ES2232020T3 - Metodo y dispositivo para realizar medidas cuantitativas de acumulaciones localizadas de particulas magneticas. - Google Patents
Metodo y dispositivo para realizar medidas cuantitativas de acumulaciones localizadas de particulas magneticas.Info
- Publication number
- ES2232020T3 ES2232020T3 ES98944568T ES98944568T ES2232020T3 ES 2232020 T3 ES2232020 T3 ES 2232020T3 ES 98944568 T ES98944568 T ES 98944568T ES 98944568 T ES98944568 T ES 98944568T ES 2232020 T3 ES2232020 T3 ES 2232020T3
- Authority
- ES
- Spain
- Prior art keywords
- detector
- magnetic
- magnetic field
- particles
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 25
- 230000005291 magnetic effect Effects 0.000 claims abstract description 48
- 239000002245 particle Substances 0.000 claims abstract description 43
- 230000005284 excitation Effects 0.000 claims abstract description 28
- 239000000758 substrate Substances 0.000 claims description 26
- 238000001514 detection method Methods 0.000 claims description 9
- 239000004020 conductor Substances 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 6
- 230000010355 oscillation Effects 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 3
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- 238000006243 chemical reaction Methods 0.000 claims 1
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- 230000004044 response Effects 0.000 description 7
- 239000003446 ligand Substances 0.000 description 6
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- 241000238366 Cephalopoda Species 0.000 description 4
- 230000035508 accumulation Effects 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 4
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/975,569 US6046585A (en) | 1997-11-21 | 1997-11-21 | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US975569 | 1997-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2232020T3 true ES2232020T3 (es) | 2005-05-16 |
Family
ID=25523154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98944568T Expired - Lifetime ES2232020T3 (es) | 1997-11-21 | 1998-08-27 | Metodo y dispositivo para realizar medidas cuantitativas de acumulaciones localizadas de particulas magneticas. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6046585A (enExample) |
| EP (1) | EP1036328B1 (enExample) |
| JP (1) | JP3760096B2 (enExample) |
| KR (1) | KR100389778B1 (enExample) |
| CN (1) | CN1128365C (enExample) |
| AT (1) | ATE280390T1 (enExample) |
| AU (1) | AU9207998A (enExample) |
| BR (1) | BR9815566B1 (enExample) |
| CA (1) | CA2311301C (enExample) |
| DE (1) | DE69827158T2 (enExample) |
| DK (1) | DK1036328T3 (enExample) |
| ES (1) | ES2232020T3 (enExample) |
| IL (1) | IL136211A (enExample) |
| WO (1) | WO1999027369A1 (enExample) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437563B1 (en) * | 1997-11-21 | 2002-08-20 | Quantum Design, Inc. | Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes |
| CA2370745A1 (en) * | 1999-02-17 | 2000-08-24 | Kilian Hennes | Method for representing biologically activated inductance-altering particles and device for carrying out the method |
| JP4171139B2 (ja) * | 1999-07-21 | 2008-10-22 | 住友電気工業株式会社 | 磁性体標識による免疫検査方法とその装置 |
| US6875621B2 (en) * | 1999-10-13 | 2005-04-05 | Nve Corporation | Magnetizable bead detector |
| US6743639B1 (en) | 1999-10-13 | 2004-06-01 | Nve Corporation | Magnetizable bead detector |
| JP2001147230A (ja) * | 1999-11-19 | 2001-05-29 | Hitachi Software Eng Co Ltd | バイオチップ読取装置及び標識試薬 |
| RU2166751C1 (ru) * | 2000-03-09 | 2001-05-10 | Никитин Петр Иванович | Способ анализа смеси биологических и/или химических компонентов с использованием магнитных частиц и устройство для его осуществления |
