BR9815566B1 - equipamento para o emprego de partìculas magnéticas para medição quantitativa de partìculas meta ou alvo bem como método para medir quantitativamente partìculas meta ou alvo acopladas a partìculas magnéticas. - Google Patents
equipamento para o emprego de partìculas magnéticas para medição quantitativa de partìculas meta ou alvo bem como método para medir quantitativamente partìculas meta ou alvo acopladas a partìculas magnéticas. Download PDFInfo
- Publication number
- BR9815566B1 BR9815566B1 BRPI9815566-0A BR9815566A BR9815566B1 BR 9815566 B1 BR9815566 B1 BR 9815566B1 BR 9815566 A BR9815566 A BR 9815566A BR 9815566 B1 BR9815566 B1 BR 9815566B1
- Authority
- BR
- Brazil
- Prior art keywords
- magnetic field
- particles
- magnetic
- sensor
- substrate
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 28
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims description 24
- 238000005259 measurement Methods 0.000 title claims description 6
- 230000005291 magnetic effect Effects 0.000 claims abstract description 44
- 239000000758 substrate Substances 0.000 claims description 26
- 239000004020 conductor Substances 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 7
- 230000010355 oscillation Effects 0.000 claims description 7
- 230000003071 parasitic effect Effects 0.000 claims description 3
- 238000003491 array Methods 0.000 claims description 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 230000003750 conditioning effect Effects 0.000 claims 1
- 230000004992 fission Effects 0.000 claims 1
- 230000005284 excitation Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 2
- 230000004044 response Effects 0.000 description 8
- 239000003446 ligand Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000009739 binding Methods 0.000 description 4
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 241000238366 Cephalopoda Species 0.000 description 3
- 230000035508 accumulation Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 1
- 244000089486 Phragmites australis subsp australis Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000002887 superconductor Substances 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/975,569 | 1997-11-21 | ||
| US08/975,569 US6046585A (en) | 1997-11-21 | 1997-11-21 | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| PCT/US1998/017815 WO1999027369A1 (en) | 1997-11-21 | 1998-08-27 | Method and apparatus for making quantitave measurements of localized accumulations of magnetic particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9815566A BR9815566A (pt) | 2000-10-31 |
| BR9815566B1 true BR9815566B1 (pt) | 2011-02-08 |
Family
ID=25523154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9815566-0A BR9815566B1 (pt) | 1997-11-21 | 1998-08-27 | equipamento para o emprego de partìculas magnéticas para medição quantitativa de partìculas meta ou alvo bem como método para medir quantitativamente partìculas meta ou alvo acopladas a partìculas magnéticas. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6046585A (enExample) |
| EP (1) | EP1036328B1 (enExample) |
| JP (1) | JP3760096B2 (enExample) |
| KR (1) | KR100389778B1 (enExample) |
| CN (1) | CN1128365C (enExample) |
| AT (1) | ATE280390T1 (enExample) |
| AU (1) | AU9207998A (enExample) |
