JP3761898B2 - 生体特異性二光子励起蛍光検出方法およびそのための装置 - Google Patents

生体特異性二光子励起蛍光検出方法およびそのための装置 Download PDF

Info

Publication number
JP3761898B2
JP3761898B2 JP52523798A JP52523798A JP3761898B2 JP 3761898 B2 JP3761898 B2 JP 3761898B2 JP 52523798 A JP52523798 A JP 52523798A JP 52523798 A JP52523798 A JP 52523798A JP 3761898 B2 JP3761898 B2 JP 3761898B2
Authority
JP
Japan
Prior art keywords
reaction
concentration
analyte
laser beam
time
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP52523798A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001506750A5 (https=
JP2001506750A (ja
Inventor
ソイニ，エルッキ
ハンニネン，ペッカ
ソイニ，ユハニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI964826A external-priority patent/FI104586B/fi
Priority claimed from FI971626A external-priority patent/FI104585B/fi
Application filed by Individual filed Critical Individual
Publication of JP2001506750A publication Critical patent/JP2001506750A/ja
Publication of JP2001506750A5 publication Critical patent/JP2001506750A5/ja
Application granted granted Critical
Publication of JP3761898B2 publication Critical patent/JP3761898B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP52523798A 1996-12-03 1997-11-18 生体特異性二光子励起蛍光検出方法およびそのための装置 Expired - Lifetime JP3761898B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FI964826A FI104586B (fi) 1996-12-03 1996-12-03 Menetelmä bioaffiniteettireaktion reaaliaikaista seuraamista varten
FI971626A FI104585B (fi) 1997-04-17 1997-04-17 Menetelmä bioaffiniteettimäärityksen dynamiikan laajentamiseksi
FI964826 1997-04-17
FI971626 1997-04-17
PCT/FI1997/000704 WO1998025143A1 (en) 1996-12-03 1997-11-18 Biospecific, two photon excitation, fluorescence detection and device

Publications (3)

Publication Number Publication Date
JP2001506750A JP2001506750A (ja) 2001-05-22
JP2001506750A5 JP2001506750A5 (https=) 2004-10-28
JP3761898B2 true JP3761898B2 (ja) 2006-03-29

Family

ID=26160267

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52523798A Expired - Lifetime JP3761898B2 (ja) 1996-12-03 1997-11-18 生体特異性二光子励起蛍光検出方法およびそのための装置

Country Status (6)

Country Link
US (1) US6361956B1 (https=)
EP (1) EP0968425B1 (https=)
JP (1) JP3761898B2 (https=)
AU (1) AU5054198A (https=)
DE (1) DE69723111T2 (https=)
WO (1) WO1998025143A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5054198A (en) * 1996-12-03 1998-06-29 Erkki Soini Biospecific, two photon excitation, fluorescence detection and device
US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
DE19935766A1 (de) * 1999-07-29 2001-02-01 Friedrich Schiller Uni Jena Bu Verfahren zur optischen Anregung von Fluorophor-markierter DNA und RNA
US7008559B2 (en) * 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
US7501092B2 (en) * 2001-06-06 2009-03-10 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
RU2296333C2 (ru) 2001-07-02 2007-03-27 Арктик Диагностикс Ой Красители на основе дифторида дипиррометенбора с двухфотонным поглощением и их применение
US7067072B2 (en) * 2001-08-17 2006-06-27 Nomadics, Inc. Nanophase luminescence particulate material
EP1460414B1 (en) * 2001-12-27 2018-09-19 ARKRAY, Inc. Concentration measuring method
US20070189359A1 (en) * 2002-06-12 2007-08-16 Wei Chen Nanoparticle thermometry and pressure sensors
US7315378B2 (en) 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
US7317532B2 (en) 2003-06-04 2008-01-08 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
US7239394B2 (en) 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
GB2402475A (en) * 2003-06-04 2004-12-08 Inverness Medical Switzerland Analyte assay reading providing prompt result declaration
GB2450351B (en) 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
ITUD20080162A1 (it) * 2008-07-08 2010-01-09 Alifax Spa Procedimento e relativa apparecchiatura per l'esecuzione di analisi diagnostiche
GB2474224A (en) * 2009-07-07 2011-04-13 Toximet Ltd Devices and methods using fluorescent polymers in solid phase extraction
CN103025859A (zh) 2010-05-25 2013-04-03 阿尔利克斯公司 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用
US8828329B2 (en) 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
FI20115285A0 (fi) * 2011-03-24 2011-03-24 Reagena Ltd Oy Menetelmä pikatestin suorittamiseksi
US9588113B2 (en) * 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
FI20165148A (fi) * 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
CN109470863B (zh) * 2016-11-22 2021-12-17 科美博阳诊断技术(上海)有限公司 免疫测定方法、用于鉴定免疫测定的系统和试剂盒
JP6980800B2 (ja) * 2016-11-22 2021-12-15 ケムクリン・ダイアグノスティックス・カンパニー・リミテッド Ｈｄ−ｈｏｏｋ効果サンプルと免疫測定を同定する方法、システム、キット及び装置
EP3619537A4 (en) * 2017-05-03 2021-03-10 Bluelight Therapeutics, Inc. Methods of determining protein structure using two-photon fluorescence measurements
TWI614502B (zh) * 2017-07-26 2018-02-11 國立成功大學 分析物濃度的檢測方法
CN110514651A (zh) * 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
CN111795956B (zh) * 2020-06-29 2021-11-02 中国科学院苏州生物医学工程技术研究所 一种判断均相时间分辨荧光免疫分析钩状效应的方法
US12546717B1 (en) * 2021-04-07 2026-02-10 Alignedbio Ab Optical molecular nanowire sensor and method

