЭлЭлСи Диагностическая система и компоненты
US9091677B2 (en) 2010-08-09 2015-07-28 Beckman Coulter, Inc. Isotonic buffered composition and method that enables counting of cells
EP3246709A3 (en) 2010-09-16 2018-02-14 The General Hospital Corporation Red blood cell dynamics for diagnosis
US9111343B2 (en) 2011-01-18 2015-08-18 Roche Diagnostics Hematology, Inc. Microscope slide coordinate system registration
CA2826914C (en) 2011-02-15 2020-12-01 Microbix Biosystems Inc. Methods, systems, and apparatus for performing flow cytometry
US8730460B2 (en) * 2011-04-08 2014-05-20 William Marsh Rice University Paper based spectrophotometric detection of blood hemoglobin concentration
WO2012142496A1 (en) 2011-04-15 2012-10-18 Constitution Medical, Inc. Measuring volume and constituents of cells
CA2833636A1 (en) 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
US20120274925A1 (en) * 2011-04-26 2012-11-01 Yong Chen Axial light loss sensor system for flow cytometery
US8502976B2 (en) * 2011-05-12 2013-08-06 Inguran, Llc UV diode laser excitation in flow cytometry
US8964171B2 (en) 2011-07-22 2015-02-24 Roche Diagnostics Hematology, Inc. Identifying and measuring reticulocytes
US9459196B2 (en) 2011-07-22 2016-10-04 Roche Diagnostics Hematology, Inc. Blood analyzer calibration and assessment
KR102104987B1 (ko) 2011-12-01 2020-04-28 파티클 머슈어링 시스템즈, 인크. 입자 크기 및 농도 측정을 위한 검출 스킴
CN104272083B (zh) 2012-02-24 2018-01-02 英士查诺尔有限公司 用于预处理细胞的系统、设备和装置
JP5543512B2 (ja) * 2012-03-09 2014-07-09 シスメックス株式会社 試料分析装置及び試料分析方法
WO2013158506A2 (en) * 2012-04-17 2013-10-24 Ehrenkranz Joel R L Device for performing a blood, cell, and/or pathogen count and methods for use thereof
KR101411428B1 (ko) * 2012-07-12 2014-06-24 한국과학기술원 집광식 휴대용 형광 검출 시스템
US10101260B2 (en) 2013-03-15 2018-10-16 Beckman Coulter, Inc. Optics system for a flow cytometer
WO2014144585A1 (en) 2013-03-15 2014-09-18 Beckman Coulter, Inc. Radiated light filtering for a flow cytometer
EP2997363A4 (en) * 2013-05-13 2016-11-30 Chiranjit Deka APPARATUS AND METHODS FOR CELL ANALYSIS
JP6225085B2 (ja) * 2013-08-30 2017-11-01 シスメックス株式会社 検体分析方法および検体分析装置
US10451482B2 (en) 2014-02-14 2019-10-22 Palo Alto Research Center Incorporated Determination of color characteristics of objects using spatially modulated light
US9207066B2 (en) 2014-02-14 2015-12-08 Palo Alto Research Center Incorporated Spatial modulation of light to determine dimensional characteristics of objects in a flow path
US9952033B2 (en) 2014-02-14 2018-04-24 Palo Alto Research Center Incorporated Spatial modulation of light to determine object length
US9528925B2 (en) 2014-02-14 2016-12-27 Palo Alto Research Center Incorporated Spatial modulation of light to determine object position
US9114606B1 (en) 2014-04-07 2015-08-25 Palo Alto Research Center Incorporated Spatial light modulation method for determining droplet motion characteristics
US9400174B2 (en) 2014-04-07 2016-07-26 Palo Alto Research Center Incorporated Monitor for particle injector
JP2016080563A (ja) * 2014-10-20 2016-05-16 日本光電工業株式会社 分析システム、分析装置
US9833557B2 (en) 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
US10641698B2 (en) 2015-06-12 2020-05-05 Cytochip Inc. Methods for complete blood count measurement
US10151682B2 (en) * 2015-07-14 2018-12-11 Teilch Llc Airborne particle measuring device
US10613096B2 (en) 2015-08-28 2020-04-07 Captl Llc Multi-spectral microparticle-fluorescence photon cytometry
WO2017078672A1 (en) 2015-11-02 2017-05-11 Chiranjit Deka Light scatter based apparatus and methods for hematology analysis using only three detectors
HU230997B1 (hu) 2015-11-12 2019-09-30 Norma Instruments Zrt Javított mérési jellemzőkkel rendelkező mérőegység
WO2017087707A1 (en) * 2015-11-18 2017-05-26 Beckman Coulter, Inc. Filtering device for analyzing instrument
WO2017106461A1 (en) 2015-12-15 2017-06-22 The General Hospital Corporation Methods of estimating blood glucose and related systems
FR3046238B1 (fr) * 2015-12-24 2018-01-26 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede d’observation d’un echantillon par imagerie sans lentille