| BR (1) | BR9815566B1 (enExample) |
| CA (1) | CA2311301C (enExample) |
| DE (1) | DE69827158T2 (enExample) |
| DK (1) | DK1036328T3 (enExample) |
| ES (1) | ES2232020T3 (enExample) |
| IL (1) | IL136211A (enExample) |
| WO (1) | WO1999027369A1 (enExample) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437563B1 (en) * | 1997-11-21 | 2002-08-20 | Quantum Design, Inc. | Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes |
| AU4102000A (en) * | 1999-02-17 | 2000-09-04 | Kilian Hennes | Method for representing biologically activated inductance-altering particles anddevice for carrying out the method |
| JP4171139B2 (ja) * | 1999-07-21 | 2008-10-22 | 住友電気工業株式会社 | 磁性体標識による免疫検査方法とその装置 |
| US6875621B2 (en) * | 1999-10-13 | 2005-04-05 | Nve Corporation | Magnetizable bead detector |
| US6743639B1 (en) | 1999-10-13 | 2004-06-01 | Nve Corporation | Magnetizable bead detector |
| JP2001147230A (ja) * | 1999-11-19 | 2001-05-29 | Hitachi Software Eng Co Ltd | バイオチップ読取装置及び標識試薬 |
| RU2166751C1 (ru) * | 2000-03-09 | 2001-05-10 | Никитин Петр Иванович | Способ анализа смеси биологических и/или химических компонентов с использованием магнитных частиц и устройство для его осуществления |
| US7241630B2 (en) * | 2000-04-10 | 2007-07-10 | Randox Laboratories, Ltd. | Paramagnetic particle detection |
| DE10020376A1 (de) * | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| US6736978B1 (en) | 2000-12-13 | 2004-05-18 | Iowa State University Research Foundation, Inc. | Method and apparatus for magnetoresistive monitoring of analytes in flow streams |
| US6518747B2 (en) | 2001-02-16 | 2003-02-11 | Quantum Design, Inc. | Method and apparatus for quantitative determination of accumulations of magnetic particles |
| CN1136923C (zh) * | 2001-03-13 | 2004-02-04 | 张兴东 | 血磁机动磁场的充磁装置 |
| AU2003207438A1 (en) * | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| US8697029B2 (en) * | 2002-04-18 | 2014-04-15 | The Regents Of The University Of Michigan | Modulated physical and chemical sensors |
| US7105359B2 (en) | 2002-11-12 | 2006-09-12 | Matsushita Electric Industrial Co., Ltd. | Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same |
| DE10309132A1 (de) * | 2003-02-28 | 2004-11-18 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel |
| KR101115903B1 (ko) | 2003-04-16 | 2012-02-13 | 세키스이가가쿠 고교가부시키가이샤 | 자성체 내포 입자 및 그의 제조 방법, 면역 측정용 입자,및 면역 측정 방법 |
| JP2007500347A (ja) * | 2003-07-30 | 2007-01-11 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 改善されたｓｎｒを持つチップ上磁性粒子センサ |
| JP3962385B2 (ja) | 2004-03-11 | 2007-08-22 | 株式会社日立製作所 | 免疫検査装置及び免疫検査方法 |
| US20050239091A1 (en) * | 2004-04-23 | 2005-10-27 | Collis Matthew P | Extraction of nucleic acids using small diameter magnetically-responsive particles |
| JP2005315677A (ja) * | 2004-04-28 | 2005-11-10 | Canon Inc | 検出装置および検出方法 |
| CA2839092C (en) * | 2004-08-03 | 2018-04-03 | Becton, Dickinson And Company | Use of magnetic material to direct isolation of compounds and fractionation of multipart samples |
| US7391091B2 (en) * | 2004-09-29 | 2008-06-24 | Nve Corporation | Magnetic particle flow detector |
| JP4669259B2 (ja) * | 2004-10-15 | 2011-04-13 | 旭化成株式会社 | 被検物質分析装置及び定量方法 |
| CN100527168C (zh) * | 2004-12-14 | 2009-08-12 | 皇家飞利浦电子股份有限公司 | 确定磁性粒子的空间分布的方法 |
