JP3760096B2 - 磁気粒子の局部的蓄積を定量的に測定する方法及び装置 - Google Patents

磁気粒子の局部的蓄積を定量的に測定する方法及び装置 Download PDF

Info

Publication number
JP3760096B2
JP3760096B2 JP2000522455A JP2000522455A JP3760096B2 JP 3760096 B2 JP3760096 B2 JP 3760096B2 JP 2000522455 A JP2000522455 A JP 2000522455A JP 2000522455 A JP2000522455 A JP 2000522455A JP 3760096 B2 JP3760096 B2 JP 3760096B2
Authority
JP
Japan
Prior art keywords
sample
magnetic field
sensor
sensor element
pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000522455A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001524675A5 (enExample
JP2001524675A (ja
Inventor
シモンズ，マイケル，バンクロフト
Original Assignee
クォンタム デザイン，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クォンタム デザイン，インク． filed Critical クォンタム デザイン，インク．
Publication of JP2001524675A publication Critical patent/JP2001524675A/ja
Publication of JP2001524675A5 publication Critical patent/JP2001524675A5/ja
Application granted granted Critical
Publication of JP3760096B2 publication Critical patent/JP3760096B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Magnetic Variables (AREA)
JP2000522455A 1997-11-21 1998-08-27 磁気粒子の局部的蓄積を定量的に測定する方法及び装置 Expired - Lifetime JP3760096B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/975,569 US6046585A (en) 1997-11-21 1997-11-21 Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto
US08/975,569 1997-11-21
PCT/US1998/017815 WO1999027369A1 (en) 1997-11-21 1998-08-27 Method and apparatus for making quantitave measurements of localized accumulations of magnetic particles

Publications (3)

Publication Number Publication Date
JP2001524675A JP2001524675A (ja) 2001-12-04
JP2001524675A5 JP2001524675A5 (enExample) 2006-02-09
JP3760096B2 true JP3760096B2 (ja) 2006-03-29

Family

ID=25523154

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000522455A Expired - Lifetime JP3760096B2 (ja) 1997-11-21 1998-08-27 磁気粒子の局部的蓄積を定量的に測定する方法及び装置

Country Status (14)

Country Link
US (2) US6046585A (enExample)
EP (1) EP1036328B1 (enExample)
JP (1) JP3760096B2 (enExample)
KR (1) KR100389778B1 (enExample)
CN (1) CN1128365C (enExample)
AT (1) ATE280390T1 (enExample)
AU (1) AU9207998A (enExample)
BR (1) BR9815566B1 (enExample)
CA (1) CA2311301C (enExample)
DE (1) DE69827158T2 (enExample)
DK (1) DK1036328T3 (enExample)
ES (1) ES2232020T3 (enExample)
IL (1) IL136211A (enExample)
WO (1) WO1999027369A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012011477A1 (ja) * 2010-07-21 2012-01-26 株式会社日立製作所 磁場計測装置