WO2017177192A1 (en) 2016-04-07 2017-10-12 The General Hospital Corporation White blood cell population dynamics
CN110199186B (zh) * 2016-11-22 2023-01-10 芯易诊有限公司 全血细胞计数测量方法
WO2018098142A1 (en) * 2016-11-22 2018-05-31 Cytochip Inc. Methods for complete blood count measurement
EP3610231A2 (en) 2017-04-13 2020-02-19 Captl LLC Photon counting and spectroscopy
JP7134184B2 (ja) * 2017-05-25 2022-09-09 アボット・ラボラトリーズ 試料分析のための方法およびシステム
US11874224B2 (en) * 2017-07-26 2024-01-16 Hamamatsu Photonics K.K. Sample observation device and sample observation method
JP7002245B2 (ja) * 2017-08-10 2022-01-20 シスメックス株式会社 血液分析装置、血液分析方法およびプログラム
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
JP7222604B2 (ja) * 2017-12-12 2023-02-15 日本光電工業株式会社 血液分析方法および血液分析装置
EP3723608B1 (en) * 2017-12-15 2023-10-11 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments
US10720755B2 (en) * 2018-02-07 2020-07-21 Elfi-Tech Ltd. Ensemble-averaged measurement of stochastic motion by current-modulating of VCSEL wavelength
US11358148B2 (en) 2018-03-30 2022-06-14 Idexx Laboratories, Inc. Point-of-care diagnostic systems and containers for same
US11541396B2 (en) 2018-03-30 2023-01-03 Idexx Laboratories, Inc. Point-of-care diagnostic systems and containers for same
ES2975718T3 (es) 2018-03-30 2024-07-12 Idexx Lab Inc Ensamblaje de óptica láser de citómetro de flujo
JP7204769B2 (ja) 2018-03-30 2023-01-16 アイデックス ラボラトリーズ インコーポレイテッド ポイント・オブ・ケア診断システムのための品質管理
WO2019206297A1 (zh) * 2018-04-28 2019-10-31 深圳迈瑞生物医疗电子股份有限公司 一种血液分析仪及分析方法
WO2020095296A1 (en) 2018-11-11 2020-05-14 Biobeat Technologies Ltd Wearable apparatus and method for monitoring medical properties
WO2020102038A1 (en) * 2018-11-12 2020-05-22 Particle Measuring Systems, Inc. Calibration verification for optical particle analyzers
US11671407B2 (en) * 2019-03-25 2023-06-06 Agostino Sibillo Laser light communications device for securely transmitting data
CN114729868A (zh) * 2019-11-22 2022-07-08 粒子监测系统有限公司 先进的用于干涉测量颗粒检测和具有小大小尺寸的颗粒的检测的系统和方法
US10813578B1 (en) 2019-12-26 2020-10-27 Biobeat Technologies Ltd. Sensor device for optical measurement of biological properties
MA55471A (fr) 2019-12-27 2022-02-09 Beckman Coulter Inc Instrument de préparation d'échantillons
US11385163B2 (en) * 2020-02-19 2022-07-12 Becton, Dickinson And Company Interferometric detection of an object on a surface using wavelength modulation and systems for same
JP2023526690A (ja) 2020-06-17 2023-06-22 アイデックス ラボラトリーズ インコーポレイテッド フローサイトメータ及びそのレーザ光学アセンブリ
EP3988921B1 (en) 2020-10-23 2025-04-30 Sysmex Corporation Flow cytometer and method of flow cytometry
CN114486645A (zh) * 2020-11-13 2022-05-13 深圳安侣医学科技有限公司 细胞悬浮液样品成像方法和系统及试剂盒
EP4030162A1 (en) * 2021-01-15 2022-07-20 Technische Universität München Calibration of devices for optical analysis of blood samples
US20240302264A1 (en) * 2021-05-10 2024-09-12 The Regents Of The University Of California Methods of analyzing shaped particles containing cells using fluorescence activated cell sorting
US20220400983A1 (en) * 2021-06-21 2022-12-22 Instrumentation Laboratory Company Determining a platelet aggregation value
WO2023010447A1 (zh) * 2021-08-05 2023-02-09 深圳迈瑞动物医疗科技股份有限公司 一种样本分析装置、动物用分析装置和样本分析方法
CN113820260B (zh) * 2021-09-30 2023-07-18 深圳市科曼医疗设备有限公司 用户状态检测方法、装置、设备和介质
CN114067315B (zh) * 2021-10-23 2022-11-29 广州市艾贝泰生物科技有限公司 细胞计数方法、装置、计算机设备和存储介质
WO2023158803A1 (en) 2022-02-18 2023-08-24 Idexx Laboratories Inc. Flow cytometry systems and methods for presenting two‑dimensional dot plot
JP2025509397A (ja) * 2022-03-11 2025-04-11 ベックマン コールター， インコーポレイテッド コントロールおよび分析器におけるその使用
WO2024019988A1 (en) * 2022-07-18 2024-01-25 Cellsbin, Inc. Devices for biological analysis
CA3271367A1 (en) 2022-11-07 2024-05-16 Idexx Laboratories Inc. SYSTEMS AND METHODS FOR IDENTIFYING PATHOLOGICAL STATES OF BLOOD BY DOT PATTERN ANALYSIS
CN116242776B (zh) * 2023-02-24 2025-09-23 深圳市科曼医疗设备有限公司 光学校准方法、装置、设备和介质
US20240345114A1 (en) * 2023-04-13 2024-10-17 Beckman Coulter, Inc. Sample preparation
WO2025183852A1 (en) * 2024-02-27 2025-09-04 Beckman Coulter, Inc. Tuning for flow cytometer