| US20060154260A1 (en) * | 2005-01-07 | 2006-07-13 | Barbour William M | Sample preparation methods for diagnostic analyses |
| US7648844B2 (en) * | 2005-05-02 | 2010-01-19 | Bioscale, Inc. | Method and apparatus for detection of analyte using an acoustic device |
| US7611908B2 (en) * | 2005-05-02 | 2009-11-03 | Bioscale, Inc. | Method and apparatus for therapeutic drug monitoring using an acoustic device |
| US7749445B2 (en) * | 2005-05-02 | 2010-07-06 | Bioscale, Inc. | Method and apparatus for analyzing bioprocess fluids |
| US7300631B2 (en) * | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
| US7405555B2 (en) * | 2005-05-27 | 2008-07-29 | Philip Morris Usa Inc. | Systems and methods for measuring local magnetic susceptibility including one or more balancing elements with a magnetic core and a coil |
| JP4758713B2 (ja) * | 2005-08-30 | 2011-08-31 | 旭化成株式会社 | 磁気センサを用いた測定装置及び測定方法 |
| GB0522968D0 (en) | 2005-11-11 | 2005-12-21 | Popovich Milan M | Holographic illumination device |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| JP4676361B2 (ja) * | 2006-03-09 | 2011-04-27 | 株式会社日立製作所 | 磁気的免疫検査装置 |
| US8337755B2 (en) * | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
| US8945946B2 (en) * | 2006-03-31 | 2015-02-03 | Canon Kabushiki Kaisha | Sensor element and detection method of magnetic particles using this element, and detection method of target substance |
| GB0718706D0 (en) | 2007-09-25 | 2007-11-07 | Creative Physics Ltd | Method and apparatus for reducing laser speckle |
| FR2900143B1 (fr) | 2006-04-24 | 2010-08-13 | Alcan Packaging Capsules | Procede de capsule et capsule de bouchage correspondante |
| FR2909169B1 (fr) * | 2006-11-29 | 2009-02-06 | Billanco | Dispositif et procede de mesure de la position d'une piece mobile. |
| US8217647B2 (en) * | 2006-12-19 | 2012-07-10 | Koninklijke Philips Electronics N.V. | Measuring agglutination parameters |
| JP5643514B2 (ja) | 2007-02-09 | 2014-12-17 | ビセン メディカル， インコーポレイテッド | ポリシクロ染料およびその使用 |
| US9068977B2 (en) * | 2007-03-09 | 2015-06-30 | The Regents Of The University Of Michigan | Non-linear rotation rates of remotely driven particles and uses thereof |
| US8076161B2 (en) * | 2007-05-31 | 2011-12-13 | Canon Kabushiki Kaisha | Target substance detection kit and target substance detection method |
| CA2692186C (en) * | 2007-06-29 | 2019-03-12 | Becton, Dickinson And Company | Methods for extraction and purification of components of biological samples |
| EP2175997A1 (en) * | 2007-07-09 | 2010-04-21 | Philips Intellectual Property & Standards GmbH | Microelectronic sensor device with magnetic field generator and carrier |
| US8354280B2 (en) * | 2007-09-06 | 2013-01-15 | Bioscale, Inc. | Reusable detection surfaces and methods of using same |
| US7994780B2 (en) * | 2007-09-14 | 2011-08-09 | General Electric Company | System and method for inspection of parts with an eddy current probe |
| CN101939646B (zh) * | 2008-02-06 | 2014-05-14 | 皇家飞利浦电子股份有限公司 | 用于ftir生物传感器的使用反馈的磁珠致动 |
| CN101603962B (zh) * | 2008-06-10 | 2013-09-11 | 熊慧 | 一种免疫纳米磁珠诊断试剂盒 |
| US9335604B2 (en) | 2013-12-11 | 2016-05-10 | Milan Momcilo Popovich | Holographic waveguide display |
| US11726332B2 (en) | 2009-04-27 | 2023-08-15 | Digilens Inc. | Diffractive projection apparatus |