| US7241630B2 (en) * | 2000-04-10 | 2007-07-10 | Randox Laboratories, Ltd. | Paramagnetic particle detection |
| DE10020376A1 (de) * | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| US6736978B1 (en) | 2000-12-13 | 2004-05-18 | Iowa State University Research Foundation, Inc. | Method and apparatus for magnetoresistive monitoring of analytes in flow streams |
| US6518747B2 (en) * | 2001-02-16 | 2003-02-11 | Quantum Design, Inc. | Method and apparatus for quantitative determination of accumulations of magnetic particles |
| CN1136923C (zh) * | 2001-03-13 | 2004-02-04 | 张兴东 | 血磁机动磁场的充磁装置 |
| WO2003057175A2 (en) * | 2002-01-02 | 2003-07-17 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| US8697029B2 (en) * | 2002-04-18 | 2014-04-15 | The Regents Of The University Of Michigan | Modulated physical and chemical sensors |
| CN100357737C (zh) * | 2002-11-12 | 2007-12-26 | 松下电器产业株式会社 | 特异结合反应测定方法、测定装置以及其中所用试剂盒 |
| DE10309132A1 (de) * | 2003-02-28 | 2004-11-18 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel |
| DE602004022395D1 (de) | 2003-04-16 | 2009-09-17 | Sekisui Chemical Co Ltd | Verfahren zur herstellung eines partikels mit darin eingebautem magnetischen material |
| EP1685418A2 (en) * | 2003-07-30 | 2006-08-02 | Koninklijke Philips Electronics N.V. | On-chip magnetic particle sensor with improved snr |
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| US7391091B2 (en) * | 2004-09-29 | 2008-06-24 | Nve Corporation | Magnetic particle flow detector |
| JP4669259B2 (ja) * | 2004-10-15 | 2011-04-13 | 旭化成株式会社 | 被検物質分析装置及び定量方法 |
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1997
- 1997-11-21 US US08/975,569 patent/US6046585A/en not_active Expired - Lifetime
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1998
- 1998-08-27 KR KR10-2000-7005512A patent/KR100389778B1/ko not_active Expired - Fee Related
- 1998-08-27 EP EP98944568A patent/EP1036328B1/en not_active Expired - Lifetime
- 1998-08-27 CA CA002311301A patent/CA2311301C/en not_active Expired - Lifetime
- 1998-08-27 JP JP2000522455A patent/JP3760096B2/ja not_active Expired - Lifetime
- 1998-08-27 BR BRPI9815566-0A patent/BR9815566B1/pt not_active IP Right Cessation
- 1998-08-27 ES ES98944568T patent/ES2232020T3/es not_active Expired - Lifetime
- 1998-08-27 DE DE69827158T patent/DE69827158T2/de not_active Expired - Lifetime
- 1998-08-27 DK DK98944568T patent/DK1036328T3/da active
- 1998-08-27 IL IL13621198A patent/IL136211A/xx not_active IP Right Cessation
- 1998-08-27 AT AT98944568T patent/ATE280390T1/de active
- 1998-08-27 AU AU92079/98A patent/AU9207998A/en not_active Abandoned
- 1998-08-27 WO PCT/US1998/017815 patent/WO1999027369A1/en not_active Ceased
- 1998-08-27 CN CN98811381A patent/CN1128365C/zh not_active Expired - Lifetime
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2000
- 2000-05-22 US US09/576,103 patent/US6275031B1/en not_active Expired - Lifetime
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| CA2311301A1 (en) | 1999-06-03 |
| KR100389778B1 (ko) | 2003-07-02 |
| CN1128365C (zh) | 2003-11-19 |
| EP1036328B1 (en) | 2004-10-20 |
| JP3760096B2 (ja) | 2006-03-29 |
| DE69827158D1 (de) | 2004-11-25 |
| WO1999027369A1 (en) | 1999-06-03 |
| IL136211A (en) | 2003-04-10 |
| US6046585A (en) | 2000-04-04 |
| EP1036328A1 (en) | 2000-09-20 |
| JP2001524675A (ja) | 2001-12-04 |
| DE69827158T2 (de) | 2005-10-13 |
| KR20010032302A (ko) | 2001-04-16 |
| BR9815566B1 (pt) | 2011-02-08 |
| HK1033771A1 (en) | 2001-09-21 |
| DK1036328T3 (da) | 2005-01-31 |
| CN1279764A (zh) | 2001-01-10 |
| CA2311301C (en) | 2005-01-18 |
| BR9815566A (pt) | 2000-10-31 |
| IL136211A0 (en) | 2001-05-20 |
| US6275031B1 (en) | 2001-08-14 |
| AU9207998A (en) | 1999-06-15 |
| ATE280390T1 (de) | 2004-11-15 |
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