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013368A (en) * 1972-09-20 1977-03-22 Akro-Medic Engineering, Inc. Sample cartridge for use in apparatus for evaluation of biological fluid
US3925018A (en) * 1973-06-08 1975-12-09 Technicon Instr Method and apparatus for quantitative analysis utilizing particulate reagent material
US4043669A (en) * 1976-05-28 1977-08-23 The United States Of America As Represented By The Secretary Of The Air Force Light scattering test apparatus
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4250394A (en) * 1979-07-19 1981-02-10 Akzona Incorporated Apparatus for determining immunochemical substances
US4818103A (en) * 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4565448A (en) * 1983-03-11 1986-01-21 E. I. Du Pont De Nemours And Company Particle counting apparatus
US4606636A (en) * 1983-10-25 1986-08-19 Universite De Saint-Etienne Optical apparatus for identifying the individual multiparametric properties of particles or bodies in a continuous flow
US4735504A (en) 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US5380663A (en) 1984-12-24 1995-01-10 Caribbean Microparticles Corporation Automated system for performance analysis and fluorescence quantitation of samples
US5093234A (en) 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US5084394A (en) 1984-12-24 1992-01-28 Vogt Robert F Method for corrective calibration of a flow cytometry using a mixture of fluorescent microbeads and cells
US4868126A (en) 1985-12-11 1989-09-19 Flow Cytometry Standards Corporation Method of calibrating a fluorescent microscope using fluorescent calibration microbeads simulating stained cells
NL8601000A (nl) * 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling Het gebruik van gepolariseerd licht in stromingscytometrie.
US5179026A (en) * 1986-11-27 1993-01-12 Toa Medical Electronics Co., Ltd. Method of classifying leukocytes by flow cytometry and reagents used in the method
US5155044A (en) * 1987-03-13 1992-10-13 Coulter Electronics, Inc. Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples
KR970007077B1 (ko) * 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 광산란 기술을 이용한 다중-부분식별 분석 방법
US5217704A (en) * 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5408307A (en) * 1988-07-11 1995-04-18 Omron Tateisi Electronics Co. Cell analyzer
CA2016699C (en) * 1989-05-15 2003-11-18 Paul N. Marshall Lytic agents and uses thereof
US4954715A (en) * 1989-06-26 1990-09-04 Zoeld Tibor Method and apparatus for an optimized multiparameter flow-through particle and cell analyzer
IE76732B1 (en) * 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
DE4109118C2 (de) * 1991-03-20 1995-04-06 Lange Gmbh Dr Bruno Verfahren zum automatischen Auswerten eines Probeninhaltsstoffes einer Wasserprobe
JP3067849B2 (ja) * 1991-07-29 2000-07-24 シスメックス株式会社 白血球分類計数用試料調製方法
JP3048260B2 (ja) * 1991-07-29 2000-06-05 シスメックス株式会社 白血球分類計数用試料調製方法
US5350695A (en) * 1991-12-05 1994-09-27 Miles Inc. Methods for the identification and characterization of reticulocytes in whole blood
US5360739A (en) * 1991-12-05 1994-11-01 Miles Inc. Methods for the identification and characterization of reticulocytes in whole blood
US5284771A (en) * 1991-12-05 1994-02-08 Miles Inc. Reagent compositions and their use in sphering cells
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
JP2804873B2 (ja) * 1992-12-17 1998-09-30 三菱電機株式会社 微粒子分析装置および微粒子分析方法
US5728351A (en) * 1993-01-21 1998-03-17 Cdc Technologies, Inc. Apparatus for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures
US5467189A (en) * 1993-01-22 1995-11-14 Venturedyne, Ltd. Improved particle sensor and method for assaying a particle
US5585246A (en) * 1993-02-17 1996-12-17 Biometric Imaging, Inc. Method for preparing a sample in a scan capillary for immunofluorescent interrogation
JP3707620B2 (ja) * 1993-05-14 2005-10-19 コールター インターナショナル コーポレイション 光散乱技術を使用した網赤血球分析方法と装置
EP1245286B1 (en) * 1993-10-22 2009-11-25 Abbott Laboratories Reaction tube and method of use to minimize contamination
JP3328032B2 (ja) 1993-11-04 2002-09-24 シスメックス株式会社 粒子分析装置
US5475487A (en) * 1994-04-20 1995-12-12 The Regents Of The University Of California Aqueous carrier waveguide in a flow cytometer
DE69527465T2 (de) * 1994-04-21 2003-05-08 Hitachi, Ltd. Überwachungsverfahren einer Färbelösung für Partikelanalysen und Kalibrierungsverfahren von Partikelanalysen
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
US5631165A (en) * 1994-08-01 1997-05-20 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
JP3375203B2 (ja) * 1994-08-08 2003-02-10 シスメックス株式会社 細胞分析装置
DE69521006T2 (de) * 1994-10-20 2001-09-20 Sysmex Corp., Kobe Reagenz und Verfahren zur Analyse fester Bestandteile im Harn
JP3324050B2 (ja) * 1994-10-31 2002-09-17 日本光電工業株式会社 白血球分類用試薬および白血球分類方法
US5691204A (en) * 1995-04-21 1997-11-25 Abbott Laboratories Compositions and methods for the rapid analysis of reticulocytes
US5650847A (en) * 1995-06-14 1997-07-22 Erkki Soini Method and device for determination of parameters of individual microparticles
US5624037A (en) * 1995-07-12 1997-04-29 Rubbermaid Office Products Inc. Collapsible letter tray kit
US5733784A (en) * 1995-11-20 1998-03-31 Abbott Laboratories Reagent system and method for the differentiation and identification of reticulocytes
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US5729582A (en) * 1996-05-31 1998-03-17 Ham; Young S. Method and apparatus for determining both density and atomic number of a material composition using Compton scattering
US5872627A (en) * 1996-07-30 1999-02-16 Bayer Corporation Method and apparatus for detecting scattered light in an analytical instrument
US5858667A (en) * 1996-09-06 1999-01-12 Litron Laboratories Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer
US5798827A (en) * 1996-11-26 1998-08-25 Coulter International Corp. Apparatus and method for determination of individual red blood cell shape
DE19700648A1 (de) * 1997-01-10 1998-07-23 Basf Ag Verfahren und Vorrichtung zur Bestimmung der Größenverteilung von verschiedenartigen Partikeln in einer Probe
US6074879A (en) * 1997-06-23 2000-06-13 Bayer Corporation Synthetic polymer particles for use as standards and calibrators in flow cytometry
US6410337B1 (en) * 1997-09-18 2002-06-25 Helena Laboratories Corporation Method of platlet function analysis using platelet count
US5917584A (en) * 1997-11-21 1999-06-29 Coulter International Corp. Method for differentiation of nucleated red blood cells
US5874310A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
US5874311A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of reticulocytes in blood
US6261519B1 (en) * 1998-07-20 2001-07-17 Lifescan, Inc. Medical diagnostic device with enough-sample indicator
US6067157A (en) * 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
US6271035B1 (en) * 1998-10-20 2001-08-07 Coulter International Corp. Methods and compositions for rapid staining of nucleic acids in whole cells
JP2000214070A (ja) * 1999-01-21 2000-08-04 Sysmex Corp シ―スフロ―セルとそれを用いた血液分析装置
US6228652B1 (en) * 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6232125B1 (en) * 1999-08-09 2001-05-15 Coulter International Corp. Method and apparatus for differentiating and enumerating leukocytes
US6478452B1 (en) 2000-01-19 2002-11-12 Coherent, Inc. Diode-laser line-illuminating system
US6320656B1 (en) * 2000-02-18 2001-11-20 Idexx Laboratories, Inc. High numerical aperture flow cytometer and method of using same
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US7053783B2 (en) * 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180082159A (ko) * 2017-01-10 2018-07-18 엘지이노텍 주식회사 입자 센싱 장치
KR102644216B1 (ko) * 2017-01-10 2024-03-05 엘지이노텍 주식회사 입자 센싱 장치