| US10634741B2 (en) * | 2009-12-04 | 2020-04-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
| FI124980B (fi) | 2010-01-20 | 2015-04-15 | Hemeltron | Ferromagneettisten hiukkasten mittausjärjestelmä |
| WO2011100358A2 (en) * | 2010-02-09 | 2011-08-18 | Fabrico Technology, Inc. | Systems and methods for detecting target analytes |
| JP6130143B2 (ja) | 2010-02-23 | 2017-05-17 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 少量の体液試料中のマーカーを判定する方法 |
| DE102010009161A1 (de) | 2010-02-24 | 2011-08-25 | Technische Hochschule Mittelhessen, 35390 | Verbesserung der Nachweisgrenze von magnetisch markierten Proben |
| US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
| US20130121879A1 (en) * | 2010-07-21 | 2013-05-16 | Hitachi, Ltd. | Magnetic-Field Measurement Device |
| US8846331B2 (en) | 2010-08-27 | 2014-09-30 | The Regents Of The University Of Michigan | Asynchronous magnetic bead rotation sensing systems and methods |
| US9778225B2 (en) * | 2010-11-15 | 2017-10-03 | Regents Of The University Of Minnesota | Magnetic search coil for measuring real-time brownian relaxation of magnetic nanoparticles |
| US9274349B2 (en) | 2011-04-07 | 2016-03-01 | Digilens Inc. | Laser despeckler based on angular diversity |
| US9816993B2 (en) | 2011-04-11 | 2017-11-14 | The Regents Of The University Of Michigan | Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells |
| GB2497249B (en) | 2011-07-12 | 2016-12-28 | Foodchek Systems Inc | Culture medium,method for culturing salmonella and e.coli and method for detecting salmonella and e.coli |
| US20140204455A1 (en) | 2011-08-24 | 2014-07-24 | Milan Momcilo Popovich | Wearable data display |
| US10670876B2 (en) | 2011-08-24 | 2020-06-02 | Digilens Inc. | Waveguide laser illuminator incorporating a despeckler |
| WO2016020630A2 (en) | 2014-08-08 | 2016-02-11 | Milan Momcilo Popovich | Waveguide laser illuminator incorporating a despeckler |
| US20150010265A1 (en) | 2012-01-06 | 2015-01-08 | Milan, Momcilo POPOVICH | Contact image sensor using switchable bragg gratings |
| JP6238965B2 (ja) | 2012-04-25 | 2017-11-29 | ロックウェル・コリンズ・インコーポレーテッド | ホログラフィック広角ディスプレイ |
| US9797817B2 (en) | 2012-05-03 | 2017-10-24 | The Regents Of The University Of Michigan | Multi-mode separation for target detection |
| WO2013167864A1 (en) | 2012-05-11 | 2013-11-14 | Milan Momcilo Popovich | Apparatus for eye tracking |
| US9933684B2 (en) | 2012-11-16 | 2018-04-03 | Rockwell Collins, Inc. | Transparent waveguide display providing upper and lower fields of view having a specific light output aperture configuration |
| US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
| US8968677B2 (en) | 2013-01-22 | 2015-03-03 | Quantum Design International, Inc. | Frazil ice conjugate assay device and method |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| CN103217365B (zh) * | 2013-03-29 | 2015-04-08 | 电子科技大学 | 一种在线油路磨粒监测装置 |
| WO2014188149A1 (en) | 2013-05-20 | 2014-11-27 | Milan Momcilo Popovich | Holographic waveguide eye tracker |
| US9727772B2 (en) | 2013-07-31 | 2017-08-08 | Digilens, Inc. | Method and apparatus for contact image sensing |
| US9983110B2 (en) | 2013-11-04 | 2018-05-29 | The Regents Of The University Of Michigan | Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes |
| US10359736B2 (en) | 2014-08-08 | 2019-07-23 | Digilens Inc. | Method for holographic mastering and replication |
| US10241330B2 (en) | 2014-09-19 | 2019-03-26 | Digilens, Inc. | Method and apparatus for generating input images for holographic waveguide displays |
| US10423222B2 (en) | 2014-09-26 | 2019-09-24 | Digilens Inc. | Holographic waveguide optical tracker |
| US10437064B2 (en) | 2015-01-12 | 2019-10-08 | Digilens Inc. | Environmentally isolated waveguide display |
| EP3245551B1 (en) | 2015-01-12 | 2019-09-18 | DigiLens Inc. | Waveguide light field displays |
| EP3248026B1 (en) | 2015-01-20 | 2019-09-04 | DigiLens Inc. | Holographic waveguide lidar |
| US9632226B2 (en) | 2015-02-12 | 2017-04-25 | Digilens Inc. | Waveguide grating device |
| US10459145B2 (en) | 2015-03-16 | 2019-10-29 | Digilens Inc. | Waveguide device incorporating a light pipe |
| WO2016156776A1 (en) | 2015-03-31 | 2016-10-06 | Milan Momcilo Popovich | Method and apparatus for contact image sensing |
| KR101904784B1 (ko) * | 2015-09-07 | 2018-10-05 | 한국전자통신연구원 | 단일 여기 코일 기반의 비선형 마그네틱 파티클 검출 장치 및 방법 |
| CN113759555B (zh) | 2015-10-05 | 2024-09-20 | 迪吉伦斯公司 | 波导显示器 |
| WO2017134412A1 (en) | 2016-02-04 | 2017-08-10 | Milan Momcilo Popovich | Holographic waveguide optical tracker |
| EP3433659B1 (en) | 2016-03-24 | 2024-10-23 | DigiLens, Inc. | Method and apparatus for providing a polarization selective holographic waveguide device |
| JP6734933B2 (ja) | 2016-04-11 | 2020-08-05 | ディジレンズ インコーポレイテッド | 構造化光投影のためのホログラフィック導波管装置 |
| KR101904781B1 (ko) * | 2016-10-12 | 2018-10-05 | 한국전자통신연구원 | Fmmd 기술의 신호 분석을 위한 신호 송수신 방법 및 이를 이용한 장치 |
| WO2018102834A2 (en) | 2016-12-02 | 2018-06-07 | Digilens, Inc. | Waveguide device with uniform output illumination |
| US10545346B2 (en) | 2017-01-05 | 2020-01-28 | Digilens Inc. | Wearable heads up displays |
| JP7399084B2 (ja) | 2017-10-16 | 2023-12-15 | ディジレンズ インコーポレイテッド | ピクセル化されたディスプレイの画像分解能を倍増させるためのシステムおよび方法 |
| KR20250027583A (ko) | 2018-01-08 | 2025-02-26 | 디지렌즈 인코포레이티드. | 도파관 셀 내의 홀로그래픽 격자의 높은 처리능력의 레코딩을 위한 시스템 및 방법 |
| EP4517439A3 (en) | 2018-01-08 | 2025-05-14 | DigiLens Inc. | Systems and methods for manufacturing waveguide cells |
| WO2019136476A1 (en) | 2018-01-08 | 2019-07-11 | Digilens, Inc. | Waveguide architectures and related methods of manufacturing |
| CN111684362B (zh) | 2018-01-08 | 2022-03-25 | 迪吉伦斯公司 | 用于制造光学波导的方法 |
| KR102839391B1 (ko) | 2018-03-16 | 2025-07-28 | 디지렌즈 인코포레이티드. | 복굴절 제어가 통합된 홀로그래픽 도파관 및 이를 제조하는 방법 |
| US11402801B2 (en) | 2018-07-25 | 2022-08-02 | Digilens Inc. | Systems and methods for fabricating a multilayer optical structure |
| DE102018215457A1 (de) | 2018-09-12 | 2020-03-12 | Siemens Healthcare Gmbh | Anpassbare MR-Lokalspule |
| WO2020149956A1 (en) | 2019-01-14 | 2020-07-23 | Digilens Inc. | Holographic waveguide display with light control layer |
| WO2020163524A1 (en) | 2019-02-05 | 2020-08-13 | Digilens Inc. | Methods for compensating for optical surface nonuniformity |
| CN113692544B (zh) | 2019-02-15 | 2025-04-22 | 迪吉伦斯公司 | 使用集成光栅提供全息波导显示的方法和装置 |
| US20220283377A1 (en) | 2019-02-15 | 2022-09-08 | Digilens Inc. | Wide Angle Waveguide Display |
| KR20210134763A (ko) | 2019-03-12 | 2021-11-10 | 디지렌즈 인코포레이티드. | 홀로그래픽 도파관 백라이트 및 관련된 제조 방법 |