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437563B1 (en) * 1997-11-21 2002-08-20 Quantum Design, Inc. Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
WO2000049407A2 (de) * 1999-02-17 2000-08-24 Kilian Hennes Verfahren zum darstellen von biologisch aktivierten induktivitätsändernden partikeln sowie vorrichtung dafür
JP4171139B2 (ja) * 1999-07-21 2008-10-22 住友電気工業株式会社 磁性体標識による免疫検査方法とその装置
US6875621B2 (en) * 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
US6743639B1 (en) 1999-10-13 2004-06-01 Nve Corporation Magnetizable bead detector
JP2001147230A (ja) * 1999-11-19 2001-05-29 Hitachi Software Eng Co Ltd バイオチップ読取装置及び標識試薬
RU2166751C1 (ru) * 2000-03-09 2001-05-10 Никитин Петр Иванович Способ анализа смеси биологических и/или химических компонентов с использованием магнитных частиц и устройство для его осуществления
US7241630B2 (en) * 2000-04-10 2007-07-10 Randox Laboratories, Ltd. Paramagnetic particle detection
DE10020376A1 (de) * 2000-04-26 2001-11-08 Inst Zelltechnologie E V Dynamische Marker
US6736978B1 (en) 2000-12-13 2004-05-18 Iowa State University Research Foundation, Inc. Method and apparatus for magnetoresistive monitoring of analytes in flow streams
US6518747B2 (en) * 2001-02-16 2003-02-11 Quantum Design, Inc. Method and apparatus for quantitative determination of accumulations of magnetic particles
CN1136923C (zh) * 2001-03-13 2004-02-04 张兴东 血磁机动磁场的充磁装置
US20030124194A1 (en) * 2002-01-02 2003-07-03 Gaw Debra A. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
US8697029B2 (en) * 2002-04-18 2014-04-15 The Regents Of The University Of Michigan Modulated physical and chemical sensors
US7105359B2 (en) 2002-11-12 2006-09-12 Matsushita Electric Industrial Co., Ltd. Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same
DE10309132A1 (de) * 2003-02-28 2004-11-18 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel
DE602004022395D1 (de) 2003-04-16 2009-09-17 Sekisui Chemical Co Ltd Verfahren zur herstellung eines partikels mit darin eingebautem magnetischen material
KR20060054351A (ko) * 2003-07-30 2006-05-22 코닌클리케 필립스 일렉트로닉스 엔.브이. 개선된 신호대 잡음비를 가진 온칩 자기 입자 센서
JP3962385B2 (ja) 2004-03-11 2007-08-22 株式会社日立製作所 免疫検査装置及び免疫検査方法
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
JP2005315677A (ja) * 2004-04-28 2005-11-10 Canon Inc 検出装置および検出方法
EP1774334B1 (en) * 2004-08-03 2017-10-04 Becton, Dickinson and Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
US7391091B2 (en) * 2004-09-29 2008-06-24 Nve Corporation Magnetic particle flow detector
JP4669259B2 (ja) * 2004-10-15 2011-04-13 旭化成株式会社 被検物質分析装置及び定量方法
EP1886278B1 (en) * 2004-12-14 2018-02-21 Philips Intellectual Property & Standards GmbH Method of determining a spatial distribution of magnetic particles
US20060154260A1 (en) * 2005-01-07 2006-07-13 Barbour William M Sample preparation methods for diagnostic analyses
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7405555B2 (en) * 2005-05-27 2008-07-29 Philip Morris Usa Inc. Systems and methods for measuring local magnetic susceptibility including one or more balancing elements with a magnetic core and a coil
JP4758713B2 (ja) * 2005-08-30 2011-08-31 旭化成株式会社 磁気センサを用いた測定装置及び測定方法
GB0522968D0 (en) 2005-11-11 2005-12-21 Popovich Milan M Holographic illumination device
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
JP4676361B2 (ja) * 2006-03-09 2011-04-27 株式会社日立製作所 磁気的免疫検査装置
US8337755B2 (en) * 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
US8945946B2 (en) * 2006-03-31 2015-02-03 Canon Kabushiki Kaisha Sensor element and detection method of magnetic particles using this element, and detection method of target substance
GB0718706D0 (en) 2007-09-25 2007-11-07 Creative Physics Ltd Method and apparatus for reducing laser speckle
FR2900143B1 (fr) 2006-04-24 2010-08-13 Alcan Packaging Capsules Procede de capsule et capsule de bouchage correspondante
FR2909169B1 (fr) * 2006-11-29 2009-02-06 Billanco Dispositif et procede de mesure de la position d'une piece mobile.
JP5970153B2 (ja) * 2006-12-19 2016-08-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 凝集パラメータの測定
EP2118206B9 (en) 2007-02-09 2018-08-29 Visen Medical, Inc. Polycyclo dyes and use thereof
US9068977B2 (en) * 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
US8927260B2 (en) * 2007-03-12 2015-01-06 Fabrico Technology, Inc. Anaylte detection system using an oscillating magnetic field
US8076161B2 (en) * 2007-05-31 2011-12-13 Canon Kabushiki Kaisha Target substance detection kit and target substance detection method
DK2171098T3 (en) * 2007-06-29 2018-05-22 Becton Dickinson Co PROCEDURES FOR EXTRACTION AND CLEANING COMPONENTS IN BIOLOGICAL SAMPLES
WO2009007797A1 (en) * 2007-07-09 2009-01-15 Koninklijke Philips Electronics N.V. Microelectronic sensor device with magnetic field generator and carrier
US8354280B2 (en) * 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US7994780B2 (en) * 2007-09-14 2011-08-09 General Electric Company System and method for inspection of parts with an eddy current probe
EP2240776B1 (en) * 2008-02-06 2014-12-24 Koninklijke Philips N.V. Magnetic bead actuation using feedback for ftir biosensor
CN101603962B (zh) * 2008-06-10 2013-09-11 熊慧 一种免疫纳米磁珠诊断试剂盒
US11726332B2 (en) 2009-04-27 2023-08-15 Digilens Inc. Diffractive projection apparatus
US9335604B2 (en) 2013-12-11 2016-05-10 Milan Momcilo Popovich Holographic waveguide display
US10634741B2 (en) * 2009-12-04 2020-04-28 Endomagnetics Ltd. Magnetic probe apparatus
FI124980B (fi) 2010-01-20 2015-04-15 Hemeltron Ferromagneettisten hiukkasten mittausjärjestelmä
US10101326B2 (en) 2010-02-23 2018-10-16 B.R.A.H.M.S Gmbh Method for determining a marker in small volume of a sample of a bodily fluid
DE102010009161A1 (de) 2010-02-24 2011-08-25 Technische Hochschule Mittelhessen, 35390 Verbesserung der Nachweisgrenze von magnetisch markierten Proben
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
WO2012027747A2 (en) 2010-08-27 2012-03-01 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation sensing systems and methods