Also Published As

Publication number Publication date
US7064823B2 (en) 2006-06-20
BRPI0111373B1 (pt) 2015-09-22
US20060203226A1 (en) 2006-09-14
CA2410894A1 (en) 2001-12-13
CA2410894C (en) 2013-04-16
ATE546722T1 (de) 2012-03-15
AU6340501A (en) 2001-12-17
WO2001094938A9 (en) 2002-10-10
EP1297334A4 (en) 2006-05-17
BR0111373A (pt) 2004-02-10
USRE42143E1 (en) 2011-02-15
MXPA02011826A (es) 2004-05-17
BRPI0111373B8 (pt) 2021-07-27
US20030030783A1 (en) 2003-02-13
JP2004506876A (ja) 2004-03-04
US7324194B2 (en) 2008-01-29
EP1297334A1 (en) 2003-04-02
WO2001094938A1 (en) 2001-12-13
EP1297334B1 (en) 2012-02-22
ES2378352T3 (es) 2012-04-11
US6784981B1 (en) 2004-08-31

Similar Documents

Publication Publication Date Title
JP4078600B2 (ja) フローサイトメトリーに基づく血液学装置
JP4468590B2 (ja) 全血液サンプルにおけるセル分析方法および装置
US11193875B2 (en) Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer
JP2863511B2 (ja) 自動分析の方法および装置
CN101074914B (zh) 尿中粒子分析仪及其方法
JP4184258B2 (ja) 光学式赤血球および白血球の弁別
US9097704B2 (en) Method for hematology analysis
Keohane Automated blood cell analysis
AU2001263405B2 (en) Flow cytometry-based hematology system
AU2001263405A1 (en) Flow cytometry-based hematology system

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060510

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070911

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071211

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20080115

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20080123

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110215

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4078600

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120215

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130215

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140215

Year of fee payment: 6

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term