| US11112468B2 (en) | 2019-04-12 | 2021-09-07 | Western Digital Technologies, Inc. | Magnetoresistive sensor array for molecule detection and related detection schemes |
| US11609208B2 (en) | 2019-04-12 | 2023-03-21 | Western Digital Technologies, Inc. | Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles |
| US11327073B2 (en) | 2019-04-12 | 2022-05-10 | Western Digital Technologies, Inc. | Thermal sensor array for molecule detection and related detection schemes |
| CN113905822B (zh) | 2019-04-12 | 2023-09-22 | 西部数据技术公司 | 使用磁传感器阵列边合成边核酸测序 |
| US20200386947A1 (en) | 2019-06-07 | 2020-12-10 | Digilens Inc. | Waveguides Incorporating Transmissive and Reflective Gratings and Related Methods of Manufacturing |
| CN114341729A (zh) | 2019-07-29 | 2022-04-12 | 迪吉伦斯公司 | 用于使像素化显示器的图像分辨率和视场倍增的方法和设备 |
| KR102775783B1 (ko) | 2019-08-29 | 2025-02-28 | 디지렌즈 인코포레이티드. | 진공 격자 및 이의 제조 방법 |
| US11208682B2 (en) | 2019-09-13 | 2021-12-28 | Western Digital Technologies, Inc. | Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags |
| US11747329B2 (en) * | 2019-11-22 | 2023-09-05 | Western Digital Technologies, Inc. | Magnetic gradient concentrator/reluctance detector for molecule detection |
| JP2024502255A (ja) | 2020-12-21 | 2024-01-18 | ディジレンズ インコーポレイテッド | 導波路ベースのディスプレイにおけるアイグロー抑制 |
| US12399326B2 (en) | 2021-01-07 | 2025-08-26 | Digilens Inc. | Grating structures for color waveguides |
| EP4288831A4 (en) | 2021-03-05 | 2025-01-15 | Digilens Inc. | Evacuated periodic structures and methods of manufacturing |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
| GB8408529D0 (en) * | 1984-04-03 | 1984-05-16 | Health Lab Service Board | Concentration of biological particles |
| JPS6390765A (ja) * | 1986-10-03 | 1988-04-21 | Nippon Telegr & Teleph Corp <Ntt> | Ｓｑｕｉｄ免疫測定法 |
| US4913883A (en) * | 1987-07-20 | 1990-04-03 | Hitachi, Ltd. | Particle agglutination immunoassay apparatus |
| JPH0619469B2 (ja) * | 1988-04-13 | 1994-03-16 | 大和製衡株式会社 | 金属等の異物混入検出器 |
| US5001424A (en) * | 1989-02-03 | 1991-03-19 | Product Resources, Inc. | Apparatus for measuring magnetic particles suspended in a fluid based on fluctuations in an induced voltage |
| TW199858B (enExample) | 1990-03-30 | 1993-02-11 | Fujirebio Kk | |
| FR2679660B1 (fr) | 1991-07-22 | 1993-11-12 | Pasteur Diagnostics | Procede et dispositif magnetique d'analyse immunologique sur phase solide. |
| US5445970A (en) * | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| US5445971A (en) * | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| CA2123644C (en) * | 1993-05-17 | 2002-03-26 | Tomoo Saito | Method and apparatus for indirect agglutination immunoassay |
| US5486457A (en) * | 1993-08-25 | 1996-01-23 | Children's Medical Center Corporation | Method and system for measurement of mechanical properties of molecules and cells |
| US5656429A (en) * | 1994-10-03 | 1997-08-12 | Adelman; Lonnie W. | Polynucleotide and protein analysis method using magnetizable moieties |
-
1997
- 1997-11-21 US US08/975,569 patent/US6046585A/en not_active Expired - Lifetime
-
1998
- 1998-08-27 AU AU92079/98A patent/AU9207998A/en not_active Abandoned
- 1998-08-27 AT AT98944568T patent/ATE280390T1/de active
- 1998-08-27 IL IL13621198A patent/IL136211A/xx not_active IP Right Cessation