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760548A (en) * 1986-06-13 1988-07-26 International Business Machines Corporation Method and apparatus for producing a curve image
US5171688A (en) * 1988-08-30 1992-12-15 Cholestech Corporation Self-corrected assay device
US5100627A (en) * 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
US5198369A (en) * 1990-04-25 1993-03-30 Canon Kabushiki Kaisha Sample measuring method using agglomeration reaction of microcarriers
DK0723146T3 (da) * 1992-09-14 2004-08-30 Stanford Res Inst Int Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker
EP0679251B1 (de) * 1993-01-18 1998-04-08 Evotec BioSystems GmbH Verfahren und vorrichtung zur bewertung der fitness von biopolymeren
US5469255A (en) * 1993-01-28 1995-11-21 Kamada; Kenji Method and apparatus for spectrometric measurement of particulate surfaces
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
FI96452C (fi) 1994-01-26 1996-06-25 Pekka Haenninen Menetelmä väriaineiden virittämiseksi
US5512745A (en) * 1994-03-09 1996-04-30 Board Of Trustees Of The Leland Stanford Jr. University Optical trap system and method
FI98765C (fi) 1995-01-16 1997-08-11 Erkki Soini Virtaussytometrinen menetelmä ja laite
FI101829B1 (fi) 1995-03-07 1998-08-31 Erkki Juhani Soini Biospesifinen määritysmenetelmä
US5891738A (en) 1995-01-16 1999-04-06 Erkki Soini Biospecific multiparameter assay method
US5631141A (en) * 1995-05-05 1997-05-20 The Regents Of The University Of California High resolution biosensor for in-situ microthermometry
US5620857A (en) * 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
AU5054198A (en) * 1996-12-03 1998-06-29 Erkki Soini Biospecific, two photon excitation, fluorescence detection and device

Also Published As

Publication number Publication date
WO1998025143A1 (en) 1998-06-11
DE69723111D1 (de) 2003-07-31
DE69723111T2 (de) 2004-02-19
US6361956B1 (en) 2002-03-26
EP0968425A1 (en) 2000-01-05
AU5054198A (en) 1998-06-29
EP0968425B1 (en) 2003-06-25
JP2001506750A (ja) 2001-05-22

Similar Documents

Publication Publication Date Title
JP3761898B2 (ja) 生体特異性二光子励起蛍光検出方法およびそのための装置
US5192510A (en) Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
CN102869982B (zh) 光学分析装置、光学分析方法
EP0670043B1 (en) Ligand assay using interference modulation
US5028545A (en) Biospecific multianalyte assay method
US7221457B2 (en) Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
JP6019144B2 (ja) ラベル粒子を検出するマイクロエレクトロニクスセンサデバイス
JP2013533469A (ja) 免疫診断における生物学的および化学的分析および用途における粒子の位置的自由度の検出のための方法および装置
US7652768B2 (en) Chemical sensing apparatus and chemical sensing method
US20090203154A1 (en) Method for Sensing a Chemical
JP2009531696A (ja) 改良型ｓｅｒｒｓ基材
JPH11503824A (ja) 生物特異性アッセイ法
WO2005095927A1 (ja) 局在プラズモン共鳴センサ及び検査装置
JP2007240361A (ja) 局在プラズモン増強センサ
EP2810042A1 (fr) Dispositif et procede pour effectuer des mesures hematologiques et biochimiques a partir d'un echantillon biologique
US12345625B2 (en) Microscopic object detection device, detection system, and detection method
JP2013512450A (ja) ビーズリーダ
JP2008157923A (ja) 化学センシング装置及び化学センシング方法
JP3400430B2 (ja) 固相、二光子励起および共焦点蛍光検出を用いた生体特異的均一アッセイ
Soini et al. Two-photon fluorescence excitation in detection of biomolecules
US6342397B1 (en) Homogeneous biospecific assay using a solid phase, two-photon excitation and confocal fluorescence detection
JPS59150325A (ja) 粒子または細胞の個々の性質の連続流束測定装置
Kumarswami Development of a multiplexing biosensor platform using SERS particle immunoassay technology
HK1183686A (en) Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050614

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20050906

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20051017

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051031

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20051213

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20060112

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100120

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100120

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110120

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110120

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120120

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120120

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130120

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term