US20140099663A1 (en) * 2010-11-15 2014-04-10 Regents Of The University Of Minnesota Gmr sensor
US9274349B2 (en) 2011-04-07 2016-03-01 Digilens Inc. Laser despeckler based on angular diversity
WO2012142179A2 (en) 2011-04-11 2012-10-18 The Regents Of The University Of Michigan Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells
KR101664175B1 (ko) 2011-07-12 2016-10-11 푸드체크 시스템스, 아이엔씨. 살모넬라 및 대장균을 배양하기 위한 배양 배지, 방법 및 살모넬라 및 대장균을 검출하기 위한 방법
US10670876B2 (en) 2011-08-24 2020-06-02 Digilens Inc. Waveguide laser illuminator incorporating a despeckler
WO2016020630A2 (en) 2014-08-08 2016-02-11 Milan Momcilo Popovich Waveguide laser illuminator incorporating a despeckler
EP2995986B1 (en) 2011-08-24 2017-04-12 Rockwell Collins, Inc. Data display
US20150010265A1 (en) 2012-01-06 2015-01-08 Milan, Momcilo POPOVICH Contact image sensor using switchable bragg gratings
EP2842003B1 (en) 2012-04-25 2019-02-27 Rockwell Collins, Inc. Holographic wide angle display
US9797817B2 (en) 2012-05-03 2017-10-24 The Regents Of The University Of Michigan Multi-mode separation for target detection
US9456744B2 (en) 2012-05-11 2016-10-04 Digilens, Inc. Apparatus for eye tracking
US9933684B2 (en) 2012-11-16 2018-04-03 Rockwell Collins, Inc. Transparent waveguide display providing upper and lower fields of view having a specific light output aperture configuration
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US8968677B2 (en) 2013-01-22 2015-03-03 Quantum Design International, Inc. Frazil ice conjugate assay device and method
WO2014144793A1 (en) 2013-03-15 2014-09-18 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
EP2970674B1 (en) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
CN103217365B (zh) * 2013-03-29 2015-04-08 电子科技大学 一种在线油路磨粒监测装置
WO2014188149A1 (en) 2013-05-20 2014-11-27 Milan Momcilo Popovich Holographic waveguide eye tracker
WO2015015138A1 (en) 2013-07-31 2015-02-05 Milan Momcilo Popovich Method and apparatus for contact image sensing
US9983110B2 (en) 2013-11-04 2018-05-29 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes
US10359736B2 (en) 2014-08-08 2019-07-23 Digilens Inc. Method for holographic mastering and replication
US10241330B2 (en) 2014-09-19 2019-03-26 Digilens, Inc. Method and apparatus for generating input images for holographic waveguide displays
WO2016046514A1 (en) 2014-09-26 2016-03-31 LOKOVIC, Kimberly, Sun Holographic waveguide opticaltracker
EP3245444B1 (en) 2015-01-12 2021-09-08 DigiLens Inc. Environmentally isolated waveguide display
EP3245551B1 (en) 2015-01-12 2019-09-18 DigiLens Inc. Waveguide light field displays
CN107533137A (zh) 2015-01-20 2018-01-02 迪吉伦斯公司 全息波导激光雷达
US9632226B2 (en) 2015-02-12 2017-04-25 Digilens Inc. Waveguide grating device
US10459145B2 (en) 2015-03-16 2019-10-29 Digilens Inc. Waveguide device incorporating a light pipe
WO2016156776A1 (en) 2015-03-31 2016-10-06 Milan Momcilo Popovich Method and apparatus for contact image sensing
KR101904784B1 (ko) * 2015-09-07 2018-10-05 한국전자통신연구원 단일 여기 코일 기반의 비선형 마그네틱 파티클 검출 장치 및 방법
CN108474945B (zh) 2015-10-05 2021-10-01 迪吉伦斯公司 波导显示器
EP3398007B1 (en) 2016-02-04 2024-09-11 DigiLens, Inc. Waveguide optical tracker
EP3433659B1 (en) 2016-03-24 2024-10-23 DigiLens, Inc. Method and apparatus for providing a polarization selective holographic waveguide device
WO2017178781A1 (en) 2016-04-11 2017-10-19 GRANT, Alastair, John Holographic waveguide apparatus for structured light projection
KR101904781B1 (ko) * 2016-10-12 2018-10-05 한국전자통신연구원 Fmmd 기술의 신호 분석을 위한 신호 송수신 방법 및 이를 이용한 장치
EP3548939A4 (en) 2016-12-02 2020-11-25 DigiLens Inc. UNIFORM OUTPUT LIGHTING WAVEGUIDE DEVICE
WO2018129398A1 (en) 2017-01-05 2018-07-12 Digilens, Inc. Wearable heads up displays
EP3698214A4 (en) 2017-10-16 2021-10-27 Digilens Inc. SYSTEMS AND METHODS FOR MULTIPLICATION OF THE IMAGE RESOLUTION OF A PIXELIZED DISPLAY
US10914950B2 (en) 2018-01-08 2021-02-09 Digilens Inc. Waveguide architectures and related methods of manufacturing
KR20250004154A (ko) 2018-01-08 2025-01-07 디지렌즈 인코포레이티드. 광 도파관의 제조 방법
CN111566571B (zh) 2018-01-08 2022-05-13 迪吉伦斯公司 波导单元格中全息光栅高吞吐量记录的系统和方法
WO2019135837A1 (en) 2018-01-08 2019-07-11 Digilens, Inc. Systems and methods for manufacturing waveguide cells
KR102839391B1 (ko) 2018-03-16 2025-07-28 디지렌즈 인코포레이티드. 복굴절 제어가 통합된 홀로그래픽 도파관 및 이를 제조하는 방법
US11402801B2 (en) 2018-07-25 2022-08-02 Digilens Inc. Systems and methods for fabricating a multilayer optical structure
DE102018215457A1 (de) 2018-09-12 2020-03-12 Siemens Healthcare Gmbh Anpassbare MR-Lokalspule
US20200225471A1 (en) 2019-01-14 2020-07-16 Digilens Inc. Holographic Waveguide Display with Light Control Layer
WO2020163524A1 (en) 2019-02-05 2020-08-13 Digilens Inc. Methods for compensating for optical surface nonuniformity
KR20250150160A (ko) 2019-02-15 2025-10-17 디지렌즈 인코포레이티드. 일체형 격자를 이용하여 홀로그래픽 도파관 디스플레이를 제공하기 위한 방법 및 장치
US20220283377A1 (en) 2019-02-15 2022-09-08 Digilens Inc. Wide Angle Waveguide Display
US20200292745A1 (en) 2019-03-12 2020-09-17 Digilens Inc. Holographic Waveguide Backlight and Related Methods of Manufacturing
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
US11609208B2 (en) 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
US12121896B2 (en) 2019-04-12 2024-10-22 Roche Sequencing Solutions, Inc. Nucleic acid sequencing by synthesis using magnetic sensor arrays
CN114207492A (zh) 2019-06-07 2022-03-18 迪吉伦斯公司 带透射光栅和反射光栅的波导及其生产方法
KR20220038452A (ko) 2019-07-29 2022-03-28 디지렌즈 인코포레이티드. 픽셀화된 디스플레이의 이미지 해상도와 시야를 증배하는 방법 및 장치
US11442222B2 (en) 2019-08-29 2022-09-13 Digilens Inc. Evacuated gratings and methods of manufacturing
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
US11747329B2 (en) * 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
KR20230119015A (ko) 2020-12-21 2023-08-14 디지렌즈 인코포레이티드. 도파로 기반 디스플레이에서의 홍목현상 억제 기술
WO2022150841A1 (en) 2021-01-07 2022-07-14 Digilens Inc. Grating structures for color waveguides
US12158612B2 (en) 2021-03-05 2024-12-03 Digilens Inc. Evacuated periodic structures and methods of manufacturing

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
GB8408529D0 (en) * 1984-04-03 1984-05-16 Health Lab Service Board Concentration of biological particles
JPS6390765A (ja) * 1986-10-03 1988-04-21 Nippon Telegr & Teleph Corp <Ntt> Ｓｑｕｉｄ免疫測定法
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
JPH0619469B2 (ja) * 1988-04-13 1994-03-16 大和製衡株式会社 金属等の異物混入検出器
US5001424A (en) * 1989-02-03 1991-03-19 Product Resources, Inc. Apparatus for measuring magnetic particles suspended in a fluid based on fluctuations in an induced voltage
TW199858B (enExample) 1990-03-30 1993-02-11 Fujirebio Kk
FR2679660B1 (fr) 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
US5445971A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445970A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
TW351766B (en) * 1993-05-17 1999-02-01 Fujirebio Kk Method and apparatus for indirect agglutination immunoassay
US5486457A (en) * 1993-08-25 1996-01-23 Children's Medical Center Corporation Method and system for measurement of mechanical properties of molecules and cells
US5656429A (en) * 1994-10-03 1997-08-12 Adelman; Lonnie W. Polynucleotide and protein analysis method using magnetizable moieties

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012011477A1 (ja) * 2010-07-21 2012-01-26 株式会社日立製作所 磁場計測装置
JP5560334B2 (ja) * 2010-07-21 2014-07-23 株式会社日立製作所 磁場計測装置

Also Published As

Publication number Publication date
BR9815566A (pt) 2000-10-31
CA2311301C (en) 2005-01-18
EP1036328A1 (en) 2000-09-20
IL136211A (en) 2003-04-10
EP1036328B1 (en) 2004-10-20
BR9815566B1 (pt) 2011-02-08
ES2232020T3 (es) 2005-05-16
CN1128365C (zh) 2003-11-19
IL136211A0 (en) 2001-05-20
AU9207998A (en) 1999-06-15
DE69827158T2 (de) 2005-10-13
CN1279764A (zh) 2001-01-10
US6046585A (en) 2000-04-04
KR100389778B1 (ko) 2003-07-02
KR20010032302A (ko) 2001-04-16
HK1033771A1 (en) 2001-09-21
CA2311301A1 (en) 1999-06-03
ATE280390T1 (de) 2004-11-15
US6275031B1 (en) 2001-08-14
WO1999027369A1 (en) 1999-06-03
DE69827158D1 (de) 2004-11-25
DK1036328T3 (da) 2005-01-31
JP2001524675A (ja) 2001-12-04

Similar Documents

Publication Publication Date Title
JP3760096B2 (ja) 磁気粒子の局部的蓄積を定量的に測定する方法及び装置
JP4657552B2 (ja) 磁性粒子の蓄積の測定方法及び装置
JP4817581B2 (ja) 磁性粒子を用いた生物学的および／または化学的混合物の分析
US8217647B2 (en) Measuring agglutination parameters
EP1421382B1 (en) Methdo and arrangement for analyzing substances
CN1457434A (zh) 用于检测和测量磁性微粒积聚物的方法和装置
Larsson et al. Magnetic transducers in biosensors and bioassays
JP5188091B2 (ja) センサ素子、ならびにこの素子を用いた磁性粒子の検出方法及び標的物質の検出方法
JP2021067687A (ja) 磁場センサ及び磁性粒子を使用して関心分析対象を検出する方法とシステム
CN101627297A (zh) 测量凝集参数
HK1033771B (en) Apparatus and methods for employing magnetic particles for quantitative measurement of target particles

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20040816

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20041115

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20041203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050509

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20050805

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20050822

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20051018

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20051021

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20051028

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051108

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20051108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20051116

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20051220

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20060106

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090113

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100113

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110113

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110113

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120113

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130113

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130113

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term