- 1998-08-27 EP EP98944568A patent/EP1036328B1/en not_active Expired - Lifetime
- 1998-08-27 WO PCT/US1998/017815 patent/WO1999027369A1/en not_active Ceased
- 1998-08-27 DK DK98944568T patent/DK1036328T3/da active
- 1998-08-27 ES ES98944568T patent/ES2232020T3/es not_active Expired - Lifetime
- 1998-08-27 BR BRPI9815566-0A patent/BR9815566B1/pt not_active IP Right Cessation
- 1998-08-27 KR KR10-2000-7005512A patent/KR100389778B1/ko not_active Expired - Fee Related
- 1998-08-27 JP JP2000522455A patent/JP3760096B2/ja not_active Expired - Lifetime
- 1998-08-27 DE DE69827158T patent/DE69827158T2/de not_active Expired - Lifetime
- 1998-08-27 CA CA002311301A patent/CA2311301C/en not_active Expired - Lifetime
- 1998-08-27 CN CN98811381A patent/CN1128365C/zh not_active Expired - Lifetime
-
2000
- 2000-05-22 US US09/576,103 patent/US6275031B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BR9815566A (pt) | 2000-10-31 |
| CN1128365C (zh) | 2003-11-19 |
| ES2232020T3 (es) | 2005-05-16 |
| HK1033771A1 (en) | 2001-09-21 |
| WO1999027369A1 (en) | 1999-06-03 |
| DK1036328T3 (da) | 2005-01-31 |
| ATE280390T1 (de) | 2004-11-15 |
| CA2311301A1 (en) | 1999-06-03 |
| US6275031B1 (en) | 2001-08-14 |
| AU9207998A (en) | 1999-06-15 |
| DE69827158D1 (de) | 2004-11-25 |
| EP1036328A1 (en) | 2000-09-20 |
| CA2311301C (en) | 2005-01-18 |
| JP3760096B2 (ja) | 2006-03-29 |
| JP2001524675A (ja) | 2001-12-04 |
| KR100389778B1 (ko) | 2003-07-02 |
| CN1279764A (zh) | 2001-01-10 |
| KR20010032302A (ko) | 2001-04-16 |
| DE69827158T2 (de) | 2005-10-13 |
| US6046585A (en) | 2000-04-04 |
| EP1036328B1 (en) | 2004-10-20 |
| IL136211A (en) | 2003-04-10 |
| IL136211A0 (en) | 2001-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9815566B1 (pt) | equipamento para o emprego de partìculas magnéticas para medição quantitativa de partìculas meta ou alvo bem como método para medir quantitativamente partìculas meta ou alvo acopladas a partìculas magnéticas. | |
| US6597176B2 (en) | Method and apparatus for making measurements of patterns of magnetic particles in lateral flow membranes and microfluidic systems | |
| CN1300598C (zh) | 用于检测和测量磁性微粒积聚物的方法和装置 | |
| RU2460058C2 (ru) | Измерение параметров агглютинации | |
| CN101627297A (zh) | 测量凝集参数 | |
| HK1033771B (en) | Apparatus and methods for employing magnetic particles for quantitative measurement of target particles | |
| HK1058550B (en) | Method and apparatus for detection and measurement of accumulations of magnetic particles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA A CLASSIFICACAO PARA INT.CL.2009.01 - G01R 33/028 Ipc: G01N 33/543 (2009.01) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/02/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
|
| B24D | Patent annual fee: restoration after fee payment | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
|
| B24D | Patent annual fee: restoration after fee payment | ||
| B25D | Requested change of name of applicant approved |
Owner name: QUANTUM DESIGN INTERNATIONAL, INC. (US) |
|
| B25G | Requested change of headquarter approved |
Owner name: QUANTUM DESIGN INTERNATIONAL, INC. (US) |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2529 DE 25-06-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |