JP4004088B2 - 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 - Google Patents

免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 Download PDF

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Publication number
JP4004088B2
JP4004088B2 JP26910596A JP26910596A JP4004088B2 JP 4004088 B2 JP4004088 B2 JP 4004088B2 JP 26910596 A JP26910596 A JP 26910596A JP 26910596 A JP26910596 A JP 26910596A JP 4004088 B2 JP4004088 B2 JP 4004088B2
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Prior art keywords
protein
cells
ifn
production
cell
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Expired - Fee Related
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JP26910596A
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English (en)
Japanese (ja)
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JPH09289896A5 (enExample
JPH09289896A (ja
Inventor
研志 穐田
善之 額田
光清 藤井
忠雄 谷本
雅司 栗本
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Hayashibara Seibutsu Kagaku Kenkyujo KK
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Hayashibara Seibutsu Kagaku Kenkyujo KK
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Priority to JP26910596A priority Critical patent/JP4004088B2/ja
Priority to CA002186423A priority patent/CA2186423C/en
Priority to EP96306997A priority patent/EP0767178A1/en
Priority to AU65881/96A priority patent/AU724940B2/en
Priority to NZ299943A priority patent/NZ299943A/en
Priority to US08/832,198 priority patent/US6242255B1/en
Publication of JPH09289896A publication Critical patent/JPH09289896A/ja
Priority to US09/752,510 priority patent/US6441138B2/en
Priority to US09/819,902 priority patent/US6403079B1/en
Publication of JPH09289896A5 publication Critical patent/JPH09289896A5/ja
Priority to KR1020040101627A priority patent/KR100491365B1/ko
Priority to US11/580,922 priority patent/US7355014B2/en
Application granted granted Critical
Publication of JP4004088B2 publication Critical patent/JP4004088B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP26910596A 1994-11-15 1996-09-20 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 Expired - Fee Related JP4004088B2 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP26910596A JP4004088B2 (ja) 1995-09-26 1996-09-20 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質
CA002186423A CA2186423C (en) 1995-09-26 1996-09-25 Protein which induces interferon-gamma production by immunocompetent cell
EP96306997A EP0767178A1 (en) 1995-09-26 1996-09-26 Protein which induces interferon-gamma production by immunocompetent cell
AU65881/96A AU724940B2 (en) 1995-09-26 1996-09-26 Protein which induces interferon-gamma production by immunocompetent cell
NZ299943A NZ299943A (en) 1996-09-20 1996-12-16 Protein stimulator of ifn-gamma in immunocompetant cells
US08/832,198 US6242255B1 (en) 1995-09-26 1997-04-08 Protein which induces interferon-gamma production by immunocompetent cell
US09/752,510 US6441138B2 (en) 1995-09-26 2001-01-03 Protein which induces interferon-γ production by immunocompetent cell
US09/819,902 US6403079B1 (en) 1995-09-26 2001-03-29 Process for producing a pharmaceutical composition containing a protein which induces interferon-γ production by an immunocompetent cell
KR1020040101627A KR100491365B1 (en) 1995-09-26 2004-12-06 Protein which induces interferon-gamma production by immunocompetent cell
US11/580,922 US7355014B2 (en) 1994-11-15 2006-10-16 Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7-270725 1995-09-26
JP27072595 1995-09-26
JP6743496 1996-02-29
JP8-67434 1996-02-29
JP26910596A JP4004088B2 (ja) 1995-09-26 1996-09-20 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質

Publications (3)

Publication Number Publication Date
JPH09289896A JPH09289896A (ja) 1997-11-11
JPH09289896A5 JPH09289896A5 (enExample) 2004-09-30
JP4004088B2 true JP4004088B2 (ja) 2007-11-07

Family

ID=27299437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP26910596A Expired - Fee Related JP4004088B2 (ja) 1994-11-15 1996-09-20 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質

Country Status (6)

Country Link
US (3) US6242255B1 (enExample)
EP (1) EP0767178A1 (enExample)
JP (1) JP4004088B2 (enExample)
KR (1) KR100491365B1 (enExample)
AU (1) AU724940B2 (enExample)
CA (1) CA2186423C (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135458B1 (en) * 1995-11-15 2006-11-14 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use
CA2238885A1 (en) * 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP3955352B2 (ja) 1997-02-25 2007-08-08 株式会社林原生物化学研究所 破骨細胞形成阻害剤
TWI227136B (en) * 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
US6432678B1 (en) 1999-06-21 2002-08-13 Smithkline Beecham Corporation Macaca cynomolgus IL 18
CA2399148A1 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
US20030044398A1 (en) * 2001-03-20 2003-03-06 Robl James M. Methods for producing antibodies in mammals
MD2053C2 (ro) * 2001-07-10 2003-07-31 Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова Remediu cu acţiune interferonogenă
JP4059648B2 (ja) * 2001-08-28 2008-03-12 独立行政法人科学技術振興機構 経口用サイトカイン誘導剤
EP1613274B1 (en) 2003-04-15 2010-03-03 GlaxoSmithKline LLC Human il-18 substitution mutants and their conjugates
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2005277404A1 (en) 2004-08-20 2006-03-02 Smithkline Beecham Corporation Methods of healing wounds by administering human IL-18
BRPI0707958B8 (pt) * 2006-02-17 2021-07-27 Sekiyama Atsuo composição e kit para testar condições mentais por uma análise de regressão logística e método de medição de condições mentais
AR065803A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Uso de un polipeptido de il- 18 humana y un anticuerpo anti- cd para preparar unmedicamento
US8168165B2 (en) 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
CN106687124B (zh) 2014-08-07 2022-03-15 冈村春树 并用il-18与分子靶向抗体的癌治疗药

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2016015B (en) * 1978-01-22 1982-05-06 Hayashibara Co Method of preparing interferon and preparations containing interferon
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
JP3109018B2 (ja) 1994-07-14 2000-11-13 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導する蛋白質
DE69519454T2 (de) * 1994-07-14 2001-05-03 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen
TW464656B (en) * 1994-11-15 2001-11-21 Hayashibara Biochem Lab Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease
JP2724987B2 (ja) * 1994-11-15 1998-03-09 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導するポリペプチド
EP1669454A3 (en) * 1996-06-27 2009-04-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma
JPH1080270A (ja) * 1996-07-19 1998-03-31 Hayashibara Biochem Lab Inc ポリペプチドをプロセッシングする酵素
US5891662A (en) * 1997-11-13 1999-04-06 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic hydrophobic microorganism

Also Published As

Publication number Publication date
CA2186423A1 (en) 1997-03-27
AU724940B2 (en) 2000-10-05
US20010018212A1 (en) 2001-08-30
KR100491365B1 (en) 2005-05-24
US6242255B1 (en) 2001-06-05
AU6588196A (en) 1997-05-15
CA2186423C (en) 2007-06-26
EP0767178A1 (en) 1997-04-09
US6403079B1 (en) 2002-06-11
JPH09289896A (ja) 1997-11-11
US6441138B2 (en) 2002-08